scholarly journals Pericardial mesothelioma in a German Shepherd dog: a case report

2013 ◽  
Vol 58 (No. 11) ◽  
pp. 594-598 ◽  
Author(s):  
S. Ceribasi ◽  
M. Ozkaraca ◽  
AO Ceribasi ◽  
H. Ozer
Keyword(s):  
Case Report ◽  
Periodic Acid ◽  
Cell Formation ◽  
Basal Membrane ◽  
German Shepherd ◽  
Neoplastic Cells ◽  
Periodic Acid Schiff ◽  
Yellow Colour ◽  
German Shepherd Dog ◽  
Pericardial Mesothelioma

In this case report, a diagnosis of pericardial mesothelioma in a four year old male German shepherd dog is described. The dog, which had anorexia, bloody diarrhoea, dehydration and depression and, died on day 10 of therapy, was systematically necropsied. At necropsy, approximately 1.5 litres of cloudy and bloody exudate were detected in the thoracic cavity. The parietal lamina of the pericardium was covered with multilobular nodular masses related with each other, 1 to 5 cm in diameter and grey-yellow in colour. There were proliferations characterised with grey-yellow colour and approximately 1 to 5 mm in length on visceral pleura. The presence of abscess foci with liquefied-centrum was observed when examining a section surface of the lung. The appearance of the oesophageal serosa, thoracic aorta and the thoracic section of the diaphragm were similar to pleura. A thickening was microscopically determined in the parietal lamina of the pleura and pericardium due to papillary proliferations consisting of cells similar to cubic or cylindrical epithelium. Severe lymphocyte and plasma cell infiltrations were observed in the pleural sections next to the lung. Neoplastic cells had nuclei with large eosinophilic granular cytoplasms and large vesicular and single nucleoli. Some neoplastic cells were determined to include intracytoplasmic vacuoles. The neoplastic cells contained some mitotic figures. It was observed that some tumour cells contributed to giant cell formation through integration. In periodic acid Schiff-haematoxylin (PAS-H) examinations it was determined that the pleural basal membrane maintained its integrity. Immunohistochemically, the tumour gave a weak positive reaction with anti-pancytokeratin staining while giving intense reaction with anti-vimentin staining.

scholarly journals Transient hyperammonaemia in an adult German shepherd dog : case report

1997 ◽  
Vol 68 (2) ◽  
Author(s):  
R.G. Lobetti ◽  
D.B. Miller ◽  
T. Dippenaar
Keyword(s):  
Case Report ◽  
Liver Disease ◽  
Urinary Tract ◽  
Drug Therapy ◽  
Urea Cycle ◽  
Urinary Tract Obstruction ◽  
German Shepherd ◽  
Cycle Enzyme ◽  
German Shepherd Dog ◽  
Urea Cycle Enzyme

A 3-year-old male German shepherd dog was presented with severe generalised seizures. The dog was protein-intolerant and showed severe hyperammonaemia on ammonia stimulation. The hyperammonaemic state was present for at least 6 weeks and then spontaneously resolved. No obvious cause (liver disease, portocaval shunts, urea cycle enzyme deficiencies, drug therapy or urinary tract obstruction) could be identified. It is possible that this dog had a variation of transient hyperammonaemic syndrome, described in man and recently in a juvenile Irish wolfhound, that extended into adulthood.

β-Mannosidosis in German Shepherd Dogs

2019 ◽  
Vol 56 (5) ◽  
pp. 743-748 ◽  
Author(s):  
Robert D. Jolly ◽  
Keren E. Dittmer ◽  
Dorian J. Garrick ◽  
Anastasia Chernyavtseva ◽  
Kim M. Hemsley ◽  
...  
Keyword(s):  
Nervous Tissue ◽  
Autosomal Recessive ◽  
Storage Disease ◽  
Periodic Acid ◽  
Causative Mutation ◽  
Lysosomal Storage ◽  
German Shepherd ◽  
Periodic Acid Schiff ◽  
Genomic Studies ◽  
Renal Tubular

A neurological disease was investigated in 3 German Shepherd pups from the same litter that failed to grow normally, appeared stiff, were reluctant to move, and were deaf. They developed intermittent seizures and ataxia and had proprioceptive defects. Histopathology showed severe vacuolation of neurons, astrocytes in nervous tissue, renal tubular epithelial cells, and macrophages in nervous tissue, spleen, and liver. Vacuoles appeared empty with no storage material stained by periodic acid–Schiff (PAS) or Sudan black stains, leading to a diagnosis of a lysosomal storage disease and in particular an oligosaccharidosis. Biochemical and genomic studies showed that this was β-mannosidosis, not previously diagnosed in dogs. A c.560T>A transition in exon 4 of the MANBA gene was found, which segregated in these and other family members in a manner consistent with it being the causative mutation of an autosomal recessive disease. This mutation led to substitution of isoleucine to asparagine at position 187 of the 885 amino acid enzyme, a change expected to have functional significance.

scholarly journals GAMBARAN MIKROSKOPIK GINJAL TIKUS WISTAR (RATTUS NORVEGICUS) SETELAH DIINDUKSI DENGAN GENTAMISIN

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
Poppy M Lintong ◽  
Carla F Kairupan ◽  
Priska L N Sondakh
Keyword(s):  
Body Weight ◽  
Epithelial Cells ◽  
Wistar Rats ◽  
Periodic Acid ◽  
Basal Membrane ◽  
Tubular Epithelial Cells ◽  
Periodic Acid Schiff ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Abstract: Gentamycin, a frequently used aminoglycoside antibiotics, has a nephrotoxic effect to human beings and animals. The purpose of this research was to find out the microscopic changes of wistar rat kidneys after gentamycin induction. This was an experimental study, using five adult wistar rats, divided into three groups. Group I was the control group; group II consisted of two rats, injected with gentamycin 0,3 ml/day (dose of 60 mg/kg body weight/day) intraperitoneally for seven days; and group III consisted of two rats, injected with gentamycin 0,3 ml/day intraperitoneally for 10 days. Group I and II were terminated at day-8, and group III at day-11. Their kidneys were processed for microscopic slides, stained with hematoxylin eosin and Periodic Acid Schiff. In microscopic evaluation, group II and III showed oedema, necrosis, apoptosis, and basal membrane destruction of tubular epithelial cells. Group III also showed fat vacuoles in these epithelial cells (macrovesicular fatty changes). Conclusion: wistar rats injected with gentamycin 60 mg/kg body weight/day for 7 and 10 days showed oedema, necrosis, apoptosis, and basal membrane destruction of tubular epithelial cells; and macrovesicular fatty changes after 10 days of gentamycin.Key words: gentamycin, necrosis tubular epithelial cells, fatty changesAbstrak: Gentamisin termasuk antibiotik golongan aminoglikosida berspektrum luas yang bersifat nefrotoksik terhadap manusia dan hewan. Tujuan penelitian ini untuk melihat perubahan mikroskopik struktur ginjal tikus Wistar setelah diberikan gentamisin. Metode penelitian eksperimental dengan menggunakan lima ekor tikus Wistar dewasa yang dibagi atas tiga kelompok. Kelompok I tanpa perlakuan; kelompok II terdiri dari dua ekor tikus perlakuan yang diinjeksi dengan gentamisin 0,3 ml/hari (dosis 60 mg/kgBB/hari) secara intraperitonial selama tujuh hari; dan kelompok III terdiri dari dua ekor tikus perlakuan yang diinjeksi dengan gentamisin 0,3 ml/hari secara intraperitonial selama 10 hari. Tikus Wistar kelompok I dan II diteminasi hari ke-8, sedangkan kelompok III diterminasi hari ke-11. Ginjal tikus kelompok I -III kemudian dibuat preparat histopatologik dengan pengecatan rutin hematoksilin eosin dan Periodic Acid Schiff (PAS). Hasil penelitian menunjukkan tikus Wistar perlakuan yang diberikan gentamisin 0,3 ml/hari selama 7 sampai 10 hari secara mikroskopik memperlihatkan pembengkakan, nekrosis, apoptosis, dan destruksi membrana basalis sel epitel tubulus; dan pada hari ke-10 terlihat vakuol-vakuol lemak pada sel epitel sehingga inti terdesak ke tepi (perlemakan makrovesikuler). Simpulan: pemberian gentamisin pada tikus Wistar dengan dosis 60 mg/kg BB/hari selama 7-10 hari menunjukkan pembengkakan, nekrosis, apoptosis sel epitel tubulus, dan membrana basalis tubulus rusak; dan setelah hari ke-10 juga terlihat perlemakan makrovesikuler.Kata kunci: gentamisin, nekrosis sel epitel tubulus, perlemakan makrovesikuler

Nodular Dermatofibrosis in a German Shepherd Dog: Case Report

2013 ◽  
Vol 16 (22) ◽  
pp. 1623-1625
Author(s):  
Carlos Eduardo Fonseca Al ◽  
Aline Goncalves Correa ◽  
Sabrina dos Santos ◽  
Sabryna Gouveia Ca
Keyword(s):  
Case Report ◽  
German Shepherd ◽  
German Shepherd Dog

scholarly journals Temporary remission of disseminated paecilomycosis in a German shepherd dog treated with ketoconazole : case report

2001 ◽  
Vol 72 (2) ◽  
Author(s):  
M.J. Booth ◽  
J.J. Van der Lugt ◽  
A. Van Heerden ◽  
J.A. Picard
Keyword(s):  
Case Report ◽  
Clinical Signs ◽  
Initial Diagnosis ◽  
Fungal Culture ◽  
German Shepherd ◽  
Laboratory Parameters ◽  
German Shepherd Dog ◽  
Fungal Hyphae ◽  
Carpal Joint

Disseminated mycosis caused by Paecilomyces varioti in a female German shepherd dog presented with chronic forelimb lameness is described. Radiographs of the swollen carpal joint revealed geographic lysis of the radial epiphysis. Diagnosis was based on cytological demonstration of fungal hyphae and chlamydiospores, as well as fungal culture of fluid obtained by arthrocentesis. Temporary remission was characterised by markedly improved clinical signs and laboratory parameters, following treatment with ketoconazole. The dog was euthanased 9 months after the initial diagnosis, following the diagnosis of multifocal discospondylitis. This appears to be the longest described period of temporary remission obtained with treatment in dogs with paecilomycosis. Clinical, clinicopathological and necropsy findings of this disease in another German shepherd dog are briefly described.

Monochorial-diamniotic twins in a German Shepherd Dog: A case report

2013 ◽  
Vol 13 ◽  
pp. 34-35 ◽  
Author(s):  
C. Urhausen ◽  
K. Wolf ◽  
N. Frohn ◽  
A. Bolling ◽  
A. Beineke ◽  
...  
Keyword(s):  
Case Report ◽  
German Shepherd ◽  
German Shepherd Dog

Neurologically presenting Whipple disease: case report and review of the literature

2008 ◽  
Vol 61 (10) ◽  
pp. 1140-1141 ◽  
Author(s):  
M J Buckle ◽  
R W Ellis ◽  
M Bone ◽  
H Lockman
Keyword(s):  
Case Report ◽  
Periodic Acid ◽  
Review Of The Literature ◽  
Healthy Male ◽  
Periodic Acid Schiff ◽  
Whipple Disease ◽  
Disease Case ◽  
Leg Weakness ◽  
Foamy Macrophages

A previously healthy male with subacute onset right leg weakness was suspected to have an astrocytoma as imaging showed a lesion. Subsequent biopsy showed the presence of foamy macrophages containing periodic acid-Schiff staining granules, suggesting Whipple disease as a possible diagnosis.

scholarly journals Case Report: Unusual Peritoneopericardial Diaphragmatic Hernia in an 8-Month-Old German Shepherd Dog, Associated With a Pericardial Pseudocyst and Coexisting Severe Pericardial Effusion Resulting in Right-Sided Heart Failure

2021 ◽  
Vol 8 ◽  
Author(s):  
Imke Hennink ◽  
Pia Düver ◽  
Ulrich Rytz ◽  
Felix Meneses ◽  
Melania Moioli ◽  
...  
Keyword(s):  
Heart Failure ◽  
Case Report ◽  
Pericardial Effusion ◽  
Cardiac Tamponade ◽  
Umbilical Cord ◽  
Umbilical Hernia ◽  
Surgical Repair ◽  
German Shepherd ◽  
German Shepherd Dog ◽  
Peritoneopericardial Diaphragmatic Hernia

Objective: This study aims to describe an unusual peritoneopericardial diaphragmatic hernia (PPDH) in an 8-month-old German shepherd dog, associated with a pericardial pseudocyst and coexisting severe pericardial effusion resulting in right-sided heart failure.Case Summary: An 8-month-old, male, intact, German shepherd dog, was referred for ascites. Echocardiography revealed a severe pericardial effusion with a cyst-like structure within the pericardium and consequently decompensated right-sided heart failure. The ascites was secondary to right-sided heart failure (cardiac tamponade). Computed tomography (CT) of the thorax and abdomen was performed and showed PPDH with severe pericardial effusion and presence of a pericardial cyst-like structure; xyphoid cleft and Y-shaped seventh sternebra; and mild thickening along the cranioventral abdominal wall consistent with scar tissue from the previous umbilical hernia surgical repair. During surgery, the PPDH was corrected, and it was revealed that the remnant of the umbilical cord passed through it, into the pericardium. The cyst-like structure was successfully resected and sent for pathology. Histopathology showed signs of a chronic suppurative inflammation, with absence of a mesothelial or endothelial wall layer, thus consistent with a pseudocyst. Based on tomographic and surgical findings, it is suspected that the pseudocyst, together with the pericardial effusion, evolved by an inflammation of the remnant of the umbilical cord during the umbilical hernia surgical repair 1 month prior to presentation. The underlying PPDH most likely favored the development of the pericardial pseudocyst. However, due to prior antibiotic therapy initiated by the private vet, an infectious origin cannot be ruled out completely.New or Unique Information Provided: There are a few case reports describing PPDH and/or pericardial pseudocysts in veterinary patients, but the current case report is unique, since it describes PPDH associated with a pericardial pseudocyst and coexisting severe pericardial effusion resulting in cardiac tamponade. As far as the authors know, such a case has not been described in veterinary medicine before.

scholarly journals Histologic and inflammatory lamellar changes in horses with oligofructose-induced laminitis treated with a CXCR1/2 antagonist

2016 ◽  
Vol 36 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Leonardo R. de Lima ◽  
Heloisa M.F. Mendes ◽  
Frederico M. Soriani ◽  
Danielle G. de Souza ◽  
Geraldo Eleno S. Alves ◽  
...  
Keyword(s):  
Chemokine Receptors ◽  
Periodic Acid ◽  
Previous History ◽  
Basal Membrane ◽  
Treated Group ◽  
Periodic Acid Schiff ◽  
Chemokine Signaling ◽  
Mixed Breed ◽  
History Of ◽  
Membrane Changes

Abstract: With the hypothesis that blocking chemokine signaling can ameliorate acute laminitis, the aim was to evaluate the therapeutic effect of intravenous DF1681B, a selective antagonist for CXCR1 and CXCR2 (chemokine receptors), in an oligofructose equine laminitis model. To twelve mixed breed clinically healthy hoses with no previous history of hoof-related lameness was administered oligofructose (10g/kg given by nasogastric tube) and divided into two groups: treated (intravenous DF1681B at 30mg/kg 6, 12, 18, and 24h after oligofructose) and non-treated groups. Laminar biopsies were performed before and 12, 36, and 72h after administering oligofructose. Samples were stained with periodic acid-Schiff (PAS) and scored from 0 to 6 according to epidermal cell and basal membrane changes. The IL-1β, IL-6, and CXCL1 RNA expressions were determined by RT-PCR. Parametric and non-parametric tests were used to compare times within each group (P<0.05). The PAS grades and IL-1β and IL-6 RNA expression increased in the non-treated group, but remained constant in the treated horses. In conclusion, DF1681B therapy reduced laminar inflammation and epidermal deterioration in treated horses. CXCR1/2 blockage should be considered therapeutically for equine acute laminitis.

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