scholarly journals Sulfonamide Use During the First Trimester of Pregnancy and Risk of Selected Congenital Anomalies Among Live Births

2016 ◽  
Vol 3 (3) ◽  
pp. 202-203
Author(s):  
Craig Hansen ◽  
Susan E Adrade ◽  
Heather Freiman ◽  
Sascha Dublin ◽  
Katie Haffenreffer ◽  
...  
Keyword(s):  
Congenital Anomalies ◽  
First Trimester ◽  
Live Births ◽  
First Trimester Of Pregnancy

scholarly journals Investigation of Metronidazole Use during Pregnancy and Adverse Birth Outcomes

2012 ◽  
Vol 56 (9) ◽  
pp. 4800-4805 ◽  
Author(s):  
Catherine A. Koss ◽  
Dana C. Baras ◽  
Sandra D. Lane ◽  
Richard Aubry ◽  
Michele Marcus ◽  
...  
Keyword(s):  
New York ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Congenital Anomalies ◽  
New York State ◽  
Multivariable Analysis ◽  
Preterm Births ◽  
First Trimester ◽  
First Trimester Of Pregnancy

ABSTRACTTo assess whether treatment with metronidazole during pregnancy is associated with preterm birth, low birth weight, or major congenital anomalies, we conducted chart reviews and an analysis of electronic data from a cohort of women delivering at an urban New York State hospital. Of 2,829 singleton/mother pairs, 922 (32.6%) mothers were treated with metronidazole for clinical indications, 348 (12.3%) during the first trimester of pregnancy and 553 (19.5%) in the second or third trimester. There were 333 (11.8%) preterm births, 262 (9.3%) infants of low birth weight, and 52 infants (1.8%) with congenital anomalies. In multivariable analysis, no association was found between metronidazole treatment and preterm birth (odds ratio [OR], 1.02 [95% confidence interval [CI], 0.80 to 1.32]), low birth weight (OR, 1.05 [95% CI, 0.77 to 1.43]), or treatment in the first trimester and congenital anomalies (OR, 0.86 [0.30 to 2.45]). We found no association between metronidazole treatment during the first or later trimesters of pregnancy and preterm birth, low birth weight, or congenital anomalies.

scholarly journals Metformin Exposure in First Trimester of Pregnancy and Risk of All or Specific Congenital Anomalies

2019 ◽  
Vol 39 (1) ◽  
pp. 23-24
Author(s):  
J.E. Given ◽  
M. Loane ◽  
E. Garne ◽  
M.C. Addor ◽  
M. Bakker ◽  
...  
Keyword(s):  
Congenital Anomalies ◽  
First Trimester ◽  
First Trimester Of Pregnancy

Pregnancy and fetal outcomes following natalizumab exposure in pregnancy. A prospective, controlled observational study

2014 ◽  
Vol 21 (2) ◽  
pp. 198-205 ◽  
Author(s):  
Neda Ebrahimi ◽  
Sandra Herbstritt ◽  
Ralph Gold ◽  
Lilyana Amezcua ◽  
Gideon Koren ◽  
...  
Keyword(s):  
Safety Data ◽  
First Trimester ◽  
Disease Modifying Drugs ◽  
Live Births ◽  
Significant Difference ◽  
Comparison Groups ◽  
Healthy Control ◽  
Fetal Safety ◽  
First Trimester Of Pregnancy ◽  
Adverse Pregnancy

Background: Safety data on first-trimester natalizumab exposure are scarce, as natalizumab is usually withdrawn three months before pregnancy. Objective: The objective of this paper is to investigate the fetal safety of exposure to natalizumab (Tysabri®) during the first trimester of pregnancy using disease-matched (DM) and healthy control (HC) comparison groups. Methods: A total of 101 German women with RRMS exposed to natalizumab during the first trimester of pregnancy were identified. Birth outcomes in the exposed group were compared to a DM group ( N = 78) with or without exposure to other disease-modifying drugs, and an HC group ( N = 97). Results: A total of 77, 69 and 92 live births occurred in the Exposed, DM and HC groups, respectively. The rates of major malformations ( p = 0.67), low birth weight (<2500 grams) ( p = 1.0) and premature birth ( p = 0.37) did not differ among groups. Higher miscarriage rates ( p = 0.002) and lower birth weights ( p = 0.001) occurred among the Exposed and DM groups, as compared to the HC; however, there was no significant difference between the Exposed and DM groups. Conclusion: Exposure to natalizumab in early pregnancy does not appear to increase the risk of adverse pregnancy outcomes in comparison to a DM group not exposed to natalizumab.

scholarly journals Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control study

BMJ ◽  
2018 ◽  
pp. k2477 ◽  
Author(s):  
Joanne E Given ◽  
Maria Loane ◽  
Ester Garne ◽  
Marie-Claude Addor ◽  
Marian Bakker ◽  
...  
Keyword(s):  
Congenital Anomalies ◽  
Case Control Study ◽  
First Trimester ◽  
Case Control ◽  
First Trimester Of Pregnancy ◽  
Control Study

ECHO 9 VIRUS INFECTION AND CONGENITAL ABNORMALITIES: A NEGATIVE REPORT

PEDIATRICS ◽  
1962 ◽  
Vol 29 (2) ◽  
pp. 261-269
Author(s):  
Herman Kleinman ◽  
James T. Prince ◽  
Wayne E. Mathey ◽  
Abraham B. Rosenfleld ◽  
Jacob E. Bearman ◽  
...  
Keyword(s):  
Public Health ◽  
Cord Blood ◽  
Congenital Anomalies ◽  
First Trimester ◽  
Public Health Nurses ◽  
Congenital Defects ◽  
First Year ◽  
Live Births ◽  
Echo Virus ◽  
First Year Of Life

Approximately 200,000 residents of Hennepin and Ramsey counties in Minnesota developed an aseptic meningitis syndrome during the summer and fall of 1957. One fourth of the patients had a maculopapular rash very similar to that of rubella. The etiologic agent was found to be ECHO virus type 9. This epidemic provided an opportunity to determine whether infection with this virus during the first trimester of pregnancy could be related to the appearance of congenital defects such as occurs in rubella. From March 3 through June 13, 1958, 10,109 liveborn infants and 105 stillborn infants were delivered in the 12 Minneapolis and 10 St. Paul hospitals serving these two counties. All mothers had been exposed to the 1957 epidemic. Public health nurses interviewed 9,990 mothers in the hospitals within a few days after birth for detailed histories of infection during pregnancy. On the basis of these interviews it was judged that 6.5% of the mothers had historic evidence of an ECHO 9 infection during pregnancy. Serologic evidence of ECHO 9 infection in the recent past was present in 19% of 853 antibody titrations carried out on cord blood specimens from abnormals and normals (controls). To discover anomalies not recognized at birth, a follow-up was carried out 11 to 12 months later by the public health nurses by telephone interviews of some 9,600 mothers. There were 356 major and minor congenital anomalies recognized during the first year of life. An additional 63 hernias were diagnosed during the first year for a total of 419 anomalies found in 10,109 live births in the study. This rate of 41.4 total anomalies per 1,000 live births, or 4.1%, is well within the rates reported by other authors. A total of 39.6% of the anomalies were diagnosed at birth and 60.4% during the first year of life. Of the anomalies, 61% occurred in males and 39% in females; 1.5% of the infants had major abnormalities and 0.74% died as a result of these anomalies during their first year of life. There were 105 stillbirths recorded, or 10.4 per 1,000 live births. This compares with a rate of 13.6 for Hennepin and Ramsey counties for the year. Among the stillbirths, 11.4% died from congenital anomalies, in comparison with 10.95% statewide for the year. A statistical analysis of the findings which compares the ECHO 9 antibody titer distributions in the cord blood of the normal and the abnormal infants does not justify the conclusion that ECHO 9 infection in the mother increases the incidence of congenital anomalies in the offspring. The only exception to this generalization is in the case of skin abnormalities, where there is a statistical suggestion of association.

scholarly journals Metformin Exposure in the First Trimester of Pregnancy and Risk of All or Specific Congenital Anomalies

2018 ◽  
Vol 73 (11) ◽  
pp. 619-620
Author(s):  
Joanne E. Given ◽  
Maria Loane ◽  
Ester Garne ◽  
Marie-Claude Addor ◽  
Marian Bakker ◽  
...  
Keyword(s):  
Congenital Anomalies ◽  
First Trimester ◽  
First Trimester Of Pregnancy

scholarly journals Congenital anomalies: Prospective study of pattern and associated risk factors in infants presenting to a tertiary hospital in Anambra State, South-east Nigeria

1970 ◽  
Vol 44 (2) ◽  
pp. 76-80
Author(s):  
OH Ekwunife ◽  
CC Okoli ◽  
JO Ugwu ◽  
VI Modekwe ◽  
AC Ekwesianya
Keyword(s):  
Risk Factors ◽  
Home Environment ◽  
Congenital Anomalies ◽  
First Trimester ◽  
Tertiary Hospital ◽  
Base Stations ◽  
Pregnancy Risk ◽  
Anambra State ◽  
First Trimester Of Pregnancy ◽  
Associated Risk Factors

Background: Contemporary understanding of the pattern of congenital anomalies is both important in its clinical management as well as in improving the overall health of the community.Methodology: All infants presenting from January to December 2102 at the centre were prospectively studied.Results: A total of 5010 infants were screened, of which 108 have congenital anomalies giving a prevalence of 2.2%. Major anomalies were noted in 101 (93.5%) infants. Only two (1.9%) were preterm. Consanguineous relationship was observed in 2 (1.9%) cases. Pre natal Ultrasound scan was done in 33(30.8%), but in only 7 (6.5%) was any anomaly detected Onitsha, a densely populated urban area contributed 45(42%) of the cases. Only 7(6.5%) of the mothers took herbal prescriptions in the first trimester of pregnancy. Risk of anomaly progressively rises, reaching a peak of 48% in the maternal age group of 26-30 years and drops steadily after. Gastrointestinal tract anomalies were most common (no. =28, 25.9%). Residences close to dump sites, telecom masts/base stations, electricity cables, industries and heavy motorised highways contributed to risk factors in 9-12 % of cases.Conclusion: More of younger mothers were affected with gastro intestinal malformations predominating. The location of home environment is a potential risk factor that will require further characterisation.Key words: Congenital disorder, Malformations, Birth defects, Risk factors, Epidemiology, Nigeria, Anambra

Aspirin consumption during the first trimester of pregnancy and congenital anomalies: A meta-analysis

2002 ◽  
Vol 187 (6) ◽  
pp. 1623-1630 ◽  
Author(s):  
Eran Kozer ◽  
Shekoufeh Nikfar ◽  
Adriana Costei ◽  
Rada Boskovic ◽  
Irena Nulman ◽  
...  
Keyword(s):  
Congenital Anomalies ◽  
Meta Analysis ◽  
First Trimester ◽  
First Trimester Of Pregnancy
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