scholarly journals Frequency of the antipsychotic therapy acute side effects in the treatment of acute psychosis

2002 ◽  
Vol 2 (1-2) ◽  
pp. 16-28
Author(s):  
Svjetlana Loga-Zec ◽  
Irfan Zulić ◽  
Nedžad Mulabegović ◽  
Ismet Cerić ◽  
Slobodan Loga ◽  
...  
Keyword(s):  
Side Effects ◽  
Prevalence Rate ◽  
Alternative Hypothesis ◽  
Statistical Tests ◽  
Psychiatric Clinic ◽  
Clinical Impression ◽  
Antipsychotic Therapy ◽  
Psychiatric Interview ◽  
Neuroleptic Therapy ◽  
Acute Side Effects

Antipsychotic drugs produce a wide spectrum of physiological actions. Some of these effects differ among the various classes of antipsychotics. This medications have indications in the treatment of acute psychotic disorders. The main goal of this investigation was to determine the incidence and prevalence of the neuroleptic therapy acute side effects. The reason for this epidemiological investigation performing was the lack of knowledge of the exact neuroleptic therapy side effects incidence. Qualitative study on this problem has not been performed yet. Antipsychotic therapy side effects prevalence rate according to the literature data is ranging from 24% to 74%. Different prevalence rate is a consequence of different antipsychotic drug usage, different drug administration method and different side effects identification. On account of all these facts, we put the hypothesis on the correlation between the antipsychotic therapy and occurred side effects. Our experiment included all patients hospitalised from December 31st 1999 to January 31st 2000 in Intensive Care Unit of Biological Psychiatry Department of Psychiatric Clinic in Sarajevo. All patients were divided in three groups according to the applied therapy. All of them met ICD-10 criteria for schizophrenia (F20-29). During our study the following examinations were performed: psychiatric interview, BRPS, scale of side effects, psychophysiological tests, general clinical impression, scale of appetite, carbon hydrate needs scale. Psychiatric and statistical evaluations were done as well. The evaluation of our examination is showing successful results in all groups of patients. The improvement of psychopathological symptoms was insignificant. Reported side effects were minimal with low incidence rate and relatively high prevalence rate. Statistical tests were calculated from the obtained data after what the null hypothesis was rejected. Consequently, an alternative hypothesis was confirmed and it indicated that the acute side effectsincidence and prevalence were within the range of expectation. Intensity of the recorded side effects was moderate to mild. On the basis of the obtained data, it has been concluded that applied antipsychotic agents did not induce more psychophysiological function impairments in the treated patients. Psychophysiological functions remained in physiological range limits and their changes were not significant. Neuroleptic therapy side effects were minimal, meaning no toxic signs or therapy discontinuations were recorded.

Functional morphology of gonads under conditions of antipsychotic therapy

2014 ◽  
Vol 60 (4) ◽  
pp. 30-34
Author(s):  
B P Volkov
Keyword(s):  
Side Effects ◽  
Functional Morphology ◽  
Antipsychotic Agents ◽  
Antipsychotic Treatment ◽  
Hormonal Activity ◽  
Antipsychotic Therapy ◽  
Functional Disturbances ◽  
Neuroleptic Therapy

Gonadotoxic side effects of antipsychotic agents are known to cause serious disturbances in both germinative and endocrine testicular functions. The hormonal activity of the testes undergo undulating changes whereas the germinative function progressively decreases from the onset of neuroleptic therapy. The morphological and functional disturbances in the testicles are especially well pronounced after 10 years of antipsychotic treatment. The morphofunctional changes in the ovaries become apparent from the very beginning of antipsychotropic therapy; they are indicative of the progressive impairment of reproductive and endocrine functions of the female gonads.

Effect of aromatherapy massage with orange essential oil on postoperative pain after cesarean section: a randomized controlled trial

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Seyedmohammad Mirhosseini ◽  
Ali Abbasi ◽  
Nastaran Norouzi ◽  
Fatemeh Mobaraki ◽  
Mohammad Hasan Basirinezhad ◽  
...  
Keyword(s):  
Side Effects ◽  
Essential Oil ◽  
Cesarean Section ◽  
Statistical Tests ◽  
Intervention Group ◽  
Nursing Intervention ◽  
Anxiety Score ◽  
Control Group ◽  
And Control ◽  
Orange Essential Oil

Abstract Objectives Many women in recent years have been willing to undergo puncture surgery for childbirth, which, like other surgeries, has physical and psychological side effects such as incision, infertility, chronic pain, and anxiety. Therefore, it is important to reduce and improve these side effects. The aim of this study was to determine the effect of foot massage with orange essential oil on pain and anxiety in women undergoing cesarean section. Methods This randomized clinical trial study was conducted in 2019 on 80 women referred to Bahar Shahroud Hospital after cesarean section surgery. The samples were divided into two groups by intervention (foot massage with orange essential oil) and control (foot massage without orange essential oil). The Spielberger scale was used to determine anxiety scores after cesarean section. In the intervention group, the feet were massaged with orange essential oil, and in the control group, the orange essential oil massage was performed without oil. Anxiety before, immediately after, and 60 min after the intervention was measured and evaluated in both groups. Data analysis was performed using descriptive and inferential statistics. Significant levels were considered for all statistical tests (p<0.05). Results The anxiety score before the intervention in the two groups of intervention and control was 57.12 ± 3.12 and 57.07 ± 3.54, respectively, which were not significantly different, but immediately after the intervention, the anxiety scores in both groups decreased significantly so that there was a further decrease in the intervention group (52.10 ± 4.75 and 56.02 ± 3.77), 1 h after the intervention, the anxiety score in the intervention group decreased compared to the previous stage and increased in the control group (50.40 ± 3.74 and 56.85 ± 4.27). Conclusions Foot massage with orange essential oil can probably be effective as a proper nursing intervention in reducing anxiety after cesarean section surgery.

Do Acute Side-Effects During Radiotherapy Predict Tumour Response in Rectal Carcinoma?

1994 ◽  
Vol 33 (4) ◽  
pp. 409-413 ◽  
Author(s):  
Olav Dahl ◽  
Arild Horn ◽  
Olav Mella
Keyword(s):  
Side Effects ◽  
Rectal Carcinoma ◽  
Tumour Response ◽  
Acute Side Effects

scholarly journals Abnormalities in Glucose Blood Level during Antipsychotic Treatment in Schizophrenia Patients

2021 ◽  
Vol 9 (T3) ◽  
pp. 340-344
Author(s):  
Faisal Idrus ◽  
Theodorus Singara ◽  
Dwiwahyu Sunarto ◽  
Saidah Syamsuddin ◽  
Sonny T. Lisal
Keyword(s):  
Side Effects ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Fasting Blood Glucose ◽  
Antipsychotic Treatment ◽  
Antipsychotic Therapy ◽  
Potential Health ◽  
Sugar Levels ◽  
Risperidone Group ◽  
Haloperidol Group

Background: Schizophrenia is one of the mental disorder with many problematic issues, in both psychologically and socially. This disease requires provision of long-term antipsychotic therapy, hence could rise other potential health problems. Antipsychotic treatment can cause serious glucometabolic side-effects, including type 2 diabetes and hyperglycemic emergency. Recent attention has also been focused on antipsychotic-induced hyperglycemic emergencies experienced by new users of typical and atypical antipsychotic. Patients treated with atypical APDs have ~10 times higher risk in developing hyperglycaemic emergencies. In our pre-eliminary study, hyperglycemia condition in new patients occurs in four  in seven patients who received typical and atypical antipsychotics. This condition is often overlooked and is not routinely evaluated. Moreover, it can develop into diabetes and increase the risk of morbidity and mortality in schizophrenia patients. In this study, we would like to determine the acute effects of metabolic (hyperglycemia) in patients treated with antipsychotic (Risperidone and Haloperidol) Measurement of blood sugar levels was performed in groups treated with haloperidol (N = 15) and treated with risperidone (N = 15). Plasma samples were taken at the beginning of treatment, in week IV, and in week VIII. The measurement of glucose levels was performed after meal and in early morning before breakfast (fasting blood glucose level 8 hours). Results: The blood sugar level after meals was significantly higher in the Risperidone group compared to the Haloperidol group  (p <0.001) after IV and VIII weeks. Meanwhile, the fasting blood sugar level was significantly higher in the Risperidone group compared to the Haloperidol group after VIII weeks of treatment ( p <0.001). Conclusions: Both antipsychotics can cause an increase in blood sugar levels. Treatment with Risperidone significantly increased the blood sugar levels compared to treatment with haloperidol. Measurement of blood sugar level is needed to monitor the metabolic effect of antipsychotic, especially in patients treated with Risperidone. It is necessary to have dietary regulation and physical activities to prevent undesired metabolic side effects.

scholarly journals Health-related factors on tobacco consumption in Turkey

2020 ◽  
Vol 50 (5) ◽  
Author(s):  
Nuray Demir ◽  
Abdulbaki Bilgic ◽  
Okan Demir ◽  
Adem Aksoy
Keyword(s):  
Prevalence Rate ◽  
Statistical Tests ◽  
Tobacco Consumption ◽  
Hurdle Model ◽  
Related Factors ◽  
Consumption Level ◽  
Double Hurdle Model ◽  
Hyperbolic Sine ◽  
Health Related ◽  
Double Hurdle

ABSTRACT: In this study, we analyzed the role of individuals’ health-related factors along with socio-demographic and economic characteristics on both the likelihood of tobacco consumption and quantity demanded levels using two competitive econometric methods: double hurdle model versus hyperbolic sine double-hurdle model. Statistical tests confirmed the dependency errors between the prevalence rate of smoking and the consumption level, whilst the inverse-hyperbolic sine double-hurdle model data fits best in describing the normalization of the data and the two data generating processes: the probability and consumption levels of cigarettes. Also, the variance-covariance of the selected model as a function of additional exogenous variables are confirmed, while the error terms between the likelihood to smoke and the consumption levels are positive and statistically significant, indicating that holding control variables fixed, the uncontrolled variables out of the system that increase the prevalence rate of smoking also boost the consumption level, or vice versa. Many individual disease variables are significant in both equations, breaking new grounds in literature for identifying how both the prevalence rate of smoking and amount have shaped.

Rapid cardiovascular effects of dexamethasone in rabbits with meconium-induced acute lung injury

2008 ◽  
Vol 86 (11) ◽  
pp. 804-814 ◽  
Author(s):  
Daniela Mokra ◽  
Ingrid Tonhajzerova ◽  
Juraj Mokry ◽  
Anna Drgova ◽  
Maria Petraskova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Side Effects ◽  
Rabbit Model ◽  
Intratracheal Instillation ◽  
Cardiovascular Effects ◽  
Meconium Aspiration Syndrome ◽  
Cardiovascular Side Effects ◽  
Acute Side Effects ◽  
Systemic Glucocorticoids

Glucocorticoids may improve lung function in newborns with meconium aspiration syndrome (MAS), but information on the acute side effects of glucocorticoids in infants is limited. In this study using a rabbit model of MAS, we addressed the hypothesis that systemic administration of dexamethasone causes acute cardiovascular changes. Adult rabbits were treated with 2 intravenous doses of dexamethasone (0.5 mg/kg each) or saline at 0.5 h and 2.5 h after intratracheal instillation of human meconium or saline. Animals were oxygen-ventilated for 5 h after the first dose of treatment. Blood pressure, heart rate, and short-term heart rate variability (HRV) were analyzed during treatment, for 5 min immediately after each dose, and for the 5 h of the experiment. In the meconium-instilled animals, dexamethasone increased blood pressure, decreased heart rate, increased HRV parameters, and caused cardiac arrhythmia during and immediately after administration. In the saline-instilled animals, the effect of dexamethasone was inconsistent. In these animals, the acute effects of dexamethasone on blood pressure and cardiac rhythm were reversed after 30 min, whereas heart rate continued to decrease and HRV parameters continued to increase for 5 h after the first dose of dexamethasone. These effects were more pronounced in meconium-instilled animals. If systemic glucocorticoids are used in the treatment of MAS, cardiovascular side effects of glucocorticoids should be considered.

Acute Side Effects of Radiation Therapy

2017 ◽  
Author(s):  
Ainaz Sourati ◽  
Ahmad Ameri ◽  
Mona Malekzadeh
Keyword(s):  
Radiation Therapy ◽  
Side Effects ◽  
Acute Side Effects ◽  
Effects Of Radiation

Varicella Vaccine Reflux

PEDIATRICS ◽  
1992 ◽  
Vol 89 (2) ◽  
pp. 353-354
Author(s):  
MARK F. MANGANO
Keyword(s):  
United States ◽  
Side Effects ◽  
Clinical Data ◽  
Varicella Vaccine ◽  
Acute Side Effects

To the Editor.— I have just completed reading the article published in Pediatrics on the live, attenuated varicella vaccine (Varivax), written by the groups from Merck Sharp & Dohme and Biogen Incorporated.1 I was quite impressed with their clinical data concerning the relatively small number of acute side effects and the apparent immunogenicity of the vaccine. Although I'm sure that more studies are in progress, on the basis of the above data, one would think that United States licensure should be right around the corner.

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