scholarly journals Preparation and Physical Stability Evaluation of Palm Oil-Based Nanoemulsion as a Drug Delivery System for Propofol

2018 ◽  
Vol 16 (02) ◽  
pp. 5-13 ◽  
Author(s):  
BAYU EKO PRASETYO ◽  
NORAZRINA AZMI ◽  
AHMAD FUAD SHAMSUDDIN
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Palm Oil ◽  
Physical Stability ◽  
Stability Evaluation

A Review on Microsponge Drug Delivery System

2020 ◽  
Vol 10 (2) ◽  
pp. 53-59
Author(s):  
Bharathi M ◽  
Mullaikodi O ◽  
Rajalingam D ◽  
Gnanasekar N ◽  
Kesavan M
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Physical Stability ◽  
Current Investigation ◽  
Considerable Time ◽  
Polymeric Structure ◽  
Point Of Interest ◽  
Time Period ◽  
Time Specific

A Microsponge (MS) is an extremely interconnected, permeable, polymeric structure that involves permeable microparticles trapping and discharging through the skin for a considerable time period. Drug delivery system (DDS) offer extended discharge with less degradation, improved physical stability along with better tolerance. The main intend of any DDS is to achieve the required amount of drug in plasma to produce the desired therapeutic and non-poisonous effect over a prolonged period of time. Specific methods for preparing MS were reviewed in this current investigation, and their pharmaceutical implementations were signed. MS have major DDS point of interest. It also improves stability, increased flexibility in formulation and increased elegance. In fact, numerous studies have reported that MS supplies are not allergic, mutagenic, and poisonous. MS creativity is used in products such as sunscreen, prescription, cosmetics, and OTC skin care. This inquiry primarily focuses on the different methods used to identify, plan and exploit MS.

Novel Self-Micro Emulsifying Drug Delivery System for safe intra muscular delivery with improved pharmacodynamics and pharmacokinetics

2021 ◽  
Vol 18 ◽  
Author(s):  
Subheet Kumar Jain ◽  
Neha Panchal ◽  
Amrinder Singh ◽  
Shubham Thakur ◽  
Navid Reza Shahtaghi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Inflammatory Diseases ◽  
Diclofenac Sodium ◽  
Physical Stability ◽  
In Vivo Studies ◽  
High Concentration

Background: Diclofenac sodium (DS) injection is widely used in the management of acute or chronic pain and inflammatory diseases. It incorporates 20 % w/v Transcutol-P as a solubilizer to make the stable injectable formulation. However, the use of Transcutol-P in high concentration leads to adverse effects such as severe nephrotoxicity, etc. Some advancements resulted in the formulation of an aqueous based injectable but that too used benzyl alcohol reported to be toxic for human use. Objective: To develop an injectable self-micro emulsifying drug delivery system (SMEDDS) as a novel carrier of DS for prompt release with better safety and efficacy. Methods: A solubility study was performed with different surfactants and co-surfactants. The conventional stirring method was employed for the formulation of SMEDDS. Detailed in vitro characterization was done for different quality control parameters. In vivo studies were performed using Wistar rats for pharmacokinetic evaluation, toxicological analysis, and analgesic activity. Results: The optimized formulation exhibited good physical stability, ideal globule size (156±0.4 nm), quick release, better therapeutics, and safety, increase in LD50 (221.9 mg/kg) to that of the commercial counterpart (109.9 mg/kg). Further, pre-treatment with optimized formulation reduced the carrageenan-induced rat paw oedema by 88±1.2 % after 4 h, compared to 77±1.6 % inhibition with commercial DS formulation. Moreover, optimized formulation significantly (p<0.05) inhibited the pain sensation in the acetic-acid induced writhing test in mice compared to its commercial equivalent with a better pharmacokinetic profile. Conclusion: The above findings confirmed that liquid SMEDDS could be a successful carrier for the safe and effective delivery of DS

scholarly journals Effect of Vegetable Oil on Self-Nanoemulsifying Drug Delivery System of Dayak Onion [Eleutherine palmifolia (L.) Merr.] Extract using Hydrophilic-lipophilic Balance Approach: Formulation, Characterization

2020 ◽  
Vol 10 (02) ◽  
pp. 210-216
Author(s):  
Esti Hendradi ◽  
Rahmi Annisa ◽  
Mochammad Yuwono
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Olive Oil ◽  
Drug Delivery System ◽  
Delivery System ◽  
Palm Oil ◽  
Tween 20 ◽  
Hydrophilic Lipophilic Balance ◽  
Selection Of ◽  
Optimal Formula

Eleutherine palmifolia is a typical plant of Kalimantan that has been empirically used by the Dayak people as a cure for various types of diseases. Self-nanoemulsifying drug delivery system (SNEDDS) is a drug delivery system that can be developed for onion Dayak to improve its absorption profile. Selection of oil phase, surfactant, and cosurfactant have an essential role in SNEDDS of Dayak onion. The aims of this study to determine the effect of the use of vegetable oils on SNEDDS using the HLB approach. Several 40 formulations in each oil phase with HLB ranging between 11 and 15 were screened to acquire stable SNEDDS composition without the presence of phase separation. Formulas optimal obtained F33 (HLB 14) using olive oil at a ratio formula of 1:7:2. F29 (HLB 14), using VCO at a formula ratio of 1:7:2. F14 (HLB 14) uses palm oil at a ratio formula of 2:7:1. The result showed that the optimal formula F33 (olive oil) with 58 nm of the particle size, 84.32 ± 0.00 of the transmittance percentage, 22.00 ± 0,18 of the emulsification time. Formula F29 (VCO) with 19.48 nm of the particle size, 91.78 ± 0.02 of the transmittance percentage, 43.00 ± 0.16 of the emulsification time. Formula F14 (palm oil) with 102 nm of the particle size, 90.93 ± 0.02 of the transmittance percentage, 110 ± 0.34 of the emulsification time. The optimal formula that has good characteristics and stability is the F29 (VCO) formula using tween 20/transcutol as the surfactant, PEG 400, as co-surfactant at a ratio formula of 1:7:2.

scholarly journals Preparation of Squalene Oil-Based Emulsion Adjuvants Employing a Self-Emulsifying Drug Delivery System and Assessment of Mycoplasma hyopneumoniae-Specific Antibody Titers in BALB/c Mice

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 667
Author(s):  
Rakesh Bastola ◽  
Jo-Eun Seo ◽  
Taekwang Keum ◽  
Gyubin Noh ◽  
Jae Woong Choi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Specific Antibody ◽  
Physical Stability ◽  
Mycoplasma Hyopneumoniae ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus ◽  
Droplet Sizes ◽  
Antibody Titers

In this study, a self-emulsifying drug delivery system (SEDDS) was employed to prepare novel squalene oil-based emulsion adjuvants. Deionized water, 0.01% and 0.02% (w/v) carbomer solutions of C-971P NF and C-940 grades were used to prepare emulsions containing 3%, 5% and 10% of squalene oil. Altogether 15 candidate emulsions were prepared and used as adjuvants for the delivery of a combination vaccine containing a porcine circovirus type 2 (PCV2) antigen and inactivated Mycoplasma hyopneumoniae (J101 strain) antigen. Most of the emulsions showed droplet sizes in the submicron range and maintained zeta potential values between −40 mV to 0 mV for six months, indicating good physical stability as a vaccine adjuvant. Emulsion-based candidate adjuvants prepared with SEDDS technology stimulated IgG, IgG1 and IgG2a like a currently commercially available adjuvant, Montanide ISATM 201, and they were safe and their Mycoplasma hyopneumoniae-specific antibody titers were considered as comparable with that of Montanide ISATM 201.

Self-Emulsifying Drug Delivery System (SEDDS) and its Pharmaceutical Applications

2020 ◽  
Vol 7 (3) ◽  
pp. 206-224
Author(s):  
Sankha Bhattacharya
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Selection Criteria ◽  
Physical Stability ◽  
Aqueous Solubility ◽  
Dosage Forms ◽  
Oral Dosage ◽  
New Approach ◽  
Subject Variability

Poor aqueous solubility, oral bioavailability, inter, and inter-subject variability, and physical stability have always been a concern for pharmaceutical formulation scientists while formulating an oral dosage form. Self-Emulsifying Drug Delivery System (SEDDS) is a promising new approach to mitigating those potential problems. The main advantages of SEDDS are that it increases the solubility and decreases the bio-degradation of lipophilic drugs. Mostly BCS II & IV Class drugs are preferable. SEDDS is an admixture of drugs, oil, surfactants, cosolvents, and stabilizers. With little energy input, they form (o/w) microemulsion within the G.I. lumen. The present review discusses the various formulations of SEDDS, selection criteria for surfactants, oils, Patentable SEDDS dosage forms, solidification technique, characterization, and future approaches.

scholarly journals TOPICAL DRUG DELIVERY OF GOSSYPIN FROM PRONIOSOMAL GEL FORMULATIONS: IN VITRO EFFICACY AGAINST HUMAN MELANOMA CELLS

2021 ◽  
pp. 144-152
Author(s):  
JAMPALA RAJKUMAR ◽  
G.V. RADHA ◽  
S. GANAPATY
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ex Vivo ◽  
Physical Stability ◽  
Entrapment Efficiency ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells

Objective: This work aimed to establish and formulate the gossypinproniosomal gel drug delivery system. Methods: Gossypin-loaded proniosomal gels (GPG) was prepared using specific non-ionic surfactants (Spans), followed by particle size (PS), entrapment efficiency (percent EE), in vitro, ex-vivo drug release, and in vitro efficacy of Gossypin against human melanoma cells (A-375). Results: The results showed that the percentage EE for the GPG is appropriate (81.3 %–95.5 %) and they are Nano-sized (189.3–912.0 nm) and the gels diffusion provided the desired sustaining effect for GPG-F7 formulation (75.5 percent). The GPG reported cell viability of 14.9±2.3 percent compared with 16.1±1.1 percent for free Gossypin at the maximum dose of 100 μg/ml for A-375 human melanoma cells after 24 hr incubation time. No major changes were seen in the percentage EE, PS of GPG after storage for 90d, in the physical stability report. Conclusion: The results obtained suggest that the proniosomal drug delivery system can enhance the flux to the skin and achieve the ideal Gossypin sustainability effect. Consequently, the use of proniosomal gel may be advantageous with regard to the topical delivery of Gossypin for melanoma treatment management.

scholarly journals An Emerging Transdermal Drug Delivery System: Fabrication and Characterization of Natural and Biodegradable Polymeric Microneedles Transdermal Patch

2021 ◽  
pp. 46-54
Author(s):  
Deepesh Lall ◽  
MOHD. Javed Naim ◽  
Shruti Rathore
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Physical Stability ◽  
Circulation System ◽  
Transdermal Patch ◽  
Transdermal Drug Delivery System ◽  
Transport Pathway

Promising drug agents are limited by their inability to reach in systematic circulation system when applied on skin, because of the excellent barrier of biological membranes, such as the stratum corneum (SC) of the skin. It is the outermost layer of the skin, SC, the principal barrier to all the topical application applied on skin. Various strategies were employed by many research group and pharmaceutical companies worldwide, for the formulation of microneedles. Therefore, microneedles (MN’s), used to puncture skin, it created the transient aqueous transport pathway and enhanced the trandermal permeability. Microneedles (MN’s) fabricated with natural and biodegradable polymer, such as carboxymethyl cellulose (CMC), and dextran. Inverse replication of micro milled master mould reproduced, solid out of natural polymeric microneedles, were subsequently assembled into transdermal patch and physiochemical characterized for dissolution index, mechanical strength constructed physical strong and uniform shape and size and inert profile. Although, dissolvable PVP and PVA based microneedle showed physical stability and MN’s, their different analyzed parameter is of promise for the fabrication matrix device of natural biodegradable polymeric microneedle transdermal drug delivery system.

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