A Review on Microsponge Drug Delivery System

2020 ◽  
Vol 10 (2) ◽  
pp. 53-59
Author(s):  
Bharathi M ◽  
Mullaikodi O ◽  
Rajalingam D ◽  
Gnanasekar N ◽  
Kesavan M
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Physical Stability ◽  
Current Investigation ◽  
Considerable Time ◽  
Polymeric Structure ◽  
Point Of Interest ◽  
Time Period ◽  
Time Specific

A Microsponge (MS) is an extremely interconnected, permeable, polymeric structure that involves permeable microparticles trapping and discharging through the skin for a considerable time period. Drug delivery system (DDS) offer extended discharge with less degradation, improved physical stability along with better tolerance. The main intend of any DDS is to achieve the required amount of drug in plasma to produce the desired therapeutic and non-poisonous effect over a prolonged period of time. Specific methods for preparing MS were reviewed in this current investigation, and their pharmaceutical implementations were signed. MS have major DDS point of interest. It also improves stability, increased flexibility in formulation and increased elegance. In fact, numerous studies have reported that MS supplies are not allergic, mutagenic, and poisonous. MS creativity is used in products such as sunscreen, prescription, cosmetics, and OTC skin care. This inquiry primarily focuses on the different methods used to identify, plan and exploit MS.

Novel Self-Micro Emulsifying Drug Delivery System for safe intra muscular delivery with improved pharmacodynamics and pharmacokinetics

2021 ◽  
Vol 18 ◽  
Author(s):  
Subheet Kumar Jain ◽  
Neha Panchal ◽  
Amrinder Singh ◽  
Shubham Thakur ◽  
Navid Reza Shahtaghi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Inflammatory Diseases ◽  
Diclofenac Sodium ◽  
Physical Stability ◽  
In Vivo Studies ◽  
High Concentration

Background: Diclofenac sodium (DS) injection is widely used in the management of acute or chronic pain and inflammatory diseases. It incorporates 20 % w/v Transcutol-P as a solubilizer to make the stable injectable formulation. However, the use of Transcutol-P in high concentration leads to adverse effects such as severe nephrotoxicity, etc. Some advancements resulted in the formulation of an aqueous based injectable but that too used benzyl alcohol reported to be toxic for human use. Objective: To develop an injectable self-micro emulsifying drug delivery system (SMEDDS) as a novel carrier of DS for prompt release with better safety and efficacy. Methods: A solubility study was performed with different surfactants and co-surfactants. The conventional stirring method was employed for the formulation of SMEDDS. Detailed in vitro characterization was done for different quality control parameters. In vivo studies were performed using Wistar rats for pharmacokinetic evaluation, toxicological analysis, and analgesic activity. Results: The optimized formulation exhibited good physical stability, ideal globule size (156±0.4 nm), quick release, better therapeutics, and safety, increase in LD50 (221.9 mg/kg) to that of the commercial counterpart (109.9 mg/kg). Further, pre-treatment with optimized formulation reduced the carrageenan-induced rat paw oedema by 88±1.2 % after 4 h, compared to 77±1.6 % inhibition with commercial DS formulation. Moreover, optimized formulation significantly (p<0.05) inhibited the pain sensation in the acetic-acid induced writhing test in mice compared to its commercial equivalent with a better pharmacokinetic profile. Conclusion: The above findings confirmed that liquid SMEDDS could be a successful carrier for the safe and effective delivery of DS

scholarly journals “Design and Synthesis of Some Cyclic Carbohydrates with Norfloxacin as Surface moiety. A Study of Sustained Relax of Drugs”.

2019 ◽  
Vol 35 (2) ◽  
pp. 577-590
Author(s):  
J. Dhevaraj ◽  
S. Vembu ◽  
S. Pazhamalai ◽  
M. Gopalakrishnan
Keyword(s):  
Escherichia Coli ◽  
Drug Delivery ◽  
Antibacterial Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Synthetic Polymer ◽  
Hydroxyl Group ◽  
Standard Drug ◽  
Polymeric Structure ◽  
Uv Spectrometry

Biocompatible and biodegradable sustained drug delivery system has been constructed from reaction between norfloxacin and cyclodextrin through secondary amine of piperazine ring and hydroxyl group of the carbohydrate. Covalent bond polymeric structure is designed by the help of chloroacetyl chloride, target dendrimer formed by removing two hydrochloride molecules. The development of cyclodextrin core drug delivery system with twenty one norfloxacin surface moiety has been synthesized by only two steps. The synthesized polymeric structure was thoroughly studied by NMR, FT-IR, MALDI and UV- spectrometry. Sustained release assessment of synthetic polymer studied through different buffer solution by UV spectrometry and norfloxacin releases rate of synthetic polymer was controlled by the concentration and the experimental medium. The microbial assessments through kinetic studies by using Escherichia coli also reveal that the norfloxacin released possesses potential antimicrobial activity. Antibacterial activity of synthesized drug delivery system has been investigated with gram-negative and gram-positive species like Escherichia coli (mtcc 443), bacillus subtilis (mtcc 2063), pseudomonas (mtcc 741), staphylococcus (mtcc 737) and proteus mirabilis (mtcc 425). The hydrophobic and hydrophilic balance and the repeat drug unit of this synthesized system are responsible for effective antibacterial activity. The minimum inhibitor concentration values of this system are very small to 100 µg/mL-1, synthesized compound shown five times improved activity against organism on comparism with standard drug. The in-vitro release of norfloxacin from obtained dendrimer was investigated.

scholarly journals Preparation of Squalene Oil-Based Emulsion Adjuvants Employing a Self-Emulsifying Drug Delivery System and Assessment of Mycoplasma hyopneumoniae-Specific Antibody Titers in BALB/c Mice

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 667
Author(s):  
Rakesh Bastola ◽  
Jo-Eun Seo ◽  
Taekwang Keum ◽  
Gyubin Noh ◽  
Jae Woong Choi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Specific Antibody ◽  
Physical Stability ◽  
Mycoplasma Hyopneumoniae ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus ◽  
Droplet Sizes ◽  
Antibody Titers

In this study, a self-emulsifying drug delivery system (SEDDS) was employed to prepare novel squalene oil-based emulsion adjuvants. Deionized water, 0.01% and 0.02% (w/v) carbomer solutions of C-971P NF and C-940 grades were used to prepare emulsions containing 3%, 5% and 10% of squalene oil. Altogether 15 candidate emulsions were prepared and used as adjuvants for the delivery of a combination vaccine containing a porcine circovirus type 2 (PCV2) antigen and inactivated Mycoplasma hyopneumoniae (J101 strain) antigen. Most of the emulsions showed droplet sizes in the submicron range and maintained zeta potential values between −40 mV to 0 mV for six months, indicating good physical stability as a vaccine adjuvant. Emulsion-based candidate adjuvants prepared with SEDDS technology stimulated IgG, IgG1 and IgG2a like a currently commercially available adjuvant, Montanide ISATM 201, and they were safe and their Mycoplasma hyopneumoniae-specific antibody titers were considered as comparable with that of Montanide ISATM 201.

Self-Emulsifying Drug Delivery System (SEDDS) and its Pharmaceutical Applications

2020 ◽  
Vol 7 (3) ◽  
pp. 206-224
Author(s):  
Sankha Bhattacharya
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Selection Criteria ◽  
Physical Stability ◽  
Aqueous Solubility ◽  
Dosage Forms ◽  
Oral Dosage ◽  
New Approach ◽  
Subject Variability

Poor aqueous solubility, oral bioavailability, inter, and inter-subject variability, and physical stability have always been a concern for pharmaceutical formulation scientists while formulating an oral dosage form. Self-Emulsifying Drug Delivery System (SEDDS) is a promising new approach to mitigating those potential problems. The main advantages of SEDDS are that it increases the solubility and decreases the bio-degradation of lipophilic drugs. Mostly BCS II & IV Class drugs are preferable. SEDDS is an admixture of drugs, oil, surfactants, cosolvents, and stabilizers. With little energy input, they form (o/w) microemulsion within the G.I. lumen. The present review discusses the various formulations of SEDDS, selection criteria for surfactants, oils, Patentable SEDDS dosage forms, solidification technique, characterization, and future approaches.

scholarly journals Invitro and invivo evaluation of anticonvulsant herbal drug loaded self nano emulsifying drug delivery system

2018 ◽  
Vol 6 (2) ◽  
pp. 38-44
Author(s):  
Vishal N Kushare ◽  
Saravanan S
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tween 80 ◽  
Extraction Process ◽  
Treated Animal ◽  
Herbal Drug ◽  
Reference Compound ◽  
Reduced Pressure ◽  
Time Period

The aim of present study was to formulate and evaluate emulsifying drug delivery system (SNEDDS) of poorly and herbal drug like () extract, which was extracted from Coriandrum seeds by using ( method extraction process). are isolated by using column chromatography and concentrated under reduced pressure by using rotary flash evaporator., an essential of Coriandrum with anti-epileptic activity.the oil phase like , Tween 80 and PEG-200 were selected as and respectively for the formulation of SNEDDS(9 formulation). all the formulation S9 shows maximum cumulative amount of drug release of about97.72%. The stored in temperature range of 400C/75% RH shown better stability up to 3 months. In activity shows that the recovery time period from convulsion of SNEDDS (200mg/kg) treated animal is as quick and almost same as reference compound ( 6mg/kg). concluded that SNEDDS is promising drug delivery systemto improve the solubility, dissolution rate and therapeutic efficacy of insoluble herbal drugs like .

scholarly journals TOPICAL DRUG DELIVERY OF GOSSYPIN FROM PRONIOSOMAL GEL FORMULATIONS: IN VITRO EFFICACY AGAINST HUMAN MELANOMA CELLS

2021 ◽  
pp. 144-152
Author(s):  
JAMPALA RAJKUMAR ◽  
G.V. RADHA ◽  
S. GANAPATY
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ex Vivo ◽  
Physical Stability ◽  
Entrapment Efficiency ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells

Objective: This work aimed to establish and formulate the gossypinproniosomal gel drug delivery system. Methods: Gossypin-loaded proniosomal gels (GPG) was prepared using specific non-ionic surfactants (Spans), followed by particle size (PS), entrapment efficiency (percent EE), in vitro, ex-vivo drug release, and in vitro efficacy of Gossypin against human melanoma cells (A-375). Results: The results showed that the percentage EE for the GPG is appropriate (81.3 %–95.5 %) and they are Nano-sized (189.3–912.0 nm) and the gels diffusion provided the desired sustaining effect for GPG-F7 formulation (75.5 percent). The GPG reported cell viability of 14.9±2.3 percent compared with 16.1±1.1 percent for free Gossypin at the maximum dose of 100 μg/ml for A-375 human melanoma cells after 24 hr incubation time. No major changes were seen in the percentage EE, PS of GPG after storage for 90d, in the physical stability report. Conclusion: The results obtained suggest that the proniosomal drug delivery system can enhance the flux to the skin and achieve the ideal Gossypin sustainability effect. Consequently, the use of proniosomal gel may be advantageous with regard to the topical delivery of Gossypin for melanoma treatment management.

scholarly journals Formulation and Evaluation of Bio-adhesive Pulsatile Drug Delivery System of Telmisartan

2020 ◽  
Vol 11 (2) ◽  
pp. 1282-1287
Author(s):  
Patil S. V. ◽  
Salokhe P. A. ◽  
Patil S. S. ◽  
Ustad J. Y. ◽  
Shedbale S. S.
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lag Time ◽  
Early Morning ◽  
Pulsatile Drug Delivery ◽  
Hypertensive Drug ◽  
Time Specific ◽  
Core Tablet

The main objective of this study was to formulate and evaluate of Bio-adhesive pulsatile drug delivery system of Telmisartan, an anti-hypertensive drug in order to achieve better therapeutic efficacy and patient compliance. The approach of combination of bio-adhesive pulsatile formulation is suitable for gastro retention and time specific drug delivery. The study was carried by preparation of fast disintegrating core tablet followed by incorporation of core tablet to design bio-adhesive pulsatile tablet by press coating. The press coated tablet was prepared with the polymersethyl cellulose and carbopol. The formulation was evaluated for precompression and post compression parameters, lag time, drug release and bio-adhesive study. All evaluation parameters were found within limits. The lag time expected for this disease was 8 hours as need of drug release for this disease was more likely to act in early morning. The 8 hour lag time was obtained in optimized formulation which has shown muco-adhesion for the same period. Thus bio-adhesive pulsatile drug delivery system could be the best precautionary alternative for the drugs having maximum absorption in stomach and used for diseases which follows circadian rhythm.

A Concise Insight on Pulsatile Drug Delivery System: An Outlook towards its Development

2021 ◽  
Vol 14 (5) ◽  
pp. 5577-5587
Author(s):  
Om M Bagade ◽  
Snehal S Sutar ◽  
Priyanka E Doke
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Patient Compliance ◽  
Delivery System ◽  
The Body ◽  
Multiple Unit ◽  
Pulsatile Drug Delivery ◽  
Pulsatile Delivery ◽  
Time Specific ◽  
The Right

In pharmaceutical science, the pulsatile drug delivery system gains more attraction because of their number of benefits over the other dosage forms. In these systems, the drug is released at right time at the right site of action, and in the right amount, it is the most beneficial and important characteristic of the PDDS system due to that the patient compliance is increased, and the drug release is after a well-defined lag time.  Moreover, this system is designed according to the circadian rhythm of the body. Because the disease has a predictable cyclic rhythm, such as Arthritis, diabetes mellitus, asthma, peptic ulcer, hypertension, cardiovascular disease the PDDS is more effective than other dosage forms.This system is a more time-specific and site-specific drug delivery system. In this system the drug is released as a pulse. The mechanism of PDDS is first diffusion then erosion and then osmosis. For the drug having a high first-pass effect and having a high risk of toxicity and side effects, these systems can be very useful. And to reduce dosing frequency and improve patient compliance this system is very helpful. There are various methods present like, single-unit systems and multiple-unit systems – which included capsular system, pulsatile delivery by osmosis, pulsatile delivery by erosion of membrane, delivery by rupture of membrane, etc.  

scholarly journals CHRONOTHERAPEUTIC DRUG DELIVERY SYSTEM: AN EMERGING APPROACH TO TREAT CIRCADIAN RHYTHMIC RELATED DISEASE

2018 ◽  
Vol 11 (8) ◽  
pp. 15
Author(s):  
Anuttam Kuila ◽  
Nagasamy Venkatesh Dhandapani ◽  
Himangshu Bhowmik ◽  
Abhishek Soni ◽  
Kammari Harish Kumar
Keyword(s):  
Drug Delivery ◽  
Circadian Rhythms ◽  
Drug Delivery System ◽  
Delivery System ◽  
The Body ◽  
Essential Information ◽  
Time Period ◽  
Insoluble Polymer ◽  
Multiple Units ◽  
Delivery Technology

The research on chronotherapy has garnered interest from scientists to understand circadian rhythms and their applications in the biological system. The area of chronotherapeutics covers essential information which is helpful to move forward and solve entanglements in current drug delivery technology. Chronotherapy is the conveying drugs in the body at the target site by maintaining perfect synchronicity with circadian rhythms. The main aim of the current rhythmic research is to formulate and design a therapeutic novel system which can deliver the drug in a desired way inside the body to treat various rhythmic diseases according to their occurrence. Drug release from an ideal chronotherapeutic system should be rapid, and the release of drug from the delivery system should also be complete after a specific or defined lag time period. Recently, scientists are involved in developing chronotherapeutic drug delivery system to treat chronological diseases such as single and multiple units using an erodible, soluble or insoluble polymer coating, and stimuli regulated drug delivery systems. In this review, we focus on the elaboration of the concept of chronotherapy, main challenges ahead during its development process, current approaches and its future applications in drug delivery in the treatment of circadian rhythmic diseases.

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