scholarly journals Neurobiology of sleep and insomnia in children with CNS tumors

2019 ◽  
Vol 5 (4) ◽  
pp. 51-59
Author(s):  
N. A. Andreeva ◽  
E. V. Kumirova
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Conflict Of Interest ◽  
Cns Tumors ◽  
Malignant Neoplasms ◽  
Common Symptom ◽  
Malignant Diseases ◽  
External Funding ◽  
The Central Nervous System

Insomnia is a common symptom in children with malignant diseases and especially in children with tumors of the central nervous system (CNS). However, little attention is paid this complication during the therapy of malignant neoplasms. Insomnia violates the quality of life of children and their immediate surroundings. In this article, the etiology, pathogenesis, and diagnostics are discussed in detail, and methods for treating this pathology are presented with two clinical cases confirming the diverse nature of insomnia in CNS tumors. Thus, the importance of an individual approach to the therapy of insomnia is emphasized.Conflict of interest. The authors declare no conflict of interest.Funding. The study was performed without external funding

scholarly journals QOL-36. USE OF CANNABINOIDS IN THE PEDIATRIC CENTRAL NERVOUS SYSTEM TUMOR POPULATION

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii438-iii438
Author(s):  
Kathleen Dorris ◽  
Jessica Channell ◽  
Ashley Mettetal ◽  
Molly Hemenway ◽  
Natalie Briones ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Cell Activity ◽  
Cns Tumors ◽  
Low Grade ◽  
Tumor Type ◽  
Central Nervous System Tumor ◽  
The Impact

Abstract BACKGROUND Cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinol (THC), are a class of compounds found in marijuana. Numerous studies in adults have examined cannabinoid use in management of cancer-related symptoms such as nausea, anorexia, and pain. Less is known about the use in the pediatric oncology population. METHODS A prospective observational study has been ongoing since 2016 at Children’s Hospital Colorado to evaluate cannabinoids’ impact using PedsQL™ modules on quality of life of pediatric patients with central nervous system (CNS) tumors who are 2–18 years old. Laboratory assessments of T-cell activity and pharmacokinetics of CBD, THC and associated metabolites are in process. Diaries with exploratory information on cannabinoid use patterns are being collected. RESULTS Thirty-three patients (14:19; male:female) have been enrolled with a median age of 6.4 years (range, 2.9–17.7 years). The most common tumor type in enrolled patients is embryonal tumors (13/33; 39%). Nine (27%) patients have low-grade glial/glioneuronal tumors, and eight (24%) had high-grade/diffuse midline gliomas. The remaining patients had ependymoma or craniopharyngioma. The median time on cannabinoids is 9 months. Most (n=20) patients have used oral products with CBD and THC. One patient continues on cannabinoid therapy in follow up. Preliminary immune function analyses identified impaired neutrophil superoxide anion production and chemotaxis in patients taking cannabinoids at early time points on therapy. CONCLUSIONS Families of children with various CNS tumors are pursuing cannabinoid therapy for both antitumor and supportive care purposes. Analysis of the impact of cannabinoids on patients’ quality of life is ongoing.

scholarly journals Justification for use of selenium-modified mineral water in medical rehabilitation of patients who underwent colon surgery due to malignant tumor (overview)

2019 ◽  
Vol 18 (6) ◽  
pp. 396-400
Author(s):  
Marat B. Uzdenov
Keyword(s):  
Quality Of Life ◽  
Large Intestine ◽  
Malignant Tumor ◽  
Mineral Water ◽  
Immune Status ◽  
Colon Surgery ◽  
Medical Rehabilitation ◽  
Malignant Neoplasms ◽  
Malignant Diseases

The article presents the justification for the use of selenium-modified low-mineralized mineral water of Chapaevsk deposit (the Karachay-Cherkess Republic), modified by selenium. It describes its effect on the state of hormonal and immune status, antioxidant system in malignant diseases of digestive organs, prevention of complications, reduction of dose of used medicines, improvement of quality of life of this category of patients. Conclusion. It is noted that the use of selenium-modified low-mineralized mineral water expands and complements the possibilities of rehabilitation and rehabilitation assistance to patients who have undergone operations on the large intestine in case of malignant neoplasms.

scholarly journals Quality of Life in Carotid Atherosclerosis: The Role of Co-morbid Mood Disorders

2016 ◽  
Vol 12 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Maria Lecca ◽  
Luca Saba ◽  
Roberto Sanfilippo ◽  
Elisa Pintus ◽  
Michela Cadoni ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Mood Disorders ◽  
Carotid Atherosclerosis ◽  
Short Form ◽  
The Central Nervous System ◽  
Dsm Iv

Introduction/Objective: To study in severe carotid atherosclerosis (CA): the frequency of mood disorders (MD); the impairment of quality of life (QoL); the role of co-morbid MD in such impairment. Methods: Case-control study. Cases: consecutive in-patients with CA (stenosis ≥ 50%). Controls: subjects with no diagnosis of CA randomized from a database of a community survey. Psychiatric diagnosis according to DSM-IV made by clinicians and semi-structured interview, QoL measured by the Short Form Health Survey (SF-12). Results: This is the first study on comorbidity on CA disease and MD in which psychiatric diagnoses are conducted by clinicians according to DSM-IV diagnostic criteria. Major Depressive Disorder (MDD) (17.4% vs 2.72%, P <0.0001) but not Bipolar Disorders (BD) (4.3% vs 0.5%, P = 0.99) was higher in cases (N=46) than in controls (N= 184). SF-12 scores in cases were lower than in controls (30.56±8.12 vs 36.81±6:40; p <0.001) with QoL comparable to serious chronic diseases of the central nervous system. The burden of a concomitant MDD or BD amplifies QoL impairment. Conclusion: Comorbid MD aggravates the impairment of QoL in CA. Unlike autoimmune diseases or degenerative diseases of the Central Nervous System, CA shows a strong risk of MDD than BD.

scholarly journals A Review of the Complex Roles of Glial Cells in Alzheimer’s Disease and Potential Glial-Oriented Therapeutic Targets

2018 ◽  
Author(s):  
Saif Shahriar Rahman Nirzhor ◽  
Rubayat Islam Khan ◽  
Sharmind Neelotpol
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Glial Cells ◽  
Therapeutic Targets ◽  
Concentration Of Ions ◽  
The Central Nervous System

The pathogenesis of Alzheimer&rsquo;s disease (AD) is very complicated and not well-understood. As more and more studies are performed with regards to this disease, new insights are coming to light. Much of the research in AD so far has been very neuron-oriented however, recent studies suggest that certain glial cells i.e. microglia, astrocytes, oligodendrocytes, and NG2 glia are linked to the pathogenesis of AD and may offer several potential therapeutic targets in the long-standing battle against AD. Glial cells are responsible for maintaining homeostasis (i.e. concentration of ions and neurotransmitters) within the neuronal environment of the central nervous system (CNS) and are crucial to the integrity of neurons. This review explores the (1) role of glial cells in AD pathogenesis, (2) complex functionalities of the components involved and (3) potential therapeutic targets that it could eventuate leading to a better quality of life for AD patients.

scholarly journals Fatigue and Affective Manifestations in Multiple Sclerosis—A Cluster Approach

2019 ◽  
Vol 10 (1) ◽  
pp. 10 ◽  
Author(s):  
Samar S. Ayache ◽  
Moussa A. Chalah
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Economic Cost ◽  
Cluster Approach ◽  
High Prevalence ◽  
The Central Nervous System ◽  
Chronic Autoimmune Disease

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, characterized by a high prevalence in young people, a drastic impact on the quality of life, and an important economic cost to society [...]

scholarly journals Neuroendocrine Changes during Menopausal Transition

Endocrines ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 405-416
Author(s):  
Andrea Giannini ◽  
Marta Caretto ◽  
Andrea R. Genazzani ◽  
Tommaso Simoncini
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Target Therapy ◽  
Menstrual Cycles ◽  
Mood Changes ◽  
The Central Nervous System ◽  
Urogenital Symptoms ◽  
Follicular Activity

Menopause is the permanent cessation of menstrual cycles following the loss of ovarian follicular activity. Quality of life of postmenopausal woman is the result of a series of psychobiological transformations, that see in the reduction of sex hormones and steroids the etiopathogenetic determinant moment. Symptoms of menopause range from somatic side such as metabolic changes, increased cardiovascular disease, irregular vaginal bleeding, urogenital symptoms, vaginal dryness, osteoporosis and risk of bones fractures to changes of central nervous system as vasomotor symptoms, sleep disruption, mood changes, migraine, sexual dysfunctions. It is fundamental to know the mechanisms underlying changes in the central nervous system during menopause, related to hypoestrogenism, to be able to create appropriate target therapy for patients, improving their quality of life. In fact, the central nervous system is now one of the major targets of sex steroids that cannot be achieved disregard when dealing with the problem of choice of a particular type of MHT.

scholarly journals Justification for use of selenium-modified mineral water in medical rehabilitation of patients who underwent colon surgery due to malignant tumor (overview)

2019 ◽  
Vol 18 (6) ◽  
pp. 396-400
Author(s):  
Marat B. Uzdenov
Keyword(s):  
Quality Of Life ◽  
Large Intestine ◽  
Malignant Tumor ◽  
Mineral Water ◽  
Immune Status ◽  
Colon Surgery ◽  
Medical Rehabilitation ◽  
Malignant Neoplasms ◽  
Malignant Diseases

The article presents the justification for the use of selenium-modified low-mineralized mineral water of Chapaevsk deposit (the Karachay-Cherkess Republic), modified by selenium. It describes its effect on the state of hormonal and immune status, antioxidant system in malignant diseases of digestive organs, prevention of complications, reduction of dose of used medicines, improvement of quality of life of this category of patients. Conclusion. It is noted that the use of selenium-modified low-mineralized mineral water expands and complements the possibilities of rehabilitation and rehabilitation assistance to patients who have undergone operations on the large intestine in case of malignant neoplasms.

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