Oxidative stress and biochemical indicators in blood of patients addicted to alcohol treated for acute ethylene glycol poisoning

Ethylene glycol (EG), in addition to its neurotoxic and nephrotoxic effects, evokes oxidative stress. The aim of this study was to assess the influence of the ethylene glycol on the biochemical indicators and oxidoreductive balance of patients treated for acute poisoning. The total study group consisted of 56 persons including 26 alcoholics who took EG as a substitute for ethyl alcohol in the course of alcohol dependence syndrome and 30 controls. Severity of poisoning, results of acid-base parameters, biochemical, and toxicological tests as well as biomarkers of the oxidative stress in blood were analyzed during the patients’ hospitalization. The key issue was to assess the oxidative stress and biochemical disturbances caused by EG and the type of treatment applied in the course of poisoning. Significant changes in some parameters were found both at time of diagnosis and after treatment initiation (ethanol as an antidote and hemodialysis). The most important differences included the activity of hepatic parameters (aspartate aminotransferase, AST) and oxidative stress markers like catalase (CAT); correlation of the lipid peroxidation products level (TBARS) with urea concentration has been shown. On the last day of the hospitalization, in some cases, the mutual correlation between the evaluated markers were observed, for example, between alanine transaminase (ALT) and glutathione reductase (GR), and urea concentration and glutathione level (GSH/GSSG). The concentration of ions (H+) had a major impact on the oxidoreductive balance, correlating with the elevated GR and GSH/GSSG levels.

Alkali-activated metallurgical slag as a sustainable adsorbent

This paper is devoted to obtaining a zeolite-containing sorbent based on metallurgical waste — slag. The synthesis of zeolite adsorbent from ash and slag was carried out by hydrochemical and thermal treatment. The initial object and the obtained material were characterized using following methods: Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive analysis, X-ray phase analysis, titrimetry. The way of converting solid-phase waste into a beneficial product has been demonstrated. The study results showed that the surface of the obtained material is saturated with functional groups (hydroxy-, carboxy-, lactone), which predetermine the ability to bind metal ions during adsorption. The adsorption capacity of the product has been estimated for iodine and methylene blue. A thermodynamic analysis of the process of sorption of copper (II) ions from an aqueous solution has been conducted. It has identified that the sorbent can also be used for the adsorptive concentration of ions of rare-earth elements by the example of lanthanum and erbium. Laboratory testing of the possible use of the sorbent to purify industrial water was carried out using the example of wastewater from a chromium plating shop

Investigation of effect of electrode polarity on electrochemistry and magnetohydrodynamics using tertiary current distribution in electroslag remelting process

Transport phenomena including the electromagnetic, concentration of ions, flow, and thermal fields in the electroslag remelting (ESR) process made of slag, electrode, air, mold, and melt pool are computed considering tertiary current distribution. Nernst–Planck equations are solved in the bulk of slag, and faradaic reactions are regarded at the metal–slag interface. Aiming at exploring electrochemical effects on the behavior of the ESR process, the calculated field structures are compared with those obtained using the classical ohmic approach, namely, primary current distribution whereby variations in concentrations of ions and faradaic reactions are ignored. Also, the influence of the earth magnetic field on magnetohydrodynamics in the melt pool and slag is considered. The impact of the polarity of electrode, whether positive, also known as direct current reverse polarity (DCRP), or negative, as known as direct current straight polarity (DCSP), on the transport of oxygen to the ingot of ESR is investigated. The obtained modeling results enabled us to explain the experimental observation of higher oxygen content in DCSP than that of DCRP operated ESR process.

The Failure Mechanisms of Precast Geopolymer after Water Immersion

Precast geopolymers with lower water/binder (0.14), which mainly consists of alkali solution, fly ash (FA) and steel slag (SS), were manufactured through molding pressing technology. The failure mechanisms of precast geopolymers after water immersion were studied by testing the loss of compressive strength, the pH of the leaching solution, the concentration of ions (Na+, Ca2+, Si4+ and Al3+), the evolution of phases, pore structure and morphology, and further discussion of the regulation evolution was performed. The results show that the harmful pores (>50 nm) of geopolymers progressively decrease from 70% to 50% after 28 days of water immersion when the content of steel slag increases from 0 to 80 wt.%. Compressive strength of geopolymers sharply reduces in the first 3 days and then increases during the water immersion process, but the phase composition varies slightly. Furthermore, increasing the content of steel slag could decrease the total porosity and further prevent the water resistance.

COMPARATIVE STUDY OF REMOVAL POLLUTANTS ( HEAVY METALS) BY AGRICULTURAL WASTES AND OTHER CHEMICAL FROM THE AQUEOUS SOLUTIONS

This study included the application of some experiments in the chemical treatment of some heavy metals elements by preparing biological surfaces that are adsorbed from natural and other chemical substances, as in preparing activated carbon prepared from charred pistachio shell with concentrated H2SO4 and Nano-Calcium Oxide prepared from CaCL2.2H2O with NaOH . The prepared materials were diagnosed with spectral techniques where the FTIR infrared spectrum proved the formation of carbonyl, hydrogen and oxygenated of the surface in activated charcoal and the hydroxyl and calcium oxide groups in the nano-calcium oxide, as the FE-SEM surface morphology was proven to form on coal blocks The surface is a network of irregular holes and a network of microscopic holes regular on the surface of nano- calcium oxide. As for X-ray diffraction technology, the crystal structures of the surface, its shapes and sizes, are shown, and that activated charcoal consists of that Many types of carbon in the form hexagonally and cuboid and rhomboid with a right angle, while technical proven size of the crystalline calcium oxide nanoscale which ranges between (54.68-67.86nm) cube-shaped. PIAC activated charcoal and n-Calcium oxide were used as sorbents in the removal of, Cd + 2, Pb + 2 ions from aqueous solutions, a study of the effect of pH, contact time, multiple weights for surface and the primary concentration of ions in a horizontal removal method , and the removal of minimal concentrations of ions in large volumes of solutions by the process of preconcentration .

Development of technology for macaroni products based on flour of grain crops and ion-zoned water

The nutritional value of food is one of the most important factors that determine the health of the population. In the macaroni market, dietary and functional products, fortified macaroni products and products of high nutritional value occupy a small segment that does not exceed 1 %. In this regard, the development of an assortment of pasta with increased nutritional value, with a directionally changed chemical composition, is relevant. In the pasta industry, an increase in the nutritional and biological value of products is achieved through the introduction of non-traditional types of raw materials and special food additives into the recipe. To reduce the deteriorating effect of corn and amaranth flour on the pasta properties of flour from durum wheat, ionized water was used with a concentration of ions of 1,000, 2,000, 3,000, 4,000 units/cm3 and ozone of 2 mg/l. It was found that ionized water has a positive effect on the properties of gluten and the quality of pasta with the addition of corn and amaranth flour. It was determined that the best quality of pasta is achieved when using ionized water with an ion concentration of 3,000 units/cm3 and ozone 2 mg/l and at dosages of amaranth flour 17.5 %, corn flour – 20 % to pasta flour. Summing up the results of the experimental study, the amount of prescription components for the production of pasta with high nutritional and biological value was optimized

Inhibition Effect of Fluoride Ion on Corrosion of 304 Stainless Steel in Occluded Cell Corrosion Stage in the Presence of Chloride Ion

The role of F− in the corrosion of stainless steel at the stage of occluded cell corrosion in a mixture of chloride, fluoride, and sulfate ions was investigated. A simulated occluded corrosion cell was designed using an elaborate simulated rust layer. Composite electrodes were used to monitor the variation of the concentration of ions, pH, and dissolved oxygen of the occluded solution. The results show that the influence of F− on the corrosion of 304 stainless steel, in the occluded cell corrosion stage, is concentration dependent. When the F−/Cl− ratio is higher than 2, the corrosion can be significantly suppressed. Analyses showed that the corrosion inhibition effect could be attributed to the migration of F− to the occluded cell, which can reduce the migration of Cl−, dampen the decrease in pH, and react with metal ions to form semi-soluble products. Meanwhile, the influence of F− on the corrosion process was also verified using drilled stainless steel specimens, demonstrating the practicality and validity of the simulated occluded cell corrosion model.

Chemically-Gated and Sustained Molecular Transport through Nanoporous Gold Thin Films in Biofouling Conditions

Sustained release and replenishment of the drug depot are essential for the long-term functionality of implantable drug-delivery devices. This study demonstrates the use nanoporous gold (np-Au) thin films for in-plane transport of fluorescein (a small-molecule drug surrogate) over large (mm-scale) distances from a distal reservoir to the site of delivery, thereby establishing a constant flux of molecular release. In the absence of halides, the fluorescein transport is negligible due to a strong non-specific interaction of fluorescein with the pore walls. However, in the presence of physiologically relevant concentration of ions, halides preferentially adsorb onto the gold surface, minimizing the fluorescein–gold interactions and thus enabling in-plane fluorescein transport. In addition, the nanoporous film serves as an intrinsic size-exclusion matrix and allows for sustained release in biofouling conditions (dilute serum). The molecular release is reproducibly controlled by gating it in response to the presence of halides at the reservoir (source) and the release site (sink) without external triggers (e.g., electrical and mechanical).

Sensing Electrochemical Signals Using a Nitrogen-Vacancy Center in Diamond

Chemical sensors with high sensitivity that can be used under extreme conditions and can be miniaturized are of high interest in science and industry. The nitrogen-vacancy (NV) center in diamond is an ideal candidate as a nanosensor due to the long coherence time of its electron spin and its optical accessibility. In this theoretical work, we propose the use of an NV center to detect electrochemical signals emerging from an electrolyte solution, thus obtaining a concentration sensor. For this purpose, we propose the use of the inhomogeneous dephasing rate of the electron spin of the NV center (1/T2★) as a signal. We show that for a range of mean ionic concentrations in the bulk of the electrolyte solution, the electric field fluctuations produced by the diffusional fluctuations in the local concentration of ions result in dephasing rates that can be inferred from free induction decay measurements. Moreover, we show that for a range of concentrations, the electric field generated at the position of the NV center can be used to estimate the concentration of ions.

The mechanism of ions in pulmonary hypertension

Pulmonary hypertension（PH）is a kind of hemodynamic and pathophysiological state, in which the pulmonary artery pressure (PAP) rises above a certain threshold. The main pathological manifestation is pulmonary vasoconstriction and remodelling progressively. More and more studies have found that ions play a major role in the pathogenesis of PH. Many vasoactive substances, inflammatory mediators, transcription-inducing factors, apoptosis mediators, redox substances and translation modifiers can control the concentration of ions inside and outside the cell by regulating the activity of ion channels, which can regulate vascular contraction, cell proliferation, migration, apoptosis, inflammation and other functions. We all know that there are no effective drugs to treat PH. Ions are involved in the occurrence and development of PH, so it is necessary to clarify the mechanism of ions in PH as a therapeutic target for PH. The main ions involved in PH are calcium ion (Ca2+), potassium ion (K+), sodium ion (Na+) and chloride ion (Cl–). Here, we mainly discuss the distribution of these ions and their channels in pulmonary arteries and their role in the pathogenesis of PH.