scholarly journals Variability of heart rhythm and features of psychological status in young hockey players

2015 ◽  
Vol 96 (4) ◽  
pp. 675-679
Author(s):  
L V Yakovleva ◽  
G N Shangareeva
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Low Frequency ◽  
Heart Rhythm ◽  
Psychological Status ◽  
Total Power ◽  
Hockey Players ◽  
Regulation Type ◽  
Vegetative Regulation ◽  
Low Frequency Waves

Aim. To study the heart rate variability and characteristics of psychological status in young hockey players in professional sports. Methods. 65 young hockey players of «Salavat Yulaev» children’s youth sports school of Olympic reserve were examined. The mean age was 14.7±0.5 years, sports experience - 8.75±1.5 years. Determination of the vegetative regulation type and spectral analysis of heart rate variability was performed on a hardware-software «Polispektr-8» complex manufactured by «Neurosoft». Vegetative regulation state was determined by the vagosympathetic balance ratio (LF/HF). The following parameters of heart rate variability were measured: TP (total power of spectrum), HF (high-frequency waves power), LF (low-frequency waves power), VLF (very low frequency waves power), heart rate was calculated. A questionnaire survey was performed using five-factor personality questionnaire known as the «Big Five». Results. Parasympathetic type of vegetative tone regulation was identified in 30 (46.1%) of young hockey players, balanced initial vegetative tone - in 28 (43.1%) patients, sympathetic type - in 7 (10.8%) patients. Changing of the vegetative regulation type in athletes with sympathetic regulation demonstrates a shift in autonomic balance towards the predominance of sympathetic influence, which is non-physiological for athletes. Such a state of maladjustment can lead to overwork, overstrain, significant reduction in work efficiency and later - to the development of diseases and injuries. According to psychological testing signs of mental and emotional stress and adaptive processes strain were revealed. Conclusion. The results of the study allow to reasonably implement a differentiated approach to psychological support of the training process taking in account the functioning of the autonomic nervous system.

scholarly journals PECULIARITIES OF HEART RATE VARIABILITY IN NEWBORNS

2018 ◽  
Vol 63 (4) ◽  
pp. 52-57 ◽  
Author(s):  
O. S. Panina ◽  
A. R. Kiselev ◽  
E. I. Borovkova ◽  
Yu. V. Chernenkov ◽  
V. V. Skazkina ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiovascular System ◽  
Low Frequency ◽  
Heart Rhythm ◽  
Regulatory Elements ◽  
Healthy Adults ◽  
Low Frequency Oscillations ◽  
Vegetative Regulation ◽  
Synchronous Recording

Heart rate variability values are potentially important for assessing vegetative dysfunction in children.The purpose of the research: a comparative study of spectral heart rate variability parameters and synchronization of low-frequency oscillations, characterizing baroreflex in the vegetative regulation of the cardiovascular system in healthy newborns and adults.15 healthy newborns and 60 healthy individuals in the age of 18-34 years old were included in the study. We performed synchronous recording of electrocardiograms and photoplethysmograms with 10 minutes duration, at rest. Were evaluated spectral heart rate variability indices and the index of synchronization of low-frequency oscillations in heart rate variability and photoplethysmograms (S index).Results. In newborns, the peak of low-frequency oscillations was predominantly in the range 0.07–0.09 Hz, and high frequency 0.40–0.50 Hz. Newborns had lower LF% values than adults: 22.8 (14.1, 29.4) vs 32.9 (25.1, 41.9) (p=0.009). The S index in newborns was 20.1 (16.9, 26.5)%, and 33.2 (21.2, 45.4)% in healthy adults (p=0.023).Conclusion. We have first demonstrated that the interaction of baroreflex regulation of heart rhythm and peripheral blood filling in healthy newborns is characterized by lower values of S index, than in healthy adults, which can be explained by the immaturity of the vegetative regulatory elements of the cardiovascular system. 

scholarly journals The Influence ofNrf2on Cardiac Responses to Environmental Stressors

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Reuben Howden ◽  
Eva Gougian ◽  
Marcus Lawrence ◽  
Samantha Cividanes ◽  
Wesley Gladwell ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
High Frequency ◽  
Low Frequency ◽  
Therapeutic Strategies ◽  
Environmental Stressors ◽  
Total Power ◽  
Airborne Pollutants ◽  
Cardiac Responses

Nrf2protects the lung from adverse responses to oxidants, including 100% oxygen (hyperoxia) and airborne pollutants like particulate matter (PM) exposure, but the role ofNrf2on heart rate (HR) and heart rate variability (HRV) responses is not known. We hypothesized that genetic disruption ofNrf2would exacerbate murine HR and HRV responses to severe hyperoxia or moderate PM exposures.Nrf2-/-andNrf2+/+mice were instrumented for continuous ECG recording to calculate HR and HRV (low frequency (LF), high frequency (HF), and total power (TP)). Mice were then either exposed to hyperoxia for up to 72 hrs or aspirated with ultrafine PM (UF-PM). Compared to respective controls, UF-PM induced significantly greater effects on HR (P<0.001) and HF HRV (P<0.001) inNrf2-/-mice compared toNrf2+/+mice.Nrf2-/-mice tolerated hyperoxia significantly less thanNrf2+/+mice (~22 hrs;P<0.001). Reductions in HR, LF, HF, and TP HRV were also significantly greater inNrf2-/-compared toNrf2+/+mice (P<0.01). Results demonstrate thatNrf2deletion increases susceptibility to change in HR and HRV responses to environmental stressors and suggest potential therapeutic strategies to prevent cardiovascular alterations.

Abstract P315: Increase in Stress May Contribute to Lower Heart Rate Variability in Healthy Young Subjects

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Amanda C Costa ◽  
Ana Gabriela C Silva ◽  
Cibele T Ribeiro ◽  
Guilherme A Fregonezi ◽  
Fernando A Dias
Keyword(s):  
Cardiovascular Disease ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Healthy Volunteers ◽  
Perceived Stress ◽  
Low Frequency ◽  
Statistical Correlation ◽  
Total Power ◽  
The Impact ◽  
Nonparametric Correlation

Background: Stress is one of the risk factors for cardiovascular disease and decreased heart rate variability is associated to increased mortality in some cardiac diseases. The aim of the study was to assess the impact of perceived stress on cardiac autonomic regulation in young healthy volunteers. Methods: 35 young healthy volunteers (19 to 29 years old, 6 men) from a Brazilian population were assessed for perceived stress by the translated and validated Perceived Stress Scale (PSS, 14 questions) and had the R-R intervals recorded at rest on supine position (POLAR RS800CX) and analyzed (5 minutes, Kubius HRV software) by Fast-Fourier Transform for quantification of Heart Rate Variability (HRV). Results: Average data (±SD) for age, heart rate, BMI, waist circumference and percentage of body fat (%BF) were: 21.3±2.7 years; 65.5±7.9 bpm; 22.3±1.9 Kg/m 2 ; 76.0±6.1 cm and 32.1±6.6%; respectively. The mean score for the PSS-14 was 23.5±7.2 and for the HRV parameter as follow: SSDN=54.8±21.2ms; rMSSD=55.9±32.2ms; low-frequency (LF)= 794.8±579.7ms 2 ; High-frequency (HF)= 1508.0±1783.0 ms 2 ; LF(n.u.)= 41.1±16.2; HF(n.u.)= 58.9±16.2; LF/HF=0.89±0.80 and Total power (TP)= 3151±2570ms 2 . Spearman nonparametric correlation was calculated and there was a significant correlation of PSS-14 scores and LF (ms 2 ) (r=−0.343; p= 0.044). Other HRV variables did not shown significant correlation but also had negative values for Spearman r (TP r=−0.265, p=0.124; HF r=−0.158; SSDN r=−0.207; rMSSD r=−0.243, p=0.160). LF/HF and LF(n.u.) did not correlate to PSS-14 having Spearman r very close to zero (LF/HF r=−0.007, p=0.969; LF(n.u.) r=−0.005, p=0.976). No correlation was found for HRV parameters and BMI and there was a trend for statistical correlation of %BF and LF (ms 2 ) (r=−0.309, p=0.071). Conclusions: These data demonstrate a possible association of perceived stress level and HRV at rest. Changes in LF can be a consequence of both sympathetic and parasympathetic activity, however, analyzing the other variables HF, TP, SSDN and rMSSD (all negative Spearman r) and due to the lack of changes in LF/HF ratio and LF(n.u.) we interpret that increased stress may be associated to decrease in overall heart rate variability. These changes were seen in healthy individuals and may point out an important mechanism in cardiovascular disease development.

Characteristics of heart rate variability in patients with acute coronary syndrome without ST segment elevation in comparison with clinical and biochemical parameters

2021 ◽  
Vol 29 (3) ◽  
pp. 369-378
Author(s):  
Aleksej A. Nizov ◽  
Aleksej I. Girivenko ◽  
Mihail M. Lapkin ◽  
Aleksej V. Borozdin ◽  
Yana A. Belenikina ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Acute Coronary Syndrome ◽  
Creatine Phosphokinase ◽  
Spectral Power ◽  
Low Frequency ◽  
Heart Rhythm ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment

BACKGROUND: The search for rational methods of primary, secondary, and tertiary prevention of coronary heart disease. To date, there are several publications on heart rate variability in ischemic heart disease. AIM: To study the state of the regulatory systems in the organism of patients with acute coronary syndrome without ST segment elevation based on the heart rhythm, and their relationship with the clinical, biochemical and instrumental parameters of the disease. MATERIALS AND METHODS: The open comparative study included 76 patients (62 men, 14 women) of mean age, 61.0 0.9 years, who were admitted to the Emergency Cardiology Department diagnosed of acute coronary syndrome without ST segment elevation. On admission, cardiointervalometry was performed using Varicard 2.51 apparatus, and a number of clinical and biochemical parameters were evaluated RESULTS: Multiple correlations of parameters of heart rate variability and clinical, biochemical and instrumental parameters were observed. From this, a cluster analysis of cardiointervalometry was performed, thereby stratifying patients into five clusters. Two extreme variants of dysregulation of the heart rhythm correlated with instrumental and laboratory parameters. A marked increase in the activity of the subcortical nerve centers (maximal increase of the spectral power in the very low frequency range with the underlying reduction of SDNN) in cluster 1 was associated with reduction of the left ventricular ejection fraction: cluster 147.0 [40.0; 49.0], cluster 260.0 [58.0; 64.0], cluster 360.0 [52.5; 64.5] % (the data are presented in the form of median and interquartile range; Me [Q25; Q75], p 0,05). Cluster 5 showed significant reduction in SDNN (monotonous rhythm), combined with increased level of creatine phosphokinase (CPC): cluster 5446,0 [186.0; 782.0], cluster 4141.0 [98.0; 204.0] IU/l; Me [Q25; Q75], p 0.05) and MВ-fraction of creatine phosphokinase; cluster 532.0 [15.0; 45.0], 4 cluster 412.0 [9.0; 18.0] IU/l; Me [Q25; Q75], p 0.05). CONCLUSIONS: In patients with acute coronary syndrome without ST segment elevation, cluster analysis of parameters of heart rate variability identified different peculiarities of regulation of the heart rhythm. Pronounced strain of the regulatory systems of the body was found to be associated with signs of severe pathology: the predominance of VLF (spectral power of the curve enveloping a dynamic range of cardiointervals in the very low frequency range) in spectral analysis with an underlying reduced SDNN is characteristic of patients with a reduced ejection fraction, and a monotonous rhythm is characteristic of patients with an increased level of creatine phosphokinase and MB-fraction of creatine phosphokinase.

scholarly journals Heart Rate Variability and Cardiovascular Reflex Tests for Assessment of Autonomic Functions in Preeclampsia

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Meenakshi Chaswal ◽  
Raj Kapoor ◽  
Achla Batra ◽  
Savita Verma ◽  
Bhupendra S. Yadav
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Pregnant Women ◽  
Frequency Domain ◽  
Low Frequency ◽  
Normal Pregnancy ◽  
Total Power ◽  
Autonomic Functions ◽  
Cardiovascular Reflex ◽  
Cardiovascular Reflex Tests

Alterations in the autonomic cardiovascular control have been implicated to play an important etiologic role in preeclampsia. The present study was designed to evaluate autonomic functions in preeclamptic pregnant women and compare the values with normotensive pregnant and healthy nonpregnant controls. Assessment of autonomic functions was done by cardiovascular reflex tests and by analysis of heart rate variability (HRV). Cardiovascular reflex tests included deep breathing test (DBT) and lying to standing test (LST). HRV was analyzed in both time and frequency domain for quantifying the tone of autonomic nervous system to the heart. The time domain measures included standard deviation of normal R-R intervals (SDNN) and square root of mean squared differences of successive R-R intervals (RMSSD). In the frequency domain we measured total power (TP), high frequency (HF) power, low frequency (LF) power, and LF/HF ratio. Cardiovascular reflex tests showed a significant parasympathetic deficit in preeclamptic women. Among parameters of HRV, preeclamptic group had lower values of SDNN, RMSSD, TP, HF, and LF (ms2) and higher value of LF in normalised units along with high LF/HF ratio compared to normotensive pregnant and nonpregnant controls. Furthermore, normotensive pregnant women had lower values of SDNN, TP, and LF component in both absolute power and normalised units compared to nonpregnant females. The results confirm that normal pregnancy is associated with autonomic disturbances which get exaggerated in the state of preeclampsia.

scholarly journals Autonomic and endothelial dysfunction with neurocirculatory asthenia in young men of call-up age

2019 ◽  
Vol 10 (2) ◽  
pp. 27-31
Author(s):  
Vladimir S. Ivanov ◽  
Lilia I. Levina ◽  
Sergey N. Ivanov ◽  
Vladimir S. Vasilenko
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Endothelial Dysfunction ◽  
Cardiac Activity ◽  
Young Men ◽  
Mean Value ◽  
Regulation Type ◽  
Vasodilator Reserve ◽  
Vegetative Regulation

Young men of call-up age with neurocirculatory were asthenia were examined for autonomic regulation of cardiac activity and vasodilatory reserve of the arteries. The functional state of the autonomic nervous system (ANS) was studied with the aid of rythmography with analyse of heart rate variability. The following parameters were studied: vegetative regulation type, responsiveness of departments of ANS and autonomic provision of cardiac activity. The type of vegetative regulation was determined by the mean value of RR interval and indication of the heart rate variability (∆RR). Reactivity of parasympathetic and sympathetic divisions of the ANS and autonomic support of cardiac activity were investigated using breathing test. To ensure vegetative dysadaptation cardiac activity includes reaction with low vegetative coverage of both divisions of the ANS and paradoxical reaction in which there is a decrease in ∆RRmax (instead of increase) and an increase in ∆RRmin instead of decrease. These reactions indicate autonomic dysfunction. Vasodilatory reserve of the arteries was investigated using ultrasonography of the brachial artery with compressive sample and determination of endothelium-dependent vasodilation. It was found that in boys with neurocirculatory asthenia vagotonic and sympathetic types of vegetative regulation are often determined by disadaptative vegetative provision of cardiac activity, which is accompanied by endothelial dysfunction with reduced vasodilator reserve of the arteries.

Elevated heart rate variability in physically active postmenopausal women: a cardioprotective effect?

1996 ◽  
Vol 271 (2) ◽  
pp. H455-H460 ◽  
Author(s):  
K. P. Davy ◽  
N. L. Miniclier ◽  
J. A. Taylor ◽  
E. T. Stevenson ◽  
D. R. Seals
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Postmenopausal Women ◽  
High Frequency ◽  
Low Frequency ◽  
Total Power ◽  
High Frequency Power ◽  
Fat Percentage ◽  
Physically Active ◽  
Frequency Power

Coronary heart disease (CHD) and cardiac sudden death (CSD) incidence accelerates after menopause, but the incidence is lower in physically active versus less active women. Low heart rate variability (HRV) is a risk factor for CHD and CSD. The purpose of the present investigation was to test the hypothesis that HRV at rest is greater in physically active compared with less active postmenopausal women. If true, we further hypothesized that the greater HRV in the physically active women would be closely associated with an elevated spontaneous cardiac baroreflex sensitivity (SBRS). HRV (both time and frequency domain measures) and SBRS (sequence method) were measured during 5-min periods of controlled frequency breathing (15 breaths/min) in the supine, sitting, and standing postures in 9 physically active postmenopausal women (age = 53 +/- 1 yr) and 11 age-matched controls (age = 56 +/- 2 yr). Body weight, body mass index, and body fat percentage were lower (P < 0.01) and maximal oxygen uptake was higher (P < 0.01) in the physically active group. The standard deviation of the R-R intervals (time domain measure) was higher in all postures in the active women (P < 0.05) as were the high-frequency, low-frequency, and total power of HRV. SBRS also was higher (P < 0.05) in the physically active women in all postures and accounted for approximately 70% of the variance in the high-frequency power of HRV (P < 0.05). The results of the present investigation indicate that physically active postmenopausal women demonstrate higher levels of HRV compared with age-matched, less active women. Furthermore, SBRS accounted for the majority of the variance in the high-frequency power of HRV, suggesting the possibility of a mechanistic link with cardiac vagal modulation of heart rate. Our findings may provide insight into a possible cardioprotective mechanism in physically active postmenopausal women.

NEUROCARDIAC-CARDIORESPIRATORY INTERACTION OF HEART-BRAIN MAILUNS SYNCHRONY AT DEEP ZEN MEDITATION

2016 ◽  
Vol 28 (06) ◽  
pp. 1650039
Author(s):  
Pei-Chen Lo ◽  
Wu Jue Miao Tian
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Low Frequency ◽  
Transition Process ◽  
Total Power ◽  
Sinus Arrhythmia ◽  
Respiration Rhythm ◽  
Scientific Hypothesis ◽  
Cardiorespiratory Interaction ◽  
Electrical Impulses

Innovatively new behaviors of heart rate variability caused by special heart-transition process were observed in the long-term, well-experienced Zen practitioners while practicing the heart-to-heart imprint sealing (HHIS) Zen meditation. HHIS Zen practice involves specific neurocardiac-cardiorespiratory interaction while on the way of realizing the heart-dominant, detached brain. Results of analyzing the electrocardiogram and respiratory signals of 10 experienced practitioners reveal several distinctive characteristics: (1) remarkably linear correlation between standard deviation of the normal R-to-R intervals, SDNN, and total power in very-low-frequency (VLF, 0.0033–0.04[Formula: see text]Hz) band of power spectrum of the heart-rate sequence, (2) time-varying VLF power dominating over the low-frequency and high-frequency power in heart rate variability (HRV) variations, (3) intermittent transition into slowly, deeply abdominal respiration inducing a boost of heart rates, (4) heart-rate baseline slowly fluctuating at 0.005–0.0067[Formula: see text]Hz, about 1.5–2 cycles in 5-min period, and (5) remarkable respiratory sinus arrhythmia (RSA) synchrony between heart rate and respiration rhythm. This paper proposes a rational scientific hypothesis for the neurocardiac-cardiorespiratory mechanism. The unique scheme of HHIS Zen meditation involves the spiritual-qi concentration and refinement for pinpointing into the particular energy centers, mailuns. Ignition by a subtle, deepest abdominal respiration, electrical impulses rapidly transmit from solar plexus to branchial plexuses to activate unique heart-transition process. Simultaneously, another branch streams upward the spinal cord to cervical plexus and brainstem that effectively harmonizes neurocardiac interactions. To investigate the underlying behaviors, time-domain and frequency-domain HRV based on continuous wavelet transform were employed.

scholarly journals Influence of heart failure severity on heart rate variability

2005 ◽  
Vol 133 (11-12) ◽  
pp. 484-491 ◽  
Author(s):  
Danijela Zamaklar-Trifunovic ◽  
Petar Seferovic ◽  
Mirjana Zivkovic ◽  
Vera Jelic ◽  
Goran Vukomanovic ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Nyha Class ◽  
Low Frequency ◽  
Total Power ◽  
Pump Failure ◽  
Spectral Components ◽  
Failure Severity ◽  
Heart Failure Severity

Introduction. Autonomic regulation of cardiovascular functions in congestive heart failure is characterised by enhanced sympathetic and diminished parasympathetic activity. The long term predominance of sympathetic tone is a significant factor in arrhythmogenesis, sudden cardiac death, and progressive pump failure. Heart rate variability (HRV) is a noninvasive method for estimating the sympatho vagal balance in cardiovascular control. Aim. The aim of this study was to analyse the influence of heart failure severity on HRV. Method. HRV was estimated through the spectral analysis of short term ECG (Cardiovit AT 60, Schiller, CH) in 63 patients (78% male, mean age 56.9?10.9 years) and 14 healthy volunteers (57.1% male, mean age 53.1?8.2 years). The following spectral components were measured: VLF (very low frequency), LF (low frequency), HF (high frequency), and total power (Tot Power). Results. All spectral components were statistically, significantly lower in patients with heart failure in comparison to healthy controls (VLF: 159.89?147.02 vs. 285.50?202.77 ms2; p=0.023, LF: 161.48?204.01 vs. 474.57?362.93 ms2; p<0.001, HF: 88.58?102.47 vs. 362.71?318.28 ms2; p<0.001), as well as total power (Tot Power: 723.39?644.52 vs. 1807.29?1204.74 ms2; p<0.001). A significant, negative correlation between HRV parameters and NYHA class was detected in heart failure patients (VLF: r=-0.391; p=0.002, LF: r=-0.401; p=0.001, and Tot Power r=-0.372; p=0.003). Ejection fraction proved to be in significant, positive correlation to VLF (r=0.541; p=0.002), LF (r=0.531; p=0.003), HF (r=0.418; p=0.020), and Tot Power (r=0.457; p=0.013). Conclusion. Significant HRV reduction is a precursor to incipient heart failure (NYHA I). In heart failure progression, total power as well as the power of all spectral components is progressively reduced. LF and Tot Power are the most prominent parameters for discriminating between the different stages of heart failure. These results could promote HRV as an important decision-making tool in heart failure treatment as well as in monitoring the results of that treatment.

scholarly journals Heart rate variability and arrhythmias evaluated with Holter in dogs with degenerative mitral valve disease

2014 ◽  
Vol 66 (2) ◽  
pp. 425-432 ◽  
Author(s):  
M.S. Oliveira ◽  
R.A.L. Muzzi ◽  
R.B. Araújo ◽  
L.A.L. Muzzi ◽  
D.F. Ferreira ◽  
...  
Keyword(s):  
Heart Failure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Mitral Valve ◽  
Mitral Valve Disease ◽  
Heart Rhythm ◽  
Valve Disease ◽  
Total Power ◽  
High Heart Rate ◽  
Parasympathetic Control

Cardiac diseases promote alterations in the autonomic control of the heart, leading to an increase in heart rate and, as a result, a decrease in heart rate variability (HRV).The aim of this study was to evaluate if the development of heart failure secondary to degenerative mitral valve disease (DMVD) concurs with changes in autonomic modulation of heart rhythm which are assessed by long electrocardiography examination (Holter). Dogs were evaluated by clinical examination and echocardiography in order to be categorized into the following groups: Control (healthy; n=6), DMVD (disease without heart failure; n=8), and DMVD heart failure (disease with heart failure; n=13). Arrhythmias and frequency domain HRV were determined by Holter. Diseased animals, when compared to healthy, had significantly lower total power, which indicates overall HRV. DMVD heart failure dogs also showed other disturbances such as high incidence of supraventricular arrhythmias, high heart rate, little amount of pauses (2.0s long between consecutive heartbeats), longer time in tachycardia, shorter time in bradycardia, low high frequency (parasympathetic control), and high low frequency (sympathetic and parasympathetic control) when compared to control (p<0.05). In DMVD dogs, Holter-derived variables changed with the development of heart failure.

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