scholarly journals Сardiovascular autonomic neuropathy as a diabetes complication

2016 ◽  
Vol 97 (6) ◽  
pp. 1000-1002
Author(s):  
I A Latfullin ◽  
Z F Kim ◽  
M A Mingazetdinov
Keyword(s):  
Diabetes Mellitus ◽  
Autonomic Neuropathy ◽  
Clinical Case ◽  
Clinical Observation ◽  
Clinical Manifestations ◽  
Diabetes Complication ◽  
Treatment And Prevention ◽  
Biventricular Failure ◽  
Mechanisms Of Development ◽  
Work Up

The article deals with one of the possible complications of diabetes mellitus - cardiovascular autonomic neuropathy as a variant of diabetic neuropathy. The basic pathogenic mechanisms of development of this condition and clinical manifestations depending on the patient’s age, duration and degree of diabetes compensation, are described. Diagnostic criteria for heart involvement in diabetes mellitus are discussed in detail, from asymptomatic course to sudden patient’s death, from instrumental findings to acute biventricular failure development. The main findings from patient’s work-up (ECG, echocardiography) are named. The principles of prevention and treatment of heart disease in diabetes mellitus are provided. Theory is accompanied by our own clinical observation and is illustrated with ECG. In the clinical case tactics of treatment and prevention of diabetic cardiopathy are suggested.

scholarly journals Cardiac diabetic autonomic neuropathy

2020 ◽  
pp. 94-102
Author(s):  
L. T. Akhmedzhanova ◽  
T. A. Belyakova ◽  
Yu. A. Podkovko ◽  
Yu. M. Shor
Keyword(s):  
Diabetes Mellitus ◽  
Autonomic Neuropathy ◽  
Clinical Case ◽  
Clinical Symptoms ◽  
Early Stage ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
Diabetic Polyneuropathy ◽  
Neurological Complications ◽  
Cardiac Autonomic Neuropathy

The prevalence of diabetes mellitus (DM) is steadily increasing and represents a significant public health problem. At the same time, the incidence of neurological complications of diabetes mellitus, especially diabetic polyneuropathy, is increasing. Cardiac autonomic neuropathy, a form of diabetic polyneuropathy, is the most serious complication of diabetes mellitus, as it is an independent risk factor for cardiovascular complications in patients with diabetes mellitus and is associated with increased mortality. Due to prolonged asymptomatic flow, cardiac autonomic neuropathy is often diagnosed at a late stage when treatment is not very effective. A targeted search for clinical symptoms of the disease and especially the conduct of cardiovascular tests, which make it possible to diagnose the pathology at an early stage, is essential. Clinical manifestations of cardiac autonomic neuropathy, methods of clinical and instrumental diagnostics, treatment of the disease are considered in detail in the article. The clinical case of a patient with type 2 diabetes mellitus and cardiac autonomic neuropathy, represented by orthostatic hypotension, which is the most disabling symptom, is considered. On the example of a clinical case the medicamentous and non-medicamentous approaches to treatment are discussed, as well as the role of antioxidant therapy, in particular, the preparation of alpha-lipoic acid («Berlithion») in the treatment of cardiac autonomic neuropathy.

COVID-19-associated orthostatic hypotension syndrome: direct and indirect mechanisms of development

2021 ◽  
Vol LIII (3) ◽  
pp. 64-70
Author(s):  
Elena G. Mendelevich ◽  
Alsu A. Saifeeva ◽  
Artur I. Kurbanov
Keyword(s):  
Nervous System ◽  
Orthostatic Hypotension ◽  
Clinical Case ◽  
Clinical Observation ◽  
Thrombus Formation ◽  
Correct Diagnosis ◽  
Aim Analysis ◽  
Angiotensin Converting Enzyme 2 ◽  
Mechanisms Of Development ◽  
Near Future

Background. The article presents an observation of the clinical case of orthostatic hypotension that developed after an infection caused by the SARS-CoV-2 virus. The issues of etiology, pathogenesis, diagnosis are outlined. The complexity of diagnosis at the stage of clinical observation is due to the comorbidity of possible mechanisms and the difficulty of determining the primary factor. Taking into account the study of variants of direct and indirect action of this 2019-nCoV, the description of the clinical observation of orthostatic hypotension supplements the data on the spectrum of manifestations of this disease. Aim. Analysis of the clinical case of the development of orthostatic hypotension in the post-acute period of COVID-19. Material. When conducting a literature review on the selected topic, various sources were considered. The search depth was over 7 years. For the recruitment of literature, Internet platforms UpToDate, PubMed, Medscape were used. Russian and foreign sources were studied. Methods. Anamnesis collection, objective research, specialized tests, laboratory and instrumental research methods, study of disease history, literature sources on orthostatic hypotension and the effect of COVID-19 on the autonomic nervous system. Results. The analysis of this case with the determination of the leading mechanism of orthostatic hypotension is extremely difficult. Probably, there is a combination of factors: direct and indirect effects on the nervous system at COVID-19. The direct effect is associated with the interaction of the virus with the angiotensin converting enzyme 2 receptors in the nervous system, which causes a significant increase in the concentration of bradykinin and the development of hypotension. An indirect effect is due to both increased thrombus formation with the development of PE, and autonomic dysfunction, within the framework of secondary polyneuropathy of fine fibers. Conclusion. It is likely that in the near future the number of such patients in the practice of doctors will increase, therefore, timely and correct diagnosis of these conditions, with their careful management, will be the fundamental postulates in the recovery of patients. Drawing attention to this topic will possibly expand our understanding of the spectrum of complications of COVID-19 and will greatly complement the information available today.

scholarly journals Progressing radiation injury of the rectum. Clinical observation

2020 ◽  
Vol 23 (3) ◽  
pp. 31-36
Author(s):  
T. E. Skvortsova ◽  
I. А. Oganezova
Keyword(s):  
Radiation Therapy ◽  
Clinical Case ◽  
Radiation Injury ◽  
Clinical Observation ◽  
Clinical Manifestations ◽  
Radiation Injuries ◽  
Common Complication ◽  
Pelvic Organs ◽  
Chronic Radiation ◽  
Progressive Course

Radiation damage to the rectum is the most common complication in radiation therapy of malignancies of pelvic organs. Clinical manifestations of chronic radiation proctitis can occur both 3 months after completion of therapy and decades later. Late radiation injuries to the intestine often has a persistent course, drug treatment is prolonged and repeated, in severe cases surgical treatment is required. The article presents literature data on pathophysiology, clinical picture, diagnostics and possibilities of treating this pathology. A clinical case reflecting the progressive course of the disease is described.

scholarly journals Characteristic of malabsorption syndrome at the modern stage

2021 ◽  
Vol 25 (1(97)) ◽  
pp. 121-126
Author(s):  
L. Zub ◽  
A. Shkarutyak
Keyword(s):  
Trace Elements ◽  
Intestinal Mucosa ◽  
Clinical Manifestations ◽  
General Term ◽  
Scientific Data ◽  
Malabsorption Syndrome ◽  
Trigger Factors ◽  
Correct Treatment ◽  
Treatment And Prevention ◽  
Mechanisms Of Development

Today, the term "malabsorption syndrome" is widely used in medical practice as a general term to describe the symptoms of indigestion, absorption, and transport by the intestinal mucosa of adequately digested foods, including vitamins and trace elements, resulting in a variety of metabolic disorders.The purpose of this review is to analyze scientific data that highlight information on modern views on the etiology, mechanisms of development and clinical manifestations of malabsorption syndrome.Conclusion. Today, data on the mechanisms of development and progression of the malabsorption syndrome have been significantly expanded. This makes it possible to develop methods of prevention of the trigger factors, timely correct treatment and prevention of complications of this syndrome.

scholarly journals MODERN VIEWS REGARDING THE ETIOPATHOGENESIS, DIAGNOSTIC, TREATMENT AND PREVENTION OF APERT SYNDROME

2020 ◽  
Vol 16 (4) ◽  
Author(s):  
V.V. Antsupva ◽  
I.V. Lastivka ◽  
D.V. Kolubakin ◽  
I.A. Ushko ◽  
О.V. Nahornyi
Keyword(s):  
Congenital Malformations ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Practical Interest ◽  
Apert Syndrome ◽  
Congenital Defects ◽  
Comprehensive Treatment ◽  
Pathogenetic Mechanisms ◽  
Treatment And Prevention ◽  
Surgical Methods

Relevance. Acrocephalosyndactyly – a group of syndromes of multiple congenital malformations (MCM), the main components of which are acrocephaly and syndactyly. The most common nosological form of this group is Apert syndrome. Given the manifestation of the syndrome at birth and severe congenital defects of the musculoskeletal system, brain, cardiovascular system, and others, this disease is of practical interest to doctors of many specialties. Objective: to generalize modern ideas about the pathogenetic mechanisms, diagnostic, treatment, and prevention of Apert syndrome. Materials and methods. Clinical case of Apert syndrome. Clinical and genealogical, biochemical, cytogenetic, instrumental methods of examination. Results. The paper presents a clinical case of Aper syndrome in a newborn girl with multiple malformations. Modern information on pathogenetic mechanisms, diagnostic, treatment, and prevention of Aper's syndrome is provided. Conclusions. Apert syndrome belongs to a group of syndromes of multiple congenital malformations that require the attention of doctors of various specialties. The main clinical manifestations of the disease are quite specific which allows establishing the diagnosis at birth. At the core of Aper's syndrome are mutations in the FGFR2 gene. There is a prenatal diagnostic of the disease. Reconstructive surgical methods of treatment have been developed. Timely comprehensive treatment and rehabilitation allow such patients to adapt to society.

scholarly journals DIABETIC ENTEROPATHY

2018 ◽  
pp. 70-74
Author(s):  
O. A. Yarmolenko ◽  
E. G. Malayeva ◽  
I. A. Khudyakov ◽  
M. N. Menshakova ◽  
L. A. Kobruseva
Keyword(s):  
Diabetes Mellitus ◽  
Small Intestine ◽  
Young Patient ◽  
Bacterial Growth ◽  
Clinical Case ◽  
Clinical Manifestations ◽  
Diabetes Mellitus Type 1 ◽  
Peristaltic Activity ◽  
Diabetic Enteropathy

Diabetic enteropathy is a rarely diagnosed complication of diabetes mellitus. According to literature sources, most researchers note an association of this complication with the manifestation of diabetic autonomic neuropathy. The main clinical manifestations of diabetic enteropathy are: disrupted peristaltic activity of the small intestine, excessive bacterial growth, diarrhea, and steatorrhea. The article describes a clinical case of diabetic enteropathy in a young patient, which developed 8 years after diabetes mellitus type 1 had been diagnosed.

scholarly journals Autonomic neuropathy in diabetes mellitus: Clinical manifestations, diagnosis and treatment

2011 ◽  
Vol 0 (2) ◽  
pp. 25
Author(s):  
Aleksey Nikolaevich Barinov ◽  
M V Novosadova ◽  
Aleksey Nikolayevich Barinov ◽  
M V Novosadova
Keyword(s):  
Diabetes Mellitus ◽  
Autonomic Neuropathy ◽  
Clinical Manifestations ◽  
Diagnosis And Treatment

scholarly journals Severe neuropathy in a patient with ischemic heart disease and type 2 diabetes

2016 ◽  
Vol 19 (5) ◽  
pp. 421-427
Author(s):  
Victor Yur'evich Kalashnikov ◽  
Olga Michailovna Smirnova ◽  
Konstantin Vladimirovich Melkozerov ◽  
Diana Dzhemalovna Beshlieva ◽  
Anastasiya Andreevna Tovarnova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Type 2 Diabetes Mellitus ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Autonomic Neuropathy ◽  
Clinical Manifestations ◽  
Acute Decompensation

The article describes a variety of severe clinical manifestations of diabetic autonomic neuropathy in patients with type 2 diabetes mellitus and coronary heart disease. The peculiarity of this case is the simultaneous onset of autonomic neuropathy and lesions of the cardiovascular system, complications of untreated diabetes, without acute decompensation in carbohydrate metabolism.

scholarly journals Agranulocytosis in General Practice: Diagnosis, Treatment, Prevention and Clinical Case

2016 ◽  
pp. 52-54
Author(s):  
Viktoriia Tkachenko ◽  
Yana Sadovnik ◽  
Nelia Vydyborets ◽  
Olha Bondar ◽  
Oksana Barkar
Keyword(s):  
General Practice ◽  
Clinical Case ◽  
Family Doctor ◽  
Clinical Manifestations ◽  
Antithyroid Drugs ◽  
Blood Tests ◽  
Antithyroid Therapy ◽  
Treatment And Prevention

The article presents literature about classification, pathogenesis, clinical manifestations, diagnosis, treatment and prevention of agranulocytosis. The clinical case of agranulocytosis in practice of family doctor is presented, it developed in patient, who was taking antithyroid therapy. The attention of physicians to monitoring indicators of general and biochemical blood tests while taking antithyroid drugs has made.

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