The Cost Impact of MIL-STD-810D

1986 ◽  
Vol 29 (4) ◽  
pp. 41-47
Author(s):  
Henry Caruso

The cost implications of applying MIL-STD-810D to environmental test programs is examined. Environmental test criteria are found likely to be similar to those in MIL-STD-810C in many cases, with the main difference being the derivation and application of the values. Method by method comparison shows little systematic impact to existing facilities for the majority of the methods. Misapplication of the document can greatly increase the facility impact. Test durations are also compared and shown to have minor impact on test schedules in most cases. The up-front cost for environmental engineering to prepare the new Data Item Descriptions is more than offset by the savings in redesign and retest costs.

2021 ◽  
Vol 27 (9) ◽  
pp. 1-9
Author(s):  
Isobel Clough

The NHS is facing an unprecedented backlog in both patient care and building maintenance, with severe implications for service delivery, finance and population wellbeing. This article is the first in a series discussing modular healthcare facilities as a potential solution to these issues, providing flexible and cost-effective spaces to allow services to increase capacity without sacrificing care quality. The first of three instalments, this paper will outline the problems facing the NHS estate, many of which have been exacerbated to critical levels by the COVID-19 pandemic, and what this means for service delivery. It will then make the case for modular infrastructure, outlining the potential benefits for healthcare services, staff and patients alike. Using modern methods of construction, this approach to creating physical space in healthcare can provide greater flexibility and a reduced impact on the environment. The next two articles in this series will go on to provide detailed case studies of successful modular implementation in NHS trusts, an analysis of the cost implications and guidance on the commissioning process and building a business case.


2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e19551-e19551
Author(s):  
Hongbo Yang ◽  
Cynthia Zhengyun Qi ◽  
Anand Dalal ◽  
Vamsi Bollu ◽  
Jie Zhang ◽  
...  

e19551 Background: The AE rates and HRU reported in multiple real-world evidence (RWE) studies of chimeric antigen receptor T-cell (CAR-T) therapies tisa-cel and axi-cel in r/r DLBCL have differed from those in their clinical trials. However, the cost implications from these findings are not well understood in existing literature. This study summarizes information from these RWE studies of tisa-cel and axi-cel and quantifies the associated costs. Methods: A literature review was conducted to identify RWE studies reporting AE rates and HRU of tisa-cel and axi-cel in the United States (US). AE rates and HRU were summarized and the associated costs were estimated using a micro-costing approach. Costs of AE management included hospitalization and pharmacy costs, such as intensive care unit (ICU) stays, inpatient admissions, and medications for the treatment of cytokine release syndrome (CRS) and neurotoxicity events (NE). HRU costs included hospitalization, ICU stays, and outpatient visit costs. Unit costs were from public health databases that are representative of US healthcare system and from literature. Costs were inflated to 2020 US dollars. A range was reported to present evidence if inputs are available from multiple studies. Results were summarized for tisa-cel and axi-cel separately. Results: Four publications were identified: Jaglowski 2019, Pasquini 2019, Riedell 2019, and Jacobson 2020. Across studies, grade 3+ CRS and NE occurred in 1%-4% and 0%-5% of tisa-cel-treated patients and 7%-16% and 20%-35% of axi-cel-treated patients, respectively. Tocilizumab usage was reported in 14%-20% of tisa-cel- and 62%-71% of axi-cel-treated patients. CAR-T infusion was inpatient for 36% of tisa-cel- and 92%-100% of axi-cel-treated patients. The median hospitalization days was 2 for tisa-cel and 15-16 for axi-cel. ICU transfer was observed for 7% and 28%-38% of tisa-cel- and axi-cel-treated patients, respectively, with median stays of 4 and 5 days, respectively. The median number of outpatient visits within 28 days after infusion was 6 for tisa-cel and 4 for axi-cel. The total estimated costs for managing AEs per patient were $843-$1,962 for tisa-cel and $5,979-$10,878 for axi-cel. The total estimated HRU costs per patient were $3,321 for tisa-cel and $32,394-33,166 for axi-cel. Conclusions: RWE studies suggest that patients with r/r DLBCL receiving tisa-cel had numerically lower AE rates, HRU, and cost burden than those receiving axi-cel in the US. The additional cost burden for axi-cel was primarily driven by the incremental ICU and hospitalization care due to a higher proportion of inpatient infusion among patients receiving axi-cel. Further research is warranted to compare the costs associated with the two CAR-Ts in r/r DLBCL.


2011 ◽  
Vol 4 (4) ◽  
pp. 385-394 ◽  
Author(s):  
J. Meneely ◽  
F. Ricci ◽  
S. Vesco ◽  
M. Abouzied ◽  
M. Sulyok ◽  
...  

Many different immunochemical platforms exist for the screening of naturally occurring contaminants in food from the low cost enzyme linked immunosorbent assays (ELISA) to the expensive instruments such as optical biosensors based on the phenomenon of surface plasmon resonance (SPR). The primary aim of this study was to evaluate and compare a number of these platforms to assess their accuracy and precision when applied to naturally contaminated samples containing HT-2/T-2 mycotoxins. Other important factors considered were the speed of analysis, ease of use (sample preparation techniques and use of the equipment) and ultimately the cost implications. The three screening procedures compared included an SPR biosensor assay, a commercially available ELISA and an enzymelinked immunomagnetic electrochemical array (ELIME array). The qualitative data for all methods demonstrated very good overall agreements with each other, however on comparison with mass spectrometry confirmatory results, the ELISA and SPR assay performed slightly better than the ELIME array, exhibiting an overall agreement of 95.8% compared to 91.7%. Currently, SPR is more costly than the other two platforms and can only be used in the laboratory whereas in theory both the ELISA and ELIME array are portable and can be used in the field, but ultimately this is dependent on the sample preparation techniques employed. Sample preparative techniques varied for all methods evaluated, the ELISA was the most simple to perform followed by that of the SPR method. The ELIME array involved an additional clean-up step thereby increasing both the time and cost of analysis. Therefore in the current format, field use would not be an option for the ELIME array. In relation to speed of analysis, the ELISA outperformed the other methods.


2019 ◽  
Vol 43 (6) ◽  
pp. 689 ◽  
Author(s):  
Yuejen Zhao ◽  
Deborah J. Russell ◽  
Steven Guthridge ◽  
Mark Ramjan ◽  
Michael P. Jones ◽  
...  

Objectives The aim of this study was to estimate the costs of providing primary care and quantify the cost impact of high staff turnover in Northern Territory (NT) remote communities. Methods This cost impact assessment used administrative data from NT Department of Health datasets, including the government accounting system and personnel information and payroll systems between 2004 and 2015, and the primary care information system from 2007 to 2015. Data related to 54 government-managed clinics providing primary care for approximately 27200 Aboriginal and non-Aboriginal people. Main outcome measures were average costs per consultation and per capita, cost differentials by clinic, year and levels of staff turnover. Linear regression and dominance analysis were used to assess the effect of staff turnover on primary care costs, after adjusting for remoteness and weighting analysis by service population. Both current and constant prices were used. Results On average, in constant prices, there was a nearly 10% annual increase in remote clinic expenditure between 2004 and 2015 and an almost 15% annual increase in consultation numbers since 2007. In real terms, the average costs per consultation decreased markedly from A$273 in 2007 to A$197 in 2015, a figure still well above the Medicare bulk-billing rate. The cost differentials between clinics were proportional to staff turnover and remoteness (both P<0.001). A 10% higher annual turnover rate pertains to an A$6.12 increase in costs per consultation. Conclusions High staff turnover exacerbates the already high costs of providing primary care in remote areas, costing approximately A$50 extra per consultation. This equates to an extra A$400000 per clinic per year on average, or A$21million annually for the NT government. Over time, sustained investments in developing a more stable primary care workforce should not only improve primary care in remote areas, but also reduce the costs of excessive turnover and overall service delivery costs. What is known about the topic? Population size and geographical remoteness are important cost drivers in remote clinics, whereas elsewhere in Australia the high use of short-term staff to fill positions has been identified as a major contributor to higher nurse turnover costs and to overall health service costs. Nursing staff expenditure accounts for a large proportion (46%) of total expenditure in NT remote health services, whereas expenditure on Aboriginal Health Practitioners (AHPs) comprises only 6%. Annual nurse turnover rates in remote NT clinics average approximately 150%, whereas levels of 40% in other contexts are considered high. What does this paper add? Annual expenditure for NT remote clinics has increased, on average, by 10% per annum between 2004 and 2015, but small declines in real expenditure have been observed from a maximum in 2012. Expenditure on nursing staff comprises 40% of overall expenditure in remote clinics, whereas expenditure on AHPs comprises less than 5%. The cost impact of every 10% increase in remote nurse and AHP annual turnover has been quantified as an extra A$6.12 per primary care consultation, which equates, on average, to an extra A$400000 per remote clinic, and an extra A$21million overall for the NT Department of Health each year. The average real expenditure per primary care consultation has decreased from A$273 in 2007 to A$197 in 2015, representing a statistically significant linear trend reduction of A$7.71 per consultation annually. What are the implications for practitioners (and other decision-makers)? Adjusting policy settings away from the high use of short-term staff to investment in appropriate training ‘pipelines’ for the remote primary care workforce may, in the medium and longer term, result in reduced turnover of resident staff and associated cost savings. Targeted recruitment and retention strategies that ensure individual primary care workers are an optimal fit with the remote communities in which they work, together with improved professional and personal support for staff residing in remote communities, may also help reduce turnover, improve workforce stability and lead to stronger therapeutic relationships and better health outcomes.


2021 ◽  
Author(s):  
◽  
Terian Le Compte

<p>The stereotype of an architect is expensive, with minimal consideration and awareness towards cost and budget. This is damaging the reputation of the profession. This thesis will look at the Next Generation Architect who combines both design and construction to understand the cost implications from the start to the completion of the project. A Next Generation Architect works with an innovative approach that is more affordable to how they currently practice. They design houses that are both economical and retain a strong design quality, through the value of the aesthetics, materials, and living conditions. An effective architect should be able to design, mindful of costs, along with the implications involved and actively manage the costs, based on design decisions made.  This research will commence by exploring tactics of affordability, housing economics, and costing and design tactics, to portray exemplars of affordable housing. Elements will be costed with data from QV costbuilder implemented through the use of Building information modelling (BIM) through Revit. The architectural value will explore the use of materials, living conditions, economics, and lifecycle to optimise the design. A series of precedents will be analysed to gain an understanding of the techniques of affordable methods used within New Zealand’s construction industry.  This thesis aims to provide architecturally designed and preliminarily costed affordable architectural products. Through a series of architecturally designed standalone houses that explore affordability, and tested through the use of architecture as a product across four sites, displaying different site conditions of the Wellington region.  This thesis will portray efficient, economic building and design techniques and cost monitoring while retaining a strong architectural quality.  The aim is to convey the contemporary role of a Next Generation Architect who works accurately with value. Who is mindful of costs and designs economically, without compromising the quality of an architecturally designed product.</p>


2000 ◽  
Vol 15 (1) ◽  
pp. 43-56
Author(s):  
Michael Spaulding

Globalization pits pressures for liberalization against state claims to political and economic sovereignty. Less powerful states in particular face strong pressure from the international trade regime to liberalize their economies irrespective of the impact on domestic stability and national goals. East Asia has been a hold-out against the global trend toward liberalization. This paper shows that the bail-out package demanded by the IMF in 1997 during the East Asian financial crisis imposed unprecedented restrictions on state governance without regard for long-term implications. The paper argues that the IMF's motivation was to harmonize financial governance of the affected economies with Western practices. However, the cost of this initiative to the stability of the region has been overlooked. The East Asian region has carved out for itself a unique niche in the international political economy by resisting penetration of Western finance capital. Already governments have fallen and deep resentments have been sewn over the reversal. More seriously for the future, assumptions that free-market liberalism can be imposed top-down ignore the extent to which economic institutions and preferences are embedded in culture.


2020 ◽  
Vol 52 (2) ◽  
pp. 03-04
Author(s):  
Gerardino Pirozzi

This examination plans to improve the nature of administration of the cost entryways by building up a lining free ecological designing based programmed cost doors. Rather than charge card to distinguish the cost clients and do the instalment, the proposed framework utilizes a noncontact innovation that usually alluded as RFdetection. The medium is recognized by the frameworks similarly as it is going from first to last the cost door. This strategy dispenses with the line at the cost entryway since the instalment is done in fly. Next, an instalment warning telephone through SMS administration. It replaces and dispenses with paper wastes around the cost doors. This article presents the equipment advancement of the proposed framework.


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