scholarly journals Anxiolytic Effects of Acute Injection of Hydro-Alcoholic Extract of Lettuce in the Elevated Plus-Maze Task in Rats

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Alireza Komaki ◽  
Zarife Khaledi Nasab ◽  
Siamak Shahidi ◽  
Abdolrahman Sarihi ◽  
Iraj Salehi ◽  
...  
Keyword(s):  
Elevated Plus Maze ◽  
Alcoholic Extract ◽  
Maze Task ◽  
Plus Maze ◽  
Acute Injection

scholarly journals Effects of the Essential Oil from Leaves of Alpinia zerumbet on Behavioral Alterations in Mice

2009 ◽  
Vol 4 (1) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Shio Murakami ◽  
Mariko Matsuura ◽  
Tadaaki Satou ◽  
Shinichiro Hayashi ◽  
Kazuo Koike
Keyword(s):  
Essential Oil ◽  
Mass Spectra ◽  
Elevated Plus Maze ◽  
Neuropsychiatric Symptoms ◽  
Retention Indices ◽  
Reproductive Hormone ◽  
Behavioral Alterations ◽  
Maze Task ◽  
Plus Maze ◽  
Alpinia Zerumbet

In phytotherapy, the essential oil from the leaves of Alpinia zerumbet ( Alpinia speciosa K. Schum.) (EOAZ) is used for neuropsychiatric symptoms, such as depression, stress and anxiety, and chronic problems that are associated with reproductive hormone imbalances in women. The chemical composition of EOAZ was analyzed by GC/MS, and the EOAZ properties inducing behavioral alterations in mice were examined by behavioral observations (BO) and an elevated plus-maze task (EPM), widely used as a method for assessing anxiolytic-like behaviors. Five major compounds, p-cymene (28.0 ± 5.0%), 1,8-cineole (17.9 ± 4.2%), terpinen-4-ol (11.9 ± 6.3%), limonene (6.3 ± 2.2%), and camphor (5.2 ± 2.1%) were identified by retention indices, mass spectra and comparison with standards. Inhalational administration of EOAZ (8.7 ppm) induced unique jumping behaviors in mice. To further investigate the behavioral regulatory mechanisms of EOAZ, we administered an intraperitoneal injection of either 10 mg/kg 5-HTP or 10 mg/kg fluoxetine prior to the EOAZ inhalations. By 5-HTP or fluoxetine pretreatments, the jumping frequencies were significantly decreased. In EPM, EOAZ (0.087 and 8.7 ppm) obviously showed the anxiolytic-like activity in mice.

Agmatine induces anxiolysis in the elevated plus maze task in adult rats

2003 ◽  
Vol 141 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Daniel Lavinsky ◽  
Nice Sarmento Arteni ◽  
Carlos Alexandre Netto
Keyword(s):  
Elevated Plus Maze ◽  
Maze Task ◽  
Adult Rats ◽  
Plus Maze

Effects of NOS inhibitors on the benzodiazepines-induced memory impairment of mice in the modified elevated plus-maze task

2013 ◽  
Vol 244 ◽  
pp. 100-106 ◽  
Author(s):  
Jolanta Orzelska ◽  
Sylwia Talarek ◽  
Joanna Listos ◽  
Sylwia Fidecka
Keyword(s):  
Memory Impairment ◽  
Elevated Plus Maze ◽  
Maze Task ◽  
Plus Maze ◽  
Nos Inhibitors

Behavioral Changes Induced by Angiotensin AT1 Receptors Blockade in the Rat Brain

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
L. Hritcu ◽  
W. Bild ◽  
A. Ciobica ◽  
V. Artenie ◽  
I. Haulica
Keyword(s):  
Angiotensin Ii ◽  
Elevated Plus Maze ◽  
Anxiety State ◽  
Avoidance Task ◽  
Maze Task ◽  
Term Memory ◽  
Y Maze ◽  
Plus Maze ◽  
The Brain

Aims:The brain renin-angiotensin system is involved in learning and memory, but the actual role of angiotensin II and its metabolites in this process has been difficult to comprehend. In the present study we assessed the role of the angiotensin AT1 receptors in certain behavioral effects of angiotensin II using their selective antagonist losartan and PD123319, intracerebroventricularly (icv) administrated.Methods:Male Wistar rats were divided into three groups: 1. sham-operated; 2. Losartan; 3. PD123319. All drugs were stereotaxically icv injected. Learning and memory tests began 2 weeks after the operation, and the ability of the rats to acquire the operant task was studied by means of Y-maze task and passive avoidance task, respectively. The anxiety state was measured in elevated plus maze.Results:Losartan and PD123319 significantly impaired spatial memory in Y-maze task, suggesting significant effects on short-term memory. In passive avoidance task, both angiotensin II antagonist, significantly decreased step-through-latency, suggesting significant effects on long-term memory. In elevated plus maze measuring anxiety, both drugs diminished anxiety state.Conclusions:Our results suggest the considerable involvement of the brain ATi angiotensin receptors in the cognition improving effects of angiotensin.

scholarly journals EVALUATION OF ANTI-ALZHEIMER ACTIVITY OF ALCOHOLIC EXTRACT OF COSTUS PICTUS D. DON LEAVES IN WISTAR ALBINO RATS

2019 ◽  
pp. 36-43
Author(s):  
PASHA KHOOSHBU ◽  
IMTIYAZ ANSARI
Keyword(s):  
Body Weight ◽  
Elevated Plus Maze ◽  
Albino Rats ◽  
Alcoholic Extract ◽  
Object Recognition Test ◽  
Albino Rat ◽  
Y Maze ◽  
Plus Maze ◽  
Wistar Albino Rats ◽  
Phytochemical Studies

Objective: The aim was to assess the effect of anti-Alzheimer’s activity of the alcoholic extract of Costus pictus D. Don Leaves in Alzheimer induce Wistar albino rats. Methods: In the present study, the efficacy of an Extract of Costus pictus D. Don (ECPDD) was evaluated against scopolamine-induced Alzheimer in the Wistar albino rat. Donepezil at a dose of 2.5 mg/kg, ECPDD was given in rat at a dose of 100 mg/kg body weight, 150 mg/kg body weight, and 200 mg/kg body weight. Anti-Alzheimer activity was assessed by victimization novel object recognition test, elevated plus maze, and Y-maze. And by biochemical test like neurotransmitter esterase activity, catalase activity, malonyldialdehyd and glutathione assays. Results: Results showed that extracts treatment prevents Alzheimer and increases the level of acetylcholine, catalase, glutathione peroxidase, and phytochemical studies identified the presence of flavonoid and alkaloid in the ECPDD. Conclusion: According to the results, it was concluded that the leave of C. pictus D. Don has significant anti-Alzheimer activity due to the presence of potent antioxidants such as flavonoid and anticholinesterase enzyme present in alkaloids.

scholarly journals Anxiolytic Effect of Ocimum basilicum Extract in Rats Tested by Elevated Plus-Maze Task

2015 ◽  
Vol 2 (2) ◽  
Author(s):  
Zahra Nemati ◽  
Samaneh Oveisi ◽  
Alireza Komaki ◽  
Siamak Shahidi
Keyword(s):  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Ocimum Basilicum ◽  
Maze Task ◽  
Plus Maze

scholarly journals Effect of hydro-alcoholic extract of Ziziphus spina-christi against scopolamine-induced anxiety in rats

2016 ◽  
Vol 11 (2) ◽  
pp. 421 ◽  
Author(s):  
Mahbubeh Setorki
Keyword(s):  
Motor Coordination ◽  
Elevated Plus Maze ◽  
Video Clip ◽  
Positive Control ◽  
Negative Control ◽  
Vehicle Group ◽  
Alcoholic Extract ◽  
Rotarod Test ◽  
Plus Maze ◽  
Injection Anxiety

<p class="Abstract">The aim of this study was to observe the effect of <em>Ziziphus spina-christi</em> extract against anxiety related behavior induced by scopolamine. Rats were randomly divided into six groups, each group consists of eight rats. Vehicle group received distilled water, negative control received scopolamine (1 mg/kg) and positive control received diazepam (1 mg/mL). Experimental groups received <em>Z. spina-christi</em> extract (50, 100 and 200 mg/kg IP) 30 min after scopolamine injection. Anxiety related behaviors were assessed using the elevated plus maze. The rotarod test was used to evaluate motor coordination. Administration of <em>Z. spina-christi</em> extract (200 mg/kg) significantly increased the time spent in the open arm of elevated plus maze. The extract also reduced the percentage of closed arms entries and time spent in the closed arms. Different concentration of <em>Z. spina-christi</em> extract didn’t affect motor coordination and balance. Hydro-alcoholic extract of <em>Z. spina-christi</em> significantly ameliorate scopolamine-induced anxiety.</p><p><strong>Video clip</strong></p><p><a href="https://youtube.com/v/LTHNppf_Euo">Elevated plus maze</a>: 1 min 58 sec </p>

scholarly journals Studying some neuroprotective effects of Calotropis procera extracts against scopolamine- induced neuropschiatric comorbidities in a rodent model of epilepsy

2021 ◽  
Vol 26 (6) ◽  
pp. 3114-3119
Author(s):  
PROSPER T. KINDA ◽  
SAMSON GUENNE ◽  
BASILE TINDANO ◽  
NOUFOU OUEDRAOGO ◽  
NABÉRÉ OUATTARA ◽  
...  
Keyword(s):  
Elevated Plus Maze ◽  
Neuroprotective Effect ◽  
Bark Extract ◽  
Calotropis Procera ◽  
Root Bark ◽  
Protective Effects ◽  
Behavioral Tests ◽  
Maze Task ◽  
Y Maze ◽  
Plus Maze

Many plants are largely used in alternative medicine of Burkina Faso for neuropsychiatric disorders treatment. However, their neuro-pharmacological properties are less evaluated through scientific studies. The present study aims to evaluate the neuroprotective effect of Calotropis procera leaves and root-bark aqueous extract, focusing on a scopolamine-induced model of epilepsy in rodents. In this study, we evaluated this plant extracts possible protective effects on the central nervous system, through the behavioral tests and the enzymes activity assays. Thus, elevated plus-maze test and Y-maze task were used to evaluate animals behavioral and UV/visible spectrophotometer methods were used to evaluate the enzyme’s activities in brain’s supernatant. Our results are showing no significant protective effects of leaves extract, but it revealed a significant neuroprotective effect of root-bark aqueous extract, as well as in the behavioral tests and the brain’s oxidative enzymes specific activity evaluation. Indeed, anti-amnesic and anxiolytic activities were observed through Y maze task and elevated plus maze tests for the groups of animals receiving root-bark extract (100 mg/kg b.w.). In these test, inhibition of disturbances of Time spent in Open Arms, Spontaneous Alternation, and Transfer Latency induced after scopolamine administration were recorded with animals received root-bark extract. Likewise, the superoxide dismutase and catalase activity disturbance induced by scopolamine were also inhibited in root-bark extract pre-administered group. Thus, our study provides biochemical and neuro-pharmacological data for traditional use of C. procera for neuropsychiatric disorders treatment, including scopolamine-induced epilepsy symptoms (mainly referring to the psychiatric comorbidities of this disorder).

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