In vivo antioxidant potential of Anogeissus latifolia bark in ethanol-induced oxidative stress in rats

2016 ◽  
Vol 3 (9) ◽  
pp. 407-411
Author(s):  
Yerra Rajeshwar
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Potential

scholarly journals Cardioprotective and Metabolomic Profiling of Selected Medicinal Plants against Oxidative Stress

2018 ◽  
Vol 2018 ◽  
pp. 1-17 ◽  
Author(s):  
Nadia Afsheen ◽  
Khalil-ur-Rehman ◽  
Nazish Jahan ◽  
Misbah Ijaz ◽  
Asad Manzoor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Medicinal Plants ◽  
Plasmid Dna ◽  
Research Work ◽  
Antioxidant Potential ◽  
Piper Nigrum ◽  
Coronary Artery Ligation ◽  
Hemodynamic Parameters ◽  
Metabolomic Profiling

In this research work, the antioxidant and metabolomic profiling of seven selected medicinally important herbs including Rauvolfia serpentina, Terminalia arjuna, Coriandrum sativum, Elettaria cardamom, Piper nigrum, Allium sativum, and Crataegus oxyacantha was performed. The in vivo cardioprotective potential of these medicinal plants was evaluated against surgically induced oxidative stress through left anterior descending coronary artery ligation (LADCA) in dogs. The antioxidant profiling of these plants was done through DPPH and DNA protection assay. The C. oxyacantha and T. arjuna showed maximum antioxidant potential, while the E. cardamom showed poor antioxidative strength even at its high concentration. Different concentrations of extracts of the said plants exhibited the protection of plasmid DNA against H2O2 damage as compared to the plasmid DNA merely treated with H2O2. The metabolomic profiling through LC-MS analysis of these antioxidants revealed the presence of active secondary metabolites responsible for their antioxidant potential. During in vivo analysis, blood samples of all treatment groups were drawn at different time intervals to analyze the cardiac and hemodynamic parameters. The results depicted that the group pretreated with HC4 significantly sustained the level of CK-MB, SGOT, and LDH as well as hemodynamic parameters near to normal. The histopathological examination also confirmed the cardioprotective potential of HC4. Thus, the HC4 being safe and inexpensive cardioprotective herbal combination could be considered as an alternate of synthetic drugs.

scholarly journals In vitro alpha-amylase inhibition and in vivo antioxidant potential of Amaranthus spinosus in alloxan-induced oxidative stress in diabetic rats

2011 ◽  
Vol 18 (1) ◽  
pp. 1-5 ◽  
Author(s):  
B.S. Ashok Kumar ◽  
K. Lakshman ◽  
R. Nandeesh ◽  
P.A. Arun Kumar ◽  
B. Manoj ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Rats ◽  
Antioxidant Potential ◽  
Alpha Amylase ◽  
Amaranthus Spinosus

scholarly journals Astaxanthin as Potential Antioxidant Agent Protects from Accumulation of Heavy-metals in Brain

2017 ◽  
Vol 1 (2) ◽  
Author(s):  
Mohammed Said Moosa Al-Bulish, Changhu Xue, Mostafa I. Waly,
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Hydrogen Peroxide ◽  
Protective Effect ◽  
Neurological Disorders ◽  
Antioxidant Properties ◽  
Body Burden ◽  
Antioxidant Potential ◽  
Antioxidant Agent

Humans are increasingly exposed to heavy-metals from food, water, medicine, vaccines, and cosmetics. The toxicity of heavy-metals in humans is briefly summarized, links the possible causal relationships between a high heavy-metals body burden and a number of neurological disorders including Alzheimer’s, Parkinson and Autism disorders. This study aimed to assess the antioxidant properties of Astaxanthin (ASTA) to determine the effect of orally administered ASTA capability of restrict accumulation and toxicity of heavy-metals in brain of rats. It also, assess against Hydrogen peroxide induced oxidative stress and antioxidant potential properties of ASTA with comparing the affectivity of 5% and 10% of ASTA in increased glutathione-recycling enzymes (GPx oxidation). A significant change was observed as increased glutathione-recycling enzymes (GPx oxidation) of rats and showed a protective effect against accumulation of Aluminum(AL) in rat’s brain tissues. The results of this in-vivo study demonstrated that ASTA 10% is more can affective in restriction of accumulation and toxicity of Al in rate brain and its contented can protects against oxidative-stress.          

Is There a Correlation Between In Vitro Antioxidant Potential and In Vivo Effect of Carvacryl Acetate Against Oxidative Stress in Mice Hippocampus?

2014 ◽  
Vol 39 (4) ◽  
pp. 758-769 ◽  
Author(s):  
Lúcio Fernandes Pires ◽  
Luciana Muratori Costa ◽  
Antonia Amanda Cardoso de Almeida ◽  
Oskar Almeida Silva ◽  
Gilberto Santos Cerqueira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Potential

In vitroandin vivoevaluation of an exopolysaccharide produced byLactobacillus helveticusKLDS1.8701 for the alleviative effect on oxidative stress

2019 ◽  
Vol 10 (3) ◽  
pp. 1707-1717 ◽  
Author(s):  
Bailiang Li ◽  
Peng Du ◽  
Etareri Evivie Smith ◽  
Song Wang ◽  
Yuehua Jiao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lactobacillus Helveticus ◽  
Antioxidant Potential

We systematically investigated thein vitroandin vivoantioxidant potential of EPS produced byLactobacillus helveticusKLDS1.8701.

scholarly journals Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 714 ◽  
Author(s):  
Giovanni Ribaudo ◽  
Marco Bortoli ◽  
Chiara Pavan ◽  
Giuseppe Zagotto ◽  
Laura Orian
Keyword(s):  
Oxidative Stress ◽  
In Silico ◽  
Rational Design ◽  
Molecular Design ◽  
Antioxidant Potential ◽  
Oxidative Stress Biomarkers ◽  
Systematic Analysis ◽  
Antioxidant Supplements

Due to high oxygen consumption, the brain is particularly vulnerable to oxidative stress, which is considered an important element in the etiopathogenesis of several mental disorders, including schizophrenia, depression and dependencies. Despite the fact that it is not established yet whether oxidative stress is a cause or a consequence of clinic manifestations, the intake of antioxidant supplements in combination with the psychotropic therapy constitutes a valuable solution in patients’ treatment. Anyway, some drugs possess antioxidant capacity themselves and this aspect is discussed in this review, focusing on antipsychotics and antidepressants. In the context of a collection of clinical observations, in vitro and in vivo results are critically reported, often highlighting controversial aspects. Finally, a new challenge is discussed, i.e., the possibility of assessing in silico the antioxidant potential of these drugs, exploiting computational chemistry methodologies and machine learning. Despite the physiological environment being incredibly complex and the detection of meaningful oxidative stress biomarkers being all but an easy task, a rigorous and systematic analysis of the structural and reactivity properties of antioxidant drugs seems to be a promising route to better interpret therapeutic outcomes and provide elements for the rational design of novel drugs.

scholarly journals Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1340
Author(s):  
Olga V. Averina ◽  
Elena U. Poluektova ◽  
Mariya V. Marsova ◽  
Valery N. Danilenko
Keyword(s):  
Oxidative Stress ◽  
Gut Microbiota ◽  
Antioxidant Properties ◽  
Natural Antioxidants ◽  
Antioxidant Potential ◽  
Diagnostic Systems ◽  
Human Gut ◽  
Human Gut Microbiota

Lactobacilli and bifidobacteria are an important part of human gut microbiota. Among numerous benefits, their antioxidant properties are attracting more and more attention. Multiple in vivo and in vitro studies have demonstrated that lactobacilli and bifidobacteria, along with their cellular components, possess excellent antioxidant capacity, which provides a certain degree of protection to the human body against diseases associated with oxidative stress. Recently, lactobacilli and bifidobacteria have begun to be considered as a new source of natural antioxidants. This review summarizes the current state of research on various antioxidant properties of lactobacilli and bifidobacteria. Special emphasis is given to the mechanisms of antioxidant activity of these bacteria in the human gut microbiota, which involve bacterial cell components and metabolites. This review is also dedicated to the genes involved in the antioxidant properties of lactobacilli and bifidobacteria strains as indicators of their antioxidant potential in human gut microbiota. Identification of the antioxidant biomarkers of the gut microbiota is of great importance both for creating diagnostic systems for assessing oxidative stress and for choosing strategies aimed at restoring the normal functioning of the microbiota and, through it, restoring human health. In this review, the practical application of probiotic strains with proven antioxidant properties to prevent oxidative stress is also considered.

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