Allografts for surgery in the closure of nasal septal intraoperative defects

Surgical correction of the deviation of nasal septum is the most frequently performed surgical interventions in Otorhinolaryngology departments. Sometimes such operations can be complicated by an intraoperative defect in the nasal septum, which is not always possible to close with autogenous tissue. Thats why it has become important to use new allogenic transplant materials in the treatment of these defects. The purpose of the study was to evaluate the effectiveness of allografts (allogeneic fascia and allogenic cartilage treated by Alloplant technology) in closure of intraoperative defects of the nasal septum. The treatment was performed to 40 patients aged 2455 who developed defect of the mucous membrane of the nasal septum during the operation for nasal spetum deviation. Patients were randomly divided into two groups of 20 people. The 1st group included patients whose allogenic transplantat materials were used in addition to their own tissues during the closure of the defect. The 2nd group consisted of patients whose autogenous tissues were used during the operation. The data of functional state of the nasal mucosa and the anatomical integrity of the nasal septum of all patients before treatment, one month and one year after the treatment were checked and compared. It was revealed that allografts (allogenic fascia and allogenic cartilage treated by Alloplant technology) demonstrated an anti-inflammatory effect, and their use in closing of intraoperative defects of the nasal septum is more effective. This procedure also accelerates improvement of the functional activity of the nasal mucosa in comparison with the use of autogenous tissues solely.

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Low Molecular Weight Heparin Improves the Inflammatory State of Acute Sinusitis Rats Through Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway

Frontiers in Pharmacology ◽

10.3389/fphar.2021.726630 ◽

2021 ◽

Vol 12 ◽

Author(s):

Tong Wu ◽

Sihan He ◽

Zan Jiao ◽

Xiang Liang ◽

Yu Chen ◽

...

Keyword(s):

Nasal Mucosa ◽

Acute Sinusitis ◽

Low Molecular Weight ◽

Upper Respiratory Tract ◽

Inflammatory Mechanism ◽

Upper Respiratory ◽

Anti Inflammatory ◽

Experimental Group ◽

Inflammatory Effect ◽

Respiratory Tract Inflammation

Introduction: Low molecular weight heparin (LMWH), a natural sulfated glycosaminoglycan with an affinity for proangiogenic factors, is produced by chemical or enzymatic depolymerization of unfractionated heparin (UFH). Known for its anticoagulant effects, LMWH has recently been reported to have a strong anti-inflammatory effect on colitis, myocarditis, and airway inflammation. However, as a newly-developed drug, its anti-inflammatory mechanism in upper respiratory tract inflammation has not been well-studied.Methods: SD rats were randomly divided into control and experimental groups. The experimental group was established by building an acute nasal sinusitis model with expansion sponges mixed with Streptococcus pneumoniae. Then the experimental group rats were subcutaneously injected with different concentrations of LMWH. After seven consecutive days of injection, some rats were sacrificed, and blood and nasal mucosa samples were taken to determine their inflammation status. The remaining acute sinusitis rats were randomly selected for a week of nasal irrigation with normal saline or saline mixed with different concentrations of LMWH. One week later, rats were sacrificed, and samples of blood and nasal mucosa were taken to determine the inflammation status.Results: Rat nasal mucosa in the model group had obvious inflammation. The degree of nasal mucosa inflammation damage in the experimental group was lower than in the experimental control group, proving that LMWH has a protective effect on the nasal mucosa and that the effect correlates with dosage. Irrigation of the nose with saline mixed with LMWH can improve the anti-inflammatory effect. Protein related to the TLR4-MyD88-NF-κB signaling pathway was activated in the acute sinusitis rat model, and LMWH can significantly inhibit its expression.Conclusion: This is the first report of the anti-inflammatory effect of LMWH in acute upper respiratory tract inflammation, together with an explanation of its anti-inflammatory mechanism. The findings contribute a theoretical basis for its potential anti-tumor effect.

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Rhinological tactics in the complex treatment of patients with severe combined cranio-facial trauma who are on mechanical ventilation

Medical Council ◽

10.21518/2079-701x-2021-18-202-211 ◽

2021 ◽

pp. 202-211

Author(s):

V. V. Dvorianchikov ◽

Yu. K. Yanov ◽

Ya. A. Nakatis ◽

V. S. Isachenko ◽

D. M. Ilyasov ◽

...

Keyword(s):

Mechanical Ventilation ◽

Mucous Membrane ◽

Head Trauma ◽

Nasal Mucosa ◽

Functional State ◽

Mucociliary Clearance ◽

Prolonged Mechanical Ventilation ◽

The Body ◽

Facial Trauma ◽

Malignant Neoplasms

Introduction. In recent years, injuries ranked fourth among the main causes of death of the population after diseases of the cardiovascular system, malignant neoplasms and infectious diseases. The clinical course of associated injuries, as a rule, is characterized by a high number of complications, much more than in isolated injuries.Objective. Explore approaches to improving otorynolaryngological tactics from the standpoint of normalizing the functional state of the nasal mucosa, as well as increasing the effectiveness of treatment of patients with severe concomitant trauma on prolonged mechanical ventilation.Materials and methods. In the process of studying the problem of impaired mucociliary clearance of the nasal mucosa, the functional state of the mucous membrane in patients with severe concomitant head trauma undergoing prolonged artificial lung ventilation was analyzed. We studied the state of one of the most important mechanisms of sanitation and local protection of the respiratory tract - mucociliary clearance, which provides the necessary potential for barrier, cleansing and immune functions. A study was made of the thermal effect of the nasal cavity, pH + of the mucous membrane, the study of the frequency of beating of the cilia of the ciliated epithelium and the rate of mucociliary transportResults and discussion. The results of the study showed that the problem of post-traumatic and nosocomial sinusitis in patients with severe concomitant head trauma must be resolved as soon as possible, with the involvement of modern diagnostic and treatment methods, including the proposed method of artificial ventilation of the nose. The severity of the patient's condition, the severity of the injuries received excludes the use of advanced methods of surgical, otorhinolaryngological treatment.Conclusion. 12:30 PMThe use of minimally invasive methods of treatment, precision technical execution, including under endovideo control, polysinusotomy made it possible not to burden the condition of the victims and exclude iatrogenic damage that could entail irreversible changes in the body and condition of the victim.

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Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000620 ◽

2019 ◽

pp. 1-9

Author(s):

Samira Salem ◽

Essaid Leghouchi ◽

Rachid Soulimani ◽

Jaouad Bouayed

Keyword(s):

Time Course ◽

Acute Inflammation ◽

Lichen Species ◽

Paw Edema ◽

Sod Activity ◽

Edema Formation ◽

Lobaria Pulmonaria ◽

Anti Inflammatory ◽

Endogenous Antioxidant ◽

Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

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Anti-inflammatory effect of Curcuma longa (turmeric) rhizome when administered topically in gel form

Planta Medica ◽

10.1055/s-0029-1234748 ◽

2009 ◽

Vol 75 (09) ◽

Cited By ~ 1

Author(s):

AH Mollik ◽

W Mozammel Haq ◽

S Chandra Bachar ◽

R Jahan ◽

M Rahmatullah

Keyword(s):

Curcuma Longa ◽

Anti Inflammatory ◽

Inflammatory Effect

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Anti-inflammatory effect of Mitragyna speciosa crude methanol extract on the guinea pig ileum

Planta Medica ◽

10.1055/s-0029-1234736 ◽

2009 ◽

Vol 75 (09) ◽

Cited By ~ 1

Author(s):

WM Shaik Mossadeq ◽

K Syamimi ◽

MP Azyyati ◽

ZA Zakaria ◽

AK Arifah ◽

...

Keyword(s):

Guinea Pig ◽

Methanol Extract ◽

Guinea Pig Ileum ◽

Mitragyna Speciosa ◽

Anti Inflammatory ◽

Crude Methanol Extract ◽

Inflammatory Effect

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Anti-inflammatory effect of Uncaria tomentosa in an experimental model of cyclophosphamide-induced hemorrhagic cystitis

Planta Medica ◽

10.1055/s-0032-1320641 ◽

2012 ◽

Vol 78 (11) ◽

Author(s):

IST Figueiredo ◽

FT Benevides ◽

NMS Queiroz ◽

LM Marques ◽

TFG Souza ◽

...

Keyword(s):

Experimental Model ◽

Hemorrhagic Cystitis ◽

Uncaria Tomentosa ◽

Anti Inflammatory ◽

Inflammatory Effect

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Therapeutic use of lowmolecular weight heparin for capillaritis alba

Phlebologie ◽

10.1055/s-0037-1622240 ◽

2008 ◽

Vol 37 (05) ◽

pp. 259-265 ◽

Cited By ~ 11

Author(s):

H. Kutzner ◽

G. Hesse

Keyword(s):

Case Studies ◽

Randomized Study ◽

Compression Therapy ◽

Venous Hypertension ◽

Therapeutic Use ◽

Prospective Randomized Study ◽

Anti Inflammatory ◽

Positive Effect ◽

Inflammatory Effect

SummaryThe reason of the so called ulcerated capillaritis alba or idiopathic atrophie blanche is vasculopathy caused by severe venous hypertension. Thrombosed and rarificated vessels worsen the oxygenation, increase permanent inflammation and impede the necessary compression therapy. The anti-inflammatory effects of heparin alleviate pain and being independent from the antithrombotic ones it needs much lower doses for treatment. This anti-inflammatory effect is now becoming more important in clinical phlebology. Case studies of more than 50 patients and one prospective randomized study of 87 patients clearly demonstrate the ameliorated healing of ulcerated atrophie blanche. In our office we could document this positive effect with 22 patients. We present the pathophysiology of low molecular heparins for ulcerated capillaritis alba and our own experiences with it.

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