scholarly journals Polycystic ovarian syndrome: long-term surgical outcomes (literature review)

2021 ◽  
Vol 8 (2) ◽  
pp. 61-66
Author(s):  
Tat'yana S. Gracheva ◽  
Elena A. Sosnova
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Literature Review ◽  
Surgical Outcomes ◽  
Polycystic Ovarian Syndrome ◽  
Common Disease ◽  
Increased Risk ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is a fairly common disease that occupies one of the leading positions among the reasons of endocrine infertility. Women with this diagnosis have an increased risk of developing diabetes mellitus, cardiovascular disease, metabolic syndrome (dyslipidemia, decreased sensitivity to peripheral tissue insulin, hyperinsulinemia). Currently, a step-by-step and individual approach to treatment has been applied, including both conservative treatments and surgical ones.

scholarly journals MANAGEMENT OF ENDOCRINE DISEASE: Metabolic effects of bariatric surgery

2016 ◽  
Vol 174 (1) ◽  
pp. R19-R28 ◽  
Author(s):  
Ricard Corcelles ◽  
Christopher R Daigle ◽  
Philip R Schauer
Keyword(s):  
Cardiovascular Disease ◽  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
Metabolic Effects ◽  
Perioperative Morbidity ◽  
Increased Risk ◽  
Long Term Impact

Obesity is associated with an increased risk of type 2 diabetes, hypertension, dyslipidemia, cardiovascular disease, osteoarthritis, numerous cancers and increased mortality. It is estimated that at least 2.8 million adults die each year due to obesity-related cardiovascular disease. Increasing in parallel with the global obesity problem is metabolic syndrome, which has also reached epidemic levels. Numerous studies have demonstrated that bariatric surgery is associated with significant and durable weight loss with associated improvement of obesity-related comorbidities. This review aims to summarize the effects of bariatric surgery on the components of metabolic syndrome (hyperglycemia, hyperlipidemia and hypertension), weight loss, perioperative morbidity and mortality, and the long-term impact on cardiovascular risk and mortality.

scholarly journals Study on the Prevalence and Characteristics of Metabolic Syndrome in Women of Reproductive Age Group with Polycystic Ovarian Syndrome

2017 ◽  
Vol 9 (4) ◽  
pp. 341-347
Author(s):  
Rekha R Madusudhanan ◽  
Bindu Nambisan ◽  
Mayadevi Brahmanandan ◽  
Sreekumari Radha
Keyword(s):  
Metabolic Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Reproductive Age ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
Ovarian Syndrome ◽  
Reproductive Age Group

ABSTRACT Introduction Polycystic ovarian syndrome (PCOS) is an endocrine disorder affecting all age groups and presenting with myriad problems like menstrual irregularities, hirsutism, anovulatory infertility, and long-term complications like diabetes, cardiovascular problems, etc. Aim Study was aimed at finding the prevalence, characteristics, and various risk factors of metabolic syndrome (MS) in reproductive age group in our hospital. Materials and methods Using statistical table, a sample size of 131 was calculated and patients were recruited as per inclusion criteria. Polycystic ovarian syndrome was diagnosed by the American Society for Reproductive Medicine (ASRM)/European Society of Human Reproduction and Embryology (ESHRE) criteria. After informed consent, a detailed history was obtained and physical examination was carried out to assess, body weight, height, body mass index (BMI), waist—hip ratio (WHR), and blood pressure (BP). Fasting blood glucose, triglycerides, and high-density lipoprotein (HDL) were measured for each woman Results Prevalence of MS in our study was 45.8%; 26.7% of patients had a combination of increased waist circumference, raised triglycerides, and low HDL; 55.2% of patients had a fasting blood sugar (FBS) levels more than 100 mg%. Age of the patient was a statistically significant risk factor of MS with 100% of patients in the age group of 35 to 39 presenting with MC. Body mass index was also a statistically significant risk factor with 82.6% with BMI > 30 having MC. Other important risk factors include a WHR more than 0.95, presence of diabetes in mother or sister, and presence of acanthosis; 71% of patients with WHR more than 0.95 had MC. Age of menarche, duration of menstrual cycles, and hirsutism showed no significant relationship. Conclusion An outstanding fact that emerged in this study was that 94% of women with PCOS had HDL values <50 mg/dL. And 58% had triglycerides more than 150 mg/dL. Hence, lifestyle modification and early intervention will hopefully spare long-term complication of PCOS. How to cite this article Madusudhanan RR, Nambisan B, Brahmanandan M, Radha S. Study on the Prevalence and Characteristics of Metabolic Syndrome in Women of Reproductive Age Group with Polycystic Ovarian Syndrome. J South Asian Feder Obst Gynae 2017;9(4):341-347.

COMPLICATIONS OF PREGNANCY IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

2011 ◽  
Vol 22 (3) ◽  
pp. 188-206
Author(s):  
MALLIKA AZIZIA ◽  
PAUL HARDIMAN
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Reproductive Age ◽  
Polycystic Ovaries ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Ovarian Syndrome

Polycystic ovary syndrome (PCOS) is a common hormonal disorder affecting around 5–8% of women of reproductive age. It has a variable clinical spectrum including hyperandrogenism, menstrual abnormalities, polycystic ovaries and metabolic features like diabetes mellitus, obesity and dyslipidaemia. The manifestation of PCOS and its impact especially on reproductive function and pregnancy are profoundly affected by associated features of obesity/raised body mass index and metabolic syndrome.

Metabolic syndrome and the menopause

2008 ◽  
Vol 14 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Risto J Kaaja
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Pharmacological Therapy ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Atherogenic Dyslipidaemia ◽  
Ovarian Syndrome

The metabolic syndrome consists of a combination of risk factors that include abdominal obesity, atherogenic dyslipidaemia, hypertension and insulin resistance. It increases the risk of cardiovascular disease and type 2 diabetes. The increased risk of cardiovascular disease is higher in women than in men. The first manifestation of metabolic syndrome may occur in pregnancy presenting as gestational diabetes or preeclampsia. Both conditions are associated with increased insulin resistance. Also metabolic syndrome is more common in polycystic ovarian syndrome. It has been suggested that there is a metabolic syndrome resulting from the menopause due to estrogen deficiency, as many of the risk factors are more prevalent in postmenopausal women. Also estrogen replacement improves insulin sensitivity and reduces the risk of diabetes. The key elements in managing the metabolic syndrome are weight reduction, increasing physical activity and diet modification. If blood pressure, lipid and glycaemic control are not achieved through these interventions then pharmacological therapy will be required.

scholarly journals Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-10
Author(s):  
Nabajyoti Deka ◽  
Swapnil Bajare ◽  
Jessy Anthony ◽  
Amrutha Nair ◽  
Anagha Damre ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
High Plasma ◽  
Insulin Sensitizers ◽  
Increased Risk

Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.

scholarly journals Diagonostic parameters of polycystic ovarian syndrome in outpatient setting

2021 ◽  
Vol 53 (1-2) ◽  
pp. 17-22
Author(s):  
Zannatul Ferdous Jesmin ◽  
Eti Saha ◽  
Farjana Yasmin ◽  
Anjuman Ara ◽  
SM Khaliduzmnan
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Clinical Feature ◽  
Cross Sectional ◽  
Total Study Population ◽  
Cystic Ovary ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathy in reproductive age women. PCOS has complex etiopathology, diverse clinical presentation and diagnostic criteria. Objective: Objective of this study was to find out the determinant clinical feature and investigations for improving diagnostic accuracy and assessment of PCOS, thereby evolving opportunity for proper treatment. Methods: This prospective cross sectional observational study was conducted in Islami Bank hospital, Khulna, from January 2017 to February 2020. Women seeking gynecological consultation in outdoor with at least one complaint of oligomenorrhoea, hirsutism, weight gain or infertility were enrolled for study. Subjects were selected on the basis of inclusion and exclusion criteria. A structured proforma, based on relevant history, laboratory work up, risk factors and co morbidities were prepared before-hand. Diagnosis of PCOS was based on Rotterdam criteria, 2003. The clinical manifestations of PCOS, frequency of different sub phenotypes and associated morbidities were measured as outcome. Results: Total study population was 202. Age of subjects were in between 13- 37 years. Thirty seven (18%) were adolescent, one hundred forty (65.7%) patients were overweight and obese. Majority of cases were married. Complaint of infertility was present in 125 (61.9%) cases. Oligomenorrhoea, hirsutism, poly cystic ovary was present in 145 (71.8%), 137 (67%), and 130 (64.4%) patients respectively. LH/FSH ratio >2 in 45 (22.3%) cases, Serum free testosterone >0.79 ngm/ml were associated with hirsutism. PCOS with clinical sub phenotypes A, B, C, and D were 38(18.9%), 72 (35.6%), 27 (13.4%) and 65 (32.2%) cases respectively. Case morbidities were Hypertension 75 (37.1%), Diabetes mellitus 18 (8.9%) and Metabolic syndrome 44 (20.1%). Link with Hypothyroidism Hyperprolactinemia were identified in 47 (19%) cases. Conclusion: Oligo-anovulatory woman with hyperandrogenism with or without poly cystic ovary were diagnosed as a largest group of PCOS-A and B sub phenotypes. Infertility, hypothyroidism, hypertension, diabetes mellitus, metabolic syndrome and endometerial hyperplasia were common. Bang Med J Khulna 2020: 53 : 17-22

KETOGENIC DIET: A NEW STRATEGY FOR HANDLING SCIZOPHRENIANS

2021 ◽  
Vol 3 (3) ◽  
pp. 99-103
Author(s):  
Sugeng Mashudi
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Literature Review ◽  
Search Engine ◽  
Ketogenic Diet ◽  
New Strategy ◽  
Negative Effect ◽  
Pubmed Search ◽  
Heart Disorders

The use of antipsychotics in the long term > 20 years has a negative effect on people with schizophrenia. Apart from the symptoms of schizophrenia, the emergence of metabolic syndrome needs attention. Metabolic syndrome as a negative effect of antipsychotics will have an impact on heart disorders and diabetes mellitus. Various approaches have been taken to reduce metabolic syndrome starting from a mideteran diet, low gluten, and a ketogenic diet. The purpose of this study was to determine the ketogenic diet as a new strategy for handling schizophrenics. This study is a literature review using the Pubmed search engine and Science direct. The key words used was the ketogenic diet and schizophrenia. A total of 3 articles were analyzed according to the PRISMA protocol. Research is needed on the effect of the ketogenic diet on improving the condition of schizophrenics.

Long-Term Metabolic Consequences in Patients with a History of Gestational Diabetes

2020 ◽  
Vol 26 (43) ◽  
pp. 5564-5572
Author(s):  
Eleni Kousta ◽  
Adamantia Kontogeorgi ◽  
Stephen Robinson ◽  
Desmond G. Johnston
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Increased Risk ◽  
Metabolic Complication ◽  
History Of

Gestational diabetes mellitus is a common metabolic complication of pregnancy. Universal guidelines on gestational diabetes have been impeded by the long-term controversies on its definition and screening strategies. The prevalence of gestational diabetes is rising all over the world, is significantly influenced by ethnicity and its rise is mainly attributed to increasing maternal obesity and age. Gestational diabetes mellitus has important long-term implications, including gestational diabetes recurrence, increased risk for developing type 2 diabetes, metabolic syndrome and cardiovascular disease for the mother. Gestational diabetes mellitus may be viewed as a chronic metabolic disorder that is identified in women during gestation and may provide a unique opportunity for the early identification and primary prevention of type 2 diabetes mellitus and cardiovascular disease in these women. In this mini-review, the evolution of screening tests for gestational diabetes and guidelines are briefly described and metabolic and cardiovascular long-term consequences of women with a history of gestational diabetes are summarized. A summary of our own St. Mary’s Hospital-UK Research series on long-term metabolic consequences of 368 women with a history of gestational diabetes of 3 different ethnic groups and 482 control women is also included. We found that approximately 2 years following delivery, 37% of women with a history of gestational diabetes had abnormal glucose concentrations, but, most importantly, even those who were normoglycaemic, postpartum displayed metabolic abnormalities on detailed testing. Future research needs to focus on the prevention of gestational diabetes long-term complications, but also in identification of pre-pregnancy predictors and risk reduction before conception.

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