scholarly journals EXPERIMENTAL JUSTIFICATION OF MODELING OF THE LIVER ABCESSES

2019 ◽  
Vol 21 (1) ◽  
pp. 18-21
Author(s):  
V VI Alipov ◽  
M S Lebedev ◽  
A G Musaelyan ◽  
D R Mustafaeva ◽  
A I Alipov ◽  
...  
Keyword(s):  
Liver Abscess ◽  
Liver Parenchyma ◽  
Laboratory Animals ◽  
Double Lumen ◽  
The Third ◽  
Cystic Cavity ◽  
Experimental Justification ◽  
Instrumental Methods ◽  
Instrumental Justification

Goal. Develop a model of purulent liver abscess (GAP), which corresponds to all the classic signs of a delimited abscess. Material and methods. Simulation of GAP was carried out in an experiment on 60 laboratory animals. Under ultrasound control (UC), a double-lumen Fogerty catheter was inserted into the established portion of the liver, a cystic cavity was formed in 3 days, which was infected and after 3 days GAP was obtained. In the modeling of GAP, clinical, planimetric, microbiological, morphological and instrumental methods of investigation were used. Results. On the third day of the experiment, a round cystic cavity of the liver with a diameter of 1,8 cm3 was formed. Three days after infection, a classic purulent abscess develops, surrounded by a dense wall formed from the liver parenchyma. As a result of the experiment, a clinical, microbiological, morphological and instrumental justification for modeling GAP with all its classic features was obtained. The conclusion. The proposed method for modeling purulent liver abscess is economically and technically profitable, minimally traumatic, provides guaranteed formation of classical GAP in the shortest possible time.

scholarly journals Radiation-Induced Metabolic Shifts in the Hepatic Parenchyma: Findings from 18F-FDG PET Imaging and Tissue NMR Metabolomics in a Mouse Model for Hepatocellular Carcinoma

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2573
Author(s):  
Yi-Hsiu Chung ◽  
Cheng-Kun Tsai ◽  
Ching-Fang Yu ◽  
Wan-Ling Wang ◽  
Chung-Lin Yang ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Liver Parenchyma ◽  
Metabolic Alterations ◽  
Nmr Metabolomics ◽  
Post Irradiation ◽  
The Third ◽  
Radiation Induced ◽  
18F Fdg ◽  
The Right ◽  
Over Time

Purpose: By taking advantage of 18F-FDG PET imaging and tissue nuclear magnetic resonance (NMR) metabolomics, we examined the dynamic metabolic alterations induced by liver irradiation in a mouse model for hepatocellular carcinoma (HCC). Methods: After orthotopic implantation with the mouse liver cancer BNL cells in the right hepatic lobe, animals were divided into two experimental groups. The first received irradiation (RT) at 15 Gy, while the second (no-RT) did not. Intergroup comparisons over time were performed, in terms of 18F-FDG PET findings, NMR metabolomics results, and the expression of genes involved in inflammation and glucose metabolism. Results: As of day one post-irradiation, mice in the RT group showed an increased 18F-FDG uptake in the right liver parenchyma compared with the no-RT group. However, the difference reached statistical significance only on the third post-irradiation day. NMR metabolomics revealed that glucose concentrations peaked on day one post-irradiation both, in the right and left lobes—the latter reflecting a bystander effect. Increased pyruvate and glutamate levels were also evident in the right liver on the third post-irradiation day. The expression levels of the glucose-6-phosphatase (G6PC) and fructose-1, 6-bisphosphatase 1 (FBP1) genes were down-regulated on the first and third post-irradiation days, respectively. Therefore, liver irradiation was associated with a metabolic shift from an impaired gluconeogenesis to an enhanced glycolysis from the first to the third post-irradiation day. Conclusion: Radiation-induced metabolic alterations in the liver parenchyma occur as early as the first post-irradiation day and show dynamic changes over time.

Seminal Vesiculitis in Three Pet Rabbits (Oryctolagus cuniculus)

2016 ◽  
Vol 52 (5) ◽  
pp. 335-340 ◽  
Author(s):  
Maria Ardiaca ◽  
Cristina Bonvehi ◽  
Marina Cuesta ◽  
Alicia Gomez ◽  
Andres Montesinos
Keyword(s):  
Abdominal Pain ◽  
Medical Treatment ◽  
Seminal Vesicle ◽  
Clinical Signs ◽  
Blood Analysis ◽  
Laboratory Animals ◽  
Experimental Conditions ◽  
Surgical Biopsy ◽  
The Third ◽  
Treatment And Diagnosis

ABSTRACT To date, descriptions of pathologic conditions of the seminal vesicle in rabbits are scarce and limited to the laboratory animals in experimental conditions. The present article describes three cases of strangury, abdominal pain, and anorexia associated with seminal vesiculitis in pet rabbits. Three non-neutered male pet rabbits aged 3.6, 1.5, and 2.1 yrs were presented with strangury, abdominal pain, and anorexia. Seminal vesiculitis was diagnosed based on clinical signs and ultrasonography findings. Vesiculectomy was performed in two cases that presented strangury refractory to medical treatment, and diagnosis was confirmed by histopathology. In the third case, the patient received medical treatment, and a sequela in the form of lithiasis of the seminal vesicle was detected 3 yrs later. Plain radiographs were nearly unremarkable, and results from complete blood analysis and urinalysis were not specific in all three cases. Contrast radiography was performed in one case, showing a dilated seminal vesicle. Ultrasound and surgical biopsy seem to be the most sensitive techniques in the diagnosis of this pathology. Seminal vesiculitis must be included in the differential diagnosis of acute or chronic strangury in male pet rabbits.

scholarly journals Evaluation of Hemodynamics in Focal Steatosis and Focal Spared Lesion of the Liver Using Contrast-Enhanced Ultrasonography with Sonazoid

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Kazue Shiozawa ◽  
Manabu Watanabe ◽  
Takashi Ikehara ◽  
Michio Kogame ◽  
Mie Shinohara ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Real Time ◽  
Liver Parenchyma ◽  
Target Lesion ◽  
Invasive Procedures ◽  
Enhancement Pattern ◽  
The Third ◽  
Fat Deposits ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography

We aim to investigate the hemodynamics in focal steatosis and focal spared lesion of the liver using contrast-enhanced ultrasonography (CEUS) with Sonazoid. The subjects were 47 patients with focal steatosis and focal spared lesion. We evaluated enhancement patterns (hyperenhancement, isoenhancement, and hypoenhancement) in the vascular phase and the presence or absence of a hypoechoic area in the postvascular phase for these lesions using CEUS. Of the 24 patients with focal steatosis, the enhancement pattern was isoenhancement in 19 and hypoenhancement in 5. Hypoechoic areas were noted in the postvascular phase in 3 patients. Of the 23 patients with focal spared lesions, the enhancement pattern was isoenhancement in 18 and hyperenhancement in 5. No hypoechoic areas were noted in the postvascular phase in any patient. The hemodynamics in focal steatosis and focal spared lesions in nondiffuse fatty liver can be observed using low-invasive procedures in real-time by CEUS. It was suggested that differences in the dynamics of enhancement in the vascular phase of CEUS were influenced by the fat deposits in the target lesion, the surrounding liver parenchyma, and the third inflow.

scholarly journals Peliosis Hepatis—The Chameleon: An Unusual Presentation Mimicking Liver Abscess

2019 ◽  
Vol 02 (02) ◽  
pp. 126-129
Author(s):  
Ruchi Rastogi ◽  
Parveen Batra ◽  
Subhash Gupta ◽  
Anjali K. Gupta ◽  
Bharat Aggarwal ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Liver Abscess ◽  
Liver Parenchyma ◽  
Unusual Presentation ◽  
Peliosis Hepatis ◽  
Morphologic Type

AbstractPeliosis hepatis is a rare vascular condition characterized by multiple randomly distributed blood-filled cavities throughout the liver, ranging in size from a few millimeters to several centimeters in diameter. The appearance of peliotic lesion on imaging varies depending on morphologic type, concomitant hemorrhagic component, and presence or absence of background hepatic steatosis. Here, we report an unusual presentation of peliosis hepatis as an exophytic mass arising in liver parenchyma, mimicking a liver abscess.

scholarly journals A retrospective analysis of pyogenic liver abscess and antibiotic resistivity of common pathogens in Peshawar

2020 ◽  
Vol 7 (12) ◽  
pp. 4190-4196
Author(s):  
Nadia Bashir ◽  
Muhammad Adnan Shereen ◽  
Abeer Kazmi ◽  
Muhammad Sajid ◽  
Hafiz Ullah
Keyword(s):  
Liver Abscess ◽  
Demographic Data ◽  
Pyogenic Liver Abscess ◽  
Liver Parenchyma ◽  
Biochemical Tests ◽  
Female Ratio ◽  
Male Predominance ◽  
Demographic Study ◽  
Life Threatening ◽  
Sensitivity Rate

Background: Pyogenic liver abscess (PLA) is a rare but life-threatening disease, with a frequency ranging from 10.83 to 17.45 per 100,000 persons. The major cause of PLA is bacterial infection of liver parenchyma. The present research study was designed to investigate the common microbes causing PLA in Peshawar (Pakistan) and to evaluate a variety of the most capable and efficient antibiotics for treatment of PLA. Methods: A 7-year (2012 - 2018) retrospective demographic study of medical records of all PLA patients (n = 379) admitted to the Hayatabad Medical Complex (HMC) and Khyber Teaching Hospital (KTH) was initially performed. The demographic study was followed by biochemical tests and antibiotic resistivity tests of microorganisms, isolated from available samples and selected from literature using web services. Results & Conclusion: The demographic data revealed that 70% of the PLA patients were under the age of 50, with male predominance (male to female ratio of 3:1). It was concluded that K. pneumonia, poly-microbes (K. pneumonia and Citrobacter), and E. coli are the most common microbes involved in causing PLA in the population of Peshawar. E.coli, Citrobacter and K. pneumonia were sensitive to Cefixime and Ciprofloxacin (100% sensitivity rate), but showed significant resistance against Amoxycillin, Oxacillin and Fusidic Acid. It is, therefore, prudent to practice susceptibility-directed antibiotic therapy.

scholarly journals COMPARATIVE CHARACTERISTICS OF THE APPLYING OF PHYSICAL METHODS AT CHOLECYSTECTOMY IN AN EXPERIMENT

2019 ◽  
pp. 52-56
Author(s):  
N. V. Cherkova ◽  
L. M. Dushik ◽  
G. M. Gerasymov ◽  
А. О. Dushik
Keyword(s):  
Cryogenic Treatment ◽  
Bile Leakage ◽  
Liver Parenchyma ◽  
Laboratory Animals ◽  
Ultrasound Exposure ◽  
Ultrasonic Scalpel ◽  
Group Iii ◽  
Group I ◽  
Comparative Aspect ◽  
Histomorphological Changes

In an experiment on laboratory animals (84 male rabbits of Shinchilla breed weighing 3 to 3.5 kg), the processes of liver tissue regeneration after cholecystectomy using electrocoagulation, cryoexposure and Harmonic scalpel (HS) at different terms were studied in a comparative aspect. The objective of the work: to study in the experiment histomorphological changes in the gallbladder bed under the influence of monopolar electrocoagulation, low temperatures and ultrasonic scalpel in a comparative aspect at cholecystectomy. Depending on the method of resection of the gallbladder and the method of hemostasis, all animals were divided into three groups. In Group I, after resection of the gallbladder, the animals underwent hemostasis of the gallbladder bed (GBB) with the help of monopolar electrocoagulation. In Group II, hemostasis was performed by the cryogenic treatment of GBB with a laparoscopic cryoapplicator. In group III, after cholecystectomy, the animals underwent hemostasis with HS. The results of the experiment made it possible to compare not only the hemostatic and cholestatic effects of various types of energy, but also to assess the grade of traumatization of the liver parenchyma in the operative intervention zone and the influence of various methods on the quality and terms of the reparative processes. The effectiveness of the HS in achieving final hemostasis with bleeding from GBB in cholecystectomy has been experimentally proven. It is determined that the depth and grade of the dystrophic process is less expressed with ultrasound exposure. The use of HS in the treatment of GBB was a safe and reliable method of stopping parenchymal hemorrhage and bile leakage from the liver parenchyma.

Pathology of Pyogenic Liver Abscess in Children

1999 ◽  
Vol 2 (6) ◽  
pp. 537-543 ◽  
Author(s):  
Fausto E.L. Pereira ◽  
Carlos Musso ◽  
Jane S. Castelo
Keyword(s):  
Liver Abscess ◽  
Liver Tissue ◽  
Penetrating Trauma ◽  
Hepatic Abscess ◽  
Pyogenic Liver Abscess ◽  
Liver Parenchyma ◽  
Larva Migrans ◽  
Morphological Evidence ◽  
Predisposing Factor ◽  
The Right

Little is known about preexisting lesions in livers of children with pyogenic liver abscess (PLA). Study of these lesions may elucidate possible predisposing factors for the disease. In Vitória, state of Espirito Santo, Brazil, PLA in children is frequently associated with helminthic infections and eosinophilia. We hypothesize that nematode infection with larvae migrating through the liver is a predisposing factor for PLA, because the infection induces immunomodulation and likely trapping of bacteria in liver granulomas. In this report, we describe observations of 22 cases of PLA in children studied at autopsy (16 cases) or in surgical biopsies (6 cases), including 17 boys and 5 girls ranging in age from 1 to 13 years (mean 4.6 years, median 3.5 years). Multiple abscesses in both lobes were found in 13 cases and a single abscess was found in the right lobe in 10 cases. All cases showed histologically classical pyogenic inflammation without morphological evidence of amoebiasis. In six cases there were granulomas similar to those caused by larva migrans visceralis (from Toxocara or other nematodes) in liver tissue not affected by the abscess. Nematode antigens in central areas of necrosis of granuloma in all six cases and fragments of a larva, possibly of Toxocara, were found on samples immunohistochemically stained with polyclonal anti- Toxocara antibodies. There were numerous eosinophils in abscesses with Charcot-Leyden crystals. Eosinophils were found frequently in portal triads far from the abscess wall. In four cases, in which bile duct ascariasis was found, worms were noted in the bile ducts, and eggs were found in liver parenchyma surrounding the abscess in two cases. Foreign-body granulomas were found in one case in which penetrating trauma was the cause of abscess. In one case there was one histiocytic granuloma whose origin was not determined. The observation of six cases of granuloma similar to larva migrans visceralis (or produced by other nematode larva) in liver tissue not directly affected by the abscess supports the hypothesis that helminth infections with larva migrating through the liver are a predisposing factor for pyogenic hepatic abscess in children.

scholarly journals Determination of the Content of Promoters in Magnetite and Wustite Phases in the Fused Iron Catalyst

2013 ◽  
Vol 15 (1) ◽  
pp. 27-29 ◽  
Author(s):  
Zofia Lendzion-Bieluń ◽  
Roman Jędrzejewski
Keyword(s):  
Aluminum Oxide ◽  
Iron Catalyst ◽  
Potassium Oxide ◽  
Oxide Content ◽  
Icp Oes ◽  
The Third ◽  
Instrumental Methods ◽  
Fused Iron Catalyst ◽  
Magnetite Phase

Taking advantage of differences in etching rates of crystallographic phases, forming an oxidized form of the fused iron catalyst, a content of promoters in main phases, magnetite and wustite, was determined. A calcium oxide content in magnetite and wustite was 0.54 wt% and 3.59 wt%, respectively. Aluminum oxide was found in the magnetite phase, and its content was 4.5 wt%. The third promoter, potassium oxide, was almost completely located outside these phases. XRD and ICP-OES instrumental methods were used in the investigations.

Surgical Treatment of Recurrent Dacryocystitis Secondary to Cystic Dilatation of the Nasolacrimal Duct in a Dog

2004 ◽  
Vol 40 (3) ◽  
pp. 216-219 ◽  
Author(s):  
Bertrand Lussier ◽  
Michel Carrier
Keyword(s):  
Surgical Treatment ◽  
Nasal Cavity ◽  
Nasolacrimal Duct ◽  
Golden Retriever ◽  
Cystic Dilatation ◽  
Surgical Exploration ◽  
The Third ◽  
Cystic Cavity ◽  
Left Maxillary Sinus ◽  
Ocular Discharge

A 3-year-old, castrated male golden retriever was presented for evaluation of recurrent ocular discharge of 4 months’ duration from the left eye. Dacryocystorhinography was performed and demarcated a cystic dilatation of the left nasolacrimal duct with obstruction of the duct distal to the cystic cavity. Surgical exploration of the left maxillary sinus was performed to confirm the diagnosis and reestablish drainage into the nasal cavity. Recovery was uneventful, and the dog has been asymptomatic for >36 months postoperatively. This report documents the third published case of surgical treatment for cystic dilatation of the nasolacrimal duct.

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