scholarly journals Evaluation of the efficiency and safety of therapy with calcium for pregnant women with symphysiopathia

2013 ◽  
Vol 62 (2) ◽  
pp. 10-16
Author(s):  
Anna Gennadyevna Dedul ◽  
Yelena Vitalyevna Mozgovaya ◽  
Tatyana Ivanovna Oparina ◽  
Gulrukhsor Khaybulloyevna Tolibova ◽  
Mariya Anatolyevna Petrosyan ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Symptoms ◽  
Mineral Metabolism ◽  
Clinical Manifestations ◽  
Placental Tissue ◽  
Urinary Calcium ◽  
Symphysis Pubis ◽  
Lower Limbs ◽  
Pubic Bone ◽  
Daily Excretion

According to the modern concepts, symphysiopathia usually occurs in the second half of pregnancy as a result of mineral metabolism violations. This complication of pregnancy mainly manifested as a pubic bone diastasis, pain in the bone of the pelvis and of the lower limbs, and cramps in the calf muscles. There are clinical manifestations of the symphysiopathia; indicators of calcium, magnesium and phosphorus in the blood and daily excretion of these minerals in the urine compared with those which have healthy pregnant women in the second and third trimesters. There is histological and immunohistochemical evaluation of placentas of patients on background treatment. The vast majority of pregnant women with symphysiopathia found increase in urinary calcium and magnesium in the urine remaining in the normal performance of mineral metabolism. According to the studies, the preparation of magnesium, calcium, and the local ultraviolet irradiation of symphysis pubis may reduce the clinical symptoms of symphysiopathia. The use of calcium supplements together with magnesium does not lead to excessive deposition of calcium salts in the placental tissue and improve metabolic function of placenta.

scholarly journals The impact of the novel coronavirus infection COVID-19 on the mother-placenta-fetus system

2021 ◽  
Author(s):  
NV Nizyaeva ◽  
NA Lomova ◽  
EL Dolgopolova ◽  
UL Petrova ◽  
TE Karapetyan ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Manifestations ◽  
Placental Tissue ◽  
Inflammatory Factors ◽  
The Novel ◽  
Placental Development ◽  
Index Group ◽  
Elevated Expression ◽  
Novel Coronavirus ◽  
The Impact

Impaired placental development during early pregnancy associated with systemic damage to the vascular endothelium in patients with COVID-19 may result in a number of complications. The study was aimed to reveal histological and immunohistochemical (IHC) features of placental tissue in pregnant women with COVID-19 at different stages of gestation, and to examine the contribution of those to pathogenesis of the disease involving mother-placenta-fetus system. The following two groups of pregnant women were studied: index group of 66 patients with COVID-19, and comparison group of 40 women with no symptoms of viral infection. Macroscopic and microscopic examination, and the IHC analysis of placental samples were carried out. Clinical and anamnestic characteristics of patients with COVID-19 were analyzed taking into account disease severity, delivery route and perinatal outcome. ICH staining using primary antibody revealed elevated expression of proinflammatory factors (TNFα, IL8) and reduced level of anti-inflammatory factors (IL4) in placental structures of patients with moderate and severe СOVID-19 (р < 0.05). The villous tree rearrangement and the development of subclinical placental insufficiency, which could in some cases be decompensated during labor, resulting in clinical manifestations of acute fetal hypoxia were detected in the placental samples obtained from the index group patients. The obstetrical tactics for mothers with COVID-19 should be decided individually based on the risk factors; continuous cardiotocography should be used during labor. It may be appropriate to conduct IHC analysis of placenta in puerperant women with COVID-19 in order to fine-tune the tactics of neonatal management and to predict possible neonatal complications.

scholarly journals Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration

Brain ◽  
2020 ◽  
Vol 143 (8) ◽  
pp. 2369-2379
Author(s):  
Tatyana Pozner ◽  
Martin Regensburger ◽  
Tobias Engelhorn ◽  
Jürgen Winkler ◽  
Beate Winner
Keyword(s):  
Clinical Symptoms ◽  
Current Knowledge ◽  
Clinical Manifestations ◽  
Lower Limbs ◽  
Pathogenic Variants ◽  
Structural Abnormalities ◽  
Neuronal Systems ◽  
And Function ◽  
The Impact

Abstract Hereditary spastic paraplegia (HSP) is a heterogeneous group of rare motor neuron disorders characterized by progressive weakness and spasticity of the lower limbs. HSP type 11 (SPG11-HSP) is linked to pathogenic variants in the SPG11 gene and it represents the most frequent form of complex autosomal recessive HSP. The majority of SPG11-HSP patients exhibit additional neurological symptoms such as cognitive decline, thin corpus callosum, and peripheral neuropathy. Yet, the mechanisms of SPG11-linked spectrum diseases are largely unknown. Recent findings indicate that spatacsin, the 280 kDa protein encoded by SPG11, may impact the autophagy-lysosomal machinery. In this update, we summarize the current knowledge of SPG11-HSP. In addition to clinical symptoms and differential diagnosis, our work aims to link the different clinical manifestations with the respective structural abnormalities and cellular in vitro phenotypes. Moreover, we describe the impact of localization and function of spatacsin in different neuronal systems. Ultimately, we propose a model in which spatacsin bridges between neurodevelopmental and neurodegenerative phenotypes of SPG11-linked disorders.

scholarly journals Coronavirus disease 2019 (COVID-19) manifestations during pregnancy in all three trimesters: A case series

2021 ◽  
Author(s):  
Elham Askary ◽  
Poordast Tahereh ◽  
Zahra Shiravani ◽  
Mohammad Ali Ashraf ◽  
Atefeh Hashemi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Vertical Transmission ◽  
Skin Diseases ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Case Series ◽  
Skin Lesions ◽  
Labor Pain ◽  
Neonatal Outcomes ◽  
Vaginal Deliveries

Background: Coronavirus disease 2019 (COVID-19) pandemic has raised concerns about the susceptibility amongst different groups of the population. Pregnant women are one such group. This study was conducted to investigate the effect of COVID-19 on pregnancy and maternal/neonatal outcomes. Case presentation: This case series was conducted on 16 pregnant women with COVID-19 from March 21 to May 11, 2020. Clinical characteristics, pregnancy complications, medication used, maternal/neonatal outcomes, and fatality rate were investigated through this study. The mean age of the patients was 30.06 yrs. Patients from all three trimesters were included (1 in first, 5 in second, and 10 in the third trimesters). The most common clinical symptoms were shortness of breath (n = 10), dry cough (n = 10), myalgia (n = 8), and chills (n = 7). Also, three cases had papulosquamous skin lesions with fissuring. The most common laboratory results were leukocytosis (n = 8), increased liver enzymes (n = 6), elevated CRP (n = 5), and thrombocytopenia (n = 4). There was one case of maternal mortality, five of premature labor pain (PLP), two of preeclampsia, and two of placenta accreta. Twelve pregnancies were terminated (nine cesarean sections, three vaginal deliveries). Among neonates, we had 6 cases of preterm labor. All neonates had negative PCR results. Conclusion: Clinical manifestations and paraclinical results were similar to nonpregnant patients. There was no evidence of vertical transmission. PLP and premature rupture of membranes (PROM) were the most common complications in the second and third trimesters of pregnant COVID-19 women, which can lead to rupture of the uterus. Termination and delivery should be planned individually. Key words: Pregnancy, COVID-19, Maternal-fetal infection transmission, Vertical transmission of infectious disease, Papulosquamous skin diseases.

Some Clinical Manifestations and Laboratory Findings of Human Gigantica Fascioliasis in Pregnant Women and Children in Central-Coastal Provinces, Vietnam, 2003-2017

2019 ◽  
Vol 4 (3) ◽  
Keyword(s):  
Pregnant Women ◽  
Clinical Symptoms ◽  
Wide Spectrum ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Fasciola Gigantica ◽  
World Health ◽  
Laboratory Findings ◽  
Laboratory Parameters ◽  
Women And Children

Introduction: Fascioliasis is a disease of the hepatobiliary system, caused by Fasciola spp that are increasing and threating of public health in the tropic areas, including of Central coastal of Vietnam. World Health Organisation estimates that at least 2.4 million people are infected in more than 70 countries worldwide, with several million at risk, and particularly, no continent is free from fascioliasis. This study carried out to evaluate several typical clinical and paracinical aspects in the pregnant women and children groups with fascioliasis. Methods: With the descriptive cross-sectional study design, and sample size in line with hospital based data. Results: the data post-analysis showed that total of 94 pregnant women and 212 child with gigantica fascioliasis were enrolled:- In the pregnant women group: the major clinical symptoms of epigastric and Chauffard Rivet triangle pain (95.74%), subshoulder muscle pain (97.87%), gastrointestinal disturbances as abdominal pain plus constipation (14.89%), loosed stool (22.34%), nausea and/or vomit (29.78%), mild fever (68%), allergic reaction with pruritis and urticaria (64.89%), mild anemia (4.26%), rare symptoms may be hepatomegaly (6.38%), chest pain, dyspnoea (43.62%), jaundice (2.13%); Laboratory parameters were positive ELISA test with Fasciola gigantica antigen (95.74%), hepatobiliary lesions by ultrasound (97.87%), majority in right liver (90.32%), eosinophilia is the predominant indicator (90.42%), In the children group: the clinical manifestations included of epigastric and Chauffard-Rivet area pain (94.34%), flatuence, nausea and intermittent vomiting (76.41%), digestive disoders (40.57%), allergy (30.66%), fatigue plus weight loss (12.74%); laboratory findings included of hepatobiliary lesions by US (100%), positive ELISA with Fasciola gigantica antigen (96.70%), eosinophil of 93.39% and 1.90% positive copro-examination with Fasciolae eggs. Conclusions: In pregnant women, symptoms are indistinguishable from hepatobiliary, digestive tract diseases or overlap with gestation terrains, and clinical signs of paediatric fascioliasis may mimic a wide spectrum of hepatobiliary disorders laboratory parameters and imaging diagnostics, especially in FasELISA, hypereosinophilia and liver lesions by ultrasound were very useful in positive diagnosis.

scholarly journals Multicenter Retro-Prospective Observational Study on Chronic Hypoparathyroidism and rhPTH (1-84) Treatment

2021 ◽  
Author(s):  
Gemma Marcucci ◽  
Guglielmo Beccuti ◽  
Giulia Carosi ◽  
Filomena Cetani ◽  
Luisella Cianferotti ◽  
...  
Keyword(s):  
Renal Function ◽  
Prospective Observational Study ◽  
Mineral Metabolism ◽  
Clinical Manifestations ◽  
Urinary Calcium ◽  
Normal Range ◽  
Open Label ◽  
Open Label Study ◽  
Urinary Parameters ◽  
Chronic Hypoparathyroidism

The use of recombinant human PTH (1-84) [rhPTH(1-84)] is approved as hormonal replacement therapy in patients with hypoparathyroidism not adequately controlled with conventional therapy. The objective of this study was to investigate the effects of 12 months of rhPTH (1-84) treatment in a cohort of patients selected according to the indications of recent hypoparathyroidism guidelines. It is a multicenter, observational, retro-prospective, open label study. Eleven Italian Endocrinological centers were involved. Fourteen adult subjects with chronic hypoparathyroidism treated with rhPTH (1-84) for 12 months were enrolled. Main outcome measures included serum and urinary parameters of mineral metabolism, renal function, oral calcium and vitamin D doses, and clinical manifestations. At 12 months, 61.5% of patients discontinued calcium supplement and 69.2% calcitriol. Mean serum calcium levels quickly normalized after initiation of rhPTH (1-84) treatment compared to baseline (p=0.009). Rare hypo-hypercalcemia episodes were reported. Renal function was maintained normal and no renal complications were reported. Serum and urinary phosphate and urinary calcium were maintained in the normal range. Mean phosphatemia levels linearly decreased from 3 months up to 12 months compared to baseline (p= 0.014). No severe adverse events were described. In conclusion, this study confirm the efficacy and safety of rhPTH (1-84) therapy.

scholarly journals Congenital chicken pox: a clinical case of a child at the age of 6 days

2018 ◽  
Vol 9 (1) ◽  
pp. 100-105
Author(s):  
Vladimir N. Timchenko ◽  
Tatyana A. Kaplina ◽  
Svetlana L. Bannova ◽  
Maria D. Subbotina ◽  
Vera F. Sukhovetskaya ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Symptoms ◽  
Respiratory Infections ◽  
Clinical Manifestations ◽  
Intrauterine Infection ◽  
Recombinant Interferon ◽  
Chicken Pox ◽  
Costs Of Treatment ◽  
Mother To Child ◽  
Rectal Suppositories

Chicken pox can be both acquired and congenital. The information is presented in the form of a diagram on the incidence of chickenpox in St. Petersburg, which shows that among children, the most common are children aged 3 to 6 years. A brief etiology of the varicella virus, a clinical picture, describing the typical and atypical forms of the disease. Due to the airborne pathway and the high infectivity of the infection, there is a risk of contracting seronegative pregnant women, which is 50%. It has been established that for 1,000 deliveries there are from 1 to 5 cases of chicken pox. In addition, the flow of chicken pox and lethality depends on the possibility of transmitting from mother to child protective specific maternal antibodies. Features of infection in pregnant women and fetus, the severity of intrauterine infection, depending on the timing of infection are described. The characteristics of varicella and neonatal chickenpox syndrome, as well as nonspecific clinical manifestations of the infectious process in the newborn are presented. We describe our own clinical observation of congenital varicella in a 6-day-old child, born from a mother who fell ill four days before the birth. The inclusion in the complex therapy of children with congenital chickenpox recombinant interferon-α2β with antioxidants (viferon rectal suppositories) contributes to the rapid positive dynamics of clinical symptoms, easier flow, prevents the layering of acute respiratory infections, reduces the material costs of treatment.

Estimation of the effi ciency of treatment of somatic dysfunctions of the pelvis bones using the technology of computer stabilography with biological feedback

2021 ◽  
pp. 52-65
Author(s):  
V. V. Andreev ◽  
A. I. Sychev
Keyword(s):  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Axial Skeleton ◽  
Diagnostic Methods ◽  
Controlled Study ◽  
Pubic Bone ◽  
Complete Regression ◽  
Pelvic Bones ◽  
Eyes Closed ◽  
Training Mode

Introduction. Somatic dysfunctions of the pelvic and sacral bones are one of the most common causes of lumbosacral pain with impaired spine statics, functional disorders of internal organs and other manifestations. Remote symptoms include torsional dural dysfunctions. Distortion of proprioceptive somatosensory afferentation blocks postural tonic reflexes of the axial skeleton and extremities, disrupts the sequence of activation of motor units of the locomotion system, changes the mechanisms for providing support and walking. Osteopathic correction of somatic dysfunctions in the region improves the condition of patients, however, in some cases, it is not possible to achieve complete regression of the identified syndromes. One of the effective corrective methods are computer technologies with the registration of the parameters of the static-dynamic function of support and maintaining balance. The possibilities of restoring reflex mechanisms can be obtained using computer stabilometry with a biofeedback program (BFB). Testing was carried out at the stage of diagnosis and follow-up: at the stage of screening, immediately after the treatment session, and 14 days after the moment of treatment. The clinical effect was compared with the results of stabilometric testing. The training sessions were carried out after registering the statokinesiogram.The aim of the research was to study the possibilities of using a stabiloplatform with BFB in in the mode of diagnosis of coordination and static-dynamic disorders of the axial skeleton in patients with various types of somatic dysfunctions of the pelvic bones and in the training mode together with the osteopathic correction of the somatic dysfunctions identified in patients.Materials and methods. In a prospective controlled study, the results of examination and treatment of 66 patients aged 23–56 years (median — 33) were analyzed, including 36 women and 39 men with somatic dysfunctions of the pelvic bones. In the main group, clinical and osteopathic signs of somatic dysfunctions of the pubic bone and ilium were revealed. The observation was carried out for 14 days. Osteopathic treatment of the corresponding type of dysfunction and stabilometric examination (3 control points) and training (3 sessions) were performed. Among the analyzed clinical manifestations, the intensity of pain syndrome and muscle-tonic reactions was taken into account. According to the results of the stabilometry, stability (RC) was assessed in the «eyes open» and «eyes closed» modes. The primary checkpoint is the start of observation and the correction procedure. Stage control after 7 days and the final observation point — 14 days. In total, 3–4 osteopathic sessions were carried out, stabilometric control was the screening stage, before and after the session, observation after 14 days from the last session.Results. There was detected decrease in pain intensity, normalization of axial balance and coordination of movements. The most significant was the decrease in the Romberg coefficient in patients with dysfunction of the iliac bones in the anterior rotation, regardless of the side: dynamics on the right: decrease from 570±12 to 295±23 % and on the left from 550±22 to 260±25 % (p<0,05).Conclusion. The combined use of osteopathic correction and physiotherapy exercises on a stabiloplatform in a training mode with BFB promotes regression of neurological and clinical symptoms, which is confirmed by all diagnostic methods used in the study — clinical neurological, clinical osteopathic, stabilometric with BFB. The best results were achieved in patients with somatic dysfunction anterior rotation of the ilium. The use of a stabiloplatform with BFB in the diagnostic mode allows obtaining objective data on the nature of the imbalance and balance disorders. The training regime contributes to the achievement of a therapeutic result in a short time (3 sessions) and can be used in inpatient and outpatient conditions of medical institutions.

scholarly journals STRATIFICATION OF PREGNANT WOMEN AT EARLY GESTATIONAL AGES BY MEANS OF OBJECTIVATION OF "PHYSIOLOGICAL ALTERATION" FACTORS, MECHANISMS OF GESTATIONAL ADAPTATION AND FETOPLACENTAL DYSFUNCTION

2016 ◽  
Vol 1 (4) ◽  
pp. 6-13
Author(s):  
Yu V Tezikov ◽  
I S Lipatov ◽  
O B Kalinkina ◽  
L Yu Gogel ◽  
T S Belokoneva ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Early Pregnancy ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Perinatal Outcomes ◽  
Early Morning ◽  
Blood Biochemical ◽  
Biochemical Indices ◽  
Hemostatic Disorders ◽  
Blood Biochemical Indices

Aim - allocation of clinical and pathogenetic variants of early gestosis in pregnant women based on clinical manifestations and markers of leading pathogenetic syndromes of gestational maladjustment. Materials and methods. 45 healthy pregnant women and 160 pregnant women with early morning sickness of varying severity were examined in the 1st trimester of gestation. The comparison group consisted of 33 healthy non-pregnant women. The survey included assessment of clinical symptoms, identification of the markers of inflammatory response, energy balance of reproductive system, functional activity of the endometrium, vascular endothelial and hemostatic disorders, and blood biochemical indices. Results. The study enabled quantitative objectivation of the factors of “physiological damage” and “the mechanisms of gestational adaptation” during physiological gestation, defining fetoplacental dysfunction as the key link of maladjustment in early pregnancy. The prevalence of pathogenetic mechanisms of the formation of early pregnancy toxicosis determined the allocation of 4 clinical-pathogenetic variants of the course of this complication of gestation. Conclusion. Differentiated approach to clinical and laboratory manifestations of early gestosis in pregnant women, taking into account the variants of the clinical course of this complication and severity assessment, enables targeted therapy and predicting the risk of development of severe forms and late obstetric complications, reduces the risk of adverse perinatal outcomes.

Clinical and pathogenetic substantiation of prevention of obstetrical complications in pregnant women with varicose disease

2016 ◽  
pp. 82-84
Author(s):  
N.G. Korniets ◽  
◽  
Y.A. Kravtsova ◽  
Keyword(s):  
Pregnant Women ◽  
Clinical Symptoms ◽  
Varicose Veins ◽  
Clinical Manifestations ◽  
Control Group ◽  
Hormonal Function ◽  
National Medical ◽  
Comparative Group ◽  
Varicose Disease ◽  
Instrumental Methods

The article presents the results of an improved method of antenatal surveillance of pregnant women with varicose disease which included the national medical drug that is a combination of 50 mg hesperidin and 450 mg diosmin (Normoven, PC «Kyiv Vitamin Factory»). Patients and methods. The study involved 49 pregnant women with varicose veins, which were divided into the basic and comparative group depending on the received treatment. The clinical and functional parameters, laboratory and instrumental methods were studied. The control group consisted of 23 pregnant women without varicose veins. Results. The absence of progression of clinical symptoms of the disease in 87.5% of pregnant women with varicose veins and improvement of the hemostatic parameters reflects the effectiveness of this therapy for the correction of the rheological properties of blood. The inclusion of hesperidin and diosmin to the complex therapy in pregnant women allowed to decrease the percentage of progression of changes in the venous system of the lower extremities almost twice. The normalization of processes of biosynthesis placental hormones in pregnant women shows the feasibility of using the drug with the systemic effects. The increase of the amplitude of instantaneous oscillations and the amplitude and duration of accelerations (p<0.05) according to the cardiotocographical observation indicates in favor of improving the state of the fetus in pregnant women. Conclusions. The inclusion of diosmin and hesperidin to the complex treatment of varicose veins in pregnant women is pathogenetically justified as it improves the degree of clinical manifestations of disease, hemostatic parameters , hormonal function of the placenta and fetus state. Key words: pregnancy, varicose veins, placental hormones, hemostatic parameters, hesperidin, diosmin.

Comparative characteristics of pregnancy-related symphysis pubis dysfunction

2021 ◽  
Vol 9-10 (219-220) ◽  
pp. 34-38
Author(s):  
Meruert Temirova ◽  
◽  
Serik Iskakov ◽  
Keyword(s):  
Pregnant Women ◽  
Clinical Manifestations ◽  
Pubic Symphysis ◽  
Symphysis Pubis ◽  
Endocrine Disorders ◽  
Minimal Risk ◽  
Disease Pathogenesis ◽  
Normal Body Weight ◽  
Pubis Symphysis ◽  
Symphysis Diastasis

The problem of an acceptable choice of the method of delivery for symphysis pubis dysfunction is relevant in modern obstetrics. Since the incidence of this condition varies between 1 in 300 and 1 in 30,000 pregnancies. And such a large variation in the frequency of symphysis pubis dysfunction is explained by the lack of a clear terminology for this disease, pathogenesis, and uniform diagnostic criteria. Purpose of the study. Analysis and comparative characteristics of pregnant women with pubis symphysis diastasis and clinical dysfunction of the pubis symphysis and without it. Material and methods. A retrospective analysis of 1210 birth histories and exchange cards of pregnant women in the period from 2015 to 2019. Results and discussion. In the group with clinical manifestations of pubic symphysis dysfunction, with overweight and obese of I, II, III degrees, as well as with diseases of the blood, cardiovascular system and endocrine disorders. And the group without clinical manifestations of pubic symphysis dysfunction consisted of multigravida with normal body weight. Conclusions. Vaginal delivery preferred by method of delivery for pregnant women with or without clinical manifestations of pubic symphysis, associated with minimal risk of pubis symphysis rupture. Keywords: pubis dysfunction, pregnancy, delivery.

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