scholarly journals Adenomyosis as an optional risk factor for uterine cancer

2004 ◽  
Vol 53 (4) ◽  
pp. 11-17
Author(s):  
D. F. Kostyuchek ◽  
N. M. Anichkov ◽  
V. А. Pechenikova
Keyword(s):  
Risk Factor ◽  
Surgical Treatment ◽  
Malignant Transformation ◽  
Uterine Cancer ◽  
Endometrial Adenocarcinoma ◽  
Age Groups ◽  
Invasive Growth ◽  
Morphological Investigation ◽  
Immunohistochemical Investigation ◽  
Stromal Component

The problem of adenomyosis malignization is controversial and insufficiently explored. Rate of the malignant transformation of adenomyosis varies from O.l to 24 per cent; as a rule, malignization of the stromal component of adenomyosis is described, works containing cancerous transformation description are isolated ones. Comparative clinical and morphological and immunohistochemical investigation of the cancerous transformation of adenomyosis (6 observations), endometrium cancer in combination with adenomyosis (16 observations), and typical adenomyosis (9 observations) is carried out. Obtained data indicate the precancerous optional significance of adenomyosis, risk of which increases in senior age groups. Endometrial adenocarcinoma does not exhibit a tendency to invasive growth into adenomyosis nidi; combined independent development of endometrium cancer and adenomyosis malignization with exo- and endophyte growth is possible, which determines the hypodiagnostics of malignizated adenomyosis. Morphological verification of malignizated adenomyosis demands comprehensive clinical and morphological investigation with broad study of operating material and with taking into consideration the stages of cancerous transformation morphogenesis established during the work. Late diagnostics and inadequate surgical treatment diagnose the unfavorable prognosis.

The importance of age as a prognostic factor in corpus cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 15005-15005
Author(s):  
A. Husain ◽  
N. Karnik Lee ◽  
M. K. Cheung ◽  
K. Osann ◽  
L. M. Chen ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Clear Cell ◽  
Radiation Treatment ◽  
Uterine Cancer ◽  
Large Population ◽  
Age Groups ◽  
Younger Patients ◽  
Stage Disease ◽  
Disease Specific ◽  
Two Age Groups

15005 Background: To determine the prognostic factors that influence the survival of younger women diagnosed with uterine cancers. Methods: Patients with a diagnosis of uterine cancer were isolated from the Surveillance, Epidemiology, and End Results (SEER) cancer database from 1988–2001 and demographic and clinico-pathologic data were collected. Patients in the database were stratified by age at diagnosis into two age groups: ≤40and >40 years old. Disease specific survival was calculated using Kaplan-Meier estimates. Results: Of the 51,471 women diagnosed with uterine cancer in the study period, 2076 patients were ≤40 and 49,395 were >40 years old. The mean age in the younger group was 35.6 and that of the older group was 65.2. The overall distribution by stage was Stage I-76%, II-8%, III-7% and IV-9%. Younger patients were more likely to be non-white (30% vs 18%, p < 0.05), have earlier stage disease (79% vs 75%, p < 0.05), grade 1 lesions (48% vs 36%, p <0.05) and sarcomas (16% vs 8%) compared to their older counterparts. The overall disease specific 5-year survival demonstrated that younger patients (≤40 years old) had a significantly improved survival prognosis in comparison to older women (93% versus 86%; p < 0.0001). This survival difference remains significant after adjusting for stage, race, surgical treatment, and radiation treatment. Subgroup analysis revealed no statistical difference in outcome between the two age groups for patients with clear cell histology. There also was no statistical significance in survival for patients with grade 2 or 3 lesions and advanced stage disease. Conclusions: Our large population based study demonstrates that younger patients (≤40) have an overall survival advantage compared to women >40 years. This difference remains significant when adjusted for stage, race, surgical treatment, and radiation treatment. Women with clear cell cancers of the uterus appear to have a poor prognosis independent of age. No significant financial relationships to disclose.

scholarly journals Retrorectal Mucinous Adenocarcinoma Arising from a Tailgut Cyst: A Case Report

2021 ◽  
pp. 147-151
Author(s):  
Manon Baverez ◽  
Emilie Thibaudeau ◽  
Vincent Libois ◽  
Olivier Kerdraon ◽  
Hélène Senellart ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Anal Canal ◽  
Malignant Transformation ◽  
Mucinous Adenocarcinoma ◽  
Tailgut Cyst ◽  
Local Invasion

We report the case of a 57-year-old woman who presented with local invasion of the anal canal by mucinous adenocarcinoma, the malignant transformation of a long-term preexisting retrorectal tailgut cyst. This progression is infrequent and justifies preemptive surgical treatment of retrorectal cysts.

Surgical treatment for secondary spontaneous pneumothorax: a risk factor analysis

Surgery Today ◽  
2021 ◽  
Author(s):  
Norikazu Kawai ◽  
Takeshi Kawaguchi ◽  
Motoaki Yasukawa ◽  
Takashi Tojo ◽  
Noriyoshi Sawabata ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Risk Factor ◽  
Surgical Treatment ◽  
Spontaneous Pneumothorax ◽  
Risk Factor Analysis ◽  
Secondary Spontaneous Pneumothorax

Characteristics, outcomes, and risk factors of ICANS after axicabtagene ciloleucel: Does age matter?

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e19556-e19556
Author(s):  
Kitsada Wudhikarn ◽  
Radhika Bansal ◽  
Arushi Khurana ◽  
Matthew Hathcock ◽  
Michael Ruff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Older Patients ◽  
Clinical Course ◽  
International Prognostic Index ◽  
Age Groups ◽  
Central Nervous System Involvement ◽  
Microvascular Disease ◽  
B Cell Lymphoma ◽  
Younger Patients

e19556 Background: CD19 chimeric antigen receptor T cell therapy possesses unique side effects including cytokine release syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS). Age is a major risk factor for ICANS. However, whether ICANS in older patients is different compared to younger patients is unknown. Herein, we report clinical course, outcomes and risk factors for ICANS in older patients with large B cell lymphoma (LBCL) treated with axicabtagene ciloleucel (axi-cel). Methods: We comprehensively reviewed detailed clinical courses of ICANS in 78 adult patients with LBCL treated with axi-cel between June 2016 and October 2020. Incidence, manifestation, risk factors, treatment, and outcomes of ICANS were compared between patients age ≥60 (n=32) and <60 (n=46) years old. Results: Baseline characteristics were comparable between older and younger patients except higher proportion of high international prognostic index and underlying cerebral microvascular disease in older patients. ICANS was observed in 16 patients in the older and 24 patients in the younger age group, with a 30-day incidence of 52% and 50%, respectively. Median time to CRS and ICANS were similar between 2 age groups. The most common initial neurological findings included aphasia, dysgraphia and encephalopathy in both age groups. Table summarizes the characteristics, clinical course and interventions of ICANS in older and younger patients. In Cox regression model, the presence of CRS was the only factor associated with ICANS in both age groups. Age, history of central nervous system involvement and cerebral microvascular disease were not associated with ICANS. Importantly, all patients had complete resolution of ICANS. No elderly patients in our cohort experienced seizure as a manifestation of ICANS. Conclusions: In our study, older age was not a risk factor for ICANS. CRS was the only factor associated with ICANS in both younger and older patients. Incidence, clinical course and neurological outcomes of ICANS in older patients treated with axi-cel were comparable to younger patients. [Table: see text]

scholarly journals Surgical treatment of a cancerous uterus

2020 ◽  
Vol 11 (9) ◽  
pp. 889-901
Author(s):  
A. P. Gubarev
Keyword(s):  
Breast Cancer ◽  
Surgical Treatment ◽  
Uterine Cancer ◽  
Malignant Neoplasm ◽  
Surgical Methods

Surgical treatment of any malignant neoplasm can make sense only when the possibility of relapses is taken into account and everything that can be achieved by art to eliminate them or prevent them. This is a principle that modern surgery persistently applies in the development of surgical methods for removing neoplasms, no matter in whatever area it develops. The greatest development in this direction has recently undergone surgery for breast cancer. At present, there can no longer be any question of removing, in addition to the neoplasm, only enlarged and infiltrated or suspicious glands, it is not enough even to remove healthy glands: in the form in which the details of this operation were developed by prof. Kocher), Watson Cheyne) and others, the removal of all tissue in the armpit and in the circumference of the musculi pectoralis majoris is a condition, the need for which can hardly be discussed. In a word, the removal of those tissues in which relapses develop more easily and most often is a rule adopted by modern surgery. Therefore, the principles that guide modern gynecology in the surgical treatment of uterine cancer seem to be completely random and poorly understood: in many cases, not the tissues that are most dangerous in the sense of relapse are removed, namely those in which relapses appear only as a rarity, or an exception and which more than others resist him.

scholarly journals TO THE QUESTION OF INDICATIONS FOR PARTIAL CERVICAL AMPUTATION IN CANCER OF THE VAGINAL UTERINE

2020 ◽  
Vol 6 (1) ◽  
pp. 10-26
Author(s):  
M. M. Mironov
Keyword(s):  
Surgical Treatment ◽  
Uterine Cancer ◽  
Radical Treatment ◽  
Genital Area ◽  
Female Sex ◽  
Long Time ◽  
Cervical Amputation ◽  
All Diseases ◽  
Female Genital

The issue of radical treatment of uterine cancer has been deservedly attracting special attention of gynecologists for a long time. In fact, this disease, which until recently was considered incurable, accounts for about 3.5% of all diseases of the female genital area; so according to the statistics of Petrov (V. Petrov. On the issue of radical surgical treatment of uterine cancer. Dis. 1888) for the ambulatory of the St. Petersburg Mariinsky hospital and clinic prof. Lebedev, embracing 5,040 gynecological patients, uterine cancer occurs in an amount of 3.5%. According to statistics prof. Ott (D. Ott. Complete vaginal uterine eruption, etc. Doctor. 1889, No. 39-49) 4228 uterine cancer is 3.7% of all gynecological patients. According to Schrder (Schroeder. Guide to diseases of female sex. Organs) for 16,800 patients, this disease occurred in 3.6%.

scholarly journals PREVALENCE OF SMOKING IN ADULT POPULATION OF IRKUTSK

2016 ◽  
Vol 1 (6) ◽  
pp. 153-156
Author(s):  
Максикова ◽  
Tatyana Maksikova ◽  
Бабанская ◽  
Evgeniya Babanskaya ◽  
Меньшикова ◽  
...  
Keyword(s):  
Risk Factor ◽  
Adult Population ◽  
Age Groups ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Noncommunicable Diseases ◽  
Age Difference ◽  
Age Group ◽  
Considerable Problem ◽  
The One

Smoking is a significant risk factor of chronic noncommunicable diseases. Smoking prevalence is variable in different populations. A study of the prevalence of this risk factor allows to estimate its contribution to the development of cardiovascular pathology, to plan the necessary amount of medical care for people using tobacco, and to determine the effectiveness of prevention activities in the region. As a result of the study, smoking frequency in population of the Irkutsk region older 18years of age or over was established as 29.5%. The number of smokers increased with age, reaching maximum value of 38.6% in the group 30–39 years. Male smokers made maximum in the age group 30–39 years, women – in the age group of 18–19 years. The average age of smokers was 34 years, the one of nonsmokers – 43 years. The age difference was 9 years, and it was lower in the group of men than in the group of women (5 and 11 years, respectively). The number of the smoking men were 3 times larger, than women: 50.2% and 13.5%, respectively. Among persons with arterial hypertension, 22.1% were smoking with the maximum frequency of smoking in age groups from 20 to 49 years. These figures point to a considerable problem of smoking in the region.

scholarly journals COMPARISON RESULTS OF SURGICAL TREATMENT LOCALIZED AND EXTENDED UTERINE CANCER

2010 ◽  
Vol 1 (3) ◽  
pp. 56-61
Author(s):  
I I Ushakov ◽  
E A Artoshina ◽  
P G Brousov ◽  
I V Nazvantsev ◽  
S A Levakov ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
High Risk ◽  
Adjuvant Radiotherapy ◽  
Primary Outcome ◽  
Outcome Measure ◽  
Uterine Cancer ◽  
Primary Outcome Measure ◽  
Pelvic Lymphadenectomy ◽  
Peritoneal Washing ◽  
Comparison Results

We selected 145 patients with endometrial carcinoma who had been treated with standard surgery (hysterectomy and BSO, peritoneal washing, palpation pelvic and para-aortic nodes) and with complete systematic pelvic lymphadenectomy (n=30 patients) or combined pelvic and para-aortic lymphadenectomy (n=30). Patients at intermediate or high risk of recurrence were offered adjuvant radiotherapy. The primary outcome measure was results of the surgical therapy.

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