Adrenal transplant for pernicious anemia. Prof. M. I. Arinkin (Vesti. Khir., Book 19)

Abstract 1. Folic acid in daily doses of 15 to 50 mg., orally, or 20 mg. intramuscularly, usually produced a submaximal reticulocytosis in patients with pernicious anemia. 2. In 3 patients the hemoglobin and red cells rose to a level of about 12.0 Gm. and 4.3 million respectively without further rise after 3 months of therapy. 3. Folic acid in the above doses failed to prevent the development or progression of neurological symptoms indicative of subacute combined sclerosis. 4. In 5 patients folic acid in doses of 5 or 10 mg. orally daily combined with ½ unit of liver extract injected intramuscularly daily produced a reticulocytosis greater than that anticipated from adequate liver extract therapy alone. 5. With combined liver extract and folic acid therapy there was evidence of improvement in the symptoms and signs of subacute combined sclerosis in 3 patients. 6. Folic acid, combined with ½ unit of liver extract, was found to produce a complete hematological remission. 7. Folic acid, alone or in combination with small doses of liver extract, produced an improvement in appetite and general well-being in patients with pernicious anemia. 8. The possible enhancing effect of liver extract when combined with folic acid cannot be due to the folic acid content of the former since 1 unit of liver extract contains only 0.38 micrograms of folic acid.31 9. Folic acid administered to a patient with macrocytic anemia due to faulty postoperative intestinal digestion and absorption, produced a complete remission in the blood picture and a marked improvement in signs and symptoms.

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Receiving a Diagnosis of Pernicious Anemia: Exploring Experiences of Relationships With Health Professionals

Journal of Patient Experience ◽

10.1177/2374373519883497 ◽

2019 ◽

Vol 7 (5) ◽

pp. 766-770 ◽

Cited By ~ 1

Author(s):

Catherine Heidi Seage ◽

Emily Glover ◽

Jenny Mercer

Keyword(s):

Medical Care ◽

Pernicious Anemia ◽

Lived Experience ◽

Health Professionals ◽

Interpretative Phenomenological Analysis ◽

Medical Profession ◽

Diagnostic Delay ◽

Vitamin B12 Deficiency ◽

Well Being ◽

Patient Centered

Objectives: Pernicious anemia (PA) is a chronic condition caused by vitamin B12 deficiency. This is a qualitative study using interpretative phenomenological analysis (IPA), which aimed to explore the patients lived experience of diagnosis and treatment. Methods: Eleven semistructured interviews were conducted in PA patients; these covered participants’ diagnostic and treatment journeys, the responses of others to their diagnosis, and the role health professionals have played in their medical care. Interviews were analyzed for recurrent themes using IPA. Results: Three superordinate themes were identified: “The struggle to achieve a diagnosis,” “The significance of a diagnosis,” and “Battling for sufficient treatment.” Participants were dissatisfied with their medical care due to diagnostic delay, insufficient treatment, and poor relationships with their health professionals. Many experienced, anticipated, and internalized stigma, which led to a reduced quality of life and withdrawal from the medical profession. Discussion: Participants’ interactions with their health professionals hindered their adaptation to their condition; this affected their psychological and physical well-being. Increased clinician awareness of stigma in the PA population symptoms and effective patient-centered communication is required.

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THE EFFECT OF FOLIC ACID ON THE CENTRAL NERVOUS SYSTEM OF NORMAL SUBJECTS AND SUBJECTS WITH ANEMIA OTHER THAN PERNICIOUS ANEMIA

Blood ◽

10.1182/blood.v5.2.148.148 ◽

1950 ◽

Vol 5 (2) ◽

pp. 148-154 ◽

Cited By ~ 5

Author(s):

JONAS WEISSBERG ◽

T. H. McGAVACK ◽

MILDRED VOGEL ◽

S. KENIGSBERG

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Folic Acid ◽

Pernicious Anemia ◽

Respiratory Infections ◽

Well Being ◽

Normal Subjects ◽

Upper Respiratory Infections ◽

The Central Nervous System ◽

Upper Respiratory

Abstract 1. The administration of 20 mg. of folic acid daily to a group of 26 normal subjects and to a group of 22 subjects with some form of anemia other than pernicious anemia for a period of six to twelve months was not harmful to the central nervous system. 2. Pre-existent neurologic changes in both groups of patients were not altered during the period of treatment with folic acid. 3. Hematologic variations in both groups were not significant during the period of treatment. 4. A sense of well being and a diminished incidence of upper respiratory infections were reported by many of the normal subjects to whom folic acid was administered.

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The Relationship Between Hearing Loss Self-Management and Hearing Aid Benefit and Satisfaction

American Journal of Audiology ◽

10.1044/2018_aja-18-0130 ◽

2019 ◽

Vol 28 (2) ◽

pp. 274-284 ◽

Cited By ~ 6

Author(s):

Elizabeth Convery ◽

Gitte Keidser ◽

Louise Hickson ◽

Carly Meyer

Keyword(s):

Decision Making ◽

Hearing Loss ◽

Hearing Aids ◽

Clinical Decision Making ◽

Hearing Aid ◽

Well Being ◽

Self Report ◽

Self Management ◽

Hearing Aid Benefit ◽

The Relationship

Purpose Hearing loss self-management refers to the knowledge and skills people use to manage the effects of hearing loss on all aspects of their daily lives. The purpose of this study was to investigate the relationship between self-reported hearing loss self-management and hearing aid benefit and satisfaction. Method Thirty-seven adults with hearing loss, all of whom were current users of bilateral hearing aids, participated in this observational study. The participants completed self-report inventories probing their hearing loss self-management and hearing aid benefit and satisfaction. Correlation analysis was used to investigate the relationship between individual domains of hearing loss self-management and hearing aid benefit and satisfaction. Results Participants who reported better self-management of the effects of their hearing loss on their emotional well-being and social participation were more likely to report less aided listening difficulty in noisy and reverberant environments and greater satisfaction with the effect of their hearing aids on their self-image. Participants who reported better self-management in the areas of adhering to treatment, participating in shared decision making, accessing services and resources, attending appointments, and monitoring for changes in their hearing and functional status were more likely to report greater satisfaction with the sound quality and performance of their hearing aids. Conclusion Study findings highlight the potential for using information about a patient's hearing loss self-management in different domains as part of clinical decision making and management planning.

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Inclusion of Transgender Voice and Communication Training in a University Clinic

Perspectives of the ASHA Special Interest Groups ◽

10.1044/persp2.sig10.109 ◽

2017 ◽

Vol 2 (10) ◽

pp. 109-115 ◽

Cited By ~ 1

Author(s):

Jennifer Oates ◽

Georgia Dacakis

Keyword(s):

Training Program ◽

Clinical Education ◽

Well Being ◽

Evidence Base ◽

Communication Training ◽

Speech Language Pathology ◽

Transgender People ◽

Language Pathology ◽

Effectiveness Of Training ◽

Negative Impacts

Because of the increasing number of transgender people requesting speech-language pathology services, because having gender-incongruent voice and communication has major negative impacts on an individual's social participation and well-being, and because voice and communication training is supported by an improving evidence-base, it is becoming more common for universities to include transgender-specific theoretical and clinical components in their speech-language pathology programs. This paper describes the theoretical and clinical education provided to speech-language pathology students at La Trobe University in Australia, with a particular focus on the voice and communication training program offered by the La Trobe Communication Clinic. Further research is required to determine the outcomes of the clinic's training program in terms of student confidence and competence as well as the effectiveness of training for transgender clients.

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Improving Feeding Outcomes in the NICU: Moving From Volume-Driven to Infant-Driven Feeding

Perspectives on Swallowing and Swallowing Disorders (Dysphagia) ◽

10.1044/sasd19.3.68 ◽

2010 ◽

Vol 19 (3) ◽

pp. 68-74 ◽

Cited By ~ 9

Author(s):

Catherine S. Shaker

Keyword(s):

Intensive Care Unit ◽

Dynamic Systems ◽

Neonatal Intensive Care ◽

Well Being ◽

Dynamic Systems Theory ◽

Feeding Problems ◽

Care Giving ◽

Extremely Preterm ◽

Extremely Preterm Infants

Current research on feeding outcomes after discharge from the neonatal intensive care unit (NICU) suggests a need to critically look at the early underpinnings of persistent feeding problems in extremely preterm infants. Concepts of dynamic systems theory and sensitive care-giving are used to describe the specialized needs of this fragile population related to the emergence of safe and successful feeding and swallowing. Focusing on the infant as a co-regulatory partner and embracing a framework of an infant-driven, versus volume-driven, feeding approach are highlighted as best supporting the preterm infant's developmental strivings and long-term well-being.

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