scholarly journals To the pathological anatomy of bulbar paralysis of vascular origin

2020 ◽  
Vol VIII (3) ◽  
pp. 16-27
Author(s):  
V. P. V.P. Maleev
Keyword(s):  
Medulla Oblongata ◽  
Clinical Picture ◽  
Pathological Anatomy ◽  
Chronic Form ◽  
Bulbar Paralysis ◽  
Vascular Origin ◽  
Severity Of The Disease

Bulbar paralysis has long been attracting the attention of neuropathologists, due to its diversity in the clinical picture, the duration of the course of the disease and the severity of the disease. In Germany, the term bulbar paralysis was first used in 1864 by Wachsmuth in relation to the chronic form, which is now called Duschenns progressive bulbar paralysis. Due to the difficulties of recognition, cases of intravital diagnosis of paralysis with lesions of the medulla oblongata were almost absent at that time. In France, the acquaintance with this disease began, apparently, a little earlier than Germany, but there and here they soon began to distinguish acute cases (Lange) of paralysis from chronic ones.

POLYNEURITIS IN CHILDREN

PEDIATRICS ◽  
1958 ◽  
Vol 22 (5) ◽  
pp. 972-990
Author(s):  
Niels L. Low ◽  
Julia Schneider ◽  
Sidney Carter
Keyword(s):  
Clinical Picture ◽  
Cranial Nerve ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Severity Of The Disease ◽  
Clinical Records

Polyneuritis in children is becoming more common. The clinical picture is variable; it may be manifested by motor and sensory findings, or by a combination of peripheral and cranial nerve signs and symptoms. The etiology is usually obscure. The pathologic picture varies with the severity of the disease and differs according to the stage at which the patient dies, but all fatal cases show the same main characteristic changes. Clinical records of 30 cases, 17 boys and 13 girls from 17 months to 16 years of age, are reviewed. The clinical manifestations, course and treatment are described.

scholarly journals The serum eosinophil cationic protein concentration in patients with bronchial asthma and its correlation with severity and exacerbation of the disease

2003 ◽  
Vol 22 (3) ◽  
pp. 249-253
Author(s):  
Snezana Kovacevic ◽  
Mirjana Bogic ◽  
Aleksandra Peric-Popadic ◽  
Sanvila Raskovic ◽  
Zikica Jovicic ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Clinical Picture ◽  
Healthy Subjects ◽  
Protein Concentration ◽  
Geometric Mean ◽  
Eosinophil Cationic Protein ◽  
Cationic Protein ◽  
Asthmatic Patients ◽  
Severity Of Disease ◽  
Severity Of The Disease

Activated eosinophilic leukocyte in asthma secretes numerous mediators, among which is ECP as well. The object of our study was to measure the serum ECP concentrations in 46 asthmatic patients with exacerabating and stable asthma, and to correlate the serum ECP concentrations with severity and exacerbation of the disease. Geometric mean of ECP in serum (Gecp) in our group of patients was 7.5 mcg/l, while it was 3.05 mcg/l in the 15 healthy subjects (controls). Highly significant correlation of serum ECP concentrations with the activity of the disease (R=0.897) and the severity of clinical picture (R=0.79) was found. The patients with stable asthma had significant correlation of ECP and the severity of disease (R=0.6). The patients with exacerbating asthma have significantly higher serum ECP concentrations than the patients with stable asthma. Serum ECP concentrations in patients with exacerbating asthma correlate with the severity of the disease.

Molar-incisor hypomineralisation (MIH) – aetiology, clinical picture, treatment

2019 ◽  
Vol 24 (1) ◽  
Author(s):  
Sylwia Kuderewska ◽  
Monika Stawiecka ◽  
Renata Milewska ◽  
Anna Kuźmiuk ◽  
Ewa Chorzewska
Keyword(s):  
Clinical Picture ◽  
Dental Enamel ◽  
Permanent Teeth ◽  
Molar Incisor Hypomineralisation ◽  
Pubmed Database ◽  
Tissue Reconstruction ◽  
Permanent Molars ◽  
Severity Of The Disease ◽  
Incisor Hypomineralisation ◽  
First Permanent Molars

Introdution. Molar-incisor hypomineralisation is a disorder of dental enamel of a systemic origin. It may affect one or all four first permanent molars, and often involves permanent incisors. Aim. The aim of this study was to present views on aetiology, clinical picture and treatment of molar-incisor hypomineralisation. Material and methods. PubMed database was reviewed for years 2003-2017, the search criteria were: “molar incisor”, “hypomineralisation”, “permanent teeth”. Results. The aetiology of MIH is multifactorial and not fully explained. Authors agree that the general health during the first 3-4 years of life has a major impact on this disorder. The clinical picture includes demarcated white, yellow or brown tissue spots, and increased porosity of the enamel. Enamel damage and defects can also occur. Therapeutic management depends on the severity of the disease and includes intensive prevention, hard tissue reconstruction, and extractions. Conclusions. Due to the increasing prevalence of this disorder, special attention should be paid to children whose health status is or was bad in the first 3-4 years of life. They are at a higher risk for this condition.

scholarly journals Towards the modern doctrine of Landry paralysis

2020 ◽  
Vol VIII (1) ◽  
pp. 97-109
Author(s):  
A. E. Yanishevsky
Keyword(s):  
Nervous System ◽  
Clinical Picture ◽  
First Principle ◽  
Pathological Anatomy ◽  
Normal Anatomy ◽  
Nervous Disease ◽  
Nervous Systems ◽  
Anatomy And Physiology ◽  
Topical Diagnosis ◽  
Symptom Complex

Pri opredѣleni kazhdago nervnago zabolѣvanya, kak" otdѣl'noy nozologicheskoy yedinitsy, sovremennaya nevropatologya kladet" v" osnovu tri glavnykh" printsipa: anatomo-fizologichesky, patologo-anatomichesky i etologichesky. Na osnovani pervago printsipa nevropatolog", pol'zuyas' faktami normal'noy anatomi i fizologi nervnoy sistemy, opredѣlyayet" v" klinicheskoy kartinѣ zabolѣvanya uklonenya v" proyavleni dѣyatel'nosti otdѣl'nykh" nervnykh" sistem", nervnykh" yedinits"nevronov". Opredѣlyaya, kakya sistemy i kakya chasti ikh" porazheny, on" stavit" topicheskuyu dagnostiku zabolѣvanya. Na osnovani dannykh" patologicheskoy anatomi nevropatolog" opredѣlyayet" kharakter" porazhenya, lezhashchago v" osnovѣ zabolѣvanya, i nakonets" opredѣlyayet" prichinu, vyzvavshuyu dannoye zabolѣvane, obuslovivshuyu bystrotu ili medlennost' yego razvitya, pol'zuyas' v" ostrykh" sluchayakh" dannymi bakterologi i toksikologi. No ne smotrya na uspѣkhi nevrapotologi, sushchestvuyet" mnogo zabolѣvany, gdѣ vsѣ tri printsipa ne mogut" byt' strogo provedeny, tak" kak" predstavlyayut' mnogo yeshche spornago. Eti zabolѣvanya predstavlyayutsya simptomokompleksom", v" osnovѣ kotorago mogut" lezhat' porazhenya, chrezvychayno raznoobraznyya po svoyey lokalizatsi, po kharakteru patologo-anatomicheskago protsessa i po etologi. K" chislu podobnago roda zabolѣvany prinadlezhit" bolѣzn', izvѣstnaya pod" imenem" ostrago voskhodyashchago paralicha Landry. Развернуть 1371/5000 When defining each nervous disease, as a separate nosological unit, modern neuropathology lays in the basis of three main principles: anatomical-physiological, pathological-anatomical and ethiological. On the basis of the first principle, the neuropathologist, using the facts of normal anatomy and physiology of the nervous system, determines in the clinical picture of the disease, the evasion in the manifestation of the activity of individual nervous systems, nervous units - neurons. Determining which systems and which parts of them are affected, he sets the topical diagnosis of the disease. Based on the data of the pathological anatomy, the neuropathologist determines the nature of the lesion underlying the disease, and finally determines the cause that caused this disease, which caused the rapidity or slowness of its development, using the data of toxicology and toxicology in acute cases. But in spite of the successes of neuropathology, there are many diseases where all three principles cannot be strictly followed, since they represent a lot more controversial. These diseases are presented as a symptom complex, in the basis of which there may be lesions, extremely diverse in their localization, in the nature of the pathological-anatomical process and in ethiology. To the number of such kind of diseases belongs the disease, known under the name of acute ascending paralysis of Landry.

scholarly journals Wallop of Symptoms and Co-morbidities on COVID-19 Outcome

2021 ◽  
Vol 15 (1) ◽  
pp. 46-51
Author(s):  
Heba H. Abo ElNaga ◽  
Hesham A. AbdelHalim ◽  
Mohamed Abdellatif ◽  
Haroun BG ◽  
Basem Elnagdy ◽  
...  
Keyword(s):  
Clinical Picture ◽  
Online Survey ◽  
Severe Disease ◽  
Time Lag ◽  
Cross Sectional ◽  
Duration Of Symptoms ◽  
Co Morbidity ◽  
Wide Range ◽  
Severity Of The Disease ◽  
Prevalent Symptom

Background: Fever, cough, fatigue, and myalgia are usually the original clinical picture of the COVID-19 pandemic, which appears non-specific and not exclusive. Objectives: To illustrate the clinical picture pattern and assess the prevalence of underlying co-morbidities and their correlation with the severity of COVID-19 infected patients. Methods: A cross-sectional online survey included 580 participants who were either suspected or confirmed with COVID-19 infection. Results: The severity of the disease significantly correlates with both age (p=.01) and the time lag of the diagnosis of COVID-19 (p=.03). Hypertension (p=.015) and diabetes mellitus (p<.01) were significantly associated with the duration of symptoms. A wide range of ages (21-60 years) seemed to be the only risk factor for the severity. When symptoms were tested, dyspnea appeared to be the most prevalent symptom, predicting a more severe disease (OR= .066, 95% CI: .022- .200), followed by diarrhea (OR= .285, 95% CI: .122-.663), then fever (OR= .339, 95% CI: .139-.824). During the examination of co-morbidities influences on the severity, the only major co-morbidity that predicted a more severe disease was IHD (OR= .218, 95% CI: .073- .648), p= .006. Conclusion: Special consideration is required for patients with COVID-19 with an associated longer gap between symptoms and diagnosis and associated co-morbidities including hypertension, diabetes, and established chronic kidney disease (CKD), for which this study proved its profound influence on the severity of the illness and duration of symptoms.

scholarly journals Epidemiology, clinical picture, diagnostics, assessment of the severity of the disease COVID-19

2020 ◽  
Vol 12 (2) ◽  
pp. 7-30
Author(s):  
V. V. Rassokhin ◽  
A. V. Samarina ◽  
N. A. Belyakov ◽  
T. N. Trofimova ◽  
O. V. Lukina ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Medical Care ◽  
Clinical Picture ◽  
Risk Groups ◽  
Underlying Disease ◽  
Literary Sources ◽  
Severity Of The Disease ◽  
Definition Of ◽  
Rheumatological Diseases ◽  
Considerable Experience

The analysis of the epidemic process associated with COVID-19 is carried out, possible scenarios of the development of events are presented. The most common anamnestic data, symptoms of infection, clinical picture and possible complications are described in detail. The features of the COVID-19 course in risk groups and the algorithms of administrative and medical actions that should underlie the provision of medical care to patients with cardiovascular, oncological, rheumatological diseases, pregnant women, etc. The section of diagnostics and examination features is of particular importance, since it includes not only the definition of the causative agent of the disease, but also the main indicators that determine the severity of the clinical picture, prognosis, the nature and extent of medical care. Considerable experience is presented in the clinical practice of computed tomography of the lungs, the method, the primary and early method for identifying not only lung lesions, but also the underlying disease — COVID-19. Information is presented from literary sources based on the experience of overcoming this formidable disease and its consequences by our colleagues, as well as the experience of domestic clinicians and scientists.

Clinical and laboratory profile of patients with COVID-19 admitted to hospital in Moscow between May and July 2020

2021 ◽  
Vol 19 (2) ◽  
pp. 5-15
Author(s):  
L.V. Kolobukhina ◽  
◽  
O.A. Burgasova ◽  
L.A. Kraeva ◽  
V.A. Gushchin ◽  
...  
Keyword(s):  
Clinical Picture ◽  
Clinical Manifestations ◽  
Rt Pcr ◽  
Main Method ◽  
Chronic Lung Diseases ◽  
Pcr Method ◽  
Laboratory Profile ◽  
Biological Substrates ◽  
Severity Of The Disease ◽  
Diagnostic Capabilities

Objective. Data of the clinical picture forms of the disease, management and diagnostic capabilities of patients with COVID-19 continue to be studied. Our study presents results from the analysis of clinical and laboratory parameters of patients with COVID-19 in the period May-June 2020, who were treated in an infectious diseases hospital in Moscow. Patients and methods. The analytical cohort included 444, 198 men, 246 women aged 18 to 95 years, who were identified with SARS-CoV-2 RNA. The severity of the disease was determined in accordance with the temporary clinical recommendations (version 6 effective April 28, 2020), NEWS. Results. The study of the clinical picture showed the variability of the spectrum of clinical manifestations of COVID-19. The most common symptoms were fever, weakness, myalgia, dry cough, shortness of breath, diarrhea. The severity of the infection was not associated with the patient's gender, but was significantly correlated with age and the presence of comorbid status, which included chronic lung diseases, obesity, diabetes mellitus, and cardiovascular diseases. Observations of patients with severe and extremely severe course revealed characteristic laboratory markers of severity. The main method of etiological diagnosis was the RT-PCR method for detecting SARS-CoV-2 RNA in the nasopharyngeal secret. To verify COVID-19, we used an additional PCR method, fecal testing for the detection of SARS-CoV-2 RNA. Key words: COVID-19, clinical features, risk factors, SARS-CoV-2 RNA, biological substrates

Ergotism. Classification of forms, clinical picture and pathological anatomy of chronic ergotism

1938 ◽  
Vol 34 (1) ◽  
pp. 105-106
Author(s):  
A. Galant
Keyword(s):  
Clinical Picture ◽  
Laboratory Data ◽  
Pathological Anatomy ◽  
The Urals ◽  
History Of ◽  
Therapeutic Measures

Based on personal observations and literature data, the author gives an exhaustive presentation of the issue of ergotism. Found their reflection in the monograph: the history of ergotism toxidemia, including ergotism in the Urals in 1926-1927, general symptomatology and classification of ergotism, laboratory data for chr. ergotism, psychosis in ergotism, pathologist, anatomy of Chr. ergotism, questions of pathogenesis, examination of ergotism, preventive and therapeutic measures in helping ergotines.

The clinical picture of ectopic (tubal) pregnancy

1927 ◽  
Vol 23 (1) ◽  
pp. 82-92
Author(s):  
A. I. Timofeev
Keyword(s):  
Ectopic Pregnancy ◽  
Clinical Picture ◽  
Tubal Pregnancy ◽  
Considerable Progress ◽  
Pathological Anatomy ◽  
Made In

Although considerable progress has been made in the study of ectopic pregnancy, particularly in relation to the development of the pathological anatomy of this disorder, there is still much controversy in this chapter of gynecology as well. Not to mention the various details of etiology that have not been fully elucidated, there is not complete unanimity in the authors' opinions even on the main issues of ectopic pregnancy therapy.

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