Quantitative characteristics of the alpha-rhythm of the electroencephalogram in depressive disorders

2021 ◽  
Vol LIII (3) ◽  
pp. 19-25
Author(s):  
Stanislav A. Galkin ◽  
Svetlana N. Vasilyeva ◽  
German G. Simutkin ◽  
Nikolay A. Bokhan
Keyword(s):  
Alpha Rhythm ◽  
Depressive Disorders ◽  
Spectral Power ◽  
Health Department ◽  
Oscillatory Activity ◽  
Reactivity Index ◽  
Control Group ◽  
Affective States ◽  
Quantitative Characteristics ◽  
Mental Health Department

The aim of research was to study the quantitative characteristics of the alpha rhythm in patients with depressive disorders. Material and methods. The study sample consisted of patients who were treated at the clinic of the Research Institute of Mental Health (department of affective states) Tomsk NIMC. A total of 84 patients (67 women, 17 men) aged 20 to 60 years with mood disorders in the framework of a depressive episode, recurrent depressive disorder and dysthymia were examined. An electroencephalogram was recorded at rest with closed and open eyes. The values of the absolute spectral power of the alpha rhythm, the parameters of the microstructure of the alpha spindle were analyzed and the reactivity index (the Berger effect) was calculated. Results. With open eyes, the spectral power of the alpha rhythm was statistically significantly higher in patients with depressive disorders in the Fp1 (p=0.041), F4 (p=0.042), F7 (p=0.046) and T4 (p=0.047) leads compared to the control. Also, in patients with depressive disorders, a predominantly low-amplitude alpha rhythm was recorded (53.6% vs. 26.7%, p=0.006). The degree of alpha-rhythm depression in the posterior temporal leads T5 (p=0.012) and T6 (p=0.006) was statistically significantly less pronounced in patients with depressive disorders compared to the control group of healthy individuals. Conclusion. The detected changes indirectly indicate a decrease in the oscillatory activity of brain processes in depressive disorders.

scholarly journals Prescription Dose Analysis of Quetiapine in the Elderly and Insomnia

2021 ◽  
Vol 3 (4) ◽  
pp. 149-156
Author(s):  
Ki Yong Lee ◽  
Seung-Ho Ryu ◽  
Jee Hyun Ha ◽  
Hong Jun Jeon ◽  
Doo-Heum Park
Keyword(s):  
Elderly Patient ◽  
Patient Group ◽  
Depressive Disorders ◽  
Drug Prescription ◽  
Immediate Release ◽  
The Elderly ◽  
Health Department ◽  
Prescription Dose ◽  
Mental Health Department ◽  
Higher Doses

Objective: The purpose of this study is to investigate the appropriate dose of quetiapine in clinical psychiatric diseases by examining the drug prescription dose in the elderly and insomnia group through an analysis of the tendency of quetiapine dose prescribed by psychiatric diagnosis.Methods: Among the patients who had been taking outpatient treatment to the mental health department for about 7 years and 8 months from May 1, 2010 to December 31, 2017, 2,794 patients who were continuously taking quetiapine immediate-release form drugs were retrospectively tested. In addition, all subjects were classified into a total of four groups according to their maintenance dose, four mental diseases that most commonly prescribe quetiapine were selected and grouped, and further analyzed whether there was a difference in prescription capacity by age and comorbidities for the insomnia group.Results: Prescription dose of quetiapine was found to be less than 50 mg in depressive disorders and insomnia, which is a relatively low dose prescribed compared to schizophrenia and bipolar disorder. In the case of insomnia, quetiapine prescribed in the elderly patient group was 30.03±9.14 mg, which was relatively high compared to the non-elderly group. And in the case of insomnia accompanied by depressive disorder, 50.28±11.41 mg was prescribed, more than 60% higher doses than that of primary insomnia.Conclusion: In the case of primary insomnia, quetiapine dose prescribed in the elderly patient group is higher than that in the non-elderly patient group.

EEG correlates of cognitive functions and neuropsychiatric disorders: A review of oscillatory activity and neural synchrony abnormalities

2020 ◽  
Vol 16 ◽  
Author(s):  
Meysam Amidfar ◽  
Yong-Ku Kim
Keyword(s):  
Psychiatric Disorders ◽  
Cognitive Functions ◽  
Spectral Power ◽  
Large Body ◽  
Oscillatory Activity ◽  
Brain Oscillations ◽  
Emotional Symptoms ◽  
Obsessive Compulsive ◽  
Neuropsychiatric Diseases ◽  
Obsessive Compulsive Disorders

Background: A large body of evidence suggested that disruption of neural rhythms and synchronization of brain oscillations are correlated with variety of cognitive and perceptual processes. Cognitive deficits are common features of psychiatric disorders that complicate treatment of the motivational, affective and emotional symptoms. Objective: Electrophysiological correlates of cognitive functions will contribute to understanding of neural circuits controlling cognition, the causes of their perturbation in psychiatric disorders and developing novel targets for treatment of cognitive impairments. Methods: This review includes description of brain oscillations in Alzheimer’s disease, bipolar disorder, attentiondeficit/hyperactivity disorder, major depression, obsessive compulsive disorders, anxiety disorders, schizophrenia and autism. Results: The review clearly shows that the reviewed neuropsychiatric diseases are associated with fundamental changes in both spectral power and coherence of EEG oscillations. Conclusion: In this article we examined nature of brain oscillations, association of brain rhythms with cognitive functions and relationship between EEG oscillations and neuropsychiatric diseases. Accordingly, EEG oscillations can most likely be used as biomarkers in psychiatric disorders.

scholarly journals An Analysis of the External Validity of EEG Spectral Power in an Uncontrolled Outdoor Environment during Default and Complex Neurocognitive States

2021 ◽  
Vol 11 (3) ◽  
pp. 330
Author(s):  
Dalton J. Edwards ◽  
Logan T. Trujillo
Keyword(s):  
External Validity ◽  
Spectral Power ◽  
Brain Activity ◽  
Outdoor Environment ◽  
Oscillatory Activity ◽  
Brain State ◽  
Beta Band ◽  
Eeg Spectral Power ◽  
Eeg Power ◽  
Human Participants

Traditionally, quantitative electroencephalography (QEEG) studies collect data within controlled laboratory environments that limit the external validity of scientific conclusions. To probe these validity limits, we used a mobile EEG system to record electrophysiological signals from human participants while they were located within a controlled laboratory environment and an uncontrolled outdoor environment exhibiting several moderate background influences. Participants performed two tasks during these recordings, one engaging brain activity related to several complex cognitive functions (number sense, attention, memory, executive function) and the other engaging two default brain states. We computed EEG spectral power over three frequency bands (theta: 4–7 Hz, alpha: 8–13 Hz, low beta: 14–20 Hz) where EEG oscillatory activity is known to correlate with the neurocognitive states engaged by these tasks. Null hypothesis significance testing yielded significant EEG power effects typical of the neurocognitive states engaged by each task, but only a beta-band power difference between the two background recording environments during the default brain state. Bayesian analysis showed that the remaining environment null effects were unlikely to reflect measurement insensitivities. This overall pattern of results supports the external validity of laboratory EEG power findings for complex and default neurocognitive states engaged within moderately uncontrolled environments.

scholarly journals EEG Data Quality: Determinants and Impact in a Multicenter Study of Children, Adolescents, and Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)

2021 ◽  
Vol 11 (2) ◽  
pp. 214
Author(s):  
Anna Kaiser ◽  
Pascal-M. Aggensteiner ◽  
Martin Holtmann ◽  
Andreas Fallgatter ◽  
Marcel Romanos ◽  
...  
Keyword(s):  
Data Quality ◽  
Large Scale ◽  
Linear Models ◽  
Spectral Power ◽  
Control Group ◽  
Continuous Performance Task ◽  
Related Data ◽  
Eyes Closed ◽  
Eeg Data ◽  
Eyes Open

Electroencephalography (EEG) represents a widely established method for assessing altered and typically developing brain function. However, systematic studies on EEG data quality, its correlates, and consequences are scarce. To address this research gap, the current study focused on the percentage of artifact-free segments after standard EEG pre-processing as a data quality index. We analyzed participant-related and methodological influences, and validity by replicating landmark EEG effects. Further, effects of data quality on spectral power analyses beyond participant-related characteristics were explored. EEG data from a multicenter ADHD-cohort (age range 6 to 45 years), and a non-ADHD school-age control group were analyzed (ntotal = 305). Resting-state data during eyes open, and eyes closed conditions, and task-related data during a cued Continuous Performance Task (CPT) were collected. After pre-processing, general linear models, and stepwise regression models were fitted to the data. We found that EEG data quality was strongly related to demographic characteristics, but not to methodological factors. We were able to replicate maturational, task, and ADHD effects reported in the EEG literature, establishing a link with EEG-landmark effects. Furthermore, we showed that poor data quality significantly increases spectral power beyond effects of maturation and symptom severity. Taken together, the current results indicate that with a careful design and systematic quality control, informative large-scale multicenter trials characterizing neurophysiological mechanisms in neurodevelopmental disorders across the lifespan are feasible. Nevertheless, results are restricted to the limitations reported. Future work will clarify predictive value.

scholarly journals AB0177 ANXIETY-DEPRESSIVE SPECTRUM IN PATIENTS WITH RHEUMATOID ARTHRITIS AND ANKYLOSING SPONDILITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1114.2-1114
Author(s):  
M. Letaeva ◽  
M. Koroleva ◽  
J. Averkieva ◽  
O. Malyshenko ◽  
T. Raskina
Keyword(s):  
Rheumatoid Arthritis ◽  
Depressive Disorders ◽  
Depression Scale ◽  
Well Being ◽  
Depressive Syndrome ◽  
Depression Screening ◽  
Anxiety And Depression ◽  
Control Group ◽  
Subjective Well Being ◽  
Anxiety Depression

Objectives:to assess the frequency of occurrence of the anxiety-depressive spectrum in patients with rheumatoid arthritis and ankylosing spondylitis.Methods:A survey was conducted of 44 patients aged from 21 to 57 years (average age - 42.3 ± 6.7 years), who were treated at GAUZ KO OKGVV. All patients had a verified diagnosis of RA and AS according to the ACR criteria and received treatment with basic drugs. The control group consisted of 40 people comparable in age and sex, without concomitant pathology of RA and AS.The depression screening card, the subjective well-being scale, and the hospital anxiety and depression scale (HADS) were used to assess and detect anxiety-depressive syndrome. The assessment of the condition is carried out over the last 2 weeks, which corresponds to the temporary diagnostic criterion for depression.The Depression Screening Scale is a 35-item self-questionnaire that assesses 7 categories of signs: sleep and appetite disorders, anxiety, emotional instability, cognitive impairment, loss of self, guilt, and suicidal tendencies. A total score of 65 and above indicates a high likelihood of depression.The Subjective Well-Being Scale is a psychodiagnostic screening tool for measuring the emotional component of subjective well-being or emotional comfort.Hospital Anxiety and Depression Scale Zigmond A.S., Snaith R.P. was developed for the primary detection of depression and anxiety in a general medical practice. The HADS scale consists of 14 statements with 4 possible answers and includes two parts: anxiety and depression. The sum of points of 8 or more is regarded as “subclinically expressed anxiety / depression”, 11 or more points - “clinically expressed anxiety / depression”.Results:According to the results of the depression screening questionnaire, 34 (77.3%) patients with RA and AS showed signs of depression, while in the control group only 6 (15%) patients tested positive for the presence of depressive disorders. According to the data obtained when assessing the scale of well-being in the main group, 26 (59.1%) patients showed signs of emotional discomfort (the indicator was 80% or more), in the control group - in 6 (15%). Using the hospital scale of anxiety and depression HADS, anxiety-depressive syndrome was detected in 36 (81.8%) patients with RA and AS: 16 (44.4%) patients had anxiety, 20 (55.6%) - depression, of them, subclinically expressed anxiety and depression were observed in 10 (27.7%) and 12 (33.3%) people, respectively. Anxiety-depressive syndrome in the control group, according to the HADS questionnaire, was detected only in 8 (20%) patients, of whom 4 (10%) patients had subclinical anxiety and 4 (10%) had signs of depression. No clinically pronounced anxiety and depression were registered in the control group.Conclusion:In most patients with rheumatoid arthritis and ankylosing spondylitis, anxiety-depressive disorders have been identified, which can directly affect both the course of the disease itself and the development of various complications. Timely diagnosis of mental disorders and close cooperation of rheumatologists, psychiatrists and psychologists in the selection of adequate therapy can improve the course and prognosis of the disease.Disclosure of Interests:None declared

scholarly journals Evaluating empathy in adolescents with conduct disorders

2016 ◽  
Vol 73 (5) ◽  
pp. 429-434 ◽  
Author(s):  
Jelena Kostic ◽  
Milkica Nesic ◽  
Miodrag Stankovic ◽  
Olivera Zikic ◽  
Jasminka Markovic
Keyword(s):  
Conduct Disorder ◽  
Negative Correlation ◽  
Behavioral Problems ◽  
Perspective Taking ◽  
Significant Negative Correlation ◽  
Conduct Disorders ◽  
Self Report ◽  
Reactivity Index ◽  
Control Group ◽  
Affective Empathy

Background/Aim. According to currently available data, there is no research dealing with evaluating empathy in adolescents with conduct disorders in our region. The aim of the research was to examine the differences in the severity of cognitive and affective empathy in adolescents with and with no conduct disorder, as well as to examine the relationship between cognitive and affective empathy and the level of externalization in adolescents with conduct disorder. Methods. This research was conducted on 171 adolescents, aged 15 to 18, using the Interpersonal Reactivity Index, Youth Self- Report and a Questionnaire constructed for the purpose of this research. Results. The results showed that adolescents with conduct disorder had significantly lower scores for Perspective Taking (t = 3.255, p = 0.001), Fantasy (t = 2.133, p = 0.034) and Empathic Concern (t = 2.479, p = 0.014) compared to the adolescents in the control group, while the values for Personal Distress (t = 1.818, p = 0.071) were higher compared to the control group, but the difference was not statistically significant. The study showed a statistically significant negative correlation between Perspective Taking and aggression (r = - 0.318, p = 0.003) and a negative correlation between Perspective Taking and the overall level of externalizing problems (r = -0.310, p = 0.004) in the group of adolescents with conduct disorder. Conclusion. This research contributes to better understanding of behavioral disorders in terms of individual factors, especially empathic reactivity. Preventive work with young people who have behavioral problems associated with empathy deficit disorder proved to be an important tool in preventing the development, or at least relieving the symptoms, of this ever more common disorder.

scholarly journals Behavioral and EEG reactions in primary school-aged children to emotionally colored verbal stimuli with the condition of their own or forced choice

2017 ◽  
Vol 8 (4) ◽  
pp. 72-90 ◽  
Author(s):  
T.A. Aiusheeva ◽  
A.E. Saprygin ◽  
A.N. Savostyanov ◽  
V.V. Stеpanova
Keyword(s):  
Primary School ◽  
Positive Emotions ◽  
Alpha Rhythm ◽  
Spectral Power ◽  
Forced Choice ◽  
Choice Situation ◽  
Verbal Stimuli ◽  
School Aged Children ◽  
Theta Range

The aim of the study is to compare behavioral and EEG reactions of primary school-aged children during the recognition of syntactic errors in emotionally (positively or negatively) colored sentences that appeal to the choice of the child differently. 20 children (mean age 9,0±0,3 years, 12 boys, 8 girls) were examined. We found out that the children with a high quality of solving a linguistic task concentrate all their attention on finding an error in the sentences, and children with a low quality of solving a task demonstrate increased emotionality, possibly connected with their unsuccessfulness. The strongest EEG reactions in the ranges of alpha- and theta- rhythms were recorded in children with slow speed and bad quality of the solution of the task. The recognition of sentences with negative emotions took longer than sentences with positive emotions. The increase of emotions (synchronization in theta range) during the recognition of negative sentences was provoked by the expectation of failure and “identification” with it. The children found the mistake better in the sentences with their own choice than in the sentences that describes the forced-choice situation. Desynchronization (i.e. decrease in the spectral power) and synchronization (i.e. increase in spectral power) was detected on the EEG in the alpha-rhythm range. Desynchronization was associated with the recognition of sentences describing the children’s own choice; synchronization was recorded when recognizing sentences describing the forced-choice situation.

scholarly journals Perception of Non-Verbal Prosody in Children with ASD

2020 ◽  
Author(s):  
Aleksandra V. Maslennikova ◽  
Galina V. Portnova ◽  
Olga V. Martynova
Keyword(s):  
Positive Emotions ◽  
Rating Scale ◽  
Spectral Power ◽  
Negative Emotions ◽  
Target Group ◽  
Control Group ◽  
Children With Asd ◽  
Spectrum Density ◽  
Healthy Control ◽  
Important Marker

AbstractParalinguistic features of the speaker, such as prosody, temp, loudness, and dynamics, are an important marker of a person’s emotional state. The deficit of processing of emotional prosody could be preferably associated with the impairments in individuals with ASD’s social behavior. The following two groups of children participated in our study: 30 preschoolers from 4 to 6 years old in the target group (39.1 ± 6.4 scores by Childhood Autism Rating Scale), 24 preschoolers of the control group from 4 to 6 years in the control group. The prosody stimuli were the combination of syllables, said with intonations of “joy,” “angry,” “sadness,” “fear,” and “calm.” Fast Fourier transform (FFT) is used to analyze power spectrum density (PSD). The resulting normalized spectrum was integrated over unit width intervals in the range of interest (2 to 20 Hz with a step in 1Hz). Children with ASD, similarly to TD children, showed the most pronounced differenced of EEG in response to prosodics of fear and anger. The significant groups’ differences in PSD were detected for sad and joy intonations. Indexes of EEG differences between pleasure and painful intonations were significantly higher in the control group than children with ASD and between sadness and calm or joy and calm intonations. This paper makes up two main contributions: In general, we obtained that children with ASD have less response to a human voice’s emotional intonation. The physical characteristics of stimuli are more critical than a sign of emotions. The effect of EEG spectral power has hemisphere specialization in the healthy control group, but not in ASD children. Since spectral power for negative emotions in the target group is higher, we proposed that ASD children worse recognize positive emotions than negative emotions.

scholarly journals Cognitive impairments in patients with treatment resistant epilepsy and complex rehabilitation

2021 ◽  
Vol 8 (2) ◽  
pp. 123-129
Author(s):  
Volodymyr Korostiy ◽  
Iryna Blazhina
Keyword(s):  
Quality Of Life ◽  
Cognitive Decline ◽  
Cognitive Training ◽  
Affective Disorders ◽  
Depressive Disorders ◽  
Cognitive Impairments ◽  
Control Group ◽  
Quality Of Life Scale ◽  
Patients With Epilepsy

Background. The study of features of comorbid pathology in patients with epilepsy is of particular interest due to the high prevalence of this pathology and a significant impact on the quality of life of patients and their social adaptation. Aim. The aim of the research was to detect versatile cognitive impairments and affective disorders in epilepsy, and to study the results of cognitive training and psychoeducation. Materials and methods. The theoretical analysis of modern scientific researches in the field of cognitive and affective impairments during epilepsy was carried out. We studied the features of clinical and psychopathological manifestations in patients, suffering from epilepsy. The study covered 146patients (85 men and 61 women) who were in inpatient care. The following psychodiagnostic techniques were used: the MOCA test, the Toronto Cognitive Assessment (TorCA), the MiniMult test, the Münsterberg test, the quality of life scale, the Hamilton scale of depression and anxiety. Results. This publication offers the results of a study of cognitive and affective disorders the quality of life in patients who suffer from epilepsy and the results of online cognitive training and psychoeducation. We found cognitive decline in 88% of patients with epilepsy and improvement of cognitive functions by methods of non-pharmacological correction. Conclusions. Affective and cognitive disorders significantly affects the quality of life of patients, their ability to work and socialization. The conducted research showed that compared to the control group of healthy persons, patients with epilepsy showed improvement in their cognitive decline, anxiety and depressive disorders. Cognitive online training appeared to be effective for the patients with epilepsy.

“Send & hold” clinical decision support rules improvement to reduce unnecessary testing of vitamins A, E, K, B1, B2, B3, B6 and C

2018 ◽  
Vol 56 (7) ◽  
pp. 1063-1070 ◽  
Author(s):  
Enrique Rodriguez-Borja ◽  
Africa Corchon-Peyrallo ◽  
Esther Barba-Serrano ◽  
Celia Villalba Martínez ◽  
Arturo Carratala Calvo
Keyword(s):  
Decision Support ◽  
Clinical Decision Support ◽  
Primary Care Physicians ◽  
Vitamin B1 ◽  
Clinical Decision ◽  
Health Department ◽  
Leadership Role ◽  
Control Group ◽  
Vitamin B3 ◽  
The Impact

Abstract Background: We assessed the impact of several “send & hold” clinical decision support rules (CDSRs) within the electronical request system for vitamins A, E, K, B1, B2, B3, B6 and C for all outpatients at a large health department. Methods: When ordered through electronical request, providers (except for all our primary care physicians who worked as a non-intervention control group) were always asked to answer several compulsory questions regarding main indication, symptomatology, suspected diagnosis, vitamin active treatments, etc., for each vitamin test using a drop-down list format. After samples arrival, tests were later put on hold internally by our laboratory information system (LIS) until review for their appropriateness was made by two staff pathologists according to the provided answers and LIS records (i.e. “send & hold”). The number of tests for each analyte was compared between the 10-month period before and after CDSRs implementation in both groups. Results: After implementation, vitamins test volumes decreased by 40% for vitamin A, 29% for vitamin E, 42% for vitamin K, 37% for vitamin B1, 85% for vitamin B2, 68% for vitamin B3, 65% for vitamin B6 and 59% for vitamin C (all p values 0.03 or lower except for vitamin B3), whereas in control group, the majority increased or remained stable. In patients with rejected vitamins, no new requests and/or adverse clinical outcome comments due to this fact were identified. Conclusions: “Send & hold” CDSRs are a promising informatics tool that can support in utilization management and enhance the pathologist’s leadership role as tests specialist.

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