scholarly journals Prescription Dose Analysis of Quetiapine in the Elderly and Insomnia

2021 ◽  
Vol 3 (4) ◽  
pp. 149-156
Author(s):  
Ki Yong Lee ◽  
Seung-Ho Ryu ◽  
Jee Hyun Ha ◽  
Hong Jun Jeon ◽  
Doo-Heum Park

Objective: The purpose of this study is to investigate the appropriate dose of quetiapine in clinical psychiatric diseases by examining the drug prescription dose in the elderly and insomnia group through an analysis of the tendency of quetiapine dose prescribed by psychiatric diagnosis.Methods: Among the patients who had been taking outpatient treatment to the mental health department for about 7 years and 8 months from May 1, 2010 to December 31, 2017, 2,794 patients who were continuously taking quetiapine immediate-release form drugs were retrospectively tested. In addition, all subjects were classified into a total of four groups according to their maintenance dose, four mental diseases that most commonly prescribe quetiapine were selected and grouped, and further analyzed whether there was a difference in prescription capacity by age and comorbidities for the insomnia group.Results: Prescription dose of quetiapine was found to be less than 50 mg in depressive disorders and insomnia, which is a relatively low dose prescribed compared to schizophrenia and bipolar disorder. In the case of insomnia, quetiapine prescribed in the elderly patient group was 30.03±9.14 mg, which was relatively high compared to the non-elderly group. And in the case of insomnia accompanied by depressive disorder, 50.28±11.41 mg was prescribed, more than 60% higher doses than that of primary insomnia.Conclusion: In the case of primary insomnia, quetiapine dose prescribed in the elderly patient group is higher than that in the non-elderly patient group.

Author(s):  
Jonathan H. Smith ◽  
Andreas Straube ◽  
Jerry W. Swanson

There is a non-controversial definition about who is an elderly patient. The age group above 85 years is the fastest growing segment in the total population. Persisting pain is not rare in this patient group and the prevalence for persisting pain is 40–79%. Migraine prevalence declines gradually after the age of 40 years, but even in the age group of 60 years and older up to 5% complain of migraine and in some patients the symptoms change towards more tension type-like headaches. Tension-type headaches are thought to be the most prevalent primary headaches in the elderly, with a 1-year prevalence of about 36%; secondary headaches often present as tension type-like headaches. A typical age-bounded headache is hypnic headache, which is only seen in patients older than 55 years of age. In the treatment of headaches in the elderly, the pharmacokinetic changes with age should be considered; the distribution volume and elimination kinetics are different in the elderly. Therefore, treatment should be initiated as ‘slow and low’.


2021 ◽  
Vol LIII (3) ◽  
pp. 19-25
Author(s):  
Stanislav A. Galkin ◽  
Svetlana N. Vasilyeva ◽  
German G. Simutkin ◽  
Nikolay A. Bokhan

The aim of research was to study the quantitative characteristics of the alpha rhythm in patients with depressive disorders. Material and methods. The study sample consisted of patients who were treated at the clinic of the Research Institute of Mental Health (department of affective states) Tomsk NIMC. A total of 84 patients (67 women, 17 men) aged 20 to 60 years with mood disorders in the framework of a depressive episode, recurrent depressive disorder and dysthymia were examined. An electroencephalogram was recorded at rest with closed and open eyes. The values of the absolute spectral power of the alpha rhythm, the parameters of the microstructure of the alpha spindle were analyzed and the reactivity index (the Berger effect) was calculated. Results. With open eyes, the spectral power of the alpha rhythm was statistically significantly higher in patients with depressive disorders in the Fp1 (p=0.041), F4 (p=0.042), F7 (p=0.046) and T4 (p=0.047) leads compared to the control. Also, in patients with depressive disorders, a predominantly low-amplitude alpha rhythm was recorded (53.6% vs. 26.7%, p=0.006). The degree of alpha-rhythm depression in the posterior temporal leads T5 (p=0.012) and T6 (p=0.006) was statistically significantly less pronounced in patients with depressive disorders compared to the control group of healthy individuals. Conclusion. The detected changes indirectly indicate a decrease in the oscillatory activity of brain processes in depressive disorders.


Author(s):  
Fernando Lefevre ◽  
Jorge Teixeira ◽  
Ana Lefevre ◽  
Lia Cardozo de Castro ◽  
Aracy Spínola

Aiming at identifying the relationship between the elderly patient facing drug prescription and health professionals, an exploratory and descriptive study of a qualitative cut was carried out using semi-structured interviews. To this end, the Collective Subject Discourse analysis technique was employed. Thirty elderly patients living in the urban area of Maring (Paran State, Brazil) were sampled. They were interviewed from February 25 to March 22, 1998 and selected from the Co-participatory pharmacy database of the Department of Pharmacy and Pharmacology, Universidade Estadual de Maring . The finding supplied eleven central Collective Subject ideas, with different discourses. The rich material provided by the study allows better understanding of the factual reality of the elderly facing drug prescription and their relationship with health professionals.


2010 ◽  
Vol 58 (3) ◽  
pp. 199-206 ◽  
Author(s):  
Rosina-Martha Csöff ◽  
Gloria Macassa ◽  
Jutta Lindert

Körperliche Beschwerden sind bei Älteren weit verbreitet; diese sind bei Migranten bislang in Deutschland und international noch wenig untersucht. Unsere multizentrische Querschnittstudie erfasste körperliche Beschwerden bei Menschen im Alter zwischen 60 und 84 Jahren mit Wohnsitz in Stuttgart anhand der Kurzversion des Gießener Beschwerdebogens (GBB-24). In Deutschland wurden 648 Personen untersucht, davon 13.4 % (n = 87) nicht in Deutschland geborene. Die Geschlechterverteilung war bei Migranten und Nichtmigranten gleich; der sozioökonomische Status lag bei den Migranten etwas niedriger: 8.0 % (n = 7) der Migranten und 2.5 % (n = 14) der Nichtmigranten verfügten über höchstens vier Jahre Schulbildung; 12.6 % (n = 11) der Migranten und 8.2 % (n = 46) der Nichtmigranten hatten ein monatliches Haushaltsnettoeinkommen von unter 1000€; 26.4 % der Migranten und 38.1 % (n = 214) der Nichtmigranten verfügten über mehr als 2000€ monatlich. Somatische Beschwerden lagen bei den Migranten bei 65.5 % (n = 57) und bei den Nichtmigranten bei 55.8 % (n = 313). Frauen wiesen häufiger somatische Beschwerden auf (61.8 %) als Männer (51.8 %). Mit steigendem Alter nahmen somatische Beschwerden zu. Mit Ausnahme der Altersgruppe der 70–74-Jährigen konnte kein signifikanter Unterschied zwischen Migranten und Nichtmigranten hinsichtlich der Häufigkeit körperlicher Beschwerden gezeigt werden. Ausblick: Es werden dringend bevölkerungsrepräsentative Studien zu körperlichen Beschwerden bei Migranten benötigt.


2021 ◽  
Vol 11 (7) ◽  
pp. 645
Author(s):  
Haewon Byeon

This cross-sectional study developed a nomogram that could allow medical professionals in the primary care setting to easily and visually confirm high-risk groups of depression. This study analyzed 4011 elderly people (≥60 years old) who completed a health survey, blood pressure, physical measurement, blood test, and a standardized depression screening test. A major depressive disorder was measured using the Korean version of the Patient Health Questionnaire (PHQ-9). This study built a model for predicting major depressive disorders using logistic regression analysis to understand the relationship of each variable with major depressive disorders. In the result, the prevalence of depression measured by PHQ-9 was 6.8%. The results of multiple logistic regression analysis revealed that the major depressive disorder of the elderly living alone was significantly (p < 0.05) related to monthly mean household income, the mean frequency of having breakfast per week for the past year, moderate-intensity physical activity, subjective level of stress awareness, and subjective health status. The results of this study implied that it would be necessary to continuously monitor these complex risk factors such as household income, skipping breakfast, moderate-intensity physical activity, subjective stress, and subjective health status to prevent depression among older adults living in the community.


Author(s):  
Dorothy Taylor ◽  
Janice Morse ◽  
Andrew Merryweather

Elderly patient falls are expensive and may cause serious harm. Studies have identified the sit-to-stand-and-walk (STSW) task as the task where the greatest number of elderly patient falls occur. There is a great need to identify the particular movement and environmental conditions that lead to these elderly patient falls. This study begins to address this gap by evaluating the elderly patient during self-selected hospital bed egress. Using an observed fall risk episode (FRE) as a fall proxy, statistically significant parameters were identified which include bed height, pausing prior to initiating gait, level of fall risk, and Stand phase. Low bed height was identified as the least safe bed height. Patient-specific bed height (PSBH) using the patient’s lower leg length (LLL) is recommended. In addition, suggested guidelines are presented for clinical application in setting PSBH without measuring the patient’s LLL.


1985 ◽  
Vol &NA; (193) ◽  
pp. 178???183 ◽  
Author(s):  
J. W. PEPIN ◽  
R. B. BOURNE ◽  
R. J. HAWKINS

1968 ◽  
Vol 23 (4) ◽  
pp. 563-563
Author(s):  
H. A. Illing
Keyword(s):  

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