scholarly journals The significance of the original characteristics of the active substance of injectable chondroitin sulfate preparations for intramuscular injections in the evidence-based medicine

2021 ◽  
Author(s):  
Svetlana M. Napalkova ◽  
Sergey V. Okovityi ◽  
Dmitry Y. Ivkin ◽  
Alexander O. Pyatibrat
Keyword(s):  
Chondroitin Sulfate ◽  
Intrinsic Viscosity ◽  
Sodium Sulfate ◽  
Method Development ◽  
Design Research ◽  
Intramuscular Injections ◽  
Science And Education ◽  
Based Medicine ◽  
Research Drug

Given the data from normative control resources and the research and development information system of the Ministry of Science and Education of the Russian Federation, we were unable to review the results and the quality of publications comprising method development and analytical validation of quantitative and qualitative values of injectable chondroitin sulfate preparations for intramuscular injections. Therefore, the results obtained in the research The development of a method for determining the intrinsic viscosity of an injectable chondroitin sodium sulfate preparation for intramuscular injections of 100 mg/ml, 2 ml remain valid, the method is considered reliable and practical. The materials and methods used in the research The development of a method for determining the intrinsic viscosity of an injectable chondroitin sulfate preparation have provided the possibility to determine the intrinsic viscosity for injectable chondroitin sodium sulfate preparations for intramuscular injections and the use of 0.2 M sodium chloride solution as a solvent. Also, the viscosity of the tested solutions in the concentration range of chondroitin sulfate 4.5-20 mg/ml was accurately сalculated, the value of the intrinsic viscosity determined for each of the preparations under test was in the range of 0.03-0.042 m3/kg. This study presents the results of a review of recent information, published in a number of academic journals, concerning modern approaches to the treatment and major clinical problems when applying chondroprotectors for arthrological diseases treatment. Considering the continuing interest in chondroprotectors, stability problems with formulations and modern possibilities in the application of machine learning in drug discovery, additional pharmaceutical design research (Drug design) is expected - from the docking stage to the quantum calculations stage.

scholarly journals Web-based Medical Education During COVID-19 Lockdown: A Step Back or a Leap to the Future?

2021 ◽  
pp. 153473462110118
Author(s):  
Anna Eleftheriou ◽  
Aikaterini Rokou ◽  
Christos Argyriou ◽  
Nikolaos Papanas ◽  
George S. Georgiadis
Keyword(s):  
Medical Education ◽  
Clinical Training ◽  
Medical Training ◽  
Medical Schools ◽  
Web Based ◽  
Clinical Exposure ◽  
Virtual Teaching ◽  
Based Medicine ◽  
The Impact

The impact of coronavirus infectious disease (COVID-19) on medical education has been substantial. Medical students require considerable clinical exposure. However, due to the risk of COVID-19, the majority of medical schools globally have discontinued their normal activities. The strengths of virtual teaching now include a variety of web-based resources. New interactive forms of virtual teaching are being developed to enable students to interact with patients from their homes. Conversely, students have received decreased clinical training in certain medical and surgical specialities, which may, in turn, reduce their performance, confidence, and abilities as future physicians. We sought to analyze the effect of telemedicine on the quality of medical education in this new emerging era and highlight the benefits and drawbacks of web-based medical training in building up future physicians. The COVID-19 pandemic has posed an unparalleled challenge to medical schools, which are aiming to deliver quality education to students virtually, balancing between evidence-based and experience-based medicine.

scholarly journals A guide to do randomized controlled trials in the field of otolaryngology

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Sameh M. Zamzam ◽  
Mosaad Abdel-Aziz ◽  
Ahmed Atef ◽  
Usama Abdel-Naseer ◽  
Mostafa Hamoda ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Study Groups ◽  
Controlled Trials ◽  
Main Body ◽  
Main Research ◽  
Randomized Controlled ◽  
New Treatment ◽  
Meta Analyses ◽  
Based Medicine

Abstract Background Randomized controlled trials (RCTs) are prospective comparative studies in which study groups are allocated randomly to intervention or serve as controls. RCT is the mainstay to achieve evidence in the literature in clinical research. A RCT is the main research design to study the effect of an intervention and the only way to confirm the value of a new treatment. Main body RCT also gives the way to generate meta-analyses and systematic reviews giving a stronger evidence for clinical practice. Evidence-based medicine (EBM) is crucial for safe, effective, and standardized patient care. Although there is an agreement on the importance of performing RCT, it can be challenging to do it efficiently including different aspects like study design, funding, randomization, blinding, follow-up, data analysis, statistics, generalization of results, and reporting of quality of the studies. Conclusion In this article, we gave a comprehensive review for RCT in otolaryngology discussing their importance, advantages, and drawbacks, types, steps, challenges, reporting their quality and their prevalence in the literature.

scholarly journals Publication by association: how the COVID-19 pandemic has shown relationships between authors and editorial board members in the field of infectious diseases

2021 ◽  
pp. bmjebm-2021-111670
Author(s):  
Clara Locher ◽  
David Moher ◽  
Ioana Alina Cristea ◽  
Florian Naudet
Keyword(s):  
Infectious Diseases ◽  
Evidence Based Medicine ◽  
Medical Community ◽  
Board Members ◽  
Evidence Based ◽  
Ripple Effect ◽  
New Type ◽  
Based Medicine

During the COVID-19 pandemic, the rush to scientific and political judgements on the merits of hydroxychloroquine was fuelled by dubious papers which may have been published because the authors were not independent from the practices of the journals in which they appeared. This example leads us to consider a new type of illegitimate publishing entity, ‘self-promotion journals’ which could be deployed to serve the instrumentalisation of productivity-based metrics, with a ripple effect on decisions about promotion, tenure and grant funding, but also on the quality of manuscripts that are disseminated to the medical community and form the foundation of evidence-based medicine.

Nursing Unit Design and Communication Patterns: What is “Real” Work?

2007 ◽  
Vol 1 (1) ◽  
pp. 58-62 ◽  
Author(s):  
Franklin Becker
Keyword(s):  
Quality Of Care ◽  
Design Research ◽  
Relevant Literature ◽  
Communication Patterns ◽  
Infection Rates ◽  
Nursing Unit ◽  
Hospital Design ◽  
Unit Design ◽  
Nurse Fatigue

While considerable attention has been paid to how the design of nursing units can help reduce nurse fatigue, improve safety, and reduce nosocomial infection rates, much less attention has been paid to how nursing unit design influences informal communication patterns, on-the-job learning, and job stress and satisfaction. Yet the literature consistently cites communication among diverse caregivers as a critical component for improving quality of care. This paper reviews relevant literature related to nursing unit design and communication patterns, and suggests an evidence-based design research agenda grounded in the concept of “organizational ecology” for increasing our understanding of how hospital design can contribute to improved quality of care.

scholarly journals Evidence based medicine? Access to information & medicines regulation in New Zealand

2021 ◽  
Author(s):  
◽  
Amy Hill
Keyword(s):  
New Zealand ◽  
Regulatory Regime ◽  
Pharmaceutical Companies ◽  
Evidence Based ◽  
Access To Information ◽  
The Public ◽  
The World ◽  
Medicines Regulation ◽  
Based Medicine

<p>This paper explores one very important issue in the regulatory regime for medicines in New Zealand and around the world- the deficit of information about medicines available to doctors, patients and independent researchers. Much of the information about safety, efficacy and quality of drugs is held and controlled by pharmaceutical companies and regulators. The public is entitled to this information in full.</p>

scholarly journals Movable Possessions: alternative housing through adaptable design

2021 ◽  
Author(s):  
Lisa Marshall
Keyword(s):  
Affordable Housing ◽  
Low Income ◽  
Design Research ◽  
Vernacular Architecture ◽  
Design Principles ◽  
Short Term ◽  
Adaptable Design ◽  
Alternative Housing ◽  
The World

Poor communities around the world have developed architecture without architects. Subsidized low-income housing has been built as if to provide only a shortterm solution. Poverty and lack of affordable housing is not a short-term problem but an ongoing issue that demands creative adaptable solutions for a changing world. Adaptable architecture is essential for the redesign of affordable housing that is environmentally, economically, and socially sustainable. In order to mend the broken bond between lower-incomes and the architectural quality of space, this design research strives to both defend and produce affordable architectural alternatives to housing through the use of adaptable design principles and strategies found within Barbados’ Vernacular Architecture, the Chattel house.

scholarly journals Design for Disassembly and the rehabilitation of public housing stock. A case study

2021 ◽  
pp. 181-191
Author(s):  
Lidia Errante ◽  
Alberto De Capua
Keyword(s):  
Public Housing ◽  
Design Research ◽  
Housing Stock ◽  
Design For Disassembly ◽  
Sustainable Building ◽  
The Public ◽  
Principles Of Design ◽  
The One

This contribution presents the meta-design research scenario of the sustainable building redevelopment of the INA Casa “Sbarre Inferiori” district in Reggio Calabria based on a twofold reflection. On the one hand, the transformative potential, both technological and formal, of the public housing stock created under the INA Casa Plan. On the other, the extension of the life cycle of the buildings and the improvement of the spatial quality of the housing according to a circular, low-tech and ecological approach. The result is an abacus of technological additions in bio-xlam conceived according to the principles of Design for Disassembly, which allows the reuse of the modules in new spatial and functional configurations, and the remanufacturing and recycling of the elements at the end of their life.

scholarly journals Review of Occupational Medicine Practice Guidelines for Interventional Pain Management and Potential Implications

2008 ◽  
Vol 3;11 (5;3) ◽  
pp. 271-289
Author(s):  
Laxmaiah Manchikanti
Keyword(s):  
Pain Management ◽  
Workers Compensation ◽  
Nerve Blocks ◽  
Steroid Injections ◽  
Epidural Steroid Injections ◽  
Interventional Pain Management ◽  
Epidural Steroid ◽  
The Cost ◽  
Based Medicine

In the modern day environment, workers’ compensation costs continue to be a challenge, with a need to balance costs, benefits, and quality of medical care. The cost of workers’ compensation care affects all stakeholders including workers, employers, providers, regulators, legislators, and insurers. Consequently, a continued commitment to quality, accessibility to care, and cost containment will help ensure that workers are afforded accessible, high quality, and cost-effective care. In 2004, workers’ compensation programs in all 50 states, the District of Columbia, and federal programs in the United States combined received an income of $87.4 billion while paying out only $56 billion in medical and cash benefits with $31.4 billion or 37% in administrative expenses and profit. Occupational diseases represented only 8% of the workers’ compensation claims and 29% of the cost. The American College of Occupational and Environmental Medicine (ACOEM) has published several guidelines; though widely adopted by WCPs, these guidelines evaluate the practice of medicine of multiple specialties without adequate expertise and expert input from the concerned specialties, including interventional pain management. An assessment of the ACOEM guidelines utilizing Appraisal of Guidelines for Research and Evaluation (AGREE) criteria, the criteria developed by the American Medical Association (AMA), the Institute of Medicine (IOM), and other significantly accepted criteria, consistently showed very low scores (< 30%) in most aspects of the these guidelines. The ACOEM recommendations do not appear to have been based on a careful review of the literature, overall quality of evidence, standard of care, or expert consensus. Based on the evaluation utilizing appropriate and current evidence-based medicine (EBM) principles, the evidence ratings for diagnostic techniques of lumbar discography; cervical, thoracic, and lumbar facet joint nerve blocks and sacroiliac joint nerve blocks; therapeutic cervical and lumbar medial branch blocks and radiofrequency neurolysis; cervical interlaminar epidural steroid injections, caudal epidural steroid injections, and lumbar transforaminal epidural injections; caudal percutaneous adhesiolysis; abd spinal cord stimulation were found to be moderate with strong recommendation applying for most patients in most circumstances. The evidence ratings for intradiscal electrothermal therapy (IDET), an automated percutaneous disc decompression and also deserve further scrutiny and analysis. In conclusion, these ACOEM guidelines for interventional pain management have no applicability in modern patient care due to lack of expertise by the developing organization (ACOEM), lack of utilization of appropriate and current EBM principles, and lack of significant involvement of experts in these techniques resulting in a lack of clinical relevance. Thus, they may result in reduced medical quality of care; may severely hinder access to appropriate, medically needed and essential medical care; and finally, they may increase costs for injured workers, third party payors, and the government by transferring the injured worker into a non-productive disability system. Key words: Guidelines, ACOEM, ASIPP, interventional pain management, interventional techniques, evidence-based medicine, systematic reviews, guideline development, AHCPR, AHRQ, IOM, AMA, AGREE, workers’ compensation, chronic pain guidelines, low back pain guidelines

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