Lipid-lowering and anti-atherosclerotic activity of the natural original enzyme preparation in the experiment
2019 ◽
Vol 17
(3)
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pp. 79-84
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The experimental large-scale investigation in vitro and in vivo is devoted to the results of a long-term study of the biological, lipid-lowering and anti-atherosclerotic activity of the original natural microbial enzyme preparation of cholesterol oxidase (CHO). In chronic experiments (rats, rabbits, dogs), low toxicity, good tolerability, and anti-atherosclerotic activity of the CHO preparation were established. To assess the effect of CHO in conditions of moderate nutritional dyslipoproteinemia, experiments were carried out in 3 species of animals (rats, guinea pigs, rabbits). It was shown the pronounced lipid-lowering effect of CHO in modeling dyslipoproteinemia.
1969 ◽
Vol 22
(03)
◽
pp. 577-583
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