scholarly journals Managing for the Long-term – Strategies for Initiating and Maintaining Successful Continuous Dopaminergic Stimulation Treatment

2012 ◽  
Vol 7 ((Suppl.1)) ◽  
pp. 31
Author(s):  
Tove Henriksen ◽  
Per Odin ◽  
Jens Volkmann ◽  
Angelo Antonini ◽  
◽  
...  
Keyword(s):  
Decision Making Process ◽  
Inclusion Criteria ◽  
Continuous Dopaminergic Stimulation ◽  
Choice Of Treatment ◽  
Short And Long Term ◽  
Selection Algorithms ◽  
More Trial ◽  
Dopaminergic Stimulation ◽  
Management Algorithms

There are many factors that may influence treatment choice in patients with Parkinson’s disease. While ‘inclusion’ criteria include the clinical need for short- and long-term improvement, there are some well defined contraindications to continuous dopaminergic stimulation (CDS) therapies, such as age, cognitive impairment, psychosis or severe orthostatic hypotension. These contraindications vary between CDS therapies and can help guide the choice of treatment. Patient preferences and the practicalities of the treatment modality also play an important part in the decision-making process. Treatment selection algorithms have been developed and presented, but they require refining and need to be expanded to include guidance on management decisions – for example, when initial CDS therapy fails. While more trial data are gathered and as management algorithms evolve, case studies continue to provide important information on practical aspects of CDS therapies.

Goal Setting in Sport and Exercise: A Research Synthesis to Resolve the Controversy

1995 ◽  
Vol 17 (2) ◽  
pp. 117-137 ◽  
Author(s):  
L. Blaine Kyllo ◽  
Daniel M. Landers
Keyword(s):  
Goal Setting ◽  
Statistical Power ◽  
Inclusion Criteria ◽  
Industrial Psychology ◽  
Analytic Review ◽  
Short And Long Term ◽  
Improved Performance ◽  
Sport And Exercise ◽  
The Many

Although the motivational technique of goal setting has consistently and reliably improved performance in industrial psychology research, this beneficial effect has not been clearly demonstrated in the sport domain. The many proposed explanations for this discrepancy have resulted in a controversy in the literature. However, scientists have overlooked the importance of statistical power. A meta-analytic review of the literature investigating the effects of goal setting on performance in sport and exercise could help to clarify the state of knowledge. The meta-analytic procedures described by Hedges and Olkin (1985) were used to statistically combine 36 studies identified as meeting inclusion criteria. Results indicate that, overall, setting goals improves sport by 0.34 of a standard deviation. Moderate, absolute, and combined short- and long-term goals were associated with the greatest effects. Additional moderator variables were identified, and the extent to which they alter the goal setting–performance relationship is discussed.

scholarly journals Long-term Complications of COVID-19

2021 ◽  
Author(s):  
Amar D. Desai ◽  
Michael Lavelle ◽  
Brian C. Boursiquot ◽  
Elaine Wan
Keyword(s):  
Current Literature ◽  
Review Article ◽  
Organ System ◽  
Future Directions ◽  
Short And Long Term ◽  
Potential Impact ◽  
Management Algorithms

SARS-CoV-2 has rapidly spread across the globe and infected hundreds of millions of people worldwide. As our experience with this virus continues to grow, our understanding of the both short and long-term complications of infection with SARS-CoV-2 continues to grow as well. Just as there is heterogeneity in the acute infectious phase, there is heterogeneity in the long-term complications seen following COVID-19 illness. The purpose of this review article is to present the current literature with regards to the epidemiology, pathophysiology and proposed management algorithms for the various long term sequalae that have been observed in each organ system following infection with SARS-CoV-2. We will also consider future directions, with regards to newer variants of the virus and their potential impact on the long-term complications observed.

Long-term Efficacy and Safety with Continuous Dopaminergic Stimulation Pump Treatments in Parkinson’s Disease

2011 ◽  
Vol 6 (3) ◽  
pp. 156 ◽  
Author(s):  
Kar in Busk ◽  
Anders Johansson ◽  
Dag Nyholm ◽  
◽  
◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Symptom Control ◽  
Cobalamin Deficiency ◽  
Dopamine Receptor Agonist ◽  
Dopaminergic Drugs ◽  
Intestinal Tube ◽  
Continuous Dopaminergic Stimulation ◽  
Dopaminergic Stimulation

Continuous dopaminergic stimulation (CDS) is important for symptom control in advanced stages of Parkinson’s disease (PD). The most efficacious approaches are pump treatments with dopaminergic drugs: subcutaneous infusion of the dopamine receptor agonist apomorphine and intestinal infusion of levodopa/carbidopa gel. Both methods decrease motor fluctuations in long-term follow-ups, including parkinsonian and dyskinetic states, when compared to conventional optimised oral therapy. Also non-motor symptoms may be improved. Adverse drug reactions are usually less pronounced although high levodopa doses, which are common with levodopa/carbidopa infusion, may cause hyperhomocysteinaemia and cobalamin deficiency. Technical complications are specific for each infusion strategy. Formation of subcutaneous nodules is the most common problem with apomorphine infusion. Dislocation of the intestinal tube is the most common problem with levodopa/carbidopa infusion. Both pump treatments may be used for 24-hour infusion in selected patients. The long-term experience is reviewed. To conclude, CDS pump treatments may be successfully used for several years in advanced PD.

Update on Levodopa/Carbidopa Intestinal Gel Infusion

2012 ◽  
Vol 7 ((Suppl.1)) ◽  
pp. 13
Author(s):  
Dag Nyholm ◽  
Keyword(s):  
Pump System ◽  
Methyl Transferase ◽  
Continuous Dopaminergic Stimulation ◽  
Number Of Publications ◽  
Off Time ◽  
Dopaminergic Stimulation

Recent data on levodopa/carbidopa intestinal gel (LCIG) infusion are discussed in this article. LCIG infusion provides improvements in ‘off’ time and dyskinesia via continuous dopaminergic stimulation (CDS). In the long-term, LCIG infusion appears to maintain efficacy without the need to increase dosages. The growing number of publications on LCIG infusion shows the increasing experience and interest in this therapy. The new data demonstrate the effects of using LCIG infusion in combination with catechol-O-methyl transferase inhibitors, and technical improvements to the pump system (e.g., to the tubing). Despite the invasive nature of LCIG infusion, nearly all patients would recommend this treatment. Furthermore, a number of larger-scale studies on this particular CDS therapy are in progress.

scholarly journals Optimizing First-Line Therapy for Advanced-Stage Classic Hodgkin Lymphoma

2021 ◽  
Vol 19 (11.5) ◽  
pp. 1335-1338
Author(s):  
Ranjana H. Advani
Keyword(s):  
Hodgkin Lymphoma ◽  
First Line ◽  
Interim Pet ◽  
First Line Therapy ◽  
Line Therapy ◽  
Classic Hodgkin Lymphoma ◽  
Choice Of Treatment ◽  
Short And Long Term ◽  
The Individual

Goals of first-line therapy in classic Hodgkin lymphoma (cHL) should focus on balancing risk versus benefit to the individual while increasing efficacy and decreasing toxicity. Overall, the ABVD regimen is well tolerated but slightly less effective, with a better safety profile compared with escalated BEACOPP. BV-AVD is somewhere in between ABVD and escalated BEACOPP on the cure/morbidity scale. Interim PET is predictive, but new prognostic biomarkers are emerging that may better identify patients at high risk for treatment failure. In patients with interim PET-negative cHL, de-escalating therapy does not impact overall survival along 1) with no proven role for radiotherapy. cHL is largely a disease of young people, and the choice of treatment should always take into account the potential for both short- and long-term toxicity with the goal of optimizing survivorship.

scholarly journals Short- and Long-Term, 11–22 Years, Results after Laparoscopic Nissen Fundoplication in Obese versus Nonobese Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Mario Schietroma ◽  
Federica Piccione ◽  
Marco Clementi ◽  
Emanuela Marina Cecilia ◽  
Federico Sista ◽  
...  
Keyword(s):  
Nissen Fundoplication ◽  
Normal Weight ◽  
Laparoscopic Nissen Fundoplication ◽  
Long Term Results ◽  
Obese Patients ◽  
Inclusion Criteria ◽  
Short And Long Term ◽  
Laparoscopic Nissen ◽  
Nonobese Patients

Background. Some studies suggest that obesity is associated with a poor outcome after Laparoscopic Nissen Fundoplication (LNF), whereas others have not replicated these findings. The effect of body mass index (BMI) on the short- and long-term results of LNF is investigated.Methods. Inclusion criteria were only patients who undergone a LNF with at least 11-year follow-up data available, patients with preoperative weight and height data available for calculation of BMI (Kg/m2), and patients with a BMI up to a maximum of 34.9.Results. 201 patients met the inclusion criteria: 43 (21.4%) had a normal BMI, 89 (44.2%) were overweight, and 69 (34.4%) were obese. The operation was significantly longer in obese patients; the use of drains and graft was less in the normal BMI group (p<0.0001). The hospital stay, conversion (6,4%), and intraoperative and early postoperative complications were not influenced by BMI.Conclusions. BMI does not influence short-term outcomes following LNF, but long-term control of reflux in obese patients is worse than in normal weight subjects.

scholarly journals Prevalence of long-term effects in individuals diagnosed with COVID-19: a living systematic review

2021 ◽  
Author(s):  
Francesca Reyes Domingo ◽  
Lisa A Waddell ◽  
Angela M Cheung ◽  
Curtis L Cooper ◽  
Veronica J Belcourt ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sleep Disturbances ◽  
Inclusion Criteria ◽  
Long Term Effects ◽  
Short Term ◽  
Prevalence Data ◽  
Point Estimates ◽  
Short And Long Term ◽  
New Research

Background: Patients have described symptoms persisting or recurring for weeks after acute COVID-19 illness referred to as post COVID-19 conditions. The objective of this living systematic review is to document the prevalence of post COVID-19 conditions 4-12 weeks (short-term) and >12 weeks (long-term) after COVID-19 diagnosis. Methods: We conducted a systematic review of primary peer-reviewed published literature reporting on the prevalence of the symptoms, sequelae and difficulties conducting usual activities ≥4 weeks after COVID-19 diagnosis. We adapted a previous search strategy used by the U.K. National Institute for Health and Care Excellence and updated it to search for new research published until January 15, 2021 in Embase, Medline, PsychInfo, and Cochrane Central. Two independent reviewers screened references; one reviewer extracted data and assessed risk of bias and certainty in the evidence while another verified them. Prevalence data from laboratory-confirmed individuals were meta-analyzed, where appropriate, using a random effects model and synthesized separately in the short- and long-term periods after COVID-19 diagnosis; data from clinically-diagnosed populations were synthesized narratively. Results: Of the 2807 unique citations, 36 observational studies met our inclusion criteria. Over 100 post COVID-19 conditions were reported in laboratory-confirmed individuals. Eighty-three percent (95%CI: 65-93%; low certainty) and 56% (95%CI: 34-75%; very low certainty) reported persistence or presence of one or more symptoms in the short- and long-term, respectively. The most prevalent symptoms in both periods included: fatigue, general pain or discomfort, sleep disturbances, shortness of breath and anxiety or depression (point estimates ranging from 22-51%; low to very low certainty). Interpretation: Our data indicate that a substantial proportion of individuals reported a variety of symptoms ≥4 weeks after COVID-19 diagnosis. Due to low certainty in the evidence, further research is needed to determine the true burden of post COVID-19 conditions.

Short- and Long-Term Results of Total vs Subtotal Thyroid- ectomies in the Surgical Treatment of Graves' Disease

Swiss Surgery ◽  
2001 ◽  
Vol 7 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Robert ◽  
Mariéthoz ◽  
Pache ◽  
Bertin ◽  
Caulfield ◽  
...  
Keyword(s):  
Recurrent Laryngeal Nerve ◽  
Nerve Palsy ◽  
Recurrent Laryngeal Nerve Palsy ◽  
Laryngeal Nerve ◽  
Long Term Results ◽  
Graves Disease ◽  
Laryngeal Nerve Palsy ◽  
Short And Long Term

Objective: Approximately one out of five patients with Graves' disease (GD) undergoes a thyroidectomy after a mean period of 18 months of medical treatment. This retrospective and non-randomized study from a teaching hospital compares short- and long-term results of total (TT) and subtotal thyroidectomies (ST) for this disease. Methods: From 1987 to 1997, 94 patients were operated for GD. Thirty-three patients underwent a TT (mostly since 1993) and 61 a ST (keeping 4 to 8 grams of thyroid tissue - mean 6 g). All patients had received propylthiouracil and/or neo-mercazole and were in a euthyroid state at the time of surgery; they also took potassium iodide (lugol) for ten days before surgery. Results: There were no deaths. Transient hypocalcemia (< 3 months) occurred in 32 patients (15 TT and 17 ST) and persistent hypocalcemia in 8 having had TT. Two patients developed transient recurrent laryngeal nerve palsy after ST (< 3 months). After a median follow-up period of seven years (1-15) with five patients lost to follow-up, 41 patients having had a ST are in a hypothyroid state (73%), thirteen are euthyroid (23%), and two suffered recurrent hyperthyroidism, requiring completion of thyroidectomy. All 33 patients having had TT - with follow-ups averaging two years (0.5-8) - are receiving thyroxin substitution. Conclusions: There were no instances of persistent recurrent laryngeal nerve palsy in either group, but persistent hypoparathyroidism occurred more frequently after TT. Long after ST, hypothyroidism developed in nearly three of four cases, whereas euthyroidy was maintained in only one-fourth; recurrent hyperthyroidy was rare.

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