Personalized medicine in non-communicable diseases: latest advances and future prospects

Kardiologiia ◽  
2021 ◽  
Vol 61 (11) ◽  
pp. 98-103
Author(s):  
O. M. Drapkina ◽  
A. A. Ivanova
Keyword(s):  
Risk Assessment ◽  
Clinical Practice ◽  
Personalized Medicine ◽  
Human Genome ◽  
Communicable Diseases ◽  
Future Prospects ◽  
Significant Progress ◽  
Non Communicable Diseases ◽  
New Methods ◽  
Genomic Technologies

Since the human genome was decoded more than 15 years ago, there has been a huge leap forward in the development of genomic and post-genomic technologies. Personalized medicine is engaged in implementing these technologies in clinical practice by developing new methods for risk assessment, diagnosis, and treatment of diseases taking into account individual features of the patient. Significant progress has been achieved in decoding genetic bases of chronic noninfectious diseases; new markers for the risk of complications and targets for effects of drugs are being searched for. This review highlights promising directions in the development of personalized medicine, the problems facing modern scientists, and possible ways to solve them

scholarly journals Presymptomatic Risk Assessment for Chronic Non-Communicable Diseases

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e14338 ◽  
Author(s):  
Badri Padhukasahasram ◽  
Eran Halperin ◽  
Jennifer Wessel ◽  
Daryl J. Thomas ◽  
Elana Silver ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Communicable Diseases ◽  
Non Communicable Diseases

scholarly journals Personalized Medicine in the Era of Genomics

2017 ◽  
pp. 297-327
Author(s):  
Navneet Kaur Soni ◽  
Nitin Thukral ◽  
Yasha Hasija
Keyword(s):  
Clinical Practice ◽  
Personalized Medicine ◽  
Environmental Factors ◽  
Human Genome ◽  
High Throughput ◽  
Genome Analysis ◽  
Human Genome Project ◽  
Clinical Information ◽  
Genome Project ◽  
Genetic Makeup

Personalized medicine is a model that aims at customizing healthcare and tailoring medicine according to an individual`s genetic makeup. It classifies individuals that differ in their susceptibility to a particular disease or response to a particular treatment into subpopulations based on individual's unique genetic and clinical information along with environmental factors. The completion of Human Genome Project and the advent of high-throughput genome analysis tools has helped in building and strengthening this model. There lies a huge potential in the implementation of personalized medicine to significantly improve the clinical outcomes; however, its implementation into clinical practice remains slow and is a matter of concern. This chapter aims at acquainting readers with the underlying concepts and components of personalized medicine supplemented with some disease-based case studies, discussing challenges and recent advancements in the implementation of the model of personalized medicine.

scholarly journals A strategic tool to improve long-term health outcomes in clinical practice: SHOR driver and association diagram

2019 ◽  
Vol 32 (1) ◽  
pp. 20-27
Author(s):  
Helena Ogink ◽  
Anna-Karin Ringqvist ◽  
Liselotte Bergqvist ◽  
Tobias Nordin ◽  
Anita Nordenson ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Health Outcomes ◽  
Communicable Diseases ◽  
Lessons Learned ◽  
University Hospital ◽  
Initial Assessment ◽  
Specific Patient ◽  
Non Communicable Diseases ◽  
Available Resources

Abstract Quality problem or issue An over-arching principle of healthcare governance in Sweden is to achieve as much health for as many patients as possible given the available resources. With high life expectancy and increased years lived with non-communicable diseases, more effective interventions in prevention and control of non-communicable diseases are needed in order to ensure high-quality healthcare. Initial assessment Few publications have described a generic and resource-effective method of implementing the perspective of health outcomes in relation to costs in a clinical Swedish university hospital context. To fill this gap, a generic method was developed at Sahlgrenska University hospital in Gothenburg, Sweden. Choice of solution A System-based driver and association diagram of Health Outcomes in relation to available Resources (SHOR) was developed. The SHOR driver and association diagram comprised different perspectives: health, patient, process, research and cost perspectives. It enabled the translation from long-term health outcomes to applications in clinical practice. Implementation Three patient groups exemplify the use and implementation of the method of SHOR association and driver diagram; bipolar disorder (psychiatry), primiparous women with spontaneous onset of labour, (obstetric care) and chronic obstructive pulmonary disease (somatic care). Evaluation The SHOR driver and association diagram enabled a structure to monitor and support quality development towards maximised health outcomes in relation to available resources and associated total costs for a specific patient group. Lessons learned This method has connected clinical practice, management and research and has been used for both strategic and operational purposes.

Personalized Medicine in the Era of Genomics

2016 ◽  
pp. 296-327 ◽  
Author(s):  
Navneet Kaur Soni ◽  
Nitin Thukral ◽  
Yasha Hasija
Keyword(s):  
Clinical Practice ◽  
Personalized Medicine ◽  
Environmental Factors ◽  
Human Genome ◽  
High Throughput ◽  
Genome Analysis ◽  
Human Genome Project ◽  
Clinical Information ◽  
Genome Project ◽  
Genetic Makeup

Personalized medicine is a model that aims at customizing healthcare and tailoring medicine according to an individual`s genetic makeup. It classifies individuals that differ in their susceptibility to a particular disease or response to a particular treatment into subpopulations based on individual's unique genetic and clinical information along with environmental factors. The completion of Human Genome Project and the advent of high-throughput genome analysis tools has helped in building and strengthening this model. There lies a huge potential in the implementation of personalized medicine to significantly improve the clinical outcomes; however, its implementation into clinical practice remains slow and is a matter of concern. This chapter aims at acquainting readers with the underlying concepts and components of personalized medicine supplemented with some disease-based case studies, discussing challenges and recent advancements in the implementation of the model of personalized medicine.

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