scholarly journals Trace mineral chelation for sustainable animal nutrition : enhancing zinc availability with L-glutamic acid N,N-diacetic acid

2021 ◽  
Author(s):  
Gavin M. Boerboom
Keyword(s):  
Glutamic Acid ◽  
Animal Nutrition ◽  
Diacetic Acid ◽  
Trace Mineral ◽  
Zinc Availability

scholarly journals Efficacy of l-glutamic acid, N,N-diacetic acid to improve the dietary trace mineral bioavailability in broilers

2020 ◽  
Vol 98 (12) ◽  
Author(s):  
Gavin M Boerboom ◽  
Ronald Busink ◽  
Coen H Smits ◽  
Wouter H Hendriks ◽  
Javier Martín-Tereso
Keyword(s):  
Glutamic Acid ◽  
Serum Zinc ◽  
Basal Diet ◽  
Trace Minerals ◽  
Fecal Excretion ◽  
Diacetic Acid ◽  
Trace Mineral ◽  
Suitable Alternative ◽  
Supplemental Zinc ◽  
Zinc Levels

Abstract Trace minerals are commonly supplemented in the diets of farmed animals in levels exceeding biological requirements, resulting in extensive fecal excretion and environmental losses. Chelation of trace metal supplements with ethylenediaminetetraacetic acid (EDTA) can mitigate the effects of dietary antagonists by preserving the solubility of trace minerals. Lack of EDTA biodegradability, however, is of environmental concern. l-Glutamic acid, N,N-diacetic acid (GLDA) is a readily biodegradable chelating agent that could be used as a suitable alternative to EDTA. The latter was tested in sequential dose–response experiments in broiler chickens. Study 1 compared the effect of EDTA and GLDA in broilers on supplemental zinc availability at three levels of added zinc (5, 10, and 20 ppm) fed alone or in combination with molar amounts of GLDA or EDTA equivalent to chelate the added zinc, including negative (no supplemental zinc) and positive (80 ppm added zinc) control treatments. Study 2 quantified the effect of GLDA on the availability of native trace mineral feed content in a basal diet containing no supplemental minerals and supplemented with three levels of GLDA (54, 108, and 216 ppm). In study 1, serum and tibia Zn clearly responded to the increasing doses of dietary zinc with a significant response to the presence of EDTA and GLDA (P < 0.05). These results are also indicative of the equivalent nutritional properties between GLDA and EDTA. In study 2, zinc levels in serum and tibia were also increased with the addition of GLDA to a basal diet lacking supplemental trace minerals, where serum zinc levels were 60% higher at the 216 ppm inclusion level. Similar to the reported effects of EDTA, these studies demonstrate that dietary GLDA may have enhanced zinc solubility in the gastrointestinal tract and subsequently enhanced availability for absorption, resulting in improved nutritional zinc status in zinc-deficient diets. As such, GLDA can be an effective nutritional tool to reduce supplemental zinc levels in broiler diets, thereby maintaining health and performance while reducing the environmental footprint of food-producing animals.

Newly Recognized Trace Mineral Elements and Their Role in Animal Nutrition

BioScience ◽  
1977 ◽  
Vol 27 (10) ◽  
pp. 674-679 ◽  
Author(s):  
W. J. Miller ◽  
M. W. Neathery
Keyword(s):  
Mineral Elements ◽  
Animal Nutrition ◽  
Trace Mineral

scholarly journals Effect of L-glutamic acid N,N-diacetic acid on the availability of dietary zinc in broiler chickens

2020 ◽  
Author(s):  
Gavin Boerboom ◽  
Ronald Busink ◽  
Coen Smits ◽  
Jan van Harn ◽  
Paul Bikker
Keyword(s):  
Glutamic Acid ◽  
Broiler Chickens ◽  
Diacetic Acid ◽  
Dietary Zinc

Effects of L-glutamic acid, N, N-diacetic acid as chelating agent on acidification of carbonate reservoirs in acidic environments

2020 ◽  
Vol 82 ◽  
pp. 103494 ◽  
Author(s):  
Yanping Shi ◽  
Lang Yu ◽  
Shuya Chen ◽  
Yichao He ◽  
Xianyu Yang ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Chelating Agent ◽  
Carbonate Reservoirs ◽  
Diacetic Acid ◽  
Acidic Environments

scholarly journals Safety and efficacy of Kelforce® (l‐glutamic acid, N,N‐diacetic acid, tetrasodium salt (GLDA‐Na4)) as a feed additive for chickens for fattening

EFSA Journal ◽  
2018 ◽  
Vol 16 (5) ◽  
Author(s):  
◽  
Guido Rychen ◽  
Gabriele Aquilina ◽  
Giovanna Azimonti ◽  
Vasileios Bampidis ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Feed Additive ◽  
Diacetic Acid ◽  
Safety And Efficacy

Dietary l-glutamic acid N,N-diacetic acid improves short-term maintenance of zinc homoeostasis in a model of subclinical zinc deficiency in weaned piglets

2022 ◽  
pp. 1-10
Author(s):  
Gavin Boerboom ◽  
Elena Ganslmaier ◽  
Josef Oeckl ◽  
Ronald Busink ◽  
Javier Martín-Tereso ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Experimental Period ◽  
Time Frame ◽  
Linear Increase ◽  
Zn Deficiency ◽  
Diacetic Acid ◽  
Weaned Piglets ◽  
Negative Effects ◽  
Short Term ◽  
Zn Status

Abstract This study compared the Zn response in selected tissues of weaned piglets fed L-glutamic acid, N,N-diacetic acid (GLDA), while challenged with short-term subclinical Zn deficiency (SZD). During a total experimental period of eight days, 96 piglets were fed restrictively (450 g/d) a high phytate (9 g/kg) diet containing added Zn at 0, 5, 10, 15, 20, 25, 45 and 75 mg/kg with and without 200 mg/kg of GLDA. No animals showed signs of clinical Zn deficiency and no phenotypical differences were observed. Broken line analysis of Zn status parameters such as liver Zn and apparently absorbed Zn indicated that the gross Zn requirement threshold was around 55 mg/kg diet. Supplementation of Zn above this threshold led to a saturation of the response in apparently absorbed Zn and linear increase in liver Zn. Bone and serum Zn responded to the dose in a linear fashion, likely due to the time-frame of Zn homoeostatic adaptation. Inclusion of GLDA into the diets yielded a higher intercept for bone Zn (P < 0·05). Liver Zn accumulation and MT1A gene expression was higher for piglets receiving GLDA (P < 0·05), indicating higher Zn influx. This study indicates that a strong chelator such as GLDA mitigates negative effects of phytate in plant-based diets, by sustaining Zn solubility, thereby improving nutritional Zn availability.

scholarly journals Tolerance and safety evaluation of L-glutamic acid, N,N-diacetic acid as a feed additive in broiler diets

2021 ◽  
pp. 101623
Author(s):  
Gavin Boerboom ◽  
Javier Martín-Tereso ◽  
Teun Veldkamp ◽  
Jan van Harn ◽  
Paul Bikker ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Safety Evaluation ◽  
Feed Additive ◽  
Diacetic Acid

scholarly journals Safety of the feed additive consisting of manganese chelates of lysine and glutamic acid for all animal species (Zinpro Animal Nutrition)

EFSA Journal ◽  
2021 ◽  
Vol 19 (3) ◽  
Author(s):  
◽  
Vasileios Bampidis ◽  
Giovanna Azimonti ◽  
Maria de Lourdes Bastos ◽  
Henrik Christensen ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Animal Species ◽  
Feed Additive ◽  
Animal Nutrition

Toxic Effects of Electrolyte and Trace Mineral Administration in the Intensive Care Unit

1991 ◽  
Vol 7 (3) ◽  
pp. 659-693 ◽  
Author(s):  
James B. Besunder ◽  
Paul G. Smith
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Toxic Effects ◽  
Trace Mineral
Sign in / Sign up

Export Citation Format

Share Document