scholarly journals Acute Stroke Research: Being Part of a Game-Changer with Dr. Dar Dowlatshahi, Scientific Director of the Ottawa Stroke Program

2015 ◽  
Vol 5 (2) ◽  
pp. 8-11
Author(s):  
Faizan Khan ◽  
Marc-Olivier Deguise

ABSTRACT:Dr. Dar Dowlatshahi, MD/PhD, is a stroke neurologist, an assistant professor at the University of Ottawa, and a neuroscientist at the Ottawa Hospital Research Institute (OHRI). As the Scientific Director of the Ottawa Stroke Program, he is conducting cutting-edge research in the area of acute stroke, with a special interest in intracerebral hemorrhage (ICH). He was part of the recent ESCAPE trial, a national groundbreaking study that has redefined the scope of stroke therapy around the world. We had the incredible opportunity of speaking with Dr. Dowlatshahi about his exciting career as a clinician-scientist, as he educated us about the unique features of stroke, informed us of the recent advancements in his research, and provided advice for interested students and trainees who want to pursue a career in academic medicine.RÉSUMÉ: Dr. Dar Dowlatshahi, MD/PhD, est un neurologue spécialisé en AVC, professeur adjoint à l’Université d’Ottawa, et un neuroscientifique à l’Institut de recherche en santé d’Ottawa (IRSO). Comme directeur scientifique du Programme d’AVC à Ottawa, il mène des recherches de pointe dans le domaine de l’AVC aigu, avec un intérêt particulier dans l’hémorragie intracérébrale (HIC). Il a fait partie de l’essai récent « ESCAPE », une étude révolutionnaire nationale qui a redéfini le cadre de la thérapie de l’AVC autour du monde. Nous avons eu l’incroyable opportunité de parler avec le Dr. Dowlatshahi à propos de sa carrière passionnante comme clinicien-chercheur. Il nous informa ainsi sur les caractéristiques uniques de l’AVC, des récents progrès dans ses recherches, et nous a fourni des conseils pour les étudiants et stagiaires voulant poursuivre une carrière en médecine académique.

2019 ◽  
Vol 9 (1) ◽  
pp. 10-14
Author(s):  
Faizan Khan ◽  
Phillip Staibano ◽  
Mimi Deng ◽  
Linda Yi Ning Fei

Dr. Benjamin Hibbert, MD, PhD, FRCPC is an interventional cardiologist, an assistant professor, as well as the director of the Vascular Biology and Experimental Medicine Laboratory at the University of Ottawa Heart Institute (UOHI). With a focus on performing revolutionary bench-to-bedside  research, Dr. Hibbert’s clinical and basic science research interests include the development of novel cardiac biomarkers, elucidating the mechanisms that underlie pathological arterial remodelling in transplant vasculopathy, and the pharmacodynamics of adjuvant  antiplatelet and antithrombotic agents in cardiac disease. We had the privilege of speaking with Dr. Hibbert about his career path, research experiences, and perspectives on the importance of the clinician-investigator program in training the oncoming generation of clinician-scientists.


2021 ◽  
pp. 147821032199946
Author(s):  
Oskar Szwabowski ◽  
Dominika Gruntkowska

In this article, we use the zombies as a metaphor for reforms in the Polish academy and a description of how neoliberalism works. According to the interpretation of the production of zombies as a critique of late capitalism, we want to show, by using an autoethnographic method, how subjectivity, relationships with others and the world are changing in the neoliberal regime. How do reforms attempt to transform subjectivity, and raise a new academic? Our co-autoethnography challenges the University of the (Un)Dead. We write together to show the experience of an insider (Oskar) and a quasi-outsider (former PhD student, Dominika). We are trying to show how nationalist authoritarianism emerges, at the same time, as part of the neoliberal regime. Our story is a record from the time of the apocalypse – an attempt to provoke. Let us trust the stories.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
H. Handelsmann ◽  
L. Herzog ◽  
Z. Kulcsar ◽  
A. R. Luft ◽  
S. Wegener

AbstractDistinct patient characteristics have been proposed for ischaemic stroke in the anterior versus posterior circulation. However, data on functional outcome according to stroke territory in patients with acute stroke treatment are conflicting and information on outcome predictors is scarce. In this retrospective study, we analysed functional outcome in 517 patients with stroke and thrombolysis and/or thrombectomy treated at the University Hospital Zurich. We compared clinical factors and performed multivariate logistic regression analyses investigating the effect of outcome predictors according to stroke territory. Of the 517 patients included, 80 (15.5%) suffered a posterior circulation stroke (PCS). PCS patients were less often female (32.5% vs. 45.5%, p = 0.031), received thrombectomy less often (28.7% vs. 48.3%, p = 0.001), and had lower median admission NIHSS scores (5 vs. 10, p < 0.001) as well as a better median three months functional outcome (mRS 1 vs. 2, p = 0.010). Predictors for functional outcome were admission NIHSS (OR 0.864, 95% CI 0.790–0.944, p = 0.001) in PCS and age (OR 0.952, 95% CI 0.935–0.970, p < 0.001), known symptom onset (OR 1.869, 95% CI 1.111–3.144, p = 0.018) and admission NIHSS (OR 0.840, 95% CI 0.806–0.876, p < 0.001) in ACS. Acutely treated PCS and ACS patients differed in their baseline and treatment characteristics. We identified specific functional outcome predictors of thrombolysis and/or thrombectomy success for each stroke territory.


Neurology ◽  
2020 ◽  
Vol 94 (7) ◽  
pp. 306-310 ◽  
Author(s):  
Michael J. Young ◽  
Robert W. Regenhardt ◽  
Thabele M. Leslie-Mazwi ◽  
Michael Ashley Stein

Stroke is the second leading cause of death worldwide and a leading cause of adult disability worldwide. More than a third of individuals presenting with strokes are estimated to have a preexisting disability. Despite unprecedented advances in stroke research and clinical practice over the past decade, approaches to acute stroke care for persons with preexisting disability have received scant attention. Current standards of research and clinical practice are influenced by an underexplored range of biases that may hinder acute stroke care for persons with disability. These trends may exacerbate unequal health outcomes by rendering novel stroke therapies inaccessible to many persons with disabilities. Here, we explore the underpinnings and implications of biases involving persons with disability in stroke research and practice. Recent insights from bioethics, disability rights, and health law are explained and critically evaluated in the context of prevailing research and clinical practices. Allowing disability to drive decisions to withhold acute stroke interventions may perpetuate disparate health outcomes and undermine ethically resilient stroke care. Advocacy for inclusion of persons with disability in future stroke trials can improve equity in stroke care delivery.


2003 ◽  
Vol 30 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Charles T. Lockett

Charles Lockett is an Assistant Professor in the School of Psychology at James Madison University, where he teaches developmental psychology as well as advanced topic courses in cultural psychology and the psychology of race and racism. A graduate of Howard University, Lockett credits Howard's Preparing Future Faculty Fellowship Program for his grasp of classroom dynamics. Lockett's research focus is examining cultural and personal identity factors that lead to achievement among minority populations. Robert Serpell, Professor of Psychology, University of Maryland, Baltimore County, is currently a visiting professor at the University of Malawi where he conducts applied developmental psychology research. He was the Director of the Doctoral Studies Program in Applied Developmental Psychology (1989 to 2001). Born and raised in England, with a BA (Oxford, 1965), and a PhD (Sussex, 1969), he is a citizen of Zambia and worked at the University of Zambia (1965 to 1989) as Head, Psychology Department, and Director, Institute for African Studies. His theoretical and applied research in Africa, Britain, and the United States has centered on the sociocultural context of children's cognitive development.


PEDIATRICS ◽  
1952 ◽  
Vol 9 (6) ◽  
pp. 801-804
Author(s):  
EDWARD A. WISHROPP ◽  
EDGAR E. MARTMER

At the annual meeting of the State Chairmen of the American Academy of Pediatrics in 1952, Dr. Edward A. Wishropp made a brief report of the plan for giving comprehensive pediatric care in Windsor, Ontario. This had been studied by the Academy's Committee on Medical Care Plans. In order that the membership of the Academy might have more information about the work of this important committee, the editor of this column requested Dr. Wishropp and Dr. Edgar E. Martmer to prepare a communication on this subject. INSURANCE PLAN REPORT THERE are many programs throughout the United States, Canada and several foreign countries, providing some degree of medical services for infants and children. These range from governmentally financed programs, offering supposedly complete care, to those furnished by individual pediatricians having agreements between the pediatrist and the parents. Because no comprehensive review of these various plans has been made, the Executive Board of the American Academy of Pediatrics created a committee to study insurance plans and programs. The president, Dr. Warren Quillian, appointed a Committee on Medical Care Plans as a fact-finding group. Serving with Dr. Edward A. Wishropp, chairman, are:[See Table In Source PDF] Some basic considerations, presented by Dr. S. J. Axelrod, Assistant Professor of Public Health at the University of Michigan, can be outlined as follows and these must serve as a working nucleus in determining a worth while and workable plan.


Author(s):  
Matthew E Ehrlich ◽  
Heather L Turner ◽  
Lillian J Currie ◽  
Max Wintermark ◽  
Bradford B Worrall ◽  
...  

Objective: To evaluate the safety and utility of CTA acquisition during initial acute stroke evaluation. We hypothesized CTA would not increase risk of renal injury or delay therapy. Design/Methods: We performed a pilot study of CTA acquisition in the acute stroke evaluation at the University of Virginia Medical Center in the first three quarters of 2014. We extracted data from Acute Stroke Team Leader consultations with additional chart review. We collected door-to-CT read times, door-to-needle times, baseline creatinine (Cr) values on presentation, and Cr values 24-48 hours after stroke alert evaluation. Differences in means of these variables were compared between those receiving CTA versus non-contrasted head CT (NCHCT) only. Additionally, we captured CTA results immediately relevant to treatment decisions. Results: Of 289 patients, 157 had CTA completed while 132 had only NCHCT. In the CTA group, 18 patients (11.5%) were treated with IV tissue plasminogen activator (tPA) compared to 11 (8.3%) in the NCHCT group, with no significant difference between groups (p=0.377). There was no difference between mean door-to-CT-read times between the NCHCT (43.07 minutes) and CTA (41.46 minutes) groups (p=0.70). Likewise, there was no significant difference in mean door-to-needle times between the NCHCT (81.36 minutes) and CTA (68.11 minutes) groups (p=0.577). There was a difference between mean Cr values on presentation (1.39mg/dL NCHCT, 1.06mg/dL CTA; p=0.004), but there was no difference between the groups at 24-48 hours (p=0.059) and no difference between the mean change in Cr values (p=0.489). No patients developed a new requirement for hemodialysis. CTA imaging revealed 14 patients with vascular anomalies, and 53 patients with severe stenosis or occlusion of a major cervical or intracranial vessel. One patient in the CTA group and none in the NCHCT group had intravascular intervention. Conclusions: Overall, CTA during acute stroke evaluations were safe and may offer clinical utility, without delaying evaluation or therapy delivery. Additional cost of acute CTA acquisition is negligible given it replaces MRA typically performed later, following admission, as standard vessel imaging. Further prospective study is required.


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