scholarly journals Gentamicin and amikacin adversely affect male infertility indicated by pharmacological, andrological and pathological evidence

2020 ◽  
Vol 9 (2) ◽  
pp. 218
Author(s):  
Hozaifa K. Elsawah ◽  
Mohamed M. Kandiel ◽  
Aziza A. Amin ◽  
Haitham M. Mokhimar ◽  
AbuBakr M. El Mahmoudy
Keyword(s):  
Male Infertility ◽  
Therapeutic Dose ◽  
Sperm Count ◽  
Serum Testosterone ◽  
Reproductive Organs ◽  
Serum Testosterone Level ◽  
Double Dose ◽  
Medication History ◽  
The Third ◽  
Significant Difference

Background: Many drugs are implicated in male infertility and screening for medication history is an important for diagnosis and treatment of the problem. The aim is to study amikacin effect on male reproductive system in comparison to gentamicin.Methods: Twenty-five male wister rats weighted 220±20 gm and aged 8 weeks were randomly divided into five groups of five. The first group received gentamicin in dose 18.25 mg/kg/day once daily (OD) (therapeutic dose). The second group received gentamicin with double dose of the first group. The third group received amikacin in dose 54.75 mg/kg/day OD (therapeutic dose). The Fourth group received amikacin with double dose of the third group. However, the fifth group served as a control and received normal saline (NS) OD. All treatments were administered intraperitoneally (IP) for 14 days. On the 15th day, blood samples and reproductive organs were obtained from all animals. Testicular tissues were prepared for genetic testing and chemical and microscopical examination.Results: Amikacin and gentamicin negatively affected reproductive organs weights, sperm parameters, serum follicle stimulating hormone and luteinizing hormone (LH) level relative to control (p<0.05). However, serum testosterone level was only affected with gentamicin (p<0.05). A significant difference between gentamicin and amikacin was found in sperm count, testis and epididymis weights and serum testosterone and LH level (p<0.05). Testicular histopathological changes were also found with the two drugs with different degrees. Effects of both gentamicin and amikacin were dose-dependent.Conclusions: Both gentamicin and amikacin adversely affect andrological function that should be monitored and controlled during application of these drugs.

scholarly journals Ciprofloxacin and levofloxacin adversely affect male infertility indicated by pharmacological, andrological and pathological evidence

2020 ◽  
Vol 9 (2) ◽  
pp. 353
Author(s):  
Haitham M. Mokhimar ◽  
Mohamed M. Kandiel ◽  
Aziza A. Amin ◽  
Hozaifa K. Elsawah ◽  
AbuBakr M. El Mahmoudy
Keyword(s):  
Male Infertility ◽  
Therapeutic Dose ◽  
Serum Testosterone ◽  
Treated Group ◽  
Reproductive Organs ◽  
Reproductive Organ ◽  
Serum Testosterone Level ◽  
Double Dose ◽  
Drug Induced ◽  
The Third

Background: Drug-induced reproductive organs toxicities is an important aetiology in investigation of male infertility. The aim is to study levofloxacin effect on male reproductive system in comparison to ciprofloxacin.Methods: Twenty-five male wister rats weighted 230±20 gm and aged 8 weeks were randomly divided into five groups of five. The first group received ciprofloxacin with dose 78.23 mg/kg/day in 2 doses (therapeutic dose). The second group received the double dose of the first group ciprofloxacin. The third group received levofloxacin with dose 39.11 mg/kg/day once daily (OD) (therapeutic dose). The Fourth group received the double dose of the third group levofloxacin. However, the fifth group served as a control and received normal saline with carboxymethylcellulose OD. All treatments were administered orally for 14 days. On the 15th day, blood samples and reproductive organs were obtained from all rats. Testicular tissues were prepared for genetic testing and chemical and microscopical examination.Results: Ciprofloxacin and levofloxacin negatively altered reproductive organ weights, sperm parameters and serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) level (p<0.05). Additionally, serum testosterone level was significantly deceased in ciprofloxacin-treated group (the double dose) (p<0.05) relative to control. The difference between ciprofloxacin and levofloxacin was significant in seminal vesicle weight and serum LH and FSH level (p<0.05). Testicular histopathological changes were also found with the two drugs with different degrees. Effects of levofloxacin and ciprofloxacin were dose-dependent.Conclusions: Both ciprofloxacin and levofloxacin adversely affect andrological function that should be monitored and controlled during application of these drugs.

scholarly journals The role of obesity in male fertility

2018 ◽  
Vol 7 (9) ◽  
pp. 3435 ◽  
Author(s):  
Meltem Mermer ◽  
Yasemin Akdevelioğlu
Keyword(s):  
Body Weight ◽  
Male Infertility ◽  
Male Fertility ◽  
Sperm Morphology ◽  
Sperm Count ◽  
Sperm Concentration ◽  
High Body Mass Index ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Testosterone Levels

Obesity causes many health problems as well as having negative effects on fertility. There is a multifaceted relationship between obesity and male infertility. Male fertility is associated with sperm concentration, motility and morphology. Testosterone (total and free) and gonadotropin levels were low and estrogen levels were found to be high in obese men. The decrease in androgen levels varies based on the degree of obesity. High body mass index is inversely related to total sperm count, sperm concentration, sperm morphology and number of motile sperm. Leptin and ghrelin are hormones that influence body weight regulation and eating behaviors. Serum leptin level, which is high in obese infertile men, showed a significant positive correlation with abnormal sperm morphology, serum FSH, LH, prolactin level and showed a significant negative correlation with sperm concentration, sperm motility and serum testosterone level. Further research is needed on the effects of ghrelin levels on male infertility. The relationship between obesity and erectile dysfunction can be explained by decreased testosterone levels and elevation of some proinflammatory cytokine levels. Decreased physical activity due to obesity, long-term sitting increases testicular temperature and affects sperm production negatively. There is a multifaceted relationship between obesity, metabolic syndrome and type 2 diabetes and serum testosterone and SHBG. Diet and exercise showed improvement in testosterone levels and sperm concentration due to decreased body weight. However, studies on this subject are extremely limited. The possible effects of weight loss on successful infertility treatment of obese men should not be ignored.

The Protective Effect of Metformin against Oxandrolone-Induced Infertility in Male Rats

2020 ◽  
Vol 26 ◽  
Author(s):  
Abdulqader Fadhil Abed ◽  
Yazun Bashir Jarrar ◽  
Hamzeh J Al-Ameer ◽  
Wajdy Al-Awaida ◽  
Su-Jun Lee
Keyword(s):  
Gene Expression ◽  
Male Infertility ◽  
Protective Effect ◽  
Histological Examination ◽  
Sperm Count ◽  
Serum Testosterone ◽  
Male Rats ◽  
P Value ◽  
Protective Effects ◽  
Rt Pcr

Background: Oxandrolone is a synthetic testosterone analogue that is widely used among bodybuilders and athletes. However, oxandrolone causes male infertility. Recently, it was found that metformin reduces the risk of infertility associated with diabetes mellitus. Aim: This study aimed to investigate the protective effects of metformin against oxandrolone-induced infertility in male rats. Methods: Rats continuously received one of four treatments (n=7) over 14 days: control DMSO administration, oxandrolone administration, metformin administration, or co-administration of oxandrolone and metformin. Doses were equivalent to those used for human treatment. Subsequently, testicular and blood samples were collected for morphological, biochemical, and histological examination. In addition, gene expression of the testosterone synthesizing enzyme CYP11A1 was analyzed in the testes using RT-PCR. Results: Oxandrolone administration induced male infertility by significantly reducing relative weights of testes by 48%, sperm count by 82%, and serum testosterone levels by 96% (ANOVA, P value < 0.05). In addition, histological examination determined that oxandrolone caused spermatogenic arrest which was associated with 2-fold downregulation of testicular CYP11A1 gene expression. However, co-administration of metformin with oxandrolone significantly ameliorated toxicological alterations induced by oxandrolone exposure (ANOVA, P value < 0.05). Conclusion: Metformin administration protected against oxandrolone-induced infertility in male rats. Further clinical studies are needed to confirm the protective effect of metformin against oxandrolone-induced infertility among athletes.

scholarly journals Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies

2021 ◽  
Vol 12 ◽  
Author(s):  
Xu Zhang ◽  
Tongtong Zhang ◽  
Xiaohan Ren ◽  
Xinglin Chen ◽  
ShangQian Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sperm Motility ◽  
Reproductive System ◽  
Sperm Quality ◽  
Sperm Count ◽  
Meta Analysis ◽  
Serum Testosterone ◽  
Male Reproductive System ◽  
Serum Testosterone Level ◽  
Testis Weight

Pyrethroids may be related to male reproductive system damage. However, the results of many previous studies are contradictory and uncertain. Therefore, a systematic review and a meta-analysis were performed to assess the relationship between pyrethroid exposure and male reproductive system damage. A total of 72 articles were identified, among which 57 were selected for meta-analysis, and 15 were selected for qualitative analysis. Pyrethroid exposure affected sperm count (SMD= -2.0424; 95% CI, -2.4699 to -1.6149), sperm motility (SMD=-3.606; 95% CI, -4.5172 to -2.6948), sperm morphology (SMD=2.686; 95% CI, 1.9744 to 3.3976), testis weight (SMD=-1.1591; 95% CI, -1.6145 to -0.7038), epididymal weight (SMD=-1.1576; 95% CI, -1.7455 to -0.5697), and serum testosterone level (SMD=-1.9194; 95% CI, -2.4589 to -1.3798) in the studies of rats. We found that gestational and lactational exposure to pyrethroids can reduce sperm count (SMD=1.8469; 95% CI, -2.9010 to -0.7927), sperm motility (SMD=-2.7151; 95% CI, -3.9574 to -1.4728), testis weight (SMD=-1.4361; 95% CI, -1.8873 to -0.9848), and epididymal weight (SMD=-0.6639; 95% CI, -0.9544 to -0.3733) of F1 offspring. Exposure to pyrethroids can increase malondialdehyde (SMD=3.3451; 95% CI 1.9914 to 4.6988) oxide in testes and can reduce the activities of glutathione (SMD=-2.075; 95% CI -3.0651 to -1.0848), superoxide dismutase (SMD=-2.4856; 95% CI -3.9612 to -1.0100), and catalase (SMD=-2.7564; 95% CI -3.9788 to -1.5340). Pyrethroid exposure and oxidative stress could damage male sperm quality. Gestational and lactational pyrethroid exposure affects the reproductive system of F1 offspring.

Hormonal regulation of reproduction and the antler cycle in the male Columbian black-tailed deer (Odocoileus hemionus columbianus). Part I. Seasonal changes in the histology of the reproductive organs, serum testosterone, sperm production, and the antler cycle

1976 ◽  
Vol 54 (10) ◽  
pp. 1617-1636 ◽  
Author(s):  
Nels O. West ◽  
H. C. Nordan
Keyword(s):  
Testosterone Level ◽  
Hormonal Regulation ◽  
Serum Testosterone ◽  
Reproductive Organs ◽  
Serum Testosterone Level ◽  
Sperm Production ◽  
Regulation Of Reproduction ◽  
Antler Growth ◽  
Testis Volume ◽  
Antler Cycle

The hormonal regulation of reproduction and the antler cycle was investigated by measuring serum testosterone, testis volume, sperm production, and the antler growth cycle of wild and captive deer. The functional relationships of the testes and accessory sex glands to reproduction and antler growth were also studied by examining these organs histologically.Reproductive activity was maximal in November when the mean serum testosterone level of the adult males was 10 ng/ml, testis volume averaged 30 cm3, and the concentration of sperm in the semen was 100 × 106 to 700 × 106/ml. In winter, the activity of the reproductive organs declined, until a minimum was reached in February or March. The antlers were cast several weeks after the serum testosterone dropped below 1 ng/ml. In spring, a significant increase in spermatogenetic activity occurred, coincident with the initiation of antler growth. The serum testosterone level, however, remained low until velvet shedding, in late summer.These findings support the hypothesis that the maturation of antlers, shedding of the velvet, and the maintenance of antlers in the hard, functional condition are dependent on testosterone. The possible significance of increased spermatogenetic activity in the spring and its relationship to antler growth are also discussed.

Aflatoxin B1-Induced Reproductive Toxicity in Male Rats

2014 ◽  
Vol 33 (3) ◽  
pp. 155-161 ◽  
Author(s):  
Ch. Supriya ◽  
B. P. Girish ◽  
P. Sreenivasula Reddy
Keyword(s):  
Aflatoxin B1 ◽  
Sperm Count ◽  
Reproductive Toxicity ◽  
Serum Testosterone ◽  
Reproductive Organs ◽  
Docking Studies ◽  
Male Rats ◽  
In Silico Docking ◽  
Male Wistar Rats ◽  
Steroidogenic Acute Regulatory

Aflatoxin B1 (AFB1), one of the most common mycotoxins found in human foods, is principally hepatotoxic; however, it also affects reproduction. The aim of the present study was to elucidate the reproductive toxic effects and possible mechanism of action of AFB1 in rats. Male Wistar rats were injected intramuscularly with doses of 10, 20, or 50 µg AFB1/kg body weight on alternate days from 45 to 100 days of age. Significant reductions in body weights, relative weights of reproductive organs, daily sperm production, epididymal sperm count, viable sperm, motile sperm, and hypoosmotic swelling-tail coiled sperm were observed. Significant decreases in testicular steroidogenic enzymes and serum testosterone levels were also observed indicating decreased steroidogenesis. In silico docking studies illustrated AFB1 binds with steroidogenic acute regulatory (StAR) protein thereby affecting the transport of cholesterol into mitochondria resulting in decreased steroidogenesis.

scholarly journals Use of Exogenous Testosterone for the Treatment of Male Factor Infertility: A Survey of Nigerian Doctors

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Olufunmilade Akinfolarin Omisanjo ◽  
Stephen Odunayo Ikuerowo ◽  
Moruf Adekunle Abdulsalam ◽  
Sheriff Olabode Ajenifuja ◽  
Khadijah Adebisi Shittu
Keyword(s):  
Medical Education ◽  
Male Infertility ◽  
Sperm Count ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Medical Practitioners ◽  
Mistaken Belief ◽  
Significant Difference ◽  
Or Practice ◽  
Structured Questionnaire

Background. Though exogenous testosterone is known for its contraceptive effects in men, it is sometimes prescribed by medical practitioners for the treatment of male factor infertility in the mistaken belief that exogenous testosterone improves sperm count. The aim of this study was to evaluate the scope of testosterone use in the treatment of male factor infertility by medical practitioners in Lagos, Nigeria.Methods. A survey using a structured questionnaire was carried out amongst doctors attending a regular Continuing Medical Education (CME) programme in Lagos, Nigeria.Results. There were 225 respondents. Most of the respondents (69.8%,n=157) indicated that exogenous testosterone increases sperm count. Only 22 respondents (9.8%) indicated (correctly) that exogenous testosterone decreases sperm count. Seventy-seven respondents (34.2%) had prescribed some form of exogenous testosterone in the treatment of male factor infertility. The vast majority of respondents who had prescribed testosterone (81.8%,n=63) thought exogenous testosterone increases sperm count. There was no statistically significant difference in the pattern of prescription across the respondents’ specialty (p=0.859) or practice type (p=0.747).Conclusion. The misuse of exogenous testosterone for the treatment of male infertility was common amongst the respondents, with most of them wrongly believing that exogenous testosterone increases sperm count.

EVALUATING THE EFFECT OF IMPROVING SPERM PRODUCTION OF VIETNAMESE DEER ANTLER ON EXPERIMENTAL ANIMALS// Academy Journal No.10(12), 2018. pp. 8-27

2018 ◽  
Author(s):  
Liudmila Vyacheslavovna Fomina ◽  
Duy Bac Nguyen ◽  
Xuan Phong Pham ◽  
Hoang Ngan Nguyen
Keyword(s):  
Valproic Acid ◽  
Sperm Count ◽  
Serum Testosterone ◽  
Reproductive Organs ◽  
Male Rat ◽  
Sperm Production ◽  
Deer Antler ◽  
Experimental Animals ◽  
Testosterone Levels ◽  
Testicular Histology

The study was conducted to evaluate the effects of improving sperm production with the use of Vietnamese deer antler velvet powder on a white rat, whose sperm count was decreased by valproic acid. The findings showed that using deer antler velvet powder at doses of 127.5 mg/kg/24 hrs, 255 mg/kg/24 hrs and 510 mg/kg/24 hrs for 6 weeks on the male rat having a low sperm count recovered the research parameters (serum testosterone levels, sperm quantity and quality, reproductive organs and testicular histology).

scholarly journals Interventional study to find out effect of human chorionic gonadotropin and antioxidants on idiopathic male infertility

2017 ◽  
Vol 6 (2) ◽  
pp. 496
Author(s):  
Namrata V. Padvi ◽  
Pooja P. Singh ◽  
Kishore M. Nadkarni ◽  
Prabhakar M. Singh
Keyword(s):  
Male Infertility ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Medical Management ◽  
Sperm Count ◽  
Semen Analysis ◽  
Semen Parameters ◽  
P Value ◽  
Idiopathic Male Infertility ◽  
Significant Difference

Background: Male contributes about 50% for cases with combined male and female infertility. When the cause is not known, it is term as idiopathic infertility. It affects 25% of men. Many advances have been made in reproductive medicine which provides great opportunities, couples which were considered untreatable now have got chance to have their own babies. Various ART procedures like ICSI have been proven as an efficient therapy in severe male factor infertility. However, the cost per cycle and complications such as multiple gestations cannot be ignored. Medical management of infertility can be specific or empirical depending on etiology. Specific medical management is use when certain etiology is identified. However, in absence of specific etiology use of empirical medical treatment can be attempted in order to improve treatment results. In this study our aim is to evaluate the effect of human chorionic gonadotropin (hCG) and antioxidants on semen parameters in men with idiopathic male infertility.Methods: Thirty men with abnormal semen parameters were included in study. Patients were treated with injection hCG-2000 IU three times a week for three months along with the antioxidants. After 3 months of treatment repeat semen analysis were performed and results were compared with pre-treated seminal parameters.Results: Results showed significant increase in sperm count (p value ≤ 0.001), total motility (p value=<0.001), and progressive forward motility (p value = <0.001), while no significant difference is seen in rest of the parameters.Conclusions: Use of hCG and antioxidants in idiopathic male infertility can significantly improve seminal parameters in idiopathic male infertility.

Sign in / Sign up

Export Citation Format

Share Document