scholarly journals Correlation of prolactin and thyroid disorders in infertile women

2017 ◽  
Vol 6 (2) ◽  
pp. 649 ◽  
Author(s):  
Priyanka Sharma ◽  
Anita Pal ◽  
Rajeev Sood ◽  
Saroj Jaswal ◽  
Suman Thakur ◽  
...  
Keyword(s):  
Thyroid Disorders ◽  
Thyroid Status ◽  
Secondary Infertility ◽  
Positive Correlation ◽  
Infertile Women ◽  
Primary Infertility ◽  
Thyroid Profile ◽  
The Impact

Background: The objective of the study was to review the impact of thyroid status on the fertility and to study the prevalence of hyperprolactinaemia in infertility.Methods: A total of 150 subjects were divided into 3 groups: 50 primary infertility, 50 secondary infertility and 50 controls. The incidence of hyperprolactinaemia and thyroid disorders was studied in all the three groups.Results: The incidence of hyperprolactinaemia was 41% in all infertile subjects (60% with primary and 22% in secondary infertility) and 6% in controls. The incidence of hypothyroidism was 17% in infertility (18% in primary and 16% in secondary infertility) and 8% in controls.Conclusions: In this study there is a positive correlation between increased prolactin levels and hypothyroidism and such patients’ exhibit ovulatory failure. All patients with infertility should undergo prolactin levels and thyroid profile.

scholarly journals Thyroid Profile in Infertile Women

2018 ◽  
Vol 1 (01) ◽  
pp. 5-10
Author(s):  
Rojina Manandhar ◽  
Bekha Laxmi Manandhar ◽  
Jyoti Sharma
Keyword(s):  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Thyroid Disorders ◽  
Thyroid Disorder ◽  
Subclinical Hyperthyroidism ◽  
Secondary Infertility ◽  
Cross Sectional ◽  
Infertile Women ◽  
Thyroid Profile

Introduction: Infertility is defined as inability to conceive after one year of regular unprotected intercourse. Thyroid disorders can lead to infertility arising from different pathophysiological mechanisms. The aim of this study is to determine the prevalence and type of thyroid disorder in infertile women and to compare the prevalence of thyroid disorder in primary and secondary infertility. Methods: A hospital-based descriptive cross-sectional study conducted in the Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal from 1st Baishak 2068 to 30th Chaitra 2068 (14th April 2011 to 12th April 2012). Results: Among 156 infertile women enrolled and analyzed in the present study, thyroid disorder was found in 12 women giving the prevalence of thyroid disorder in infertile women as 7.7%. Hypothyroidism was more common comprising 6.4% of all infertile women, out of which subclinical hypothyroidism was 3.8% and clinical hypothyroidism was 2.6%. Hyperthyroidism was seen in 1.3% of all infertile women of which subclinical hyperthyroidism was 0.64% and clinical hyperthyroidism was 0.64%. Prevalence of thyroid disorder in primary infertility was 9.8% and in secondary infertility it was 3.7%. Among the 12 infertile women with thyroid disorder, four infertile women (33%) conceived. Three cases of hypothyroidism conceived after treatment and one case of subclinical hyperthyroidism conceived without any treatment. Conclusions: This study shows that thyroid dysfunction shows a significant role in infertility. Proper management of the thyroid dysfunction can result regain of fertility. Therefore, routine screening is required to all cases of infertility for possible thyroid disorders.

P–499 infertility impact on perceived quality of life and sexual satisfaction in Spanish women with primary and secondary infertility

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
N Uriart. Beitia ◽  
P Guerr. Mora ◽  
M Penad. Abilleira
Keyword(s):  
Quality Of Life ◽  
Sexual Satisfaction ◽  
Measurement Instrument ◽  
Perceived Quality ◽  
Secondary Infertility ◽  
Infertile Women ◽  
Fertility Treatments ◽  
Perceived Quality Of Life ◽  
The Impact

Abstract Study question Are there any differences relating to the perceived quality of life (QoL) and sexual satisfaction among infertile women? Summary answer There were no differences between women who already had a baby and those who did not relating to the perceived QoL and sexual satisfaction. What is known already Infertility is a medical disease with a high social component with a 16% prevalence. There have been many investigations regarding to the physical part of the infertility but the sexual and marital satisfaction has not been as intensively investigated. The importance of the psychological counseling in fertility treatments has already been proven, but the significance of sexual satisfaction on individual’s perception on QoL has not been as deeply studied. Study design, size, duration A transversal descriptive study was done. 313 heterosexual married women with fertility problems were recruited in collaboration with the Spanish patient association “Red Nacional de Infértiles”. The Fertility quality of life tool (FertiQoL) was selected to measure the perceived QoL and the Index of Sexual Satisfaction (ISS) was chosen to study the degree of sexual satisfaction. The data collection was made between January and February 2020 and all the information was gathered online. Participants/materials, setting, methods 313 women filled the questionnaire which had 4 different modules: A sociodemographic module (sex, age, studies, time trying to conceive, moment of treatment and offspring), two modules for each measurement instrument and a last module in which they could write their personal experiences regarding to the infertility journey. ANOVA and t-Student statistical analyses were done to compare the different independent variables. To see if FertiQoL could explain the sexual satisfaction a regression analysis was made. Main results and the role of chance To achieve 95% power (α = 0.05) and an effect size of 0.25, a minimum sample size of 210 was needed and a sample of 313 women was recruited. There were no statistical differences between women with previous offspring and those who did not in neither of the FertiQoL subscales (Emotional: 7,4 ± 3,884 vs. 7,34 ± 4,235; Mind/Body: 9,65 ± 5,098 vs. 8,66 ± 4,979; Relational: 16,88 ± 4,807 vs. 16,3 ± 4,956; Social: 10,52 ± 5,02 vs. 10,1 ± 4,801; Tolerability: 5,91 ± 4,114 vs. 6,65 ± 3,357; Environment: 12,71 ± 5,02 vs. 11,42 ± 4,963) nor in the ISS questionnaire (47,48 ± 6,488 vs. 47,22 ± 7,35). Regarding to the power of the FertiQoL instrument and the perceived QoL to predict the sexual satisfaction, the regression model showed that the sexual satisfaction could be explained in 26,3% of the cases by the relational and mind/body subscales of the FertiQol tool. This model showed the inherent relationship between marital and personal wellbeing in order to obtain a better sexual satisfaction. Limitations, reasons for caution As the study had a transversal design, no cause-effect relationships could be done. It would be desirable to establish a longitudinal study in order to determine a more accurate relationship between the studied variables. Wider implications of the findings: This study showed that the impact of infertility in women with secondary infertility diagnose could be at least as high as in women with primary infertility diagnose. FertiQoL would be a reasonable instrument to estimate the sexual satisfaction of infertile women. Sexology should be part of the infertility counselling programs. Trial registration number Not applicable

scholarly journals Laparoscopy as a diagnostic tool in evaluation of female factors in infertility

2017 ◽  
Vol 6 (3) ◽  
pp. 864 ◽  
Author(s):  
Chaitra Krishna ◽  
Prathima S. ◽  
Savitha Chandraiah ◽  
Anitha G. S.
Keyword(s):  
Diagnostic Laparoscopy ◽  
Polycystic Ovary ◽  
Well Being ◽  
Common Finding ◽  
Infertile Couple ◽  
Polycystic Ovaries ◽  
Male Factor ◽  
Secondary Infertility ◽  
Infertile Women ◽  
Primary Infertility

Background: Infertility leads to considerable personal suffering and disruption of family life. According to United Nations "Reproductive health is a state of complete physical mental and social well-being and not merely the absence of disease or infirmity in all matters relating to the reproductive system and to its functions and processes". The objective of present study was to find out different causes of female infertility with diagnostic laparoscopy and their comparative frequency in primary and secondary infertility.Methods: It is a prospective study conducted on all infertile women and they underwent diagnostic laparoscopy for primary and secondary infertility during the study period. Couples who had not lived together for at least 12 months, and those with male factor infertility were excluded. Data were collected on a proforma, and analyzed on SPSS package for windows version 10. Frequencies were calculated for laparoscopic findings regarding primary and secondary infertility.Results: Fifty infertile women underwent laparoscopy during the study period, 35 (70%) had primary infertility while 15 (30%) secondary infertility. 10 (28.5%) patients with primary and 3 (20%) patients with secondary infertility had no visible abnormality. The common finding was tubal blockage in 10 (28.5%) and 5 (33.3%) cases of primary and secondary infertility respectively. 9 (25.7%) cases of primary infertility were detected as polycystic ovaries (PCO) and 2 (13.3%) in cases of secondary infertility. Endometriosis was found in 1 case with primary infertility and 2 (13.3%) cases with secondary infertility. Fibroid was found in 3 (8.57%) and 1 (6.6%) cases of primary and secondary infertility respectively.Conclusions: Most common causes responsible for infertility were tubal occlusion and polycystic ovary. Infertile couple should be thoroughly investigated. Laparoscopy in infertility can be used for a definitive diagnosis.

STUDY OF LAPAROSCOPIC EVALUATION OF FEMALE FACTORS IN INFERTILITY AT ANMMCH, GAYA, BIHAR

2021 ◽  
pp. 60-62
Author(s):  
Pankaj Kumar Chaudhary ◽  
Anupam Chaurasia ◽  
Lata Shukla Dwivedy ◽  
Debarshi Jana
Keyword(s):  
Diagnostic Laparoscopy ◽  
Polycystic Ovaries ◽  
Male Factor ◽  
Secondary Infertility ◽  
Infertile Women ◽  
Medical College ◽  
Primary Infertility ◽  
Common Causes ◽  
Tubal Blockage ◽  
Laparoscopic Evaluation

Objective:To nd out different causes of female infertility with diagnostic laparoscopy and their comparative frequency in primary and secondary infertility. Study Design:Acase series. Place and Duration of Study: Department of Obstetrics and Gynaecology, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, August 2018 to July 2019. Methodology:All infertile women underwent diagnostic laparoscopy for primary and secondary infertility during the study period were included. Couples who had not lived together for at least 12 months, and those with male factor infertility were excluded. Data were collected on a proforma, and analysed on SPSS package for windows version 10. Frequencies were calculated for laparoscopic ndings regarding primary and secondary infertility. Results: Fifty infertile women underwent laparoscopy during the study period, 32 (64%) had primary infertility while 18 (36%) secondary infertility. Eight (25.0%) patients with primary and 2 (11.1%) patients with secondary infertility had no visible abnormality. The common nding was tubal blockage in 7 (21.9%) and 6 (33.3%) cases of primary and secondary infertility respectively. Five (15.6%) cases of primary infertility were detected as polycystic ovaries (PCO) which was not found in cases of secondary infertility. Endometriosis was found in 4 (12.5%) cases with primary infertility and 2 (11.1%) cases with secondary infertility. Pelvic inammatory disease (PID) was found in 1 (3.1%) and 2 (16.7%) cases of primary and secondary infertility respectively. Peritubal and periovarian adhesions were detected in 2 (6.3%) cases with primary infertility and 4 (22.2%) cases with secondary infertility. Fibriod was found in 2 (6.3%) and 1 (5.6%) cases of primary and secondary infertility respectively. Ovarian cyst detected in 2 (6.3%) cases with primary infertility while none was found in cases of secondary infertility. Conclusion: Most common causes responsible for infertility were tubal occlusion, endometriosis, peritubal and periovarian adhesions. Ovarian causes were seen in primary infertility only

scholarly journals Prevalence of thyroid disorders among infertile women with menstrual irregularities

2018 ◽  
Vol 6 (1) ◽  
pp. 22-25
Author(s):  
Nazlima Nargis ◽  
Abu Kholdun Al Mahmood ◽  
Iqbal Karim
Keyword(s):  
Cross Sectional Study ◽  
Thyroid Disorders ◽  
Secondary Infertility ◽  
Cross Sectional ◽  
Detailed History ◽  
Infertile Women ◽  
Ovulatory Dysfunction ◽  
Menstrual Irregularities ◽  
Menstrual History ◽  
History Of

Background: The infertility problem is more common phenomenon among the women now a days and has increased over past 30 years. The present study was carried out to see the prevalence of thyroid disorders among infertile women with menstrual irregularities.Methods: It was a cross sectional study conducted at the Department of Obstetrics and Gynecology, Ibn Sina Medical College, Dhaka from January to December 2016. After taking informed consent, total 160 infertile women and 100 normal fertile women volunteers were selected on OPD basis between age group of 18-45 years. Out of 160 infertile women, 100 were of primary infertility and 60 of secondary infertility. Participants were selected on the basis of detailed history, clinical examination and laboratory investigations. Detailed history of participants including age, menstrual history, obstetric history, history of any medications were taken.Results: There was a higher prevalence of hypothyroidism in the infertile women as compared to the fertile one in the study group, particularly in secondary infertility. Oligomenorrhoea was most common in infertile women. Hypothyroidism is commonly associated with ovulatory failure. Hence, assessment of serum TSH is mandatory in the work up of all infertile women, especially those presenting with menstrual irregularities. So the basic approach should be to identify those hypothyroid individuals who have greatest risk for the development of infertility.Conclusion: Long standing hypothyroidism may develop ovulatory dysfunction. So identifying and treating hypothyroidism at an earlier stage before the appearance of ovulatory dysfunction can have potentially great preventive value.Bangladesh Crit Care J March 2018; 6(1): 22-25

scholarly journals Histopathological Study of Endometrium in Infertility: Experience in A Tertiary Level Hospital

2018 ◽  
Vol 8 (2) ◽  
pp. 132-137
Author(s):  
Mousumi Ahmed ◽  
Nazma Afroze ◽  
Mahjabin Sabiha
Keyword(s):  
Endometrial Hyperplasia ◽  
Tertiary Care ◽  
Histopathological Study ◽  
Care Hospital ◽  
Secretory Phase ◽  
Secondary Infertility ◽  
Morphological Pattern ◽  
Infertile Women ◽  
Proliferative Phase ◽  
Primary Infertility

Background: Infertility refers to inability to achieve conception even after one year of unprotected coitus by a couple. It is a global health problem and affects 8-10% couple worldwide. Infertility can be primary or secondary and there are many causes of infertility involving both male and female partner. A wide range of investigations can be done to find out the causes of infertility. Endometrial biopsy or curettage or aspiration followed by histopathological study is a safe procedure. It not only shows the hormonal response of endometrium but also diagnose other endometrial pathology causing infertility. The study was performed to find out the morphological pattern of endometrium in infertile women in a tertiary care hospital to find out the causes of infertility and subsequent treatment of the patients.Methods: It was a cross sectional prospective study, conducted in the Department of Histopathology and Cytopathology in a tertiary care hospital in Dhaka for a period of two years from Jan 2015 to Dec 2016. It included 196 referred cases endometrial curettage or biopsy samples of infertile women, collected between days 21 to 23 of menstrual cycle. The endometrial samples obtained from patients suffering from diseases other than infertility were excluded from the study. Hematoxylin and Eosin (H&E) stained histopathological slides were prepared from the samples and examined under microscope. Reported results and relevant data were recorded in SPSS data collection sheet and statistical analysis was carried out.Results: A total of 196 cases of endometrial biopsy or curettage samples of both primary and secondary infertile women were studied. Age ranged from 20 years to 40 years with a mean age of 29.91±4.32years. 70.92% cases presented with primary infertility and 29.08% cases presented with secondary infertility. Proliferative phase/anovulation (41.33%) was found as the most common morphological pattern of endometrium in infertile women followed by secretory phase (40.30%). Endometrial hyperplasia, inadequate sample, nonspecific ednometritis and tuberculous endometritis were found in 10.72% , 6.12% , 6.12% and 0.51% cases respectively. In primary infertility, proliferative phase / anovulation (43.17%) was also the predominant pattern followed by secretory phase (37.40%) and endometrial hyperplasia (11.52%). Whereas, secretory phase( 47.37%) was the most common pattern of endometrium in secondary infertility, followed by proliferative phase (36.37%) and endometrial hyperplasia (8.77%). Primary infertility was most frequently presented in 26-30 years of age, whereas, secondary infertility was more prevalent in later age group.Conclusion: Histopathological study of endometrium gives us valuable information of endometrium in infertility. Morphological pattern of endometrium in our study was quite similar to other studies conducted in different countries with some variations. This study may help other studies in future to find out the cause of infertilityBirdem Med J 2018; 8(2): 132-137

scholarly journals Study of implications of thyroid status over feto-maternal outcomes in pregnancy

2020 ◽  
Vol 9 (5) ◽  
pp. 1946
Author(s):  
Smruti Gedam ◽  
Bharat Bhushan
Keyword(s):  
Subclinical Hypothyroidism ◽  
Screening Method ◽  
Maternal Outcomes ◽  
Thyroid Disorders ◽  
Thyroid Status ◽  
Fetal Complications ◽  
Clinically Significant ◽  
Maternal Thyroid ◽  
Thyroid Profile ◽  
In Pregnancy

Background: Thyroid disorders are reported at clinically significant prevalence during pregnancy, affecting ~5% of all pregnancies. Maternal thyroid status during pregnancy purportedly affects fetal as well as maternal outcomes. The objective of present study was to analyse the relationship of thyroid status in pregnancy and various maternal and fetal outcomes.Methods: In this hospital based observational study, a total of 913 pregnant women were enrolled as per fixed criteria and all the study participants were screened for thyroid disorders. Further, they were followed up throughout pregnancy and puerperium and evaluated for various maternal and fetal complications by predefined outcome measures. The results were compared by subgroup analysis.Results: Of the 913 patients screened, 105 were diagnosed with thyroid abnormality and followed up till delivery, with newborn thyroid profile on day 7. Total 49 patients were diagnosed with anaemia (46.66%), of which 46 (43.80%) had subclinical hypothyroidism (p <0.05); along with pregnancy induced hypertension in 42 (40%) cases of which 40 (38.09%) had subclinical hypothyroidism were observed to have statistically significant associations. Intrauterine growth restriction (IUGR) (37, 35.23%) and prematurity (19, 18.1%) were the most common fetal occurrences; the association of IUGR and subclinical hypothyroidism being statically significant.Conclusions: Thyroid disorders during pregnancy are commonly associated with maternal and fetal complications and thyroid profile is recommended as universal screening method in early pregnancy to diagnose and start required treatment early.

scholarly journals Hysterosalpingographic Evaluation of Uterus and Fallopian Tubes of Infertile Women

2017 ◽  
Vol 6 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Manoj Bhattarai ◽  
Sita Pokhrel Ghimire
Keyword(s):  
Fallopian Tube ◽  
Uterine Cavity ◽  
Categorical Variables ◽  
P Value ◽  
Fallopian Tubes ◽  
Secondary Infertility ◽  
Radiological Investigation ◽  
Infertile Women ◽  
Primary Infertility ◽  
Significant Difference

Background: Hysterosalpingography (HSG) is a routinely performed radiological investigation for evaluation of uterine cavity morphology and fallopian tube patency in infertile women. This study was undertaken to describe patterns of HSG findings and to assess any significant difference in uterine and fallopian tube findings in women with primary and secondary infertility in eastern part of Nepal.Material and Methods: Hospital based cross sectional descriptive study was conducted by retrospectively analyzing HSG records of 216 infertile women (both primary and secondary infertility) done from April 2014 to August 2016. Radiological findings in uterus and fallopian tubes were recorded and analyzed. Association between two categorical variables was examined by Chi-square test.Results: Majority of infertile women (53.2%) had primary infertility. Abnormal HSG was seen in 44.9% infertile women and higher in secondary infertility (57.4%) than with primary infertility (33.9%) (OR = 2.63, 95% CI = 1.51 – 4.57, P value = 0.001). Tubal abnormality was common than uterine abnormality (36.1% versus 8.8%, P value= 0.001). Tubal abnormalities were higher in women with secondary infertility than with primary infertility (52.5% versus 21.7%), whereas uterine abnormalities were common with primary infertility compared to secondary infertility (12.2% versus 5.0%) (P value= 0.001).Conclusion: Abnormal HSG was more associated with secondary infertility. Infertility was significantly associated with tubal abnormality than with uterine abnormality. Tubal abnormalities are common in women with secondary infertility whereas uterine abnormalities are common in women with primary infertility and are statistically significant.Journal of Nobel Medical CollegeVolume 6, Number 1, Issue 10 (January-June, 2017), Page: 63-71

scholarly journals Laparoscopy: the tool for infertility

2017 ◽  
Vol 6 (12) ◽  
pp. 5544
Author(s):  
Neelima P. Shah ◽  
Prashant D. Shah
Keyword(s):  
Blue Dye ◽  
Secondary Infertility ◽  
Tubal Patency ◽  
Infertile Women ◽  
Primary Infertility ◽  
Therapeutic Laparoscopy ◽  
Therapeutic Value ◽  
Ovarian Pathology ◽  
Infertility Patients

Background: Most of the healthy couples conceive within a year after marriage. The infertility patients have become important part of clinical practice. Diagnostic and therapeutic Laparoscopy plays major role in the management of these cases. We investigated hale 50 infertile women with laparoscopy. This study was undertaken to ascertain the diagnostic and therapeutic role of Laparoscopy in female infertility.Methods: We evaluated 50 couples having infertility. The cases of primary and secondary infertility were evaluated. The laparoscopy was done under general anaesthesia. The pelvic organs were examined, and tubal patency was tested with chromo-perturbation by using Methylene blue dye. The findings were noted. The therapeutic intervention was done in the cases where it was necessary.Results: Total 50 cases of infertility were studied. Thirty were of primary infertility and 20 were of secondary infertility. The patients with primary infertility were younger with mean age of 20 years. The duration of infertility ranged from 1.5 to 8 years. We detected total 21 (42%) patients with ovarian pathology, 5 (10%) with tubal, four (8%) with peritoneal factor 3 (6%) with endometriosis. One patient had uterine fibroid and 16 (32%) cases had normal laparoscopic findings.Conclusion: This study supported the diagnostic and therapeutic value of laparoscopy in managing infertile women. It helped in detection of pelvic pathology. It also helped to plan further management in the form of IUI or IVF.

scholarly journals Hypothyroidism and early pregnancy loss: an overview

2020 ◽  
Vol 9 (12) ◽  
pp. 5065
Author(s):  
Puja Verma ◽  
Dipti Roy
Keyword(s):  
Early Pregnancy ◽  
Pregnancy Loss ◽  
First Trimester ◽  
Thyroid Disorders ◽  
Early Pregnancy Loss ◽  
Thyroid Status ◽  
The Mean ◽  
Adverse Pregnancy ◽  
Thyroid Profile ◽  
Status Of Women

Background: Thyroid disorders are associated with adverse pregnancy outcomes and can lead to spontaneous miscarriages.Methods: One hundred and four women with early pregnancy loss were enrolled in this study and thyroid profile was done. Thyroid status of women was established on the basis of standard cut-off levels. Prevalence of hypothyroidism (both overt and subclinical) was calculated.Results: The mean TSH level was 2.3±1.3 μIU/l. Twenty two women had increased TSH level (>2.5 μIU/l) accounting to 21.15% of total women and rest 78.84% women were euthyroid. 15.38% of women presenting with early pregnancy loss were overt hypothyroid and 5.76% of women had subclinical hypothyroidism. The mean TSH level in hypothyroid group was 4.9±2.1.Conclusions: Hypothyroidism if untreated can lead to first trimester abortions. All pregnant women should be screened for thyroid disorders in their first visit and treatment should be started at the earliest.

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