LDH as a prognostic marker in hypertensive pregnancy

Background: Pregnancy induced hypertension (PIH) is a global problem with a 5-15% incidence rate in India and complicating 10-17% of all pregnancies. These are multisystem disorders and lead to a lot of cellular death. LDH is an intracellular enzyme and its level is increased in these women due to cellular death. So, serum LDH levels can be used to assess the extent of cellular death and thereby the severity of disease in this group of women. The objective of the study was to correlate the severity of the disease, maternal and perinatal outcome with Lactic Dehydrogenase (LDH) levels in serum in patients of preeclampsia and eclampsia.Methods: A prospective comparative study was conducted in the department of Obstetrics and Gynecology, JSS Medical Hospital, Mysore.Results: LDH levels were significantly elevated in women with preeclampsia and eclampsia (<0.001). Higher LDH levels had significant correlation with high blood pressure (P <0.10) as well as poor maternal and perinatal outcome.Conclusions: High serum LDH levels correlate well with the severity of the disease and poor outcomes in patients of preeclampsia and eclampsia.

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Incidence of retinal changes in pregnant women due to pregnancy induced hypertension and its correlation with clinical profile

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20201238 ◽

2020 ◽

Vol 9 (4) ◽

pp. 1640

Author(s):

Himanshy Rai ◽

Zakia Rahman

Keyword(s):

Sudden Onset ◽

Response To Treatment ◽

Positive Finding ◽

Pregnancy Induced Hypertension ◽

Medical College ◽

Induced Hypertension ◽

Grade Ii ◽

Mild Preeclampsia ◽

Severity Of The Disease ◽

Routine Therapy

Background: Pregnancy induced hypertension (PIH) is associated with many other pathological complications. Pathological changes of this disease appear to be related to vascular endothelial dysfunction and its consequences. One such complication or effect of PIH is retinal changes.Methods: This observational study was conducted of 110 cases over a period of 12 months from March 2018 to February 2019 in department of obstetrics of gynecology in Kamla Raja Hospital, G. R. Medical College, Gwalior, Madhya Pradesh. All the patients who fulfilled the diagnostic criteria of PIH admitted in the obstetric ward.Results: Retinopathic changes were noted in 36.36% out of which grade I, grade II, grade III and grade IV have 11.82%, 8.18%, 10.19% and 5.45% cases respectively. In + proteinuria 10.9% of cases have positive findings, in ++ proteinuria 18.18% cases have positive findings, in +++ 7.27% cases have retinopathy but severity increases with a grade of proteinuria. 40% cases retinopathic changes of mild preeclampsia have positive finding, 36.36% in severe preeclampsia and 23.64% in cases of eclampsia. As overall severity of PIH increases retinopathies in patients increases.Conclusions: Visual symptoms are few in patients with PIH and often absent unless the macula is involved. Sudden onset of headache, which is resistant to routine therapy in these patients, may be the warning symptom before the onset of first convulsion. By repeated fundus examinations at regular intervals one can assess the severity of the disease and also response to treatment instituted.

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PREVALENCE OF FUNDUS CHANGES IN PREGNANCY INDUCED HYPERTENSION – A CLINICAL STUDY

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i5.278 ◽

2019 ◽

Vol 3 (5) ◽

Cited By ~ 1

Author(s):

Manpreet Kour ◽

Vijayta Gupta

Keyword(s):

Clinical Study ◽

Pregnancy Induced Hypertension ◽

Induced Hypertension ◽

Changes In Pregnancy ◽

Severity Of The Disease ◽

In Pregnancy

To evaluate prevalence of fundus changes in Pregnancy Induced Hypertension (PIH) and to find the correlation of the findings with the levels of hypertension and with the severity of the disease.

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PREGNANCY INDUCED HYPERTENSION;

The Professional Medical Journal ◽

10.29309/tpmj/2014.21.03.2125 ◽

2014 ◽

Vol 21 (03) ◽

Author(s):

Asghar Khan ◽

Amin Fahim ◽

Aneela Qureshi ◽

Ghulam Shah Nizamani ◽

Mohammad Ahmed Azmi

Keyword(s):

University Hospital ◽

Control Group ◽

P Value ◽

Pregnancy Induced Hypertension ◽

Severity Of Disease ◽

Induced Hypertension ◽

Mild Preeclampsia ◽

Group 3 ◽

Group 2 ◽

Group 1

Objective: To assess the early detection of thrombocytopenia in womenpresenting with varying degree of pregnancy induced hypertension (PIH). Study Design: A casecontrol study. Place of Study: Hematology laboratory Isra University Hospital Hyderabad.Duration of Study: From July 2009 to December 2010. Materials and Methods: Total 130pregnant women were included in this study. The subjects were divided into three groups asGroup 1 with pre-eclampsia, Group 2 with eclampsia and Group 3 with normotensive pregnantwomen as control group. The Group 1 was further divided into two sub groups such as Subgroup1a with mild preeclampsia and Sub-group 2b with severe pre-eclampsia. Results:Anticoagulated whole blood samples (5cc) from all subjects were analyzed for the detection ofthrombocytopenia for the possible involvement of pregnancy induced hypertension. It was notedthat out of total subjects, 33(25.39%) had mild pre-eclampsia, 17(13.07%) had severe preeclampsia,15(11.54%) had eclampsia and 65 (50.0%) were normotensive pregnant women.Based on the comparative findings, the results showed significant differences between group 3and group 1a (p-value 0.001), group 3 and group 1b (p-value 0.001), group 2 and group 3 alsoshowed same results (p-value 0.001) but the subjects of group 1a and 1b when compared,showed non-significant findings (p value 0.955). Conclusion: The results suggested that earlydetection of platelet count provide significant role for the assessment of severity of disease inwomen with pregnancy induced hypertension when compared with normotensive pregnantwomen.

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Immunoglobulin E levels and pregnancy-induced hypertension: Japan Environment and Children’s Study

Scientific Reports ◽

10.1038/s41598-021-88227-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Hyo Kyozuka ◽

◽

Tsuyoshi Murata ◽

Toma Fukuda ◽

Yuta Endo ◽

...

Keyword(s):

Immunoglobulin E ◽

Late Onset ◽

First Trimester ◽

High Serum ◽

Pregnancy Induced Hypertension ◽

Serum Ige ◽

Japanese Cohort ◽

Increased Risk ◽

Induced Hypertension ◽

Hypertensive Disorders In Pregnancy

AbstractHigh serum immunoglobulin E (IgE) levels are associated with cardiovascular events. We aimed to evaluate the association between total IgE levels during the first trimester of pregnancy and pregnancy-induced hypertension (PIH) development in a large Japanese cohort. We analysed data pertaining to singleton primipara pregnancies recorded in the Japan Environment and Children’s Study involving births from 2011 to 2014. Serum IgE levels were determined using the immunonephelometric technique. High serum IgE was defined as level ≥ 170 IU/ml. Hypertensive disorders in pregnancy (HDP) were categorized into early onset (Eo) PIH (developed < 34 weeks) or late onset (Lo) PIH (developed ≧ 34 weeks). A multiple logistic regression model was used to estimate the risk of high serum IgE levels on PIH, Eo-PIH, and Lo-PIH. Overall, 32,518 participants were enrolled. The prevalence of total, Eo-, and Lo-PIH was 3.2%, 0.6%, and 2.3%, respectively. Patients with high serum IgE levels had an increased risk of Lo-HDP (adjusted odds ratio [aOR]:1.19, 95% confidence interval 1.01–1.40). No correlation was found with either PIH (total) or Eo-PIH. High serum IgE levels during the first trimester were associated with the risk of Lo-PIH. Our results could influence and shape further research regarding the pathogenesis of Lo hypertension.

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Elevated serum ?hCG and dyslipidemia in second trimester as predictors of subsequent Pregnancy Induced Hypertension

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v40i3.25230 ◽

2015 ◽

Vol 40 (3) ◽

pp. 97-101 ◽

Cited By ~ 1

Author(s):

MP Mallick ◽

S Ray ◽

R Medhi ◽

S Bisai

Keyword(s):

Pregnant Women ◽

Elevated Serum ◽

High Serum ◽

Subsequent Pregnancy ◽

Pregnancy Induced Hypertension ◽

Second Trimester ◽

Singleton Pregnancy ◽

Community Based ◽

Colorimetric Test ◽

Induced Hypertension

Objectives: To test the hypothesis that pregnant women with high serum ?hCG level and serum dyslipidemia in second trimester are more prone to develop subsequent Pregnancy Induced Hypertension (PIH). Materials & Methods: One hundred pregnant women with singleton pregnancy between 14 and 20 weeks of gestation attending antenatal outpatient department (OPD) of SMCH were studied. Serum ?hCG was estimated by two-site chemiluminescent-immunometric method. Serum lipid profile was evaluated by enzymatic colorimetric test with Lipid Clearing Factor (LCF). Results: Eighteen cases developed PIH while eighty two cases remained normotensive. The serum ?hCG level was significantly high (p?0.001) in those women developing PIH. Serum concentration of total cholesterol in women who subsequently developed PIH was significantly higher than that of normotensive group (p ?0.05). Mean TG value in PIH group was higher than the normotensive group. Level of LDL in PIH group was also significant (p?0.05). Conclusion: Present study showed that elevated serum ?hCG and Dyslipidemia in second trimester can be considered as predictors of subsequent PIH / Pre-eclampsia. However, there is need of large community based prospective study to validate the result.Bangladesh Med Res Counc Bull 2014; 40 (3): 97-101

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