scholarly journals To assess ovulation in infertile women using urinary luteinizing hormone surge kits versus transvaginal ultrasonography

2021 ◽  
Vol 11 (1) ◽  
pp. 114
Author(s):  
Urmila Karya ◽  
Vibha Chauhan ◽  
Anupam Rani
Keyword(s):  
Good Alternative ◽  
Dose Requirement ◽  
Normal Cycle ◽  
Lh Surge ◽  
Infertile Women ◽  
Negative Effect ◽  
Randomized Control ◽  
Luteinizing Hormone Surge ◽  
Group 2 ◽  
Group 1

Background: The study was conducted to evaluate the efficacy of urinary LH surge kits and TVS to detect ovulation in induced cycles and to compare the ovulation rates by both methods.Methods: Prospective experimental randomized control trial on 72 women with an ovulatory infertility aged 18-35 years, fulfilling the inclusion criteria were given letrozole for ovulation induction. All were randomly divided in two groups. Group 1 woman were asked to check ovulation by urinary LH surge kits and group 2 women were called for follicle monitoring by TVS.Results: Letrozole has no negative effect on endometrium; induced cycle has larger diameter of follicle (median: 22 mm). In induced cycle ovulation occurs later compared to normal cycle (D-16) and half of the women had a BMI more than the recommended WHO criteria (average was 25.28 kg/m2). Number of letrozole cycles (p=0.2642), dose requirement (p=0.0812) and pregnancy rates (10.26% versus 18.19%) were comparable in both groups.Conclusions: TVS is objective, accurate and thus standard modality for ovulation detection. LH surge kit is subjective, having more chances of error but can be used as a good alternative in certain settings like woman of remote area, woman having fear of invasive modality and COVID era woman who are afraid to visit hospital repeatedly.

scholarly journals The difference in outcome of patients with open inguinal hernia repair by using delayed absorbable sutures instead of non-absorbable sutures for mesh fixation

2020 ◽  
Vol 8 (1) ◽  
pp. 24
Author(s):  
Ali G. Mohammed Redha ◽  
Adil A. Jaber ◽  
Aqeel M. Nasser
Keyword(s):  
Hernia Repair ◽  
Mesh Fixation ◽  
Good Alternative ◽  
P Value ◽  
Absorbable Sutures ◽  
Significant Difference ◽  
The Difference ◽  
Group 2 ◽  
One Year ◽  
Group 1

Background: Different methods are found for mesh fixation in inguinal hernioplasty both open and laparoscopic. In open technique, sutures have been the method of choice for their reduced costs and surgeons’ habits. Whether absorbable instead of non-absorbable sutures can be used still a matter of debate in view of hernia recurrence and post-operative complications.Methods: This is a prospective done on 158 male patients with uncomplicated unilateral inguinal hernias. Two groups of 69 patients were evaluated after periods up to 1 year after open hernioplasty by using delayed absorbable sutures in one group (group 1) and non-absorbable sutures in the other group (group 2) for fixation of mesh.Results: In spite of a noticeable reduction in complication in the group 1 in term of number and percentage when compared with group 2 mainly chronic pain, there is no significant difference (p value>0.05). However, these results are associated with zero recurrence in both groups during a period of one year follow up.Conclusions: Delayed absorbable sutures are good alternative of non-absorbable sutures in open mesh hernia repair associated with less complications and almost no increase in chance of recurrence.  

P–711 The association between thyroid autoimmunity and serum level of anti-Müllerian hormone in infertile patients with normal ovarian reserve undergoing in vitro fertilisation

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
A Albu ◽  
D Albu
Keyword(s):  
Serum Level ◽  
Ovarian Reserve ◽  
Thyroid Autoimmunity ◽  
In Vitro Fertilisation ◽  
Free T4 ◽  
Infertile Women ◽  
Group 2 ◽  
Infertile Patients ◽  
Group 1

Abstract Study question Is there a relationship between thyroid autoimmunity and serum level of anti-müllerian hormon (AMH) in infertile women with normal ovarian reserve undergoing in vitro fertilisation (IVF)? Summary answer In infertile women with normal ovarian reserve serum AMH level above 5ng/ml is associated with higher level of thyroid hormones and less frequent thyroid autoimmunity What is known already Previous studies suggest that thyroid autoimmunity is associated with a decreased ovarian reserve. Moreover, it was reported that thyroid hormone administration could improve serum AMH level. However, the relationship between serum AMH level and thyroid autoimmunity and function in infertile women with normal ovarian reserve undergoing IVF is largely unknown. Since in IVF the serum AMH level is an important marker which dictate the management of the couple, the identification of all the factors possibly related to this parameter is very important. Study design, size, duration: We performed a retrospective study in the Department of Reproductive Medicine of a private hospital. The medical records of all consecutive patients who underwent IVF between January 2015 and December 2018 with all causes of infertility were reviewed. Study group included 581patients with a mean age of 34.4±4.1 years, mean AMH of 3.78±2.4 ng/mL, mean serum TSH level of 1.89±1 microUI/ml and mean serum free T4 level of 1.05±0.98 ng/dl. Participants/materials, setting, methods Patients with known thyroid disorders or under thyroid hormone treatment at the moment of evaluation were excluded. Only patients with serum level of thyroid stimulating hormone (TSH), free tyroxine (free T4), anti thyroid peroxidase antibodies (ATPO,) anti thyroglobulin antibodies (ATG), AMH and age available for analysis were included in the study. This parameters are evaluated on a systematic basis in all the patients undergoing IVF in our Department, except very few cases. Main results and the role of chance Patients were divided according to their serum AMH level in two groups: group 1 with AMH level 5 ng/ml and below (n = 450 patients) and group 2 with AMH above 5 ng/ml (n = 131 patients). When the two groups were compared we found that patients in group 2 were younger in comparison with patients in group 1 (32.9±3.8 versus 35±4 years, p < 0.0001). After adjustment for age, patients in group 2 had significantly higher serum free T4 level (1.07±0.12 versus 1.04±0.14 ng/dl, p = 0.015), lower ATG (17.59±41.8 UI/ml versus 39.4±136.16 UI/ml, p < 0.018) and presented less frequently with high ATPO antibodies (35% versus 41.8%, p = 0.047). In a logistic regression model with AMH as a dependent variable, free T4, but not TSH was independently and positively associated with higher AMH levels (above 5 ng/ml) (p = 0.025) after adjustment for anti thyroid antibodies levels. Morever, in this logistic model the presence of high ATPO, but not ATG, were negatively related to higher AMH level (p = 0.037). Limitations, reasons for caution Patients included in this study are infertile patients with indication for IVF treatment. Therefore, the results of this study should be used with caution in other populations Wider implications of the findings: Our study suggest that serum AMH level might be related to thyroid autoimmunity, but also to thyroid hormones levels. If confirmed by further studies, this findings could offer a way to improve serum AMH level and to better understand the markers of ovarian reserve in an IVF setting. Trial registration number NA

scholarly journals Orthosiphon versus Placebo in Nephrolithiasis with Multiple Chronic Complaints: A Randomized Control Trial

2009 ◽  
Vol 6 (4) ◽  
pp. 495-501 ◽  
Author(s):  
Amorn Premgamone ◽  
Pote Sriboonlue ◽  
Srinoi Maskasem ◽  
Wattana Ditsataporncharoen ◽  
Bungornsri Jindawong
Keyword(s):  
Myofascial Pain ◽  
White Blood Cells ◽  
Analog Scale ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
Randomized Control ◽  
Group 2 ◽  
Primary Measure ◽  
Group 1

Nephrolithiasis in the communities of Northeast Thailand frequently presents with multiple chronic health complaints, i.e. myofascial pain, back pain, dyspepsia, arthralgia, headache, fatigue, frank paresthesia, dysuria and any of these aggravated by purine-rich food (PRF). We assessed the efficacy of Orthosiphon in treating subjects with at least two active symptoms and negative for urine white blood cells. Subjects were randomly allocated to two groups. Crude extract of Orthosiphon given in a capsule (equivalent to 1.6–1.8 g of dried leaves of Orthosiphon) two times a day to Group 1 (n= 36) and a placebo to Group 2 (n= 40) for 14 days. The medication for each subject was packed and its code kept secret until the data analysis. Both groups were asked not to consume any of 25 purine-rich foods (PRFs) during treatment. The primary measure was the reduced sum of active severity symptoms as recorded using the visual analog scale before and after therapy (i.e. on day 7 and 14). The data on 76 subjects were processed. The mean of the total scores (95% CI) of the symptoms in each group were decreased significantly (P< 0.001); 185.6 (153.3, 218.0) to 94.7 (58.2, 131.2) in the Orthosiphon group and 196.1 (164.4, 227.8) to 89.6 (62.8, 116.5) in the placebo group. When comparing between groups, no statistically significant difference was found. The mean consumption in PRFs was significantly decreased (P< 0.001) in both groups; however, Orthosiphon did not have additional benefit over placebo at 7 and 14 days of treatment during which they reduced these foods.

scholarly journals The acrylic's design or the addition of internal orthodontic wire changes the resistance of orthodontic plates?

2013 ◽  
Vol 42 (6) ◽  
pp. 449-453
Author(s):  
Matheus Melo Pithon ◽  
Érica Luiza Santana Moreira Sousa ◽  
Davi Novaes Ladeia Fogaça ◽  
William Soares da Silva ◽  
Luciano Brito Rodrigues ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Mechanical Characteristics ◽  
Testing Machine ◽  
Good Alternative ◽  
Significance Level ◽  
Orthodontic Wire ◽  
Group 3 ◽  
Group 2 ◽  
Universal Mechanical Testing Machine ◽  
Group 1

OBJECTIVE: Evaluate resistance of Hawley retainers in three different acrylic configurations in order to evaluate if its format or the addition of internal wire interferes in its resistance. MATERIAL AND METHOD: 45 Hawley retainers were fabricated, divided into three groups (n = 15): Group 1 - acrylic covering the entire hard palate, Group 2 - plate with relief at the deepest region of the palate, leaving it with a "U" conformation and Group 3 - similar to Group 2, with the addition of 0.7mm wire 2cm internally of the acrylic at the region of the palatine ridges. The compressive strength was tested in a universal mechanical testing machine (Stable Microsystems, London, United Kingdom), measuring the applied force until plate rupture occurred. The differences between the formats being compared by the Kruskal-Wallis test. The significance level was set at 5% (α = 0.05). RESULT: Group 1 showed the highest resistance, with a mean of about five times higher than Group 2 and three times higher than Group 3. CONCLUSION: acrylic reduction in dental retainer plates is directly related to the reduction of its compressive strength, the inclusion of orthodontic wire inside the acrylic increases the resistance of the plate, being a good alternative when more comfort is wanted for the patient without loss of the mechanical characteristics of the dental retainers.

Effect of bovine follicular fluid treatment and progesterone priming on luteal function in GnRH-treated seasonally anoestrous ewes

1996 ◽  
Vol 62 (3) ◽  
pp. 443-450 ◽  
Author(s):  
G. F. Basiouni ◽  
M. Khalid ◽  
W. Haresign
Keyword(s):  
Follicular Fluid ◽  
Corn Oil ◽  
Pulse Amplitude ◽  
Follicle Development ◽  
Lh Surge ◽  
Luteal Function ◽  
Treatment Groups ◽  
Early Stages ◽  
Group 2 ◽  
Group 1

AbstractThe main objective of the present experiment was to investigate whether progesterone priming eliminates defective luteal function in seasonally anoestrous ewes induced to ovulate with pulsatile GnRH treatment by synchronizing the early stages of follicle development. This was achieved by suppressing and synchronizing the early stages of follicle development with bovine follicular fluid (bFF) and then investigating whether this was sufficient to eliminate defective luteal function following the induction of ovulation with GnRH. Ewes in group 1 (no. = 10) were injected s.c. with 2 ml bFF at 8-h intervals for a period of 3 days before the start of GnRH treatment. Animals in group 2 (no. = 10), ivhich served as positive controls, were given a single i.m. injection of 20 mg progesterone 3 days before the start of GnRH treatment, while those in group 3 (no. = 10), which served as negative controls, were injected with corn oil alone at this time. Ewes in all the three groups were induced to ovulate by administration of 2-hourly injections of GnRH (250 ng per injection) for 54 h. Frequent blood samples for LH, FSH, and oestradiol were collected around the time of both progesterone/bFF injections and GnRH treatment, as well as daily thereafter to monitor luteal function.The bFF injections given to animals in group 1 resulted in a significant (P<0·001) suppression of FSH concentrations, followed by a rebound rise in concentrations after the cessation of treatment. GnRH treatment significantly (P < 0·05) increased both mean LH pulse amplitude and overall mean LH concentrations in all the three groups, while LH pulse frequency was increased only in non-bFF-treated ewes. Plasma oestradiol concentrations 24 h after the start of GnRH treatment were significantly (P < 0·05) higher in groups 2 and 3 compared with group 1. These differences in the patterns of oestradiol concentrations over time were associated with a significant (P <0·05) delay in the onset of the pre-ovulatory LH surge in ewes treated witli bFF (group 1). However, there was no difference in either the duration or the height of pre-ovulatory LH surge between the three treatment groups. Ewes in all three treatment groups ovulated in response to GnRH treatment. However, both laparoscopic examination and plasma progesterone concentrations revealed that the incidence of normal luteal function was significantly (P < 0·05) higher in group 2 (10/10) compared with groups 1 (2/10) and 3 (4/10), with no difference between groups 1 and 3. Overall, these results suggest that progesterone priming does not eliminate defective luteal function through synchronizing early stages offollicle development.

scholarly journals Functional properties of hemostasis in piglets after short-term overheating against the background of corrective action

2020 ◽  
Vol 17 ◽  
pp. 00169
Author(s):  
Vladimir V. Zaitsev ◽  
Marina V. Mekhanikova ◽  
Svetlana V. Shestakova ◽  
Tatyana P. Ryzhakina
Keyword(s):  
Platelet Aggregation ◽  
Control Group ◽  
Platelet Activity ◽  
Large White ◽  
White Breed ◽  
Negative Effect ◽  
Group A ◽  
Group 2 ◽  
Experimental Group ◽  
Group 1

Catosal is considered to be a highly effective bio-stimulator. It showed his properties in animals, realizing the stimulation of their tissues and organs. The purpose of this research is to determine the effect of Catosal on hemostatic parameters in piglets that experienced overheating. 58 piglets at the age of 2.5 months, which belonged to a large white breed, were taken into work. All animals as a result of an accidental emergency shutdown of the air conditioning system in the pigsty suffered overheating for 3 hours. These animals were randomly divided into two comparable groups. One was named experimental; the other was called control 1. Pigs of the experimental group (21 heads) received intramuscular injections of 2.5 ml of Catosal daily for 5 consecutive days, from the next day after an overheating episode. The control group 1 consisted of piglets with a total number of 21. After an overheating episode, they were under the usual conditions of a pigsty and did not receive any effects. In experimental piglets and piglets of the control group 1, all indicators were recorded in the outcome and after 30 days. Control group 2 consisted of 32 completely healthy piglets that were kept under standard conditions of a pigsty for their entire lives. They were examined once. Catosal injections in the observed piglets after overheating led to a decrease in spontaneous and stimulated platelet aggregation to normal levels. Against the background of the use of Catosal in the piglets that made up the experimental group, a weakening of hemocoagulation was found, which improved blood circulation in their tissues. Piglets of control group 1 showed an increase in platelet aggregation and blood coagulation. This had a very negative effect on hemorheology in them and weakened their metabolism. We can assume that in piglets after overheating, in the absence of optimizing effects, hemostasis is activated. This adversely affects the course of microcirculation and inhibits growth. Injections in piglets after overheating of the Catosal lead to a weakening of hemocoagulation and platelet activity to optimum values. This normalizes the course of microcirculation in the internal organs of animals.

Lack of an effect of morphine or naloxone on the oestrogen-induced LH surge in anoestrous ewes

1988 ◽  
Vol 119 (1) ◽  
pp. 89-93 ◽  
Author(s):  
R. J. E. Horton ◽  
I. J. Clarke
Keyword(s):  
Positive Feedback ◽  
Opioid Peptide ◽  
Endogenous Opioid ◽  
Opioid Agonist ◽  
Endogenous Opioid Peptide ◽  
Lh Surge ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

ABSTRACT To determine whether opioid mechanisms modulate the positive feedback effect of oestrogen on LH secretion, anoestrous ewes were given a single injection of 50 μg oestradiol benzoate (OB), followed by infusions of morphine or naloxone. All sheep were injected i.m. with 50 μg OB at 00.00 h. In experiment 1, sheep were given i.v. infusions of the following: group 1, 12 ml saline/h from 09.00 to 15.00 h (n=12); group 2, 40 mg naloxone/h from 09.00 to 12.00 h (n = 5); group 3, 40 mg naloxone/h from 10.00 to 14.00 h (n = 5); group 4, 10 mg morphine/h from 09.00 to 15.00 h (n = 5); and group 5, 20 mg morphine/h from 09.00 to 15.00 h (n = 5). Jugular blood samples were taken at 30-min intervals to monitor LH surges, which commenced 13.0 ± 0·6 h after injection of OB in control (OB plus saline) ewes. The infusions of naloxone or morphine did not affect the timing or magnitude of the oestrogen-induced LH surge. To examine the possibility that opioidergic regulation of the LH surge occurred earlier than the infusion regimens in experiment 1, sheep were infused from the time of the OB injection (00.00 h) until 15.00 h. In this experiment (experiment 2), sheep were given i.v. infusions of the following: group 1, 4·2 ml saline/h (n=5); group 2, 20 mg naloxone/h (n=5); and group 3, 20 mg morphine/h (n=5). As in experiment 1, treatment with neither the opioid agonist or antagonist was able to alter the positive feedback response of OB. These results suggest that neither the timing of the LH surge or the peak concentrations of LH achieved in plasma are influenced by opiates in this model. This suggests that in contrast to the rat, the mechanisms responsible for generating the oestrogen-induced preovulatory-like LH surge in the anoestrous ewe do not involve any endogenous opioid peptide mechanisms. J. Endocr. (1988) 119, 89–93

Positive and Negative Placebo Effects Resulting from the Deceptive Administration of an Ergogenic Aid

2007 ◽  
Vol 17 (3) ◽  
pp. 259-269 ◽  
Author(s):  
Christopher J. Beedie ◽  
Damian A. Coleman ◽  
Abigail J. Foad
Keyword(s):  
Linear Trend ◽  
Placebo Treatment ◽  
Ergogenic Aid ◽  
Placebo Effects ◽  
Significant Linear Trend ◽  
Negative Belief ◽  
Negative Effect ◽  
Group 2 ◽  
Experimental Trials ◽  
Group 1

The article describes a study examining placebo effects associated with the administration of a hypothetical ergogenic aid in sport. Forty-two team-sport athletes were randomly assigned to 2 groups. All subjects completed 3 × 30-m baseline sprint trials after which they were administered what was described to them as an ergogenic aid but was in fact 200 mg of cornstarch in a gelatin capsule. Group 1 was provided with positive information about the likely effects on performance of the substance, whereas Group 2 was provided with negative information about the same substance. The sprint protocol was repeated 20 min later. Although for Group 1 mean speed did not differ significantly between baseline and experimental trials, a significant linear trend of greater speed with successive experimental trials suggested that positive belief exerted a positive effect on performance (P < 0.01). Group 2 ran 1.57% slower than at baseline (P < 0.01, 95% confidence intervals 0.32–2.82%), suggesting that negative belief exerted a negative effect on performance. Collectively, data suggest that subjects’ belief in the efficacy or otherwise of a placebo treatment might significantly influence findings in experimental research.

scholarly journals Epidural analgesia/anesthesia as a method of birth anesthesia: effect on the course of childbirth, on the parturient and fetus

2020 ◽  
pp. 28-29
Author(s):  
A.V. Horianska ◽  
V.O. Zabolotnov
Keyword(s):  
Postpartum Period ◽  
Fetal Distress ◽  
Vacuum Extraction ◽  
Continuous Administration ◽  
Continuous Epidural Infusion ◽  
Negative Effect ◽  
Perinatal Center ◽  
Level Of Knowledge ◽  
Group 2 ◽  
Group 1

Objective. To assess the effect of epidural anesthesia/analgesia (EA) on the course of labor, childbirth and the fetus. Materials and methods. Analysis of the main indicators of the perinatal center for 2013-2018, taking into account the implementation of EA. The outcome of childbirth was analyzed in 521 patients who underwent EA by continuous administration of a local anesthetic into the epidural space – continuous epidural infusion (CEI). Questionnaire among 100 women in labor, of which 55 used EA (group 1) and 45 – did not (group 2). Results and discussion. Among 521 persons the EA was performed: for obstetric indications (46.2 %), due to somatic pathologies (23.6 %), exclusively at the request of the mother (55.6 %). At the same time, the woman’s desire and insistence were combined with other indications in 13 % of cases. Out of 521 cases of the use of EA in childbirth cesarean section (CS) was applied in 88 (16.8 %) cases. The frequency of emergency CS performed in childbirth during the period under review was 4 %. Against the background of EA CS was used 4.2 times more often. CS in EA was performed in connection with fetal distress in 60 cases (68.1 %). At the same time, Apgar was <6 points in 6 cases, which is 6.8 % of the total number of CS. This indicates hyperdianostic fetal stress in women with EA. The effect of opening the cervix and EA on the frequency of CS has been studied: optimal for EA is the opening of the cervix by 4-5 cm, when the frequency of CS is minimal (6.3 %). When performing EA childbirth ended with vacuum extraction of the fetus in 9.5 % of mothers. According to the birthcenter, the frequency of vacuum extraction is 3.3 %. In EA, vacuum extraction was performed almost 2.8 times more often. According to the study, the vast majority of women believe that analgesia should only be indicated. One in four women in group 1 expressed their attitude to pain relief in this way: “If it is possible, why not?”. In group 1, 96 % of women were focused on EA. Whereas in group 2, mothers were almost equally familiar with all possible methods of analgesia, although the level of knowledge about EA is also high. It was found out that the largest share were women who had no problems in the postpartum period (53 % and 64 %, respectively). The vast majority of mothers (92 %) are satisfied with the analgesic effect of EA. It suggests that, according to the most of women, EA should be used as a method of analgesia during childbirth. Conclusions. EA performance is optimal when opening the cervix by 4-5 cm. Early use of EA up to 3 cm and/or non-smoothed cervix in primiparous women is limited, because against its background significantly increases the frequency of CS. The frequency of urgent CS and vacuum extraction with the use of EA increases. The obtained data did not reveal a negative effect of EA on the fetus (newborn). Most mothers are satisfied with EA and consider it the best method of analgesia for childbirth. The use of EA is insignificant, but still increases the risk of complications in the postpartum period.

The feasibility, acceptability and preliminary efficacy of parent-targeted interventions in vaccination pain management of infants: a pilot randomized control trial (RCT)

2021 ◽  
Author(s):  
Shokoufeh Modanloo ◽  
Sandra Dunn ◽  
Dawn Stacey ◽  
Denise Harrison
Keyword(s):  
Pain Management ◽  
Randomized Control Trial ◽  
Management Strategies ◽  
Clinical Trial Registration ◽  
Targeted Interventions ◽  
Registration Number ◽  
Randomized Control ◽  
Group 2 ◽  
Pilot Randomized Control Trial ◽  
Group 1

Aim: To evaluate the feasibility, acceptability and preliminary efficacy of parent interventions for improving the use of pain management strategies during vaccination of infants, a two-armed pilot randomized control trial (RCT) was conducted. Materials & methods: 151 parents were randomized in two groups: Group 1) ‘Be Sweet to Babies' videos and a tip sheet (n = 76); Group 2) As per Group 1 plus a motivational interviewing informed Affirmative Statements and Questions (AS&Q) (n = 75). Results & conclusion: Feasibility was evaluated by success of the recruitment (151 people in a week), rates of completed consent forms (85%), and surveys (59%). Over 94% satisfaction with interventions, processes and 88% intention to recommend the strategies to others determined the acceptability. Preliminary efficacy was evident by over 95% use of pain management strategies following the interventions. Clinical trial registration number: NCT03968432 .

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