scholarly journals A study of fasting lipid profile in chronic kidney disease patients

2019 ◽  
Vol 7 (6) ◽  
pp. 2282 ◽  
Author(s):  
Sandeep Singh ◽  
A. K. Pathak ◽  
Neelakanth U. Parappanavar
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
P Value ◽  
Low Density ◽  
Healthy Controls ◽  
Group 3 ◽  
Group 2

Background: Dyslipidemia is very much common in chronic kidney disease patients and is responsible for cardiovascular disease (CKD) which is most common cause of mortality in them. So, it is necessary to study the lipid profile in CKD patients to prevent morbidity and mortality.Methods: Subjects each of 50 in number are grouped into healthy controls (group-1), CKD patients without hemodialysis (group-2), CKD patients with hemodialysis (group-3). After fasting of 12 hours, lipid profile is assessed in all cases.Results: In this study, there is increase in Total cholesterol (TC), Low Density lipoprotein (LDL), very Low-Density lipoprotein (VLDL) and Triglycerides (TG) and decrease in High Density Lipoprotein (HDL) in all CKD patients compared to healthy controls (p-value for each parameter <0.001). There is increase in TC, TG and VLDL in diabetic CKD patients compare to non-diabetic CKD patients and p-value for each parameter is <0.05. It was found that TG and VLDL increase and HDL decrease in group-3 compare to group-2 is statistically significant (p-value for each <0.05) and no significant variation in TC and LDL in these groups.Conclusions: Present study demonstrated that there is dyslipidemia in CKD patients irrespective of mode of management, but the derangement is much more common and significant in CKD with hemodialysis group and they are at risk of cardiovascular disease. It is better to start lipid lowering drugs which decreases disease progression and dyslipidemia.

A STUDY OF FASTING LIPID PROFILE IN CHRONIC KIDNEY DISEASE PATIENTS AT MEDICINE DEPARTMENT OF ANMMCH, GAYA, BIHAR

2021 ◽  
pp. 75-76
Author(s):  
Bharat Bhushan ◽  
Debarshi Jana
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
P Value ◽  
Low Density ◽  
Healthy Controls ◽  
Group 3 ◽  
Group 2

Background: Dyslipidemia is very much common in chronic kidney disease patients and is responsible for cardiovascular disease (CKD) which is most common cause of mortality in them. So, it is necessary to study the lipid prole in CKD patients to prevent morbidity and mortality. Methods: Subjects each of 50 in number are grouped into healthy controls (group-1), CKD patients without hemodialysis (group-2), CKD patients with hemodialysis (group-3). After fasting of 12 hours, lipid prole is assessed in all cases. Results: In this study, there is increase in Total cholesterol (TC), Low Density lipoprotein (LDL), very Low-Density lipoprotein (VLDL) and Triglycerides (TG) and decrease in High Density Lipoprotein (HDL) in all CKD patients compared to healthy controls (p-value for each parameter <0.001). There is increase in TC, TG and VLDL in diabetic CKD patients compare to non-diabetic CKD patients and p-value for each parameter is <0.05. It was found that TG and VLDL increase and HDL decrease in group-3 compare to group-2 is statistically signicant (p-value for each <0.05) and no signicant variation in TC and LDL in these groups. Conclusions: Present study demonstrated that there is dyslipidemia in CKD patients irrespective of mode of management, but the derangement is much more common and signicant in CKD with hemodialysis group and they are at risk of cardiovascular disease. It is better to start lipid lowering drugs which decreases disease progression and dyslipidemia.

scholarly journals Effect of Force 6® Poultry (Curcumin) on Lipid profile in Broiler chicken in presence of IBD vaccine

2015 ◽  
Vol 39 (1) ◽  
pp. 100-104
Author(s):  
Amjed H. Ulaiwi
Keyword(s):  
Lipid Profile ◽  
Broiler Chicken ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Experimental Period ◽  
Negative Control ◽  
Low Density ◽  
Group 4 ◽  
Group 3 ◽  
Group 2

      The aim of this study was to investigate effect of Force 6® Poultry on lipid profile in broiler chicken in presence of IBD vaccine. Two hundred chicks at one day old were divided into four equal groups as: Group 1; 50 day old unvaccinated chicks were given (50 gm/ton) of Force 6® Poultry (curcumin) along the experimental period (35 days), chicks in group 2; were given IBD vaccine in (15-day old) (BURSINE-2), chicks in group 3 were vaccinated  with IBD at (15-day old) and given Force 6® Poultry  along time of experimental (with 50 gm/ton). Group 4, 50 chicks were saved as negative control. Blood samples were collected from heart for lipid profile detection and included (cholesterol, triglyceride, high-density lipoprotein HDL, very low density lipoprotein VLDL, low-density lipoprotein LDL). The result of lipid profile showed significant (P˂0.05) differences with higher value between groups which were (G2, G4) which did not receive force 6 poultry than group (G1, G3) which received force 6 poultry for (cholesterol, triglyceride, HDL, LDL,VLDL). In conclusion, the Force 6® Poultry had main effect to improve lipid profile of treated groups than these groups untreated.

To Study Thyroid Function and Lipid Profile Levels in Chronic Kidney Disease Patients in a Tertiary Care Hospital of North India

2021 ◽  
Vol 8 (32) ◽  
pp. 2980-2987
Author(s):  
Navjot Kaur Layal ◽  
Tejinder Sikri ◽  
Jaskiran Kaur ◽  
Jasmine Kaur ◽  
Hardeep Singh Deep
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Lipid Profile ◽  
Thyroid Dysfunction ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Care Hospital ◽  
Low T3 ◽  
Group A

BACKGROUND Chronic kidney disease (CKD) includes a spectrum of different pathophysiology processes associated with abnormal kidney function, and a progressive decline in GFR. Progression of CKD is associated with having a number of complications, including thyroid dysfunction, dyslipidaemia, and cardiovascular diseases. METHODS The present study was conducted among 60 CKD patients (cases) and 60 healthy controls to compare their thyroid and lipid profile, who attended the Department of Medicine in SGRDIMSR, Sri Amritsar from January 2019 to December 2020.These 60 CKD patients were grouped as group A. Group A was further divided into various stages as per KIDGO staging according to GFR. 60 healthy individuals were taken as controls and were kept as Group B. Demographic features (age and sex) and medical history of diabetes mellitus, hypertension were noted and blood samples (5mL) were analysed for blood urea, serum creatinine, free triiodothyronine (T3), free thyroxine (T4), thyroid stimulating hormone (TSH), total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low density lipoprotein (VLDL) and triglycerides. RESULTS Thyroid dysfunction was observed in patients of CKD, the most common being overt hypothyroidism (56.6 %) followed by subclinical hypothyroidism (16.6 %), low T3 (15 %), and hyperthyroidism (1.6 %). Hypercholesterolemia, low HDL, elevated LDL, VLDL and triglyceride levels were observed in 74.9 %, 85.0 %, 38.3 %, 41.6 % and 76.6 % patients, respectively. Patients with CKD with 5 had significantly higher risk of having thyroid dysfunction and dyslipidaemia as compared to patients with stage 3 and 4. CONCLUSIONS Thyroid dysfunction and dyslipidaemia were common in patients with CKD. Prevalence of hypothyroidism, dyslipidaemia increases with progression of CKD. Hence early detection of thyroid dysfunction and dyslipidaemia is imperative to improve mortality and morbidity of CKD patients. KEYWORDS Chronic Kidney Disease, Dyslipidaemia, Thyroid Dysfunction

scholarly journals Does Lipid Profile Affect Thrombin Generation During Ramadan Fasting in Patients With Cardiovascular Risks?

2016 ◽  
Vol 23 (8) ◽  
pp. 980-986 ◽  
Author(s):  
Mouna Sassi ◽  
Taher Chakroun ◽  
Saoussen Chouchène ◽  
Ilhem Hellara ◽  
Hamdi Boubaker ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Thrombin Generation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Healthy Controls ◽  
Cardiovascular Risks ◽  
Ramadan Fasting ◽  
Cholesterol Levels ◽  
Plasmatic Coagulation ◽  
Group 2

There is evidence that diet and variation in lipid metabolism can influence blood coagulation, but little is known about the effect of Ramadan fasting on plasmatic coagulation pattern. We investigated the effect of Ramadan fasting on thrombin generation (TG) in patients with cardiovascular disease (CVD) risks, and we aimed to assess the effect of lipid profile on TG parameters. The study was conducted in 36 adults having at least 2 CVD risks and in 30 healthy controls. Coagulation pattern was assessed by both classical clotting times and TG test. A complete lipid profile was performed simultaneously. Patients were invited 2 times: 1 week before Ramadan and during the last week of the Ramadan. The TG parameters were not different in patients with CVD risks compared to healthy controls. Fasting had no effect on plasmatic coagulation parameters and on TG profile. Individual analysis of the mean rate index (MRI) of TG revealed 3 groups: group 1 with no modification of MRI, group 2 with a significant increase in MRI (81.64 nM/min vs 136.07 nM/min; P < .001), and group 3 with a significant decrease in MRI (125.27 nM/min vs 73.18 nM/min; P = .001). Only in group 2, a significant increase was observed in total cholesterol and low-density lipoprotein cholesterol. Changes in lipid profile during Ramadan fasting did not influence the global coagulation pattern in patients with CVD risks. Whereas, a significant increase in the propagation phase of TG was associated with a significant increase in cholesterol levels, which was not found with the other TG parameters.

scholarly journals Status of Lipid Profile among the Hypertensive Patients in Bangladesh

2014 ◽  
Vol 9 (1) ◽  
pp. 13-17 ◽  
Author(s):  
CM Reza ◽  
ASMA Kabir ◽  
Tuhin Biswas ◽  
Kamrun Nahar Choudhury ◽  
Md Zahidur Rahman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Hypertensive Patients

Back ground: Hypertension and dyslipidemia are associated with oxidative stress and are major causes of cardiovascular disease amounting to 30% of global death rate. It is widely accepted that cardiovascular disease is associated with hypertension and increased blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides. In contrast, a low level of high density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. Hypertension is a major public health problem in developed and developing countries. Methods: This study was a cross sectional study in which 159 diagnosed hypertensive patient and 75 with normal blood pressure (normotensive) were enrolled. These patients sought a through health cheek up including blood pressure assessment between May 2012 to April 2013 in Tairunnessa Memorial Medical College and Hospital. Lipid parameter total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by enzymatic colorimetric test. Results: The mean of Systolic blood pressure and Diastolic blood pressure of hypertensive were higher than normotensive (p<0.001). The serum levels of total cholesterol, triglyceride and LDL-C in hypertensive subject were higher than normotensive and statistically significant (p<0.001). Serum HDL-C was significantly lower (p<0.001) in hypertensive patients than in normotensive. Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke. DOI: http://dx.doi.org/10.3329/uhj.v9i1.19505 University Heart Journal Vol. 9, No. 1, January 2013; 13-17

scholarly journals Study on Lipid Profile in Offspring of Dyslipidemic Parents

2012 ◽  
Vol 17 (1) ◽  
pp. 37-40
Author(s):  
MKH Azad ◽  
SS Hussain ◽  
MBK Choudhury ◽  
FR Mowsumi
Keyword(s):  
Cardiovascular Disease ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Genetic Predisposition ◽  
Matched Control ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
The Mean ◽  
Age And Sex

As dyslipidemia is responsible for remarkable cause of cardiovascular disease which is considered as the number one cause of death globally, this study was undertaken to evaluate the lipid profile status of offspring of dyslipidemic parents in comparison with the offspring of normolipidemic parents. In this study, carried out on 89 subjects, the mean total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-c) and low density lipoprotein (LDL-c) were 162.18 ± 20.97, 168.98 ± 33.51, 39.09 ± 3.62 and 90.41 ± 18.64 mg/dl respectively in adolescents with parental dyslipidemia and 158.38 ± 12.67, 157.22 ± 15.06, 40.51 ± 2.90 and 86.42 ± 12.39 mg/dl respectively in control adolescents. There were significant differences (p < 0.05) of TG and HDL-c between cases and controls where HDL-c choesterol was significantly lower in offspring of dyslipidemic parents then the offspring of normolipidemic parents. The findings of this study reflect the association of offspring dyslipidemia with parental dyslipidemia, probably due to some genetic predisposition. Offspring of dyslipidemic parents have higher levels of TC, TG, LDL-c and lower level of HDL-c compared to age and sex matched control subjects. DOI: http://dx.doi.org/10.3329/jdnmch.v17i1.12191 J. Dhaka National Med. Coll. Hos. 2011; 17 (01): 37-40

Statins for Treatment of Dyslipidemia in Chronic Kidney Disease

2006 ◽  
Vol 26 (5) ◽  
pp. 523-539 ◽  
Author(s):  
Sabin Shurraw ◽  
Marcello Tonelli
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
General Population ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Statin Treatment ◽  
Controlled Trials ◽  
Low Density ◽  
Randomized Controlled

Dyslipidemia is a potent cardiovascular (CV) risk factor in the general population. Elevated low-density lipoprotein cholesterol (LDL-C) and/or low high-density lipoprotein (HDL-C) are well-established CV risk factors, but more precise determinants of risk include increased apoprotein B (ApoB), lipoprotein(a) [Lp(a)], intermediate and very low-density lipoprotein (IDL-C, VLDL-C; “remnant particles”), and small dense LDL particles. Lipoprotein metabolism is altered in association with declining glomerular filtration rate such that patients with non dialysis-dependent chronic kidney disease (CKD) have lower levels of HDL-C, higher triglyceride, ApoB, remnant IDL-C, remnant VLDL-C, and Lp(a), and a greater proportion of oxidized LDL-C. Similar abnormalities are prevalent in hemodialysis (HD) patients, who often manifest proatherogenic changes in LDL-C in the absence of increased levels. Patients treated with peritoneal dialysis (PD) have a similar but more severe dyslipidemia compared to HD patients due to stimulation of hepatic lipoprotein synthesis by glucose absorption from dialysate, increased insulin levels, and selective protein loss in the dialysate analogous to the nephrotic syndrome. In the dialysis-dependent CKD population, total cholesterol is directly associated with increased mortality after controlling for the presence of malnutrition–inflammation. Treatment with statins reduces CV mortality in the general population by approximately one third, irrespective of baseline LDL-C or prior CV events. Statins have similar, if not greater, efficacy in altering the lipid profile in patients with dialysis-dependent CKD (HD and PD) compared to those with normal renal function, and are well tolerated in CKD patients at moderate doses (≤ 20 mg/day atorvastatin or simvastatin). Statins reduce C-reactive protein as well as lipid moieties such as ApoB, remnants IDL and VLDL-C, and oxidized and small dense LDL-C fraction. Large observational studies demonstrate that statin treatment is independently associated with a 30% – 50% mortality reduction in patients with dialysis-dependent CKD (similar between HD- and PD-treated patients). One recent randomized controlled trial evaluated the ability of statin treatment to reduce mortality in type II diabetics treated with HD (“4D”); the primary end point of death from cardiac cause, myocardial infarction, and stroke was not significantly reduced. However, results of this trial may not apply to other end-stage renal disease populations. Two ongoing randomized controlled trials (SHARP and AURORA) are underway evaluating the effect of statins on CV events and death in patients with CKD (including patients treated with HD and PD). Recruitment to future trials should be given a high priority by nephrologists and, until more data are available, consideration should be given to following published guidelines for the treatment of dyslipidemia in CKD. Additional consideration could be given to treating all dialysis patients felt to be at risk of CV disease (irrespective of cholesterol level), given the safety and potential efficacy of statins. This is especially relevant in patients treated with PD, given their more atherogenic lipid profile and the lack of randomized controlled trials in this population.

Comparison of different equations for estimation of low-density lipoprotein (LDL) – cholesterol

2020 ◽  
Vol 45 (5) ◽  
pp. 601-611
Author(s):  
Mehmet Fatih Alpdemir ◽  
Medine Alpdemir
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Turkish Population ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

AbstractObjectivesThe aim of this study was to compare low-density lipoprotein cholesterol (LDL-C) estimations using various formulas with directly measured LDL-C (d-LDL-C) in the Turkish population.Material and methodsA total of 1,478 participants who were aged between 18 and 80 were classified into five groups according to serum triglyseride (TG) concentration as follows: <100, 100–199, 200–299, 300–399, and 400–1000 mg/dL. Glucose (Glu), LDL-C, total cholesterol (TC), HDL-C, TG, and HbA1C were measured with Cobas 6000 c501. d-LDL-C concentrations were measured by a homogenous direct assay using reagents. We investigated the accuracy 10 equations that are Friedewald, De Cordova, Ahmadi, Anandaraja, Teerakanchana, Chen, Hattori, Vujovic, Puavillai, and Hatta for estimating LDL-C in this study.ResultsIn group 1, Anandaraja formula correlated best with d-LDL-C (r=0.367), but this correlation is weakly. In group 2; Teerakanchana formula (r=0.931), in group 3; Friedewald and Teerakanchana formulas (r=0.935, r=0.961), in group 4; Teerakanchana formula (r=0.950) and in group 5, Anandaraja formula (r=0.792) correlated best with d-LDL-C.ConclusionsIn this study, although there was a strong correlation between d-LDL-C measurement and estimated LDL-C formulas, there was a negative bias between results of these formulas and the d- LDL-C.

scholarly journals OP0104 DIFFERENCES IN LOW-DENSITY LIPOPROTEIN (LDL) PARTICLE COMPOSITION AND OXIDATION MAY UNDERLIE THE PARADOXICAL ASSOCIATION OF LOW LDL WITH HIGHER CORONARY ATHEROSCLEROSIS BURDEN IN RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 58.1-58
Author(s):  
G. Karpouzas ◽  
S. Ormseth ◽  
E. Hernandez ◽  
M. Budoff
Keyword(s):  
Rheumatoid Arthritis ◽  
Coronary Atherosclerosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Relative Content ◽  
Low Density ◽  
Cvd Risk ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background:The association between cholesterol and cardiovascular disease (CVD) risk is attenuated in Rheumatoid arthritis (RA). In fact, RA patients in the lowest low-density lipoprotein (LDL) group (<70mg/dl) may experience unexpectedly high CVD risk.Objectives:We here explored whether patients with LDL<70mg/dl (Group 1) had higher coronary atherosclerosis burden compared to other LDL groups (Group 2: 70≤LDL≤130 and Group 3: LDL>130), as a reason for this risk. We further evaluated whether low LDL in group 1 associated with differences in inflammation, LDL particle composition or oxidation.Methods:One hundred fifty RA patients without symptoms or history of CVD underwent coronary atherosclerosis evaluation with computed tomography angiography. Coronary artery calcium (CAC), number of segments with plaque (segment involvement score), stenotic severity (segment stenosis score), and extensive (>4 segments with plaque) or obstructive disease (>50% stenosis) were assessed. Lipoprotein classes and subclasses were directly measured. Oxidized LDL (oxLDL) was measured with monoclonal antibody E06. Chemiluminescence Elisa quantified IgG and IgM antibodies to oxLDL (anti-oxLDL) and apoB100 immune complexes (IC). Proinflammatory cytokines were measured with Erenna Immunoassay. Robust linear and logistic regression models- adjusted for Framingham D’Agostino score, obesity, disease activity, bDMARD and statin treatment- evaluated associations between LDL groups and plaque outcomes. Similar models evaluated adjusted differences in LDL subclasses, oxLDL, anti-oxLDL, anti-ApoB100 IC, and cytokines across LDL groups.Results:Group 1 patients had higher coronary plaque burden (Figure 1A) and 2.8 times greater risk of extensive or obstructive disease (adjusted OR 2.82 [95% CI 1.12-7.17], P = 0.031) compared to LDL>70 groups. Among statin naïve patients, those with LDL<70 also had higher oxLDL (log-transformed adjusted mean 2.55 [95% CI 2.34-2.77] versus 2.27 [95% CI 2.19-2.36], P = 0.018 for LDL>70). Notably, Group 1 patients also had higher anti-oxLDL IgG and anti-ApoB100 IgG IC levels compared to other groups (Figure 1B). LDL subclass relative content in the LDL particle differed across groups (Figure 1C). Lp(a) was higher in LDL particles in Group 1 (adjusted mean 16.04% [95% CI 11.75-20.33], versus 10.48% [95% CI 8.20-12.75] in Group 2, P = 0.026 and 7.41% [95% CI 0.77-14.04] in Group 3, P = 0.033). Notably, Lp(a) content strongly associated with oxLDL overall (r = 0.83, P < 0.0001). This association was stronger for Group 1 compared to others (P < 0.005, Figure 1D). No differences in RA activity, CRP, TNF-α, IL-17A, or IL-17F were seen across groups. However, Group 1 had higher IL-6 (log-transformed adjusted mean 1.98 [95% CI 1.64- 2.32] versus 1.57 [95% CI 1.45-1.70], P = 0.028 in Group 2 and 1.32 [95% CI 0.84-1.80], P = 0.031 in Group 3). IL-6 associated with both IgG anti-oxLDL (P = 0.015) and anti-apoB100 IC (P = 0.016). Log-transformed IL-6 further associated with higher log-transformed CAC (adjusted B 0.41 [95% CI 0.01-0.81], P = 0.049).Conclusion:RA patients with LDL<70 mg/dl had higher coronary atherosclerosis burden. Low circulating LDL in that group may reflect higher oxidation; this was mostly linked to the larger Lp(a) relative content of LDL and its significantly higher oxidation potential in that group. OxLDL immune recognition was linked to higher IgG anti-oxLDL Ab and anti-ApoB100 IC levels in the LDL<70 group, which further associated with higher IL-6 elaboration and atherosclerosis burden.Disclosure of Interests:George Karpouzas Speakers bureau: Sanofi/ Genzyme/ Regeneron, Consultant of: Sanofi/ Genzyme/ Regeneron, Grant/research support from: Pfizer, Sarah Ormseth: None declared, Elizabeth Hernandez: None declared, Matthew Budoff Consultant of: Pfizer

scholarly journals Effect of Guiera senegalensis and Natron on Serum Indices of Cardiac Function of Postpartum Rats

2021 ◽  
pp. 32-46
Author(s):  
Aminu Lailaba Abubakar ◽  
Jabir Aliyu Danyaya ◽  
Kabiru Abubakar ◽  
Magaji Umar Faruk ◽  
Yusuf Saidu
Keyword(s):  
Body Weight ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Albino Rats ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Guiera Senegalensis ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Peripartum cardiomyopathy (PPCM) is a rare but devastating cardiac failure of indeterminate etiology occurring in late pregnancy or early puerperium. The prevalence of PPCM in Northern Nigeria could be attributed to the unique customary puerperal practices of prolonged consumption oflarge quantities of Guiera senegalensis and Natron. This study investigated the effect of decoction of G. senegalensis with and without Natron on cardiac markers, lipid profile and histology ofheart in postpartum female albino rats using standard methods.Thirty-five (35)female albino rats of body weights 190-200 g of five month were randomly grouped into seven (7) of five rats each. Group 2, 3 and 4 were orally administered with 100, 200 and 300 mg/kg body weight of G. senegalensis. Group 5, 6 and 7 were orally administered with 100, 200 and 300 mg/kg body weight (1:1) of G. senegalensis and Natron by gavage, whereas group 1 received distilled water. The study revealed significant (p< 0.05) decrease in triglyceride(TG) in group 2 to VII, high density lipoproteincholesterol (HDL-c) in group 2, 5 and 6, very low density lipoprotein- cholesterol (VLDL-c) in group 3 to V, couples with significant (p< 0.05) increase in low density lipoprotein cholesterol (LDL-c) in group 2, 3, 5 and 7, and for (AIX) in group 2, total cholesterol(TC) in group 2, 3 and 7 when compared with control. Significant (p< 0.05) increase in Lactate dehydrogenase (LDH) in group 3 to 7, and Myoglobin (MB) in group 3 was observed. Significant (p< 0.05) decrease in Troponin I (TnI) in group 2 and 4 was seen. There were no significant (p>0.05) changes in Troponin T (Tn T), aspartate amino transferase (AST) and Creatine Kinase(CK-NAC) of the treatment group when compared to control group. Histopathological examination of section of the heart revealed ventricular dilatation, hypertrophied with enlarged nuclei, stretched, and irregular and mural thrombi in group 2 to 4 and 7. Inflammation in group 5 and 7, Pigment deposited in group 4 to 7 and Mild fibrosis in group 3 were observed. The study demonstrates that consumption of G. senegalensis and Natron for 28 days’induces dyslipidemia and causes changes in the heart of postpartum rats and thus may contribute to the pathogenesis of PPCM.

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