Correlational study of interleukin-6 with albuminuria in type 2 diabetes mellitus

Background: Individuals with type 2 diabetes display features of low-grade inﬂammation. Mediators of inﬂammation such as IL-6 have been proposed to be involved in the events causing as well as progression of diabetes. Diabetic nephropathy is one of the commonest causes of chronic kidney failure throughout the world. Although diabetic nephropathy is traditionally considered a non-immune disease, accumulating evidence now indicates that immunologic and inflammatory mechanisms play a significant role in its development and progression.Methods: This cross sectional study was conducted in the department of medicine, UPUMS, Saifai. The study was conducted from June 2018 to February 2019. A total of 80 type 2 diabetes patients were included in the study. After informed consent, patients were recruited. FBS, PPBS, HbA1C, 24 Hrs Urinary protein and interleukin-6 levels were measured. The data was analysed using SPSS 23. Pearson co relation co efficient was determined between IL -6, HbA1c and Urinary protein.Result: A total of 80 type 2 diabetes patients were studied. The study subjects were divided into 3 groups based on the urinary protein level into normo-albuminuria, Micro- albuminuria and macro- albuminuria. FBS, PPBS, HBA1c, 24 Hrs Urinary protein and Interleukin – 6 were significantly associated with proteinuria (p<0.001). Urinary protein was positively correlated with IL-6 (R2=0.57, p<0.01). The blood glucose was positively correlated with IL-6 (R2=0.413, p-0.01).Conclusion: Raised IL-6 levels in diabetics revealed the presence of inflammation. Our study showed positive correlation between IL-6, HBA1c and Urinary protein.

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Association between poor psychosocial conditions and diabetic nephropathy in Japanese type 2 diabetes patients: A cross-sectional study

Journal of Diabetes Investigation ◽

10.1111/jdi.12641 ◽

2017 ◽

Vol 9 (1) ◽

pp. 162-172 ◽

Cited By ~ 2

Author(s):

Hiroyo Ninomiya ◽

Naoto Katakami ◽

Taka-aki Matsuoka ◽

Mitsuyoshi Takahara ◽

Hitoshi Nishizawa ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Nephropathy ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Psychosocial Conditions ◽

Diabetes Patients

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High prevalence of lower extremity peripheral artery disease in type 2 diabetes patients with diabetic nephropathy and the role of netrin-1 levels

Endocrine Abstracts ◽

10.1530/endoabs.49.gp96 ◽

2017 ◽

Author(s):

Ahmet Kor ◽

Suleyman Baldane ◽

Suleyman Hilmi Ipekci ◽

Kamile Marakoglu ◽

Ali Altinok ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Nephropathy ◽

Lower Extremity ◽

Peripheral Artery Disease ◽

Peripheral Artery ◽

High Prevalence ◽

Artery Disease ◽

Diabetes Patients

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DIABETIC FOOT CARE KNOWLEDGE AND ITS ASSOCIATED FACTORS AMONG TYPE 2 DIABETES PATIENTS

International Journal of Research -GRANTHAALAYAH ◽

10.29121/granthaalayah.v9.i8.2021.4159 ◽

2021 ◽

Vol 9 (8) ◽

pp. 59-69

Author(s):

A Gomathi ◽

S. Kamalam ◽

Jeevaanand N

Keyword(s):

Type 2 Diabetes ◽

Associated Factors ◽

Target Organ Damage ◽

Good Practice ◽

Health Centre ◽

Care Practice ◽

Foot Care ◽

Cross Sectional ◽

Diabetes Patients

Background: Diabetes is traditionally known as a “silent disease,” exhibiting no symptoms until it progresses to severe target organ damage. Aims & Objective: The study was conducted to determine the knowledge of foot care ,knowledge regarding foot care practice and its associated factors among type 2 diabetes patients. Material and Methods: A Community based cross-sectional study was conducted at a primary health centre, Pondicherry, 107 subjects were selected by convenience sampling technique. Data was collected from December 2020 to March 2021, among type 2 diabetes who attended the diabetic clinic. A validated pretested questionnaire was used to assess the knowledge of foot care, knowledge regarding foot care practice and its associated factors among type 2 diabetes patients. Data was analysed using SPSS 21. Results: Among 107 diabetes patients 68(75.6%) of them had poor knowledge and only 2 (2.2%) of them had good practice. There was highly significant (p<0.001) relationship between knowledge of foot care and knowledge regarding foot care practice scores. There was highly significant association (p<0.05) between the knowledge of foot care with selected demographic variables of gender, occupation, alcohol consumption, regularity of treatment and source of information. Conclusions: It is a need of the hour to conduct health education programme to create awareness among rural people for better glycaemic control and prevention of ulcer foot in type 2 diabetes mellitus patients.

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