scholarly journals Predictable factors for intervention with heparin free plasmapheresis in impending liver cell failure due to consumption of phosphorus rodenticide

2019 ◽  
Vol 7 (8) ◽  
pp. 3026 ◽  
Author(s):  
Deepa S. Banjan ◽  
Kavita Sane ◽  
Sachchidanand Wattamvar ◽  
Mahesh More
Keyword(s):  
Liver Cell ◽  
Public Hospital ◽  
Liver Enzymes ◽  
Serum Alkaline Phosphatase ◽  
Time Interval ◽  
Liver Transplants ◽  
Significant Drop ◽  
Yellow Phosphorus ◽  
Final Treatment ◽  
Phosphorus Containing

Background: Yellow phosphorus containing rodenticide poisoning are common in Adult critical care. They cause coagulopathy and liver cell failure in humans. Till date, only liver transplants had been advocated as the final treatment of fulminant liver failure occurring as a complication of rodenticide poisoning. In this study, an innovative Treatment approach was given to liver cell failure cases who had consumed yellow phosphorus paste.Methods: Retrospective analysis of case records of liver cell failure cases due to the consumption of phosphorus containing Rodenticide poisonings, were analysed for a period of 1 year from January 2018 to January 2019 in a public hospital. Medical case records were obtained from records department and Postmortem registers. Symptoms, signs, investigations, treatments, complications, and outcomes were tabulated.Results: Total 11 cases were studied. 8 cases of liver cell failure and coagulopathy in whom therapeutic heparin free plasmapheresis was given, recovered completely from liver cell failure. A significant drop in Haemoglobin, platelet count, PT INR Ratio and rise in serum alkaline phosphatase, were the predictable factors used for the intervention of therapy with 5 cycles of heparin free plasmapheresis to eliminate toxic effects of phosphorus on liver cells and in the blood. A comparative analysis of untreated cases (n=3) vs treated with plasmapheresis (n=8), showed a significant statistical difference (P <0.005) in outcomes with a degree of freedom=2.Conclusions: Plasmapheresis can be a therapeutic treatment for liver cell failure caused due to the consumption of yellow phosphorus.  Predictable factors for impending liver cell failure in whom plasmapheresis will be of benefit are dependent upon prothrombin time, INR ratio, Liver enzymes and time interval between consumption and onset of liver cell failure.

Studies of the Toxicological Potential of Tripeptides (L-Valyl-L-prolyl-L-proline and L-lsoleucyl-L-prolyl-L-proline): II. Introduction

2005 ◽  
Vol 24 (4_suppl) ◽  
pp. 5-11 ◽  
Author(s):  
Bruce K. Bernard ◽  
Yasunori Nakamura ◽  
Izuki Bando ◽  
John H. Mennear
Keyword(s):  
Blood Pressure ◽  
Clinical Signs ◽  
Chemical Properties ◽  
Clinical Pathology ◽  
Good Health ◽  
Fermented Milk ◽  
Time Interval ◽  
Significant Drop ◽  
Safety Testing ◽  
Chemical Structures

The consumption of fermented milk to maintain good health, including the maintance of normal blood pressure, is an ancient tradition in a number of areas of the world (e.g., East Asia, France). Recent studies have suggested that fermented milk has a normotensive effect in hypertensive rats and humans, but no effect on blood pressure in normotensive rats and humans. Two tripeptides, L-valyl-L-prolyl-L-proline (VPP) and L-isoleucyl-L-prolyl-L-proline (IPP), have been identified as possessing significant angiotensin-converting enzyme inhibitory activity and are therefore believed to be the source of the normotensive effects. This document, the second of nine chapters, provides information on these two tripeptides, including physical/chemical properties, molecular weights, chemical structures, normal consumption in the diet, manufacturing information, regulatory approval in Japan, and Japanese consumption of food containing enhanced levels of VPP plus IPP. In addition, the results of studies in rats and humans conducted to evaluate the effect of these substances on blood pressure are presented. The research suggests that in adult normotensive volunteers, consumption of up to 7.92 mg of VPP and 4.52 mg IPP daily for 2 weeks causes neither clinical signs nor biologically meaningful effects on systolic or diastolic blood pressure, pulse rate, or clinical pathology (serum chemistry or hematology). However, when a similar study was performed using mildly and moderately hypertensive adults as subjects and they consumed 2.52 mg of VPP and 1.64 mg of IPP per day, a significant drop in systolic blood pressure was detected for a prolonged time interval. This chapter also introduces the issue of safety testing for these substances and describes the information to be found in the subsequent seven chapters.

scholarly journals Effects on Productive Performance, Tibia Calcium and Phosphorous Retention, and Liver Enzymes Activity of Acidified and Alkalinized Diets in Broiler Chicken

2016 ◽  
Vol 16 (3) ◽  
pp. 797-809 ◽  
Author(s):  
Rouhollah Nourmohammadi ◽  
Heshmatollah Khosravinia ◽  
Nazar Afzali ◽  
Milad Manafi
Keyword(s):  
Broiler Chicken ◽  
Liver Enzymes ◽  
Serum Alkaline Phosphatase ◽  
Bone Mineralization ◽  
Control Diet ◽  
Average Daily Gain ◽  
Broiler Chicks ◽  
Productive Performance ◽  
Enzymes Activity ◽  
Tibia Ash

AbstractA 35-day experiment was carried out to study the effects of acidified and alkalinized diets on zootechnical indices, tibial calcium and phosphorous retention, bone mineralization and liver enzymes activity using 250 Ross 308 male broiler chicks. Five treatments consisting of a control diet (CD), CD acidified using 10, 20 and 30 g/kg citric acid (CA) and CD alkalinized with Ca (OH)2 (8.9 g/kg in growth period and 8.6 g/kg in finisher period) were examined in 5 replicates of 10 birds each from day 7 up to day 42 of age. Inclusion of 30 g/kg CA significantly increased body weight, average daily gain (ADG), average daily feed intake (ADFI), feed efficiency, tibia ash, tibia Ca content, at day 42 of age (P<0.05). Serum alkaline phosphatase and lactate dehydrogenase activities were elevated in the birds fed with the 30 g/kg CA-treated diet at day 42 of age (P<0.05). Alkalinized diet significantly reduced ADFI, tibia ash, tibial P and Ca contents, bone breaking strength and plasma Ca concentration (P<0.05). It was concluded that the diet acidified with 30 g/kg CA promoted productive performance and tibia mineralization in broiler chicken. Alkalinized diet suppressed growth performance of the birds perhaps through disrupted mineral absorption and altered liver enzymes activity.

scholarly journals Study on the different type of hydrological input towards the accuracy of catchment discharge hydrograph

2021 ◽  
Vol 920 (1) ◽  
pp. 012042
Author(s):  
N A Safrudin ◽  
M A Wahab ◽  
S M Z Makhtar ◽  
N A Seman ◽  
A N Kamarudzaman ◽  
...  
Keyword(s):  
Measurement Techniques ◽  
Rain Gauge ◽  
Rainfall Data ◽  
Storm Event ◽  
Time Interval ◽  
Storm Events ◽  
Significant Drop ◽  
Storm Water Management Model ◽  
Measurement Tools ◽  
Hydrological System

Abstract For hydrological applications, several rainfall measurement techniques are available, each with its own spatial and temporal resolution and errors. When these rainfall datasets are used as input for hydrological models, errors and uncertainties are propagated throughout the hydrological system. This research paper is using rainfall data from two different measurement tools namely rain gauge and radar. Using these two types of measurement tools, it is expected dissimilar output due to the different working principle. Arau catchment in Perlis were selected as the study area. The rainfall data used is in the unit of intensity with time interval 10 minutes for both instruments. Storm Water Management Model 5 (SWMM5) were used as model to simulate the discharge of catchment area. Sensitivity analysis is carried out in this study to determine the major parameters that influence to shape of hydrograph and peak flow. Then, calibration process using five (5) storm events have been performed using available information such as conduits lengths, shape of conduits, impervious and pervious surface using trial and error process. Good correlation between observed and simulated hydrograph on 18 September 2006 has been found to be the best Correlation coefficient (r) and Root mean square error (RMSE) equal to 0.92 and 0.14 respectively. The same parameter used for that storm event was chosen to be applied in validation event. Validation results also in the acceptable range with r is found more than 50% correlation. Next, using the rainfall data captured by radar that converted using equation Z=40R1.6 developed by researcher [1] for the similar date of storm event and similar catchment conditions, all the hydrograph shape shows significant drop. As a conclusion, different type of measurement tools for rainfall gives significant different to the catchment discharge and can be seen that rain gauge are better to use to simulate rainfall compared to the radar.

scholarly journals The Fractionation of the Phosphorus-containing Proteins of Rat Liver Cell Sap.

1956 ◽  
Vol 10 ◽  
pp. 1045-1045 ◽  
Author(s):  
John Glomset ◽  
Jon Bremer ◽  
Stina Ställberg-Stenhagen ◽  
Einar Stenhagen ◽  
B. Thorell
Keyword(s):  
Rat Liver ◽  
Liver Cell ◽  
Phosphorus Containing

Plasmapheresis in lethal yellow phosphorus poisoning: a scope for recovery

2021 ◽  
Vol 14 (4) ◽  
pp. e239676
Author(s):  
Jithin Mathew ◽  
John Gnanaraj ◽  
Abhishekh Basavarajegowda ◽  
Ramanathan Venkateswaran
Keyword(s):  
Liver Transplantation ◽  
Lethal Dose ◽  
Definitive Treatment ◽  
Dramatic Improvement ◽  
Phosphorus Poisoning ◽  
Yellow Phosphorus ◽  
Phosphorus Containing ◽  
Lethal Yellow ◽  
Grade 3

A 16-year-old girl presented with grade 3 hepatic encephalopathy (HE) following suicide attempt after consuming a lethal dose of yellow phosphorus containing rodenticide. Although she was a candidate for liver transplantation, it could not be done. In the absence of a specific antidote for yellow phosphorus poisoning, the patient was managed conservatively. In addition, low volume-therapeutic plasma exchange (LV-TPE) was initiated, which resulted in a dramatic improvement in HE. Although liver transplantation is the definitive treatment, this case has shown that TPE has a promising role as a ‘bridge to recovery’ in situations where transplantation is not feasible. We describe our experience with the above-mentioned case, along with the sequence of clinical recovery and the trend in biochemical parameters during follow-up. The patient made a full recovery and is doing well.

scholarly journals N-ACETYLCYSTEINE, A BOON FOR YELLOW PHOSPHORUS-INDUCED ACUTE LIVER FAILURE? A CASE REPORT

2019 ◽  
pp. 1-3 ◽  
Author(s):  
AASHIQ AHAMED SHUKKOOR ◽  
NIMMY ELIZABETH GEORGE ◽  
SARAVANAN THANGAVELU
Keyword(s):  
Case Report ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Lethal Dose ◽  
Supportive Therapy ◽  
Phosphorus Poisoning ◽  
Yellow Phosphorus ◽  
Phosphorus Containing ◽  
History Of ◽  
Anti Oxidant

Rat killer, in the form of a paste, is a commonly used rodenticide in India. It contains 3% yellow phosphorus, which is a local and a systemic toxin that damages all tissues it contacts. The lethal dose of yellow phosphorus is about 1 mg/kg of body weight. We present a case report of a 30-year-old female patient with an alleged history of intake of 30 g rat killer paste mixed with one glass juice with suicidal intent. She presented with clinical features of acute liver failure (ALF) and was treated with N-acetylcysteine (NAC) infusion with other supportive therapy and recovered completely within 13 days. Poisoning with yellow phosphorus needs to be studied in the aspect of treatment, due to the lack of any specific antidote. The patient factors that help in the recovery also need to be investigated. Although highly lethal, the recovery of ALF due to yellow phosphorus-containing rodenticide is possible. Early intravenous administration of NAC, which acts as glutathione substitute, anti-inflammatory agent, and anti-oxidant could contribute to complete resolution of ALF in yellow phosphorus poisoning.

scholarly journals Can Serum TGF-BETA 1 Be Used to Evaluate the Response to Antiviral Therapy of Haemophilic Patients with HCV-Related Chronic Hepatitis ?

2008 ◽  
Vol 21 (4) ◽  
pp. 1007-1012 ◽  
Author(s):  
G. Tarantino ◽  
A. Coppola ◽  
P. Conca ◽  
E. Cimino ◽  
G. Di Minno
Keyword(s):  
Chronic Hepatitis ◽  
Liver Enzymes ◽  
Surrogate Marker ◽  
Therapy Response ◽  
Tgf Beta ◽  
Short Term ◽  
Significant Drop ◽  
Congenital Coagulation Disorders ◽  
Baseline Values

Congenital coagulation disorders limit the use of liver biopsy, especially when repeated assessment is needed. TGF-beta 1 plays a pivotal role in inducing fibrosis and has been proposed as its surrogate marker. Aiming at validating the clinical utility of this cytokine, fifteen haemophilic patients suffering from HCV-related chronic hepatitis were treated with Peg-IFN alpha2β plus Ribavirin. Serum TGF-beta 1, viral load and liver enzymes were analyzed at baseline and at six, twelve, and eighteen months. As expected, patients initially showed significantly higher TGF-beta 1 levels than age-matched controls (43.8 ng/mL, 28.7–46.4 vs. 26.9 ng/mL, 23.0–34.0, median and 95% CI; p=0.004). The end of therapy response rate was 67%. The main finding was a significant drop in TGF-beta 1 at six months compared to baseline values; this drop de facto predicted the levels reached in the following six months, which were fixed at lower concentrations (37.0 ng/mL, 21.9–43.8 and 27.0 ng/mL, 24.1–44.0 respectively; p<0.009), independently of treatment outcome (three patients were breakthrough, twelve were sustained virological responders (SVRs). During the treatment period none had clinical or biochemical signs of inflammation in other areas. Treatment was followed by a six-month follow-up, at the end of which TGF-beta 1 was increased compared to the previous values, reaching the initial levels in ten SVRs (45 ng/mL, 24.5–52.9). Interestingly, at a longer follow-up, two out of ten SVRs, who displayed the highest values of TGF-beta 1, relapsed. Serum TGF-beta 1 could be used to assess therapeutic outcome and short-term prognosis of HCV-related chronic hepatitis.

CATHODIC DISBONDING OF INDUSTRIAL CHLORINATED RUBBER-BASED PRIMER USED IN RUBBER/METAL COMPOSITES: AN ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY ANALYSIS

2016 ◽  
Vol 89 (4) ◽  
pp. 712-723 ◽  
Author(s):  
I. Ismail ◽  
M. K. Harun
Keyword(s):  
Electrochemical Impedance Spectroscopy ◽  
Impedance Spectroscopy ◽  
Cathodic Polarization ◽  
Electrochemical Impedance ◽  
Steel Substrate ◽  
Time Interval ◽  
Significant Drop ◽  
Coating Degradation ◽  
Adhesion Failure ◽  
Bode Plots

ABSTRACT Chemlok 205 primer is a common bonding agent used together with a top coat in rubber/metal–bonded composites. Recent studies indicated that a stand-alone Chemlok 205 primer failed when its metal substrate underwent corrosion. The failure was suspected to be caused by coating degradation, followed by cathodic disbonding, induced from the corrosion reaction. Therefore, in this work, the effect of cathodic polarization on the coating delamination was further investigated. The work intends to focus on understanding the adhesion failure processes involved. Thus, electrochemical impedance spectroscopy (EIS) was employed on a stand-alone industrial coating Chemlok 205 primer on mild steel substrate subjected to cathodic polarization potential of −0.8 V versus Ag/AgCl reference electrode in 0.5 M NaCl. The coating barrier properties were interpreted through Nyquist and Bode plots of the EIS plots for a selected time interval. The data obtained were modeled against three distinguished electrical equivalent circuits representing the stages of coating degradation against time. Analysis through Nyquist and Bode plots indicated that the stand-alone Chemlok 205 primer coating experienced a significant drop in coating impedance before experiencing adhesion loss. The changes in the coating capacitance and coating resistance indicated that the coating underwent degradation first before adhesion failure.

Sign in / Sign up

Export Citation Format

Share Document