scholarly journals Effect of phototherapy on serum calcium level in term newborns

2017 ◽  
Vol 4 (6) ◽  
pp. 1975
Author(s):  
Cyril Ignatious Rozario ◽  
Preethi S. Pillai ◽  
Ranamol T.
Keyword(s):  
Birth Weight ◽  
Blood Group ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Neonatal Hyperbilirubinemia ◽  
Preterm Neonates ◽  
P Value ◽  
Term Neonates ◽  
Term Newborns

Background: Hyperbilirubinemia is one of the most prevalent problems in neonates. Jaundice is observed during first week of life in approximately 60% of term neonates and 80 % of preterm neonates. Phototherapy is one of the routine methods for management of hyperbilirubinemia. The aim of this study is to assess the effect of phototherapy on serum calcium level in term newborns with neonatal hyperbilirubinemia who undergo phototherapy and to find out the association between effect of phototherapy on serum calcium level and birth weight, postnatalage, type of feeding and blood group incompatibility.Methods: 100 newborns with neonatal hyperbilirubinemia admitted in newborn nursery were selected for the study. Serum calcium estimation was done before phototherapy. All newborns were subjected to double surface phototherapy. After 48 hours of phototherapy serum calcium was estimated and compared with earlier value.Results: Out of 100 newborns studied 67 babies had a decrease in serum calcium level after 48 hrs of phototherapy. And this reduction in calcium level was found to be statistically significant (p value <0.001). Only 3 babies developed hypocalcemia (serum calcium <7 mg/dl). None of them were symptomatic. There was no significant association between reduction in serum calcium level and birth weight, postnatalage, type of feeding and blood group incompatability.Conclusions: There is signiticant reduction in serum calcium level after phototherapy but risk of hypocalcemia is low in healthy full-term neonates. No significant association was found between reduction in serum calcium level and birth weight, postnatal age,type of feed, and blood group incompatibility.

Phototherapy Induced Hypocalcemia in Neonates with Unconjugated Hyperbilirubinemia

2021 ◽  
Vol 11 (1) ◽  
pp. 4-8
Author(s):  
Amna Khan ◽  
Anila Farhat ◽  
Hamayun Anwar ◽  
Sajid Shamim ◽  
Mujeeb Ur Rehman ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Categorical Variables ◽  
P Value ◽  
Cross Sectional ◽  
Unconjugated Hyperbilirubinemia ◽  
Before And After

Objective: To determine the frequency of hypocalcemia in neonates with unconjugated hyperbilirubinemia receivingphototherapy.Study design and setting: Cross sectional study conducted at neonatal intensive care unit, King Abdullah Teaching Hospital,Mansehra for one year from December 2017 to November 2018.Methodology: Total 213 full term stable neonates of either gender with jaundice were studied in this study. Out of which,143 with unconjugated hyperbilirubinemia were exposed to phototherapy while 70 neonates with exaggerated physiologicalhyperbilirubinemia taken as control were not exposed to phototherapy. Serum calcium level was determined through bloodtest before and after 24 hours of phototherapy. SPSS version 22 was used to analyze the data. Frequency and percentageswere used to describe categorical variables like gender and hypocalcemia. Hypocalcemia was stratified by age and genderto see effect modifiers. Post stratified chi-square test was applied in which p value = 0.05 was considered as significancevalue.Results: In study group, 143 neonates who received phototherapy had mean age of 7 days ± 2.62 SD. Total 65% neonateswere male and 35% neonates were female. Mean serum calcium level of neonates before and after provision of phototherapywas 9.28 mg/dl ± 0.23 and 8.54 mg/dl ± 0.68 respectively, which is statistically significant. The frequency of hypocalcemiawas 40% in neonates with unconjugated hyperbilirubinemia after 24 hours of phototherapy.Conclusion: Hypocalcemia is an important complication in neonates with unconjugated hyperbilirubinemia after continuousphototherapy. Hypocalcemia has clinical impact and adds to morbidity, and if left untreated, can lead to mortality.

scholarly journals Association of Serum Calcium with Acute Myocardial Infarction

2017 ◽  
Vol 8 (1) ◽  
pp. 16-20
Author(s):  
SN Chowdhury ◽  
N Sultana ◽  
AH Chowdhury ◽  
P Mazumder ◽  
N Sharmin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Fasting Blood Glucose ◽  
P Value ◽  
Medical College ◽  
Student’S T

Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide. The incidence of AMI is dependent on certain traditional predisposing risk factors. In addition to the traditional risk factors, raised serum calcium level is also being considered as an associated factor for AMI. The aim of the study is to evaluate the association of serum calcium level with acute myocardial infarction in a tertiary level hospital in Bangladesh. This case control study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from January 2013 to December 2013. In this study, 50 diagnosed cases of AMI and 50 age and sex matched apparently healthy subjects were selected from DMCH purposively according to the selection criteria. Blood pressure, height and weight were measured and BMI was calculated. Biochemical parameters- serum calcium and fasting blood glucose in two groups were estimated in mmol/l. Then serum calcium was compared between two groups to observe the association with AMI. Results were analyzed statistically in SPSS version 17.0. Unpaired student's 't'-test and Spearman correlation analysis was done. All the results were expressed as mean ±SD and p value <0.05 was accepted as level of significance. Present study showed that serum calcium level was significantly higher(p=.001) in cases (2.61±.15 mmol/l) when compared with that of controls (2.13±.15mmol/l). Serum calcium also showed a significant positive correlation with AMI (rho=0.858, p=0.001).Findings of study concludes that increased serum calcium is associated with AMI.Bangladesh J Med Biochem 2015; 8(1): 16-20

scholarly journals Comparative Evaluation of Serum Calcium and Magnesium Level in Preeclamptic and NonPreeclamptic Women in a Tertiary Hospital in Southern Nigeria

2018 ◽  
Vol 14 (12) ◽  
pp. 437
Author(s):  
Allagoa DO. ◽  
Agbo OJ. ◽  
Orluwene CG.
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Serum Magnesium ◽  
Serum Levels ◽  
Tertiary Hospital ◽  
Magnesium Level ◽  
P Value ◽  
Serum Magnesium Level ◽  
Calcium And Magnesium

Background: Calcium and magnesium are two micronutrients whose role in the development of preeclampsia has been investigated over the years. There is paucity of studies on the role of serum levels of calcium and magnesium in the development of preeclampsia in south-south Nigeria. Objective: Our study evaluated the serum level of calcium and magnesium in preeclamptic and non preeclamptic women in a Tertiary Hospital in southsouth Nigeria. Methodology: We carried out a comparative study in which 52 preeclamptic and 52 non preeclamptic women, who satisfied the eligibility criteria, were enrolled for the study. Data entry and statistical analysis was done using statistical software (IBM SPSS® for windows version 21.0). Data were analyzed for mean and standard deviation. Comparison of serum levels of elements between the two groups was performed by student t-test, and P value < 0.05 was considered as statistically significant. Results: The serum calcium level was statistically lower in the women who developed preeclampsia compared to those who did not (8.37±0.91 mg/dl vs 9.33±1.15mg/dl, p<0.001). The serum magnesium level was not statistically different between women who had preeclampsia and those who did not (1.79±0.24mg/dl vs 1.88±0.37mg/dl, p = 0.102). The systolic and diastolic blood pressure showed a significant negative correlation with serum calcium level, unlike serum magnesiun level in those that had preeclampsia. Conclusion: This study showed that women who developed preeclampsia demonstrated reduced serum calcium level and no reduction in serum magnesium level. This study support the hypothesis that hypocalcaemia, unlike hypomagnecaemia, is a possible aetiology of preeclampsia.

scholarly journals A study on effect of phototherapy in term new-born in a tertiary care centre in south Rajasthan

2021 ◽  
Vol 9 (1) ◽  
pp. 94
Author(s):  
Neetu Beniwal ◽  
Nishant Dangi ◽  
Anuradha Sanadhya ◽  
Mohammed Asif
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Prospective Observational Study ◽  
Tertiary Care ◽  
Loose Stool ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Term Neonates ◽  
Medical College

Background: Phototherapy is a safe and effective method for management of neonatal hyperbilirubinemia with no serious untoward side effects. Hypocalcemia is a common and lesser observed adverse effect of phototherapy.Methods: This study was a prospective observational study done in department of pediatrics, RNT Medical College, Udaipur (Rajasthan). Serum calcium level was observed in term neonates admitted for phototherapy.Results: Out of total 80 neonates included in study 40 received phototherapy and 40 were control. Neonates receiving phototherapy had significantly lower level of serum calcium. Other complication were rashes, loose stool, fever and dehydration.Conclusions: We can conclude from this study that hypocalcemia is a significant complication of phototherapy in newborn and probably monitoring of serum calcium level in babies under phototherapy is warranted.

Phototherapy Induced Hypocalcemia in Neonates with Unconjugated Hyperbilirubinemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Amna Khan ◽  
Anila Farhat ◽  
Hamayun Anwar ◽  
Sajid Shamim ◽  
Mujeeb Ur Rehman ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Categorical Variables ◽  
P Value ◽  
Cross Sectional ◽  
Unconjugated Hyperbilirubinemia ◽  
Before And After

Objective: To determine the frequency of hypocalcemia in neonates with unconjugated hyperbilirubinemia receivingphototherapy.Study design and setting: Cross sectional study conducted at neonatal intensive care unit, King Abdullah Teaching Hospital,Mansehra for one year from December 2017 to November 2018.Methodology: Total 213 full term stable neonates of either gender with jaundice were studied in this study. Out of which,143 with unconjugated hyperbilirubinemia were exposed to phototherapy while 70 neonates with exaggerated physiologicalhyperbilirubinemia taken as control were not exposed to phototherapy. Serum calcium level was determined through bloodtest before and after 24 hours of phototherapy. SPSS version 22 was used to analyze the data. Frequency and percentageswere used to describe categorical variables like gender and hypocalcemia. Hypocalcemia was stratified by age and genderto see effect modifiers. Post stratified chi-square test was applied in which p value = 0.05 was considered as significancevalue.Results: In study group, 143 neonates who received phototherapy had mean age of 7 days ± 2.62 SD. Total 65% neonateswere male and 35% neonates were female. Mean serum calcium level of neonates before and after provision of phototherapywas 9.28 mg/dl ± 0.23 and 8.54 mg/dl ± 0.68 respectively, which is statistically significant. The frequency of hypocalcemiawas 40% in neonates with unconjugated hyperbilirubinemia after 24 hours of phototherapy.Conclusion: Hypocalcemia is an important complication in neonates with unconjugated hyperbilirubinemia after continuousphototherapy. Hypocalcemia has clinical impact and adds to morbidity, and if left untreated, can lead to mortality.

scholarly journals Level of Serum Calcium in Psoriatic Patients

2016 ◽  
Vol 5 (2) ◽  
pp. 29-32
Author(s):  
Masuda Khatun ◽  
Mollah Md Abu Sayed ◽  
MD Shah Alam ◽  
Farida Yeasmin ◽  
Lubna Khondker
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
College Hospital ◽  
Medical College ◽  
Control Subjects ◽  
The Mean

Various forms of skin disease like psoriasis have been found to show disturbances in systemic calcium metabolism in some cases. Calcium is the major regulator of keratinocytes differentiation. The main objective of this study was to find out the serum calcium level of patients with psoriasis in comparison with control subjects without psoriasis. The present study was a case control study from July 2015 to June 2016. Consecutive type of sampling method was followed in this study. The case group was consisting of 30 psoriatic patients and the control group was consisting of 30 non psoriatic patients attended in Skin and VD department of Dhaka Medical College Hospital (DMCH) and Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. The mean age of the psoriatic group was 35.57±7.75 years (minimum 22 years and maximum 50 years), while it was 35.17±7.32 years (minimum 23 years and maximum 48 years) in the control group. The mean serum calcium level in psoriatic patients was 8.84±0.95 mg/dl (minimum 7.2mg/dl and maximum 10.2 mg/dl) while in controls it was 9.49±0.90 mg/dl (minimum 7.7 mg/dl and maximum 10.9 mg/dl). Statistical difference was observed between case and control participants with p-value <0.05. Hypocalcemia was observed in 33.33% psoriatic patients as compared 10% in controls (P value <0.05). In conclusion, serum calcium levels were lower in psoriatic patients than in control subjects. It is better to include dairy foods as calcium resource in daily diet of patients suffering from psoriasis. CBMJ 2016 July: Vol. 05 No. 02 P: 29-32

scholarly journals The effect of phototherapy on serum calcium level in neonates with hyperbilirubinemia: a cross sectional study

2020 ◽  
Vol 7 (8) ◽  
pp. 1772
Author(s):  
Anjali Vasant Kale ◽  
Pranoti Uttam Jadhao ◽  
Aashna Valecha ◽  
Sreelekha Kethepalli
Keyword(s):  
Standard Deviation ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Cross Sectional Study ◽  
Water Soluble ◽  
Neonatal Hyperbilirubinemia ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Before And After

Background: Neonatal Hyperbilirubinemia is one of the leading causes for admission in NICU in the first week of life. This condition if left untreated may lead to irreversible neurological damage hence increasing mortality and morbidity in newborns. Neonatal Hyperbilirubinemia is treated with phototherapy which employs blue wavelengths of light to change unconjugated bilirubin in the skin. The bilirubin is then converted to less toxic water-soluble photo-isomers that are excreted in the bile and urine. There are several toxic effects to the use of this treatment, one of them being hypocalcemia.Methods: This study has been done at Mahatma Gandhi Institute of Medical Sciences in 2016-2018 on 100 new-borns to prove the effect of phototherapy on serum calcium levels in neonates with hyperbilirubinemia. New-born who were admitted in NICU for Hyperbilirubinemia were screened according to inclusion and exclusion criteria, their sample for serum calcium and serum bilirubin levels were taken as pre and post phototherapy samples.Results: It was observed that the mean Serum calcium level before phototherapy in neonates was 9.31 mg/dl with standard deviation of 0.69 mg/dl. Whereas after phototherapy mean serum calcium level in neonates was 8.88 mg/dl with standard deviation of 0.73 mg/dl. There was statistically significant mean difference in serum calcium level at before and after phototherapy in neonates (p<0.0001).Conclusions: This study proves the hypothesis that phototherapy can cause hypocalcemia in neonates with hyperbilirubinemia.

scholarly journals ACUTE ISCHEMIC STROKE

2018 ◽  
Vol 25 (02) ◽  
pp. 297-301
Author(s):  
Lal Badshah ◽  
Asim Khan ◽  
Shahida Malik
Keyword(s):  
Ischemic Stroke ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Case Series ◽  
Sampling Technique ◽  
Medical Ward ◽  
P Value ◽  
Male Patients ◽  
One Year

Objectives: Objective of this study is to assess the correlation between severityof ischemic stroke on NIHSS and calcium level in patients presented with acute ischemic stroke.Study Design: Descriptive case series and non-probability purposive sampling technique wasused in this study. Setting: South Medical ward& East Medical Ward, Department of Medicine,Mayo hospital, Lahore. Period: One year from 5th January 2015 to 4th January 2016. Material &Methods: Informed consent was taken from all the patients. Patients of both genders between35-70 years of age were included in this study. Demographic record (name, age, sex, contact)were also obtained. Then patients were admitted in ward and were followed up there. Meanwhileno calcium supplement was advised. Then after 72 hours of admission, blood sample weredrawn by using 5cc BD syringe and were sent to the laboratory of the hospital to assess serumcalcium level. NIHSS score after 72 hours of admission were assessed and noted. Pearsoncorrelation coefficient was calculated to measure the correlation between calcium level andNIHSS score. P-value≤0.05 were considered as significant. Results: In this present studythe mean age of the patients was noted as 51.47±9.653 years, the male patients were 76%whereas female patients were 24%. The mean serum calcium level after 72 hours of the patientswas noted as 7.26±1.41 mg/dl, while the man NIHSS was noted as 23.01±10.38.There wasnegative and Significant correlation was found between the serum calcium level (mg/dl) after72 hours and NIHSS after 72 hours of the patients i.e. r=-0.899 (P<0.05). Conclusion: Ourstudy results showed the negative correlation between the serum calcium level and NIHSS ofischemic stroke patients which showed that more decrease in calcium level will lead to moresevere condition of stroke.

Effects of Phototherapy on Hyperbilirubinemia and Serum Calcium Level in Neonates Admitted in a Tertiary Care Hospital

2020 ◽  
Vol 33 (1) ◽  
pp. 5-10
Author(s):  
Shahida Yeasmin ◽  
Md Shahidul Islam Tarafder ◽  
Md Rustam Ali ◽  
KM Saiful Islam ◽  
Md Sanaul Haque ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Serum Bilirubin ◽  
Neonatal Hyperbilirubinemia ◽  
Total Serum Bilirubin ◽  
Total Serum ◽  
Care Hospital ◽  
Increased Risk ◽  
Significant Difference

Background: Jaundice is most common problem in neonatal period. It is commonly managed by phototherapy. However, phototherapy may cause hypocalcaemia and create serious complications like convulsion. So, neonatal hyperbilirubinemia associated with hypocalcaemia has increased risk of neurotoxicity. Objective: To determine the effects of conventional single surface phototherapy on serum calcium and serum bilirubin in neonatal hyperbilirubinemia. Methodology: This longitudinal type of descriptive study was conducted in the neonatal unit of Rajshahi Medical College Hospital during January 2016 to December 2017. One hundred forty neonates both term and preterm with jaundice were included into this study. Conjugated hyperbilirubinemia, blood group, Rh incompatibilities, jaundice on 1stday, very LBW babies and very sick neonates were excluded from this study. All neonates were under conventional single surface phototherapy. Total calcium, direct and indirect serum bilirubin were estimated before starting phototherapy and serum calcium level and total bilirubin estimated every 24 hours interval . Results were analyzed statistically by paired student t’ test and z’ test. Results: Total serum bilirubin and calcium level fall significantly and among all groups after phototherapy. Mean SD of serum bilirubin 17.14±4.20 mg/dl before phototherapy and 13.37±3.80 mg/dl after receiving (p <0.001). Mean SD of serum calcium level significantly decreased from baseline value of 9.45±10 mg/dl and 9.24±1.24 mg/dl after phototherapy. Analysis of complications revealed 19(13.6 %) developed hypocalcaemia and has significant difference between serum calcium level before and after phototherapy (p<0.04). Conclusion: Total serum bilirubin and calcium level was reduced by single conventional phototherapy. Phototherapy causes hypocalcaemia in neonate but phototherapy associated hypocalcaemia causing convulsion was not noted. TAJ 2020; 33(1): 5-10

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