scholarly journals Clinico-epidemiological profile of hepatitis A virus and hepatitis E virus co-infection in pediatric age group: a hospital based retrospective study

2019 ◽  
Vol 6 (2) ◽  
pp. 588 ◽  
Author(s):  
Shikha Handa ◽  
Sanober Wasim ◽  
B. P. Kalra ◽  
Anil Rawat ◽  
Vipan Chandar ◽  
...  
Keyword(s):  
Developing Countries ◽  
Retrospective Study ◽  
Hepatitis E Virus ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Tertiary Care ◽  
Hepatitis E ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group

Background: Hepatitis-A virus (HAV) and Hepatitis E virus (HEV) are two major hepatotropic viruses of great public health importance in the developing countries like India. Both HAV and HEV are enterically transmitted and there are speculations that their co-infection might be associated with a more severe clinical course and increased rate of mortality. The objective of this study is to determine the prevalence, clinical features and biochemical parameters of Hepatitis A and Hepatitis E co-infection in hospitalized patients at a tertiary care centre in Uttarakhand.Methods: It is a retrospective study, covering a period of 4years and conducted in Himalayan Institute of Medical Sciences, SRHU Jolly Grant, Dehradun. Records of the patients with Hepatitis A and Hepatitis E co-infection were retrieved and analyzed.Results: Out of total 125 patients of acute viral hepatitis, 13 patients had HAV and HEV co-infection. 100% of the patients with co-infection presented with complaints of fever and jaundice, followed by 76.92% with vomiting, 69.23% with pruritis, 61.53% with pain in abdomen and 23.07% with altered sensorium. Mean Bilirubin, ALT, AST were 8.69±7.27 mg/dl, 2030.69±1726.93IU/L and 1880.07±1881.11IU/L respectively. Average duration of stay was 8.2 days. Encephalopathy was seen in 2 patients. However, no mortality was reported.Conclusions: Co-infection of HAV and HEV is not rare in pediatric age group. Knowledge about this will be of immense help for planning of future vaccination strategies and for better sanitation program in developing countries like India.

Asymptomatic Viral Hepatitis Types A and B in an Adolescent Population

PEDIATRICS ◽  
1978 ◽  
Vol 62 (6) ◽  
pp. 1026-1030
Author(s):  
Edward Tabor ◽  
Richard Jones ◽  
Robert J. Gerety ◽  
Jacques A. Drucker ◽  
A. R. Colon
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Pediatric Population ◽  
Age Group ◽  
Pediatric Age ◽  
Adolescent Population ◽  
Pediatric Age Group ◽  
B Virus ◽  
History Of ◽  
Patient Use

Sera from 95 adolescents were examined for markers of hepatitis B virus (HBV) infection and hepatitis A virus (HAV) infection. HBV markers were found in eight adolescents (8%) and evidence of previous HAV infection was found in 18 adolescetits (19%); none had a history of clinically recognizable hepatitis. These findings support the growing evidence that HBV and HAV infections are diseases of the pediatric age group, amid that testing of HBV vaccines when they become available for patient use will have to include a pediatric population.

scholarly journals Prevalence of hepatitis A virus and hepatitis E virus in the patients presenting with acute viral hepatitis in Rohtak, Haryana, India

2019 ◽  
Vol 7 (5) ◽  
pp. 1792 ◽  
Author(s):  
Sarita Rawat ◽  
P. S. Gill ◽  
Tanuj Gupta ◽  
Praveen Malhotra ◽  
Aparna Parmar
Keyword(s):  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Hepatitis E Virus ◽  
Hepatitis A ◽  
Acute Viral Hepatitis ◽  
Hepatitis A Virus ◽  
Hepatitis E ◽  
Interquartile Range ◽  
Seroprevalence Rate ◽  
Age Group

Background: Hepatitis A virus (HAV) and hepatitis E virus (HEV) cause acute hepatitis in humans and are transmitted mainly through the fecal-oral route. They pose major health problems in developing countries. This study was done to determine prevalence of HAV and HEV in patients presenting with AVH and the co-infection of HAV and HEV in these patients.Methods: The study was conducted in the virology research and diagnostic laboratory, PGIMS Rohtak during the study period of August 2017-December 2018. The study population included sera of individuals from all age group who were suspected of acute viral hepatitis (AVH). All the sera were screened for IgM antibody to HEV and HAV using IgM capture ELISA.Results: HEV IgM ELISA test   was performed in 307 patients (mean age 34 years;), with an overall seroprevalence rate of 138(44.9%). HAV antibodies were detected in 109 subjects, with a median age of 9.5 years the seroprevalence of HAV was 34 (31.1%). HEV seropositivity was highest in the age group 20-30 years. Mean age was 34 years whereas the interquartile range was from 14-71 years. HAV infection was positive mainly in the age group <10 years. With interquartile range from 6-16 years. Out of total 34 patients positive for HAV infection males were 20 (58.8%), whereas females were 14(41.1%). HEV IgM was positive in 138 patients, out of which male were 96 (69.56%) and females were 42 (30.43%). HEV IgM was positive in 138 patients, out of which male were 96 (69.56%) and females were 42 (30.43%). HAV and HEV seen to be prevalent all with highest predominance seen towards the end of monsoons (August and September) and beginning of winters.Conclusions: The present study also points toward HEV being the prime etiological agent for outbreaks of acute hepatitis in the studied region of Haryana (Rohtak), India. A comparatively lower HAV prevalence may be the consequence of an overall declining trend due to improved living standards and environmental hygiene.

scholarly journals Frequency of Hepatitis A & E Infections in Adult Patients of Acute Hepatitis

Esculapio ◽  
2020 ◽  
Vol 16 (03, july 2020-Septmber 2020) ◽  
Author(s):  
Rukhsana Gulzar ◽  
Rehma Dar ◽  
Qurat ul Ain ◽  
Humair Ahmad ◽  
Syed Saqib Ali ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Tertiary Care ◽  
Hepatitis E ◽  
Adult Patients ◽  
Care Hospital ◽  
Antibody Testing ◽  
The Mean

Objective: To study the frequency of Hepatitis A Virus and Hepatitis E Virus infections in adult patients of acute hepatitis in a Tertiary Care Hospital in Lahore. Methods: All samples received from medical units (indoor and outdoor) of Mayo hospital Lahore from 26 Feb.2019 to 26.Sept.2019, for Hepatitis A & E IgM antibody testing by ELISA were included in the study. The results and other relevant information were recorded on proforma. Results: Out of 690 study subjects, 62% were male and 38% were female. The mean age ± SD was 33.8 + 7.4years. The percentage of HAV or HEV infected cases was 59%,and 41% were not infected with HAV or HEV. The frequency and percentage of Hepatitis AVirus was 62(15%),whereas the frequency and percentage of HEV was 327(80%) and that of co-infection with HAV and HEV was 21(5%). The mean + SD age of Hepatitis AVirus was 35.2 + 5.0,whereas the mean + SD age of Hepatitis E Virus and co-infection with Hepatitis A and Hepatitis E Virus were 31.45 + 2.3 and 22.6 + 6.3 years, respectively. Conclusion: Hepatitis E Virus is the commonest cause of acute hepatitis in our study,followed by hepatitis A Virus and coinfection of HAV and HEV. Key words: Frequency, Hepatitis A infection, Hepatitis E infection, Co- infection Hepatitis A & Hepatitis E.

scholarly journals Study of acute viral hepatitis with special reference to fulminant hepatic failure

2018 ◽  
Vol 5 (4) ◽  
pp. 1533
Author(s):  
Rajesh N. Pankhaniya ◽  
Yogesh N. Parikh ◽  
Dhanya Soodhana Mohan
Keyword(s):  
Hepatic Encephalopathy ◽  
Viral Hepatitis ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Hepatitis E Virus ◽  
Hepatitis A ◽  
Acute Viral Hepatitis ◽  
Hepatitis A Virus ◽  
Hepatitis E ◽  
Age Group

Background: Fulminant hepatic failure is a complication of viral hepatitis and is one of the leading causes of death in hospitalized children with viral hepatitis in India.Methods: All the patients suspected to have acute viral hepatitis and/or fulminant hepatic failures with hepatic encephalopathies were included in the study and the diagnosis was made on the basis of history, clinical examination including a detailed neurological examination. Triage scoring, Glasgow coma scale, encephalopathy grading were recorded at the time of admission and necessary investigations were carried out.Results: The occurrence of acute viral hepatitis and fulminant hepatic failure was 200 (2.004%) and 40 (0.401%) respectively during study period. Highest occurrence of 35.50% in the age group of 4-6 years, yellowish discoloration of the eyes or the urine was the most common presenting complaint. Only 45 % of the children who had fulminant hepatic failure survived and mortality was found to be 100% in those children who had grade 4 hepatic encephalopathy. Mortality was higher in those children who had duration of more than 10 days between the onset of jaundice and encephalopathy. Mortality was higher in those with prothrombin time between 41 to 50 seconds and with serum ammonia level more than 200 mmol/l.  Hepatitis A virus was the most common cause of fulminant hepatic failure and Hepatitis E virus with hepatic encephalopathy was associated with 100 % mortality.Conclusions: Hepatitis A infection though associated with a good prognosis, younger age group (< 6 years) and co infection with Hepatitis E virus have a poor prognosis. Good hygiene practices and early immunization could be a step towards the prevention of Hepatitis A infection.

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