scholarly journals Cord lipid profile comparison of newborns of hypertensive mothers

2020 ◽  
Vol 7 (5) ◽  
pp. 1038
Author(s):  
Kanwalpreet Kaur ◽  
Karuna Thapar ◽  
Preeti Malhotra

Background: To compare the cord blood lipid profile of 100 newborn babies born to hypertensive (Group A) and normotensive mothers (Group B).Methods: Total 100 newborns were taken, 50 born to hypertensive mothers and 50 to normotensive mothers. 5ml umbilical venous blood was collected, after clamping the cord, from placental side of the cord and sent to laboratory for centrifugation. Serum was analysed for lipid profile by spectrophotometry by siemens dimensional Rxl- Total Cholesterol, Triglycerides, High density lipoprotein and Low density lipoprotein and Very low density lipoprotein. Comparison of the cord blood lipid levels in both the groups was done.Results: Cord blood lipid profile was deranged in newborns of hypertensive mothers with Cord TC, TG and LDL being statistically significantly higher than the mean reference value and 95th centile. Cord blood of term newborns of hypertensive mothers had Cord TC TG and LDL being statistically higher whereas only Cord TC being statistically higher in preterm neonates of hypertensive mothers.Conclusions: Cord blood lipid levels were significantly deranged in newborns of hypertensive mothers. This helps us in providing the target population at risk and cord blood lipid profile of newborn serving as an indirect guide for lifestyle modifications and helping in early intervention and prevention of future coronary heart disease.

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0250573
Author(s):  
Huiping Gao ◽  
Haiying Wang ◽  
Guangliang Shan ◽  
Rui Liu ◽  
Haiyuan Chen ◽  
...  

Objective Dyslipidemia is a leading risk factor for cardiovascular and cerebrovascular diseases. By collecting the blood lipid profiles among adult residents of Shenmu City in Shaanxi Province, China, we aim to assess and elucidate the prevalence and risk factors of dyslipidemia in this city. Method Stratified multistage sampling was used to survey 4,598 permanent adult residents in five areas of Shenmu (2 communities in the county seat, 2 in the southern area and 2 in the northern area) from September 2019 to December 2019. Questionnaire surveys and physical examinations were conducted. Data were analyzed using SPSS software version 26.0. Results The average level of total cholesterol (TC) is 4.47mmol/L, that of triglyceride (TG) 1.32mmol/L, high-density lipoprotein cholesterol (HDL-C) 1.27mmol/L, apolipoprotein A1 (ApoA1) 1.44g/L, low-density lipoprotein cholesterol (LDL-C) 2.7mmol/L and apolipoprotein B (ApoB) 0.97g/L. The prevalence of hypercholesterolemia (HTC), hypertriglyceridemia (HTG), low high-density lipoprotein (HDL-C) and high low-density lipoprotein (LDL-C) is 22.4%, 33.3%, 14.5%, and 5.81%, respectively, and the overall prevalence of dyslipidemia is 48.27%. Furthermore, blood lipid levels and prevalence of dyslipidemia vary by region, age, gender, occupation and educational level. Nine risk factors of dyslipidemia were identified, which are living in county seat or northern industrial area, increasing age, male, overweight or obesity, abdominal obesity, smoking, hypertension, abnormal glucose metabolism (pre-diabetes or diabetes) and hyperuricemia. Conclusion The blood lipid levels and dyslipidemia prevalence of adults in Shenmu City are higher comparing to national averages of China. Combining risk factors of dyslipidemia, early detection and public health interventions are necessary in high-risk population for associated cardiovascular and cerebrovascular diseases prevention.


2017 ◽  
Vol 6 (1) ◽  
pp. 119-125
Author(s):  
Charlie Slowey

Abstract Context: There are numerous studies on the effects of smoking and antiretroviral use separately on a HIV patient’s blood lipid profile, however there has never been a study conducted that measures the intensity of cigarette use combined with antiretroviral therapy on a patient’s blood lipid profile. Aims: To assess the effects of the intensity of cigarette usage and antiretroviral therapy on a patient’s blood lipid profile. Setting and Design: This cross-sectional study was carried out in a regional HIV clinic in Cork University Hospital between June 2016 and August 2016. Methods: 40 patients were interviewed in order to gather cigarette usage data and patient files were reviewed in order to gather blood lipid profile results and antiretroviral therapy data. Results: There was no statistically significant difference (P>0.05) in the means of cholesterol (4.99 vs 5.47), high-density lipoprotein (1.22 vs 1.07), low-density lipoprotein (3.13 vs 3.03), nor triglycerides (1.54 vs 2.45) in smokers versus non-smokers. Low-density lipoprotein in mild and moderate smokers was increased compared to non-smokers. Conclusions: These results show that smoking combined with nucleoside reverse transcriptase inhibitor use has no significant change in blood lipid measurements when compared to controls.


2020 ◽  
Vol 30 (3) ◽  
Author(s):  
Asadollah Kermani ◽  
Kokab Namakin ◽  
Gholam Reza Sharifzadeh ◽  
Gholam Reza Faal

Background: Coronary heart diseases (CAD) and their risk factors are among the major causes of death in Iran. Since these risk factors begin to develop early in life, it is vital to diagnose those newborns at high risk of CAD. Objectives: The present study investigated the umbilical cord blood lipid profile of term and preterm neonates. Methods: In this cross-sectional study, the lipid profiles of 292 neonates, of which 276 were term and 16 preterm, were examined at a teaching hospital. Results: The lipid profile results of total cholesterol, triglycerides, high density lipoprotein, and low density lipoprotein were 69.8, 34.9, 23.6, and 31.5 in term neonates and 80.5, 25.5, 25.1, and 38 in preterm neonates, respectively. Conclusions: According to the current paper, the lipid profiles of eastern Iranian neonates were similar to those reported in global studies. Moreover, except for triglycerides in the female neonates, lipid profiles were significantly higher among the male neonates.


2019 ◽  
Vol 6 (6) ◽  
pp. 2273 ◽  
Author(s):  
Pooja Pradeep ◽  
Arunkumar T. ◽  
Sundari S.

Background: The fetal-origin hypothesis and fetal programming emphasize the profound and sustained impact of factors related to fetal health on the development of chronic disease in adulthood. Several studies suggested that low birth weight and preterm birth linked to abnormalities in cord lipid profile and higher prevalence of atherosclerotic cardiovascular disease. Authors objectives was to estimate and compare cord lipid profile in term, pre-term, and post-term neonates.Methods: In the study group, there were 200 healthy Polish newborns. Newborn characteristics included sex, gestational age at birth, Apgar score, and anthropometric data (weight and length at birth, neonatal ponderal index, head, chest and abdominal circumferences, placental weight, and placental-fetal weight ratio). Cord blood samples were collected for total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG). Information regarding selected maternal factors was collected. Neonates were classified into preterm (<37 weeks) and term (≥37 weeks) based on new Ballard scoring.Results: The preterm had higher Total cholesterol compared to Term and post term and it was Statistically Significant with a p value of < 0.001. The preterm had higher Triglycerides compared to term and post term and it was statistically significant with a p value of <0.01. The preterm had higher HDL compared to Term and post term and it was statistically significant with a p value of <0.001. The preterm had higher LDL compared to Term and post term it was statistically significant with a p value of <0.001. The preterm had higher VLDL compared to Term and post term and it was statistically significant with a p value of <0.01.Conclusions: Abnormal intrauterine milieu created by maternal changes during gestation may bear a profound impact on lipid metabolism in neonates, which may account for their differences in lipid profile and anthropometry at birth.


2021 ◽  
Vol 12 (6) ◽  
pp. 8184-8194

Imperata cylindrica is a well-known species of perennial rhizomatous grass native to tropical South East Asia, which possesses extensive medicinal value. It has major constituents such as saponin, flavonoid, phenols, and glycosides, efficacious as an anti-hyperlipidemia. Studies of pharmacological activities of I. cylindrica, a nutritious, medicinal herb, showed that it could cause blood lipid levels to be reduced. This systematic review article was designed to determine the existing studies related to the efficacy of I. cylindrica to lower blood lipid levels. PubMed and Scopus databases were used to search for suitable keywords such as Imperata cylindrica, cogongrass, hypolipidemic, triglyceride, cholesterol, low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL). Based on provided protocol, in this systematic review, we extracted the data and evaluated the quality of articles by two reviewers. (4) Results 73 articles were the search results and based on the inclusions and exclusions criteria, 8 articles were included in the final review. These studies demonstrated that two active compounds of I. cylindrica: flavonoids and saponins, were beneficial to reduce blood lipid levels. However, further clinical studies are urgently required to provide adequate evidence on the use application of I. cylindrica in medicinal properties.


2013 ◽  
Vol 12 (5) ◽  
pp. 29-33
Author(s):  
S. A. Matveeva

Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology. 


2014 ◽  
Vol 43 (1) ◽  
pp. 21-24 ◽  
Author(s):  
GB Das ◽  
ME Hossain ◽  
MA Akbar

This study was conducted with 180 female Swiss albino mice to examine the effects of supplementing broiler fat in the diets of mice on blood lipid profile. Twenty one days old mice were collected from ICDDRB, Mohakhali, Dhaka. They were randomly distributed in four groups having three replications each. Each replicate group had 15 mice. Results revealed that supplementation of broiler fat in mice diet significantly changed (p<0.05) triglyceride (TG) and low density lipoprotein (LDL) among groups. The control group (T0) had the highest level of cholesterol and LDL. Cholesterol, TG and LDL markedly increased (p<0.05) in all dietary treatment groups, while high density lipoprotein (HDL) significantly (p<0.01) decreased after supplementation of experimental diets. It was concluded that all the dietary treatments in general increased blood cholesterol, TG and LDL in mice fed broiler fat with different oil supplements. However, the soybean and palm oil group was comparatively better than other groups in respect of cholesterol, HDL and LDL at the blood lipid profile of mice. Therefore, it can be concluded that consumption of broiler fat with soybean and palm oil could be less harmful for mice.DOI: http://dx.doi.org/10.3329/bjas.v43i1.19380 Bang. J. Anim. Sci. 2014. 43 (1): 21-24


2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Rosa Maria Dias ◽  
Jose Luiz Fernandes Vieira ◽  
Bianca da Conceição Cabral ◽  
Isameriliam Rosaulem Pereira da Silva ◽  
Laelia Maria Barra Feio Brasil ◽  
...  

Background. Changes in lipid profile are commonly reported in adult patients with malaria. However, a few studies evaluated lipid abnormalities in children continuously exposed toP. vivax.Objective. To evaluate lipid abnormalities in children withP. vivaxinfection and to assess if parasite count or the history of malaria correlates with lipid levels at admission.Methods. A total of 75 children were included in the study, from which 43 were slide confirmed infection byP. vivax. Serial blood samples were collected at admission and, on days 7 and 14, evaluated for the colorimetric measurements of triglycerides, very low-density lipoprotein (VLDL), total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL).Results. The levels of total cholesterol, LDL, and HDL were significantly lower in malaria cases. The levels of VLDL and triglycerides were significantly higher in children with malaria. Such changes were transient and were not associated with parasite counting as well as with the history of malaria of patients.Conclusion. There are significant lipid abnormalities in children with low level ofP. vivaxinfection and mild signs and symptoms of the disease, which are not associated with parasitaemia and previous episodes of disease.


2016 ◽  
Vol 18 (1) ◽  
pp. 22 ◽  
Author(s):  
Nurul Frasiska ◽  
Edjeng Suprijatna ◽  
Siti Susanti

This study was aimed to evaluate the effect of diet containing waste of seaweed Gracilaria sp. on local duck blood lipid profiles including cholesterol, triglycerides, low density lipoprotein (LDL), and high density lipoprotein (HDL). The material in this study were  72 female Tegal ducks aged 22 weeks with 1,318 ± 121 gaverage body weight, diets containing Gracilaria sp. waste (GW) with 18% protein and 2900 kcal/kg metabolic energy and 150 g/ton feed commercial multi-enzyme (ME).  Data were subject to Completely Randomized Design with 6 treatments, (T0) Basal Diets, (T0+) Basal Diets with ME, (T1) Diets with 10% GW, (T1+) Diets with 10% GW + ME, (T2+) Diets with 12.5 % GW + ME, and (T3+) Diets with 15% GW + ME. The treatment was givenfor 12 weeks and blood sample was taken onthe last week. The serum was separated and analyzed for blood lipid profiles using CHOD-PAP. Results showed that diet with 12.5%GW  plus multi-enzyme additives significantly (P<0.05) affected blood lipid profiles of local duck, tended to lower triglycerides and LDL Cholesterol, but increase blood HDL levels.


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