scholarly journals Comparative study of cord blood lipid profile in preterm and post term neonates

2019 ◽  
Vol 6 (6) ◽  
pp. 2273 ◽  
Author(s):  
Pooja Pradeep ◽  
Arunkumar T. ◽  
Sundari S.

Background: The fetal-origin hypothesis and fetal programming emphasize the profound and sustained impact of factors related to fetal health on the development of chronic disease in adulthood. Several studies suggested that low birth weight and preterm birth linked to abnormalities in cord lipid profile and higher prevalence of atherosclerotic cardiovascular disease. Authors objectives was to estimate and compare cord lipid profile in term, pre-term, and post-term neonates.Methods: In the study group, there were 200 healthy Polish newborns. Newborn characteristics included sex, gestational age at birth, Apgar score, and anthropometric data (weight and length at birth, neonatal ponderal index, head, chest and abdominal circumferences, placental weight, and placental-fetal weight ratio). Cord blood samples were collected for total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG). Information regarding selected maternal factors was collected. Neonates were classified into preterm (<37 weeks) and term (≥37 weeks) based on new Ballard scoring.Results: The preterm had higher Total cholesterol compared to Term and post term and it was Statistically Significant with a p value of < 0.001. The preterm had higher Triglycerides compared to term and post term and it was statistically significant with a p value of <0.01. The preterm had higher HDL compared to Term and post term and it was statistically significant with a p value of <0.001. The preterm had higher LDL compared to Term and post term it was statistically significant with a p value of <0.001. The preterm had higher VLDL compared to Term and post term and it was statistically significant with a p value of <0.01.Conclusions: Abnormal intrauterine milieu created by maternal changes during gestation may bear a profound impact on lipid metabolism in neonates, which may account for their differences in lipid profile and anthropometry at birth.

2020 ◽  
Vol 7 (5) ◽  
pp. 1038
Author(s):  
Kanwalpreet Kaur ◽  
Karuna Thapar ◽  
Preeti Malhotra

Background: To compare the cord blood lipid profile of 100 newborn babies born to hypertensive (Group A) and normotensive mothers (Group B).Methods: Total 100 newborns were taken, 50 born to hypertensive mothers and 50 to normotensive mothers. 5ml umbilical venous blood was collected, after clamping the cord, from placental side of the cord and sent to laboratory for centrifugation. Serum was analysed for lipid profile by spectrophotometry by siemens dimensional Rxl- Total Cholesterol, Triglycerides, High density lipoprotein and Low density lipoprotein and Very low density lipoprotein. Comparison of the cord blood lipid levels in both the groups was done.Results: Cord blood lipid profile was deranged in newborns of hypertensive mothers with Cord TC, TG and LDL being statistically significantly higher than the mean reference value and 95th centile. Cord blood of term newborns of hypertensive mothers had Cord TC TG and LDL being statistically higher whereas only Cord TC being statistically higher in preterm neonates of hypertensive mothers.Conclusions: Cord blood lipid levels were significantly deranged in newborns of hypertensive mothers. This helps us in providing the target population at risk and cord blood lipid profile of newborn serving as an indirect guide for lifestyle modifications and helping in early intervention and prevention of future coronary heart disease.


2014 ◽  
Vol 8 (3) ◽  
pp. 195
Author(s):  
Lilik Kustiyah ◽  
Maya Utami Widhianti ◽  
Mira Dewi

The objective of this study was to analyze the association of fiber consumption with nutritional status and blood lipid profile in dyslipidemic adults. The design study was cross sectional survey involving 79 subjects. The results showed that there were significant correlations between energy intake with High Density Lipoprotein (HDL) cholesterol and total cholesterol, fat intake with BMI (Body Mass Index), and BMI with Low Density Lipoprotein (LDL) cholesterol and total cholesterol (p&lt;0.05). There was no significant correlation between consumption of fiber with nutritional status and blood lipid profile (p&gt;0.05). In conclusion, most of the dyslipidemia subjects were obese. Dyslipidemia subjects should keep their intake of energy and fat in recommended ranges in order not to be obese and keep the BMI in normal range to avoid abnormalities of blood lipid profile.<br /><br />


2013 ◽  
Vol 12 (5) ◽  
pp. 29-33
Author(s):  
S. A. Matveeva

Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology. 


2014 ◽  
Vol 43 (1) ◽  
pp. 21-24 ◽  
Author(s):  
GB Das ◽  
ME Hossain ◽  
MA Akbar

This study was conducted with 180 female Swiss albino mice to examine the effects of supplementing broiler fat in the diets of mice on blood lipid profile. Twenty one days old mice were collected from ICDDRB, Mohakhali, Dhaka. They were randomly distributed in four groups having three replications each. Each replicate group had 15 mice. Results revealed that supplementation of broiler fat in mice diet significantly changed (p<0.05) triglyceride (TG) and low density lipoprotein (LDL) among groups. The control group (T0) had the highest level of cholesterol and LDL. Cholesterol, TG and LDL markedly increased (p<0.05) in all dietary treatment groups, while high density lipoprotein (HDL) significantly (p<0.01) decreased after supplementation of experimental diets. It was concluded that all the dietary treatments in general increased blood cholesterol, TG and LDL in mice fed broiler fat with different oil supplements. However, the soybean and palm oil group was comparatively better than other groups in respect of cholesterol, HDL and LDL at the blood lipid profile of mice. Therefore, it can be concluded that consumption of broiler fat with soybean and palm oil could be less harmful for mice.DOI: http://dx.doi.org/10.3329/bjas.v43i1.19380 Bang. J. Anim. Sci. 2014. 43 (1): 21-24


2017 ◽  
Vol 6 (1) ◽  
pp. 119-125
Author(s):  
Charlie Slowey

Abstract Context: There are numerous studies on the effects of smoking and antiretroviral use separately on a HIV patient’s blood lipid profile, however there has never been a study conducted that measures the intensity of cigarette use combined with antiretroviral therapy on a patient’s blood lipid profile. Aims: To assess the effects of the intensity of cigarette usage and antiretroviral therapy on a patient’s blood lipid profile. Setting and Design: This cross-sectional study was carried out in a regional HIV clinic in Cork University Hospital between June 2016 and August 2016. Methods: 40 patients were interviewed in order to gather cigarette usage data and patient files were reviewed in order to gather blood lipid profile results and antiretroviral therapy data. Results: There was no statistically significant difference (P>0.05) in the means of cholesterol (4.99 vs 5.47), high-density lipoprotein (1.22 vs 1.07), low-density lipoprotein (3.13 vs 3.03), nor triglycerides (1.54 vs 2.45) in smokers versus non-smokers. Low-density lipoprotein in mild and moderate smokers was increased compared to non-smokers. Conclusions: These results show that smoking combined with nucleoside reverse transcriptase inhibitor use has no significant change in blood lipid measurements when compared to controls.


2020 ◽  
Vol 30 (3) ◽  
Author(s):  
Asadollah Kermani ◽  
Kokab Namakin ◽  
Gholam Reza Sharifzadeh ◽  
Gholam Reza Faal

Background: Coronary heart diseases (CAD) and their risk factors are among the major causes of death in Iran. Since these risk factors begin to develop early in life, it is vital to diagnose those newborns at high risk of CAD. Objectives: The present study investigated the umbilical cord blood lipid profile of term and preterm neonates. Methods: In this cross-sectional study, the lipid profiles of 292 neonates, of which 276 were term and 16 preterm, were examined at a teaching hospital. Results: The lipid profile results of total cholesterol, triglycerides, high density lipoprotein, and low density lipoprotein were 69.8, 34.9, 23.6, and 31.5 in term neonates and 80.5, 25.5, 25.1, and 38 in preterm neonates, respectively. Conclusions: According to the current paper, the lipid profiles of eastern Iranian neonates were similar to those reported in global studies. Moreover, except for triglycerides in the female neonates, lipid profiles were significantly higher among the male neonates.


Author(s):  
Ni Kadek Warditiani ◽  
Ni Made Widi Astuti ◽  
Pande Made Nova Armita Sari ◽  
Dewa Ayu Swastini ◽  
I Made Agus Gelgel Wirasuta

To evaluate the effect of Ipomea batatas tuber extract (IBTE) on blood lipid profile and atherogenic index in plasma (AIP) of dyslipidemia rats. First, IBTE was extracted by methanol. Fat-rich diets was given for 30 days to induce dyslipidemia in rats. Then, IBTE was given to dyslipidemia rats for 21 days. Lipid profiles in the form of total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), high lipoprotein-cholesterol (HDL-C) and AIP in rats were measured and analyzed. The results showed that administration of IBTE 150, 300 and 600mg/kg BW was able to improve the blood lipid profile of dyslipidemia rats, where there was a decrease in levels of TC, TG and LDL-C, and an increase in HDL-C levels. In line with this, the AIP value has also decreased. The conclusion was IBTE have affect to improve the blood lipid profile of dyslipidemia rats and the AIP.


Author(s):  
DAP. Rasmika Dewi ◽  
DG. Diah Dharma Santhi ◽  
DM Sukrama ◽  
AA. Raka Karsana

This study aims to know and determine the lipid profile in patients with hyperlipidemia who consumed Generic Simvastatin comparedwith its patent product contained in the Formularium at Sanglah Hospital. The observations made, were the measurement of the totalcholesterol and low-density lipoprotein (LDL) before and after the drug administration. A total of 30 subjects who met the inclusioncriteria, were divided into two (2) groups, each group consist of 15 persons, the first group was given 20 mg generic Simvastatin(1 tablet daily) for 15 days and Group II given 20 mg patent Simvastatin (1 tablet daily) for 15 day. After 15 days, their blood sampleswere taken and examined for total cholesterol and LDL. Once the data were collected, statistical analysis was done by using the normalitytest, homogeneity and t. Statistical analysis using p-value less than or equal to 0.05 was the limit of significance. The statistical analysisshowed that the data was normally distributed and homogeneous (p≥0.05). The T-test showed that there were significant differencesin the levels of total cholesterol and LDL serum samples before and after the administration of generic simvastatin and patents the(sig.=0.000). However, there was no significant difference in decreased levels of totall cholesterol samples between the generic Simvastatinand patent (sig=0.365 with α=0.05 level). Besides this, there was also no significant difference in the decreased levels of LDL betweengeneric Simvastatin and the patent one (sig=0.372 with α=0.05 level).


2006 ◽  
Vol 13 (04) ◽  
pp. 621-626
Author(s):  
FAIQA FAYYAZ ◽  
Miss. Saman Batool ◽  
MUHAMMAD NAWAZ ◽  
Asma Lodhi ◽  
MISS. FATIMA ARIF

A study had been being undertaken to estimate the dietaryeffects on blood lipid profile of young male and female university students. Lipid profile is a group of teststhat are often ordered together to determine risk of coronary heart diseases by estimating blood cholesterol,low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides. For the estimation, bloodsamples of each 30 female and male volunteers had been centrifuged and plasma had been separated foranalysis. Levels of lipid profile parameters had been measured by recommended kit method and colordeveloped had been measured by spectrophotomer. The results had been presented as mean±SD. Femalevolunteers had an average±SD value for cholesterol 183.1±14.8, for triglycerides 183.2±22.5, for HDL51±6.2 and for LDL 95.5±15.7, whereas male volunteers had an average ±SD value for cholesterol190±14.9, for triglycerides 222.5±18.2, for HDL 41.4±5.8 and for LDL 104.2±17.1. It had been concludedthat values of triglycerides and cholesterol were higher than the normal values for both female and malevolunteers because the content of saturated fatty acids was higher in their diets, use of vegetables, fruitsand fruit juices was very low, in some cases the number of meals taken per day was more than 5 which isnot desirable in adult people especially when their lifestyle is sedentary and in some cases smoking alteredthe levels of cholesterol and triglycerides.


2017 ◽  
Vol 21 (2) ◽  
pp. 73-75
Author(s):  
S Vinod Babu ◽  
Anusha R Jagadeesan ◽  
Jothimalar Ramalingam

ABSTRACT Introduction Obesity is emerging as an epidemic worldwide. Obesity is associated with a number of comorbid conditions, such as diabetes mellitus, hypertension, cancer, dyslipidemia, cardiovascular abnormalities, anemia, obstructive sleep apnea, and psychosocial abnormalities. Aim This study aims at comparing the lipid profile levels of obese and nonobese men. Materials and methods This was a case—control study conducted at a tertiary care center. Totally, 80 men in the age group of 20 to 47 years attending the master health checkup were included in the study, out of which 40 men with normal body mass index (BMI) of 18 to 25 belonged to group I and 40 men with increased BMI of 30 and above belonged to group II. Lipid profile parameters, such as triglycerides (TGLs), total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were estimated in them. The data were statistically analyzed using Statistical Package for the Social Sciences (SPSS) software version 15.0. Results Statistically significant difference was found in the total cholesterol levels with a p-value of 0.040 while the difference in LDL cholesterol was statistically highly significant with a p-value of 0.040. Conclusion Among lipid profile parameters, only total cholesterol and LDL cholesterol showed significant difference between the obese and nonobese individuals. However, the other parameters like HDL cholesterol and TGLs did not show any significant difference. How to cite this article Babu SV, Jagadeesan AR, Ramalingam J. A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup. Indian J Med Biochem 2017;21(2):73-75.


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