scholarly journals Effect of maternal hemoglobin and iron status on fetal hemoglobin, iron status, growth and maturity

2021 ◽  
Vol 9 (1) ◽  
pp. 62
Author(s):  
Mohammad Moaaz Kidwai ◽  
V. R. Anand ◽  
Deepika Gulathi
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Fetal Hemoglobin ◽  
Maternal Serum ◽  
Deficiency Anemia ◽  
Cross Sectional ◽  
Maternal Anemia ◽  
Iron Stores ◽  
Iron Profile

Background: Iron deficiency anemia during pregnancy is a major health issue in India. However, the status of iron stores in infants born to iron depleted mothers remains controversial and inadequately investigated. The present study is therefore an attempt to understand whether maternal anemia and iron stores have any significant effect on iron status and growth of fetus.Methods: This is a prospective, cross-sectional, hospital based study conducted at Mata Chanan Devi Hosital, Janakpuri, New Delhi. Hemoglobin and iron profile of 100 newborns and their mothers were taken. Mothers were divided into anemic and non anemic group to see the effect of maternal anemia on fetus.Results: A total of 100 newborns and their mothers were analysed. Cord hemoglobin and iron profile was significantly reduced in anemic compared to non anemic group. Birth weight of newborn was significantly reduced only in moderately anemic group as compared to non anemic group but there was no difference seen in length and head circumference.Conclusions: Maternal serum ferritin levels should be measured for the diagnosis of occult iron deficiency in the fetus so that timely measures can be taken to prevent iron deficiency anemia in the newborn.

scholarly journals Effect of Maternal Iron Deficiency Anemia on the Iron Store of Newborns in Ethiopia

Anemia ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Betelihem Terefe ◽  
Asaye Birhanu ◽  
Paulos Nigussie ◽  
Aster Tsegaye
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Complete Blood Count ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Iron Store ◽  
Cross Sectional ◽  
Iron Deficient

Iron deficiency anemia among pregnant women is a widespread problem in developing countries including Ethiopia, though its influence on neonatal iron status was inconsistently reported in literature. This cross-sectional study was conducted to compare hematologic profiles and iron status of newborns from mothers with different anemia status and determine correlation between maternal and neonatal hematologic profiles and iron status in Ethiopian context. We included 89 mothers and their respective newborns and performed complete blood count and assessed serum ferritin and C-reactive protein levels from blood samples collected from study participants. Maternal median hemoglobin and serum ferritin levels were 12.2 g/dL and 47.0 ng/mL, respectively. The median hemoglobin and serum ferritin levels for the newborns were 16.2 g/dL and 187.6 ng/mL, respectively. The mothers were classified into two groups based on hemoglobin and serum ferritin levels as iron deficient anemic (IDA) and nonanemic (NA) and newborns of IDA mothers had significantly lower levels of serum ferritin (P=0.017) and hemoglobin concentration (P=0.024). Besides, newborns’ ferritin and hemoglobin levels showed significant correlation with maternal hemoglobin (P=0.018;P=0.039) and ferritin (P=0.000;P=0.008) levels. We concluded that maternal IDA may have an effect on the iron stores of newborns.

scholarly journals IRON DEFICIENCY ANEMIA:

2012 ◽  
Vol 19 (02) ◽  
pp. 155-158
Author(s):  
SAEED SIDDIQUI ◽  
ATIF SITWAT HAYAT ◽  
M. KHALID SIDDIQUI ◽  
Naila Atif ◽  
Hamayun Shah
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
High Altitude ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Cross Sectional Study ◽  
Deficiency Anemia ◽  
Cross Sectional ◽  
Child Bearing ◽  
Age Range

Objectives: To estimate the frequency of iron deficiency anemia in a sample of population of pregnant women residingpermanently at high altitude of ≥5000 feet in different areas of district Abbottabad. Study Design: Cross sectional Study. Place & duration ofStudy: Northern Institute of Medical Sciences Abbottabad: From 17 August 2009 to 15 June 2010. Subjects and Methods: This study wascarried out on hundred pregnant women residing permanently at an altitude of ≥5000 feet above sea level in district Abbottabad. The agerange was fixed to 15-45 (child bearing age ) years. Suspected study participants having anemia were tested for iron status by serum ferritintest. Pregnant women having both anemia and iron deficiency were labeled as patients of Iron deficiency anemia. Results: The age range was15-41 years with a mean of + / - SD of 28.13 + / - 6.61. All women were of low and middle socioeconomic class with 74 % illiteracy. 60 % of womenhad birth spacing of two or less than two years. 64 % of pregnant women had three children. Anemia was detected in 74 % (X2 =9.42 p > 0.05),iron deficiency in 66 % (X2 = 14.76 p <0.01) and iron deficiency anemia in 60 % (X2 = 13.56 p < 0.01). Conclusions: High altitude residentpregnant women remain at high risk of developing iron deficiency anemia because of illiteracy, poverty and ignorance. With adequate nutritionand health education the problem can be addressed effectively.

scholarly journals Frequency of fetal iron deficiency anemia at the time of birth in obese mothers.

2021 ◽  
Vol 28 (7) ◽  
pp. 973-977
Author(s):  
Amna Aziz ◽  
◽  
Hajra Sultana ◽  
Saima Qadir ◽  
Saima Ashraf ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Maternal Obesity ◽  
Umbilical Vein ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Deficiency Anemia ◽  
Childbearing Age ◽  
Singleton Pregnancy ◽  
Cross Sectional

Objectives: To determine frequency of fetal iron deficiency anemia at the time of birth in obese mothers. Study Design: Cross-sectional Descriptive study. Setting: Department of Obstetrics and Gynecology, Nishtar Hospital Multan. Period: September 2018 to February 2019. Material & Methods: A total of 368 obese pregnant women with singleton pregnancy between 37 -40 weeks of gestation were included in the study after informed consent. Cord blood was collected after delivery via syringe aspiration from the umbilical vein. Fetal Iron status in the form of serum iron, hemoglobin, transferrin saturation was measured with calorimetric endpoint assay. Obesity in pregnancy is defined as BMI equal and more than 30kg/m2. Fetal iron deficiency anemia was defined as fetal hemoglobin less than 14.5g/dl, fetal iron 97.3micro gram/dl and transferrin saturation 39.6% at birth. Results: Among 368 cases, 87.8% of cases were having their BMI 30kg/m2 to 34.9kg/m2. BMI between35kg/m2 to 39.9kg/m2 was noted in 10% of cases and in 2.2% of cases BMI was equal to or more than 40kg/m2. Frequency of neonatal iron deficiency anemia was 22.8%. Conclusion: There is a increase prevalence of obesity in women of childbearing age however maternal obesity has no significant correlation of fetal iron deficiency anemia.

scholarly journals TEA CONSUMPTION AND IRON-DEFICIENCY ANEMIA AMONG PREGNANT WOMAN IN BOGOR DISTRICT, INDONESIA

2019 ◽  
Vol 10 (2) ◽  
pp. 91-100
Author(s):  
Putri Bungsu Machmud ◽  
Ratna Djuwita Hatma ◽  
Ahmad Syafiq
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Iron Status ◽  
Demographic Data ◽  
Secondary Data ◽  
Deficiency Anemia ◽  
Tea Consumption ◽  
Cross Sectional

Background. Anemia in pregnancy is an essential problem due to affect to not only the mother’s life but also to baby’s life. An iron deficiency causes about 75 percent of anemia during pregnancy. Objective. This study aimed to identify risk factors for iron deficiency among pregnant women and determine the possible link between iron status and tannin levels associated with tea consumption. Method. The population-based cross-sectional studies were conducted from secondary data of previous thesis-research in 2013, “Pengaruh Kadar Tanin pada Teh Celup terhadap Anemia Gizi Besi (AGB) pada Ibu Hamil di UPT Puskesmas Citeureup Kabupaten Bogor Tahun 2012”. The study population consisted of 94 randomly selected pregnant women. The inclusion criteria were pregnant women who participated in the previous study and have a complete antenatal care record. Demographic data were collected, including data on age, working status, gestational stage, time since last pregnancy, and parity. The information included nutritional variables, such as iron supplements, nutritional status, and iron intake. Also, data for tannin level grouped as low, medium, and high based on the frequency of daily tea consumption and tea-making habits. The linear model analysis was used to determine the influence of tea consumption on serum ferritin levels. Results. The results showed that time since last pregnancy (<2 years), parity (more than two children), reduced consumption of foods containing heme, and levels of tannin consumption (low, medium, or high) were predictors of iron-deficiency anemia. The results also suggested that tannin levels were inversely proportional to serum ferritin levels. Conclusion. Pregnant women who consumed tea with a low tannin level had the highest serum ferritin levels, whereas those who drank tea with medium and high tannin levels had the lowest serum ferritin levels.

scholarly journals Prevalence of Iron Deficiency Anemia in Biochemically Defined Moderate to Severely Anemic patients in a Tertiary Care Centre

2019 ◽  
Vol 57 (219) ◽  
Author(s):  
Niharika Shah ◽  
Sairil Pokharel ◽  
Deebya Raj Mishra ◽  
Purbesh Adhikari
Keyword(s):  
Bone Marrow ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Tertiary Care ◽  
Deficiency Anemia ◽  
Iron Store ◽  
Ferritin Concentration ◽  
Functional Iron Deficiency ◽  
Iron Stores

Introduction: Anemia due to iron deficiency and chronic diseases is common occurrence in developing country like Nepal, the latter seen in patients with various inflammatory, autoimmune, and malignant disorders . The Intensive method of marrow iron examination, which this study has employed, provides clinically useful iron status classification in cases of functional iron deficiency. The aim of the study is to find out the prevalence of iron deficiency anemia in biochemically defined moderate to severe anemic patients in tertiary care center. Methods: A descriptive cross-sectional study was done in 43 patients who underwent bone marrow aspiration for evaluation of any cause and had moderate to severe anemia at the same time over a period of one year from Nov 2015 to 2016. Ethical clearance was obtained from Institutional Review Committee. The bone marrow iron stores were assessed by“intensive method” apart from the routinely used Gale’s method. Data was collected and entry were done in Statistical Package for Social Sciences version 24. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: The intensive grading system demonstrated normal marrow iron store in 13 (30.2%), depleted iron stores in 3 (7%), functional iron deficiency in 14 (32.6%), and combined deficiency in 13 (30.2%) patients. Mean log ferritin concentration was lower in patients with depleted iron stores (2.2μg/l) than in those with normal (2.7μg/l), and functional iron deficiency (2.4μg/l). The mean log ferritin in combined deficiency was lower than the mean log ferritin concentration in iron store deficiency (1.9μg/l). Conclusions: The prevalence of functional iron deficiency anemia was greatest when the intensive method for assessment of bone marrow iron was used, thus differentiating four different iron status categories, including functional iron deficiency, from actual iron store deficiency, avoiding unnecessary iron supplementation in the former group.

Perbedaan Kadar Brain Derived Neurotropic Factor Neonatus Dari Ibu Hamil Normal Dan Anemia Defisiensi Besi

2018 ◽  
Vol 3 (3) ◽  
pp. 568
Author(s):  
Ainal Mardiah ◽  
Arni Amir ◽  
Andi Friadi ◽  
Ellyza Nasrul
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Community Health ◽  
Health Center ◽  
Iron Deficiency Anemia ◽  
Community Health Center ◽  
Deficiency Anemia ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Neurotropic Factor

<p><em>Iron deficiency anemia is anemia caused by iron deficiency in the blood. Maternal iron deficiency affects the low iron reserves in neonates </em><em>and it also influences on </em><em>Brain Derived Neurotropic Factor (BDNF) </em><em> which affects cognitive function.</em><em> </em><em>The purpose of this study was to determine the difference mean of BDNF in neonates from normal pregnant women and pregnant women with iron deficiency. </em><em>The design of this research was Cross Sectional</em><em> </em><em>design. This research was conducted in Community Health Center of Lubuk  Buaya, Ambacang Community Health Center, Community Health Center of Ikur Koto Health Center and Biomedical Laboratory of Andalas University on February 2017 to April 2018. There were 42 pregnant women was selected as sample e of this research. The samples were chosen by Consecutive Sampling. Then, the sample is divided into two groups: normal pregnant women and pregnant women with iron deficiency anemia. BDNF are examined by the ELISA. Next, the data were analyzed by using T test. The levels of BDNF neonates in normal pregnant group was 3.65(ng/ml) and the anemia pregnant group was 1.74(ng/ml) (p &lt;0.05). There was significant difference of BDNF levels in neonates from normal pregnant women and pregnant women with iron deficiency anemia. </em><em>The conclusion of this study is there is a difference of average BDNF in neonates from normal pregnant women and pregnant women with iron deficiency.</em></p><p> </p><p>Anemia defisiensi besi adalah anemia yang disebabkan karena kekurangan zat besi dalam darah. Defisiensi besi  maternal berdampak pada rendahnya cadangan besi pada neonatus dan berdampak terhadap ekspresi Brain Derived Neurotropic Factor (BDNF) yang berpengaruh pada fungsi kognitif. Tujuan penelitian ini adalah untuk mengetahui perbedaan rerata kadar BDNF pada neonatus dari ibu hamil normal dan ibu hamil defisiensi besi. Desain penelitian ini adalah Cross Sectional. Penelitian dilakukan di Puskesmas Lubuk Buaya, Puskesmas Ambacang, Puskesmas Ikur Koto dan Laboratorium Biomedik Universitas Andalas pada bulan Februari 2017 – Juli 2018. Sampel Penelitian adalah ibu hamil sebanyak 42 orang yang dipilih secara Consecutive Sampling, sampel dibagi menjadi dua kelompok yaitu ibu hamil normal dan ibu hamil anemia defisiensi besi. BDNF diperiksa dengan metode ELISA. Data dianalisa menggunakan uji T test. Kadar BDNF neonatus pada ibu kelompok normal adalah 3,65(ng/ml) dan kelompok ibu anemia adalah 1,74(ng/ml) (p&lt;0,05). Terdapat perbedaan bermakna kadar BDNF pada neonatus dari ibu hamil normal dan ibu anemia defisiensi besi. <em></em></p>

Fortification of tempeh with encapsulated iron improves iron status and gut microbiota composition in iron deficiency anemia condition

2018 ◽  
Vol 48 (6) ◽  
pp. 962-972 ◽  
Author(s):  
Rio Jati Kusuma ◽  
Aviria Ermamilia
Keyword(s):  
Iron Deficiency ◽  
Gut Microbiota ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Deficiency Anemia ◽  
Microbiota Composition ◽  
Iron Fortification ◽  
Iron Matrix ◽  
Content Type ◽  
Gut Microbiota Composition

Purpose Iron deficiency anemia (IDA) is one of the most major micronutrient deficiencies worldwide. Food fortification is one strategy for reducing IDA in the population despite concern regarding the gut pathogenic bacteria overgrowth. The purpose of this study was to evaluate the effect of iron encapsulation in banana peel matrix on iron status and gut microbiota composition in iron deficiency anemia. Design/methodology/approach Anemia was induced in 35 male Sprague Dawley rats of age two weeks by the administration of iron-free diet for two weeks. Rats then randomly divided into control, iron-fortified tempeh (temFe) dose 10 and 20 ppm, iron matrix-fortified tempeh dose 10 and 20 ppm and iron matrix fortified tempeh dose 10 and 20 ppm with probiotic mixture. Blood was drawn at Weeks 2 and 6 for hemoglobin and serum iron analysis. Rats were sacrificed at the end of Week 6, and cecal contents were collected for Lactobacillus, Bifidobacteria and Enterobactericeae analysis. Findings Hemoglobin and serum iron were significantly increased (p < 0.05) in all iron-fortified group with the highest value found in iron matrix dose 20 ppm (10.71 ± 0.15 g/dl and 335.83 ± 2.17 µg/dl, respectively). The cecal Lactobacillus and Bifidobacteria did not differ significantly between groups. Cecal Enterobactericeae was significantly different (p < 0.05) among groups with the lowest level in the temFe-20 (2.65 ± 0.78 log CFU) group. Research limitations/implications The use of commercial inoculum instead of pure Rhizopus oligosporus mold for developing the fortified tempeh may impact the effect of product on cecal gut microbiota composition, as different molds and lactic acid bacteria can grow in tempeh when using commercial inoculum. Social implications In Indonesia, iron fortification is conducted primarily in noodles and flour that limits the impact of iron fortification for reducing IDA in population. Iron fortification in food that was daily consumed by people, that is, tempeh, is potential strategy in reducing IDA in population. Originality/value Tempeh fortification using encapsulated iron improved iron status and gut microbiota composition in iron deficiency anemia.

scholarly journals Occurrence of neonatal diarrhea in calves with iron-deficiency anemia

2019 ◽  
Vol 73 (1) ◽  
pp. 1-9
Author(s):  
Radisa Prodanovic ◽  
Sreten Nedic ◽  
Oliver Radanovic ◽  
Vesna Milicevic ◽  
Ivan Vujanac ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Enterotoxigenic Escherichia Coli ◽  
Deficiency Anemia ◽  
Fecal Samples ◽  
Gut Function ◽  
History Of ◽  
Neonatal Calves ◽  
Diarrheic Calves

Introduction. Neonatal calves are often deficient in iron. Accumulating evidence indicates that iron status is associated with disease pathologies including diarrhea. Our objective was to examine the association between iron status and gut function in neonatal calves with and without a history of calf diarrhea. Materials and Methods. Calves were divided into two groups based on their history of diarrhea; the first group were diarrheic calves (n=6) and the second group were non-diarrheic healthy calves (n=6). Blood samples (n=12) were collected at day 12 of age and erythrogram determination and measurements of serum iron and total iron binding capacity were performed. Hematological values were measured using an automatic analyzer, and biochemical properties were determined spectrophotometrically. Fecal samples were obtained from all calves and pH measured using semi quantitative test strips as well as being examined by bacterial cultivation for enterotoxigenic Escherichia coli, Salmonella spp. and Clostridium perfringens, by RT-PCR for the presence of bovine rotavirus, bovine coronavirus and bovine viral diarrhea virus, and by microscopy for the presence of Cryptosporidium parvum. Results and Conclusions. There were significant iron-related changes for most hematological indices in diarrheic calves; and iron (Fe) deficiency and microcytic, hypochromic anemia were diagnosed. The pH of the feces was significantly higher in diarrheic calves than in the non-diarrheic healthy group (P<0.01). All fecal samples were negative for the analyzed enteric pathogens. According to the results obtained, calves experiencing iron deficiency anemia exhibit changes in gut function leading to diarrhea as compared with a matched group of healthy calves.

scholarly journals Comparisons Between Serum Levels of Hepcidin and Leptin in Male College-Level Endurance Runners and Sprinters

2021 ◽  
Vol 8 ◽  
Author(s):  
Shinsuke Nirengi ◽  
Hirokazu Taniguchi ◽  
Aya Ishibashi ◽  
Mami Fujibayashi ◽  
Nao Akiyama ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Body Fat ◽  
Iron Status ◽  
Deficiency Anemia ◽  
Blood Levels ◽  
College Level ◽  
Positive Correlation ◽  
Male College ◽  
Endurance Runners

Background: Hepcidin-25 is a 25 amino acid hepatokine and a key regulator of iron metabolism related to iron deficiency anemia. Recent studies have suggested that an elevated hepcidin level is correlated with low energy availability. Leptin is an appetite-suppressing adipokine and has been reported to stimulate hepcidin production in animals and cultured cells. While leptin is modulated by exercise, it is known that endurance runners and sprinters practice different types of exercise. This study investigated and compared the relationships between hepcidin and leptin levels, iron status, and body fat to understand better the risk of iron deficiency anemia in endurance runners and sprinters.Methods: Thirty-six male college track and field athletes (15 endurance runners and 21 sprinters) were recruited for this study. Dietary intake, body composition, and blood levels of ferritin, hepcidin-25, leptin, and adiponectin were measured. Correlations between hepcidin levels and ferritin, body fat, leptin, and adiponectin were evaluated using Pearson's correlation coefficient for each group.Results: The endurance runners had lower hepcidin levels and higher leptin and adiponectin levels compared with sprinters. Ferritin was positively correlated with hepcidin-25 levels in both the endurance and sprinter groups. A positive correlation was observed between hepcidin-25 and body fat or leptin levels only in sprinters.Conclusion: This is the first study investigating the relationship between blood levels of hepcidin and leptin in athletes. The positive correlation between hepcidin-25 and leptin was observed in sprinters but not endurance runners.

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