scholarly journals Accuracy of imaging findings compared with that of histopathological findings of the ovarian lesions

2019 ◽  
Vol 6 (2) ◽  
pp. 419
Author(s):  
Ponnam Bharath Kumar ◽  
Prem Sai Reddy
Keyword(s):  
Imaging Techniques ◽  
Malignant Lesion ◽  
Specific Information ◽  
Imaging Findings ◽  
Post Contrast ◽  
Abdominal Sonography ◽  
Histopathological Findings ◽  
Tissue Contrast ◽  
Organ Specific ◽  
Ovarian Pathology

Background: Newer imaging techniques have emerged, and it is necessary to study their accuracy in comparison to the gold standard of histopathology for increasing accuracy of diagnosis. Ovarian tumors are difficult to diagnose when they are of small size. But their diagnosis should be done at an earlier stage for effective outcome of the management of these tumors. The objective was to study accuracy of imaging findings compared with that of histopathological findings of the ovarian lesions.Methods: This study was done for a period of two years from December 2010 to May 2012. A total of 30 patients who were clinically suspected to have ovarian pathology were referred to us for ultrasonography. In 30 patients, who were referred for sonography a total of 36 ovarian masses was found? Each patient was examined by Trans abdominal sonography / Trans vaginal sonography, MRI (Pre and Post contrast) and CT when required.Results: Sonography could detect the origin of mass accurately in 29 (80.5 %) masses and MRI could detect the origin accurately in 34 (94.4%) masses. Sonography characterized 33/36 (91.6%) masses correctly. MRI correctly characterized 34/36 (94.5%) cases and tissue content was identified correctly. The sensitivity of imaging findings for correctly identifying malignant lesions was 100% and sensitivity for correctly making a benign diagnosis was 92.5%. The specificity of imaging findings for correctly identifying malignant lesion was 92% and specificity for correctly making a benign diagnosis was 84.6 %.Conclusions: MRI is significantly superior to US in all respects due to the excellent soft tissue contrast and organ-specific information generated in the pelvis.

Inflammatory pseudotumor of the Liver. A Report of Two Cases with Unusual Histologic Picture

1995 ◽  
Vol 81 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Alessandro Uccheddu ◽  
Gavino Faa ◽  
Alessandro Cois ◽  
Rossano Ambu
Keyword(s):  
Laboratory Tests ◽  
Inflammatory Pseudotumor ◽  
Clinical Presentation ◽  
Imaging Techniques ◽  
Malignant Lesion ◽  
Specific Information ◽  
Actual Nature ◽  
Cut Surface ◽  
Gross Examination ◽  
Surrounding Parenchyma

Two cases of inflammatory pseudotumor (IPT) of the liver are reported. Clinical presentation was vague and aspecific. Laboratory tests and data from imaging techniques provided no specific information on the actual nature of the lesions and were misleading, suggesting a malignant lesion in one patient and a complicated hydatid cyst in the other. On gross examination, the tumors appeared yellowish ore grey-yellow in color, with a firm cut surface and well circumscribed from the surrounding parenchyma, although a true capsule was not evident. Variability in the histological pattern was also observed, even though the major finding was in both cases an admixture of lymphocytes, plasmacells, granulocytes and monocytes. Lymphocytes were immunohistochemically heterogeneous; monocytes showed in one case large hyperchromic atypical nuclei, confirming the previously, reported possibility that some cases of IPT may be mistaken for sarcomas. Further evidence is added in support of the hypothesis that some liver IPT may result from the evolution of cholangitic abscesses.

scholarly journals In vivo imaging techniques: a new era for histochemical analysis

2016 ◽  
Author(s):  
A. Busato ◽  
P. Fumene Feruglio ◽  
P.P. Parnigotto ◽  
P. Marzola ◽  
A. Sbarbati
Keyword(s):  
Magnetic Resonance ◽  
In Vivo Imaging ◽  
Diffusion Tensor ◽  
Technological Development ◽  
Imaging Techniques ◽  
Resonance Spectroscopy ◽  
Preclinical Research ◽  
Tissue Contrast ◽  
Magnetic Resonance Imaging Mri

In vivo imaging techniques can be integrated with classical histochemistry to create an actual histochemistry of water. In particular, Magnetic Resonance Imaging (MRI), an imaging technique primarily used as diagnostic tool in clinical/preclinical research, has excellent anatomical resolution, unlimited penetration depth and intrinsic soft tissue contrast. Thanks to the technological development, MRI is not only capable to provide morphological information but also and more interestingly functional, biophysical and molecular. In this paper we describe the main features of several advanced imaging techniques, such as MRI microscopy, Magnetic Resonance Spectroscopy, functional MRI, Diffusion Tensor Imaging and MRI with contrast agent as a useful support to classical histochemistry.

scholarly journals Salivary Gland Pathology in IgG4-Related Disease: A Comprehensive Review

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Ilaria Puxeddu ◽  
Riccardo Capecchi ◽  
Filippo Carta ◽  
Antonio Gaetano Tavoni ◽  
Paola Migliorini ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Imaging Techniques ◽  
Elevated Serum ◽  
Clinical Aspects ◽  
Related Disease ◽  
Multiple Organs ◽  
Igg4 Related Disease ◽  
Serum Igg4 ◽  
Organ Specific ◽  
Clinical Pictures

IgG4-related disease (IgG4-RD) is a rare fibroinflammatory condition that can affect almost any organ, characterized by swollen lesions and often by eosinophilia and elevated serum IgG4 concentrations. The diagnosis of IgG4-RD is a challenging task: in fact, single or multiple organs can be affected and clinical, serological, and histological findings can be heterogeneous. In IgG4-RD, the involvement of salivary glands is observed in 27% to 53% of patients. Several organ-specific conditions, now recognized as different manifestations of IgG4-related sialadenitis (IgG4-RS), were viewed in the past as individual disease entities. The study of salivary glands may sometimes be complex, because of the number of pathological conditions that may affect them, often with overlapping clinical pictures. Integration of different imaging techniques is often required in the case of swelling of salivary glands, even though biopsy remains the gold standard for a definite diagnosis of IgG4-RS. Thus, in this review, we discuss new insights in the pathogenesis of IgG4-RD, focusing on its clinical aspects and the tools that are currently available for a correct differential diagnosis when the salivary glands are involved.

Biochemical investigation of rheumatic diseases

2013 ◽  
pp. 451-456
Author(s):  
Berenice Lopez ◽  
Patrick J. Twomey
Keyword(s):  
Rheumatic Diseases ◽  
Wide Spectrum ◽  
Imaging Techniques ◽  
Measurement Technology ◽  
Loss Of Function ◽  
Sample Collection ◽  
Biochemical Tests ◽  
Metabolic Bone ◽  
Routine Monitoring ◽  
Organ Specific

It is important for rheumatologists to have an understanding of biochemical tests including an awareness of their limitations. The biological variability of an analyte both within and between individuals, the limitations of the measurement technology, the sensitivity of laboratory internal quality control and external quality assurance procedures, as well as interlaboratory variations in practices including sample collection procedures, may all impact on the interpretation of a result. Biochemical tests are often requested to monitor organ-specific dysfunction arising as an adverse consequence of pharmacotherapy or as a component of a systemic rheumatic disease, although dysfunction may also reflect infection or coincidental pathology. Patients with rheumatic diseases are at high risk of renal and hepatic disease. Serum creatinine and its derivative estimated glomerular filtration rate (eGFR) are the most readily available surrogate markers of GFR and are used to assess renal impairment and monitor its course. However, the use of creatinine alone lacks sensitivity and a substantial loss of function must occur before creatinine levels are increased. Additional biochemical screening for kidney damage can be performed by assessment of glomerular integrity, including proteinuria or albuminuria and haematuria. A wide spectrum of rheumatic diseases can affect the liver with various degrees of involvement and hepatic pathology. These often present with cholestatic or hepatitic biochemical profiles. The medical management of rheumatic diseases also involves medications that are hepatotoxic, and routine monitoring of liver function is recommended. This approach is not problem-free and may be improved by quantitative determinations of non-invasive markers of liver fibrosis in the future. Together with imaging techniques, biochemical tests play an important role in the assessment and differential diagnosis of metabolic bone disease.

scholarly journals Magnetic resonance imaging of salivary glands

2019 ◽  
Author(s):  
Danielle Ayumi Nishimura ◽  
Ana Luiza Esteves Carneiro ◽  
Kaisermann Costa ◽  
Wladimir Gushiken de Campos ◽  
Jefferson Xavier de Oliveira ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Salivary Glands ◽  
Imaging Techniques ◽  
Neck Region ◽  
Evaluation Instrument ◽  
Resonance Imaging ◽  
Tissue Contrast ◽  
Excellent Method ◽  
Magnetic Resonance Imaging Mri

Salivary glands tumors account for 2-5% of tumors in the head and neck region, possibly being benign or malignant. Magnetic resonance imaging (MRI) presents high soft tissue contrast resolution, thus being an excellent method for salivary gland analysis. The objective of this literature review is to analyze MRI as an evaluation instrument for the diagnosis of salivary glands lesions. Compared to other imaging techniques, MRI can better evaluate the relationship between adjacent anatomical structures, presenting greater sensitivity and specificity.

Diagnosis of breast implant rupture: imaging findings and relative efficacies of imaging techniques.

1994 ◽  
Vol 163 (1) ◽  
pp. 57-60 ◽  
Author(s):  
L I Everson ◽  
H Parantainen ◽  
T Detlie ◽  
A E Stillman ◽  
P N Olson ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Breast Implant ◽  
Imaging Findings ◽  
Implant Rupture ◽  
Rupture Imaging ◽  
Breast Implant Rupture

scholarly journals The Role of Imaging in Radiation Therapy Planning: Past, Present, and Future

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Gisele C. Pereira ◽  
Melanie Traughber ◽  
Raymond F. Muzic
Keyword(s):  
Treatment Planning ◽  
Planning Process ◽  
Imaging Modality ◽  
Imaging Techniques ◽  
Treatment Options ◽  
Three Dimensional ◽  
Dose Calculation ◽  
Positron Emission ◽  
Tissue Contrast ◽  
Anatomical Information

The use of ionizing radiation for cancer treatment has undergone extraordinary development during the past hundred years. The advancement of medical imaging has been critical in helping to achieve this change. The invention of computed tomography (CT) was pivotal in the development of treatment planning. Despite some disadvantages, CT remains the only three-dimensional imaging modality used for dose calculation. Newer image modalities, such as magnetic resonance (MR) imaging and positron emission tomography (PET), are also used secondarily in the treatment-planning process. MR, with its better tissue contrast and resolution than those of CT, improves tumor definition compared with CT planning alone. PET also provides metabolic information to supplement the CT and MR anatomical information. With emerging molecular imaging techniques, the ability to visualize and characterize tumors with regard to their metabolic profile, active pathways, and genetic markers, both across different tumors and within individual, heterogeneous tumors, will inform clinicians regarding the treatment options most likely to benefit a patient and to detect at the earliest time possible if and where a chosen therapy is working. In the post-human-genome era, multimodality scanners such as PET/CT and PET/MR will provide optimal tumor targeting information.

scholarly journals Radiological Imaging and CA125 Correlation as Predictive Variables in Ovarian Pathologies

2021 ◽  
pp. 187-195
Author(s):  
S. Varsha ◽  
C. Bhavya Sree ◽  
Karthik Krishna Ramakrishnan ◽  
Seena Cheppala Rajan ◽  
Muthiah Pichandi
Keyword(s):  
Clinical Symptoms ◽  
Malignant Lesion ◽  
Tumour Marker ◽  
Epithelial Differentiation ◽  
Ca 125 ◽  
Imaging Findings ◽  
Radiological Imaging ◽  
Medical College ◽  
Predictive Variables ◽  
Biological Potential

Introduction: Primary Ovary Neoplasms are the most frequent tumors showing epithelial differentiation. Tumour Marker CA-125, glycoprotein synthesized mainly by neoplastic cells with epithelial differentiation. Serum Level of CA-125 has a biological potential of these lesions. This study is mainly done to evaluate the association between serum CA-125 levels and imaging findings and to predict malignancy in various ovarian lesions. Objectives: To evaluate the capacity of CA125 and Imaging findings to predict malignancy in various ovarian pathologies. Materials and Methods: Study area: Department of Radiology, Saveetha Medical College and Hospital, Chennai, Study design: Retrospective study. Study period: 6months. Study population: Patients with history and clinical symptoms of ovarian lesions and USG detected ovarian lesions confirmed on Radiological Imaging. Sampling method: Purposive sampling Sample size: 30. Inclusion criteria: Patients with clinically suspected ovarian lesions or indeterminate ovarian lesions on USG who underwent Radiological imaging and CA-125 estimation. Exclusion criteria: Children less than 12years of age are excluded from this study. Results: Among 30 cases, 19(63.33%) were benign and 2(6.67%) were borderline and 9(30%) were malignant lesion in the present study. Ovarian pathologies is mostly seen in women of age above 25 yrs(86.67%). In this study Ovarian lesions are more commonly seen in married women(86.67%) and menstruating women(56.67%). Out of 30 Cases, Serum CA-125 level <35IU/ml is seen among 13(43.33%) and level >35IU/ml is seen among 17(56.67%). Out of 17 women with CA-125 level >35IU/ml, 9 had malignant lesions on histopathology while 7 women had benign lesions and 1 women had borderline lesion. Conclusion: The present study shows significant association of Serum CA-125 levels with mixed solid cystic ovarian lesions ill defined margins (possible Malignant Ovarian lesions) (p<0.05) especially in Post-menopausal women.

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