scholarly journals Peripheral neuropathy in people living with human immunodeficiency virus and acquired immunodeficiency syndrome on antiretroviral therapy

2021 ◽  
Vol 8 (10) ◽  
pp. 1524
Author(s):  
Joshua L ◽  
Medo M. Kuotsu ◽  
Nyamnyei Konyak ◽  
Ksh Birendra Singh ◽  
N. Biplab Singh ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Peripheral Neuropathy ◽  
Antiretroviral Therapy ◽  
Hiv And Aids ◽  
People Living With Hiv ◽  
Duration Of Treatment ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Living With Hiv

Background: Peripheral neuropathy is a common neurological complication in people with human immunodeficiency virus (HIV) infection. HIV-associated sensory neuropathy (HIV-SN) is defined as the presence of neuropathic symptoms and at least an abnormal perception of vibrations of a 128 Hz tuning fork on the great toe or abnormal ankle reflexes or both. Brief peripheral neuropathy screening (BPNS) tool is employed in identifying HIV-SN based on a directed symptom questionnaire and limited clinical examination. The present study was conducted to determine the prevalence and drug regimens related to peripheral neuropathy in people living with HIV and Acquired immunodeficiency syndrome (AIDS) on antiretroviral therapy (ART) so as to help improve the care for those on ART. The objective was to study the prevalence of peripheral neuropathy in people living with HIV and AIDS on ART using AIDS clinical trials group validated BPNS tools.Methods: Cross-sectional study on 198 HIV-seropositive cases aged above 18 years on ART attending centre of excellence (CoE) ART centre, RIMS Imphal. The presence of peripheral neuropathy was examined by using a BPNS among the participants.Results: Peripheral neuropathy was found in 46 (23.2%) out of 198 participants using BPNS. In this study a positive association between the duration of treatment with ART and use of protease inhibitor regimes with the development of peripheral neuropathy was significant.Conclusions: Peripheral neuropathy in patient with HIV and AIDS on ART had significant association with duration of treatment with ART and use of protease inhibitor combination in the ART regime. 

scholarly journals HIV/AIDS SEBAGAI “RUANG” PELAYANAN PASTORAL GEREJA

2020 ◽  
Vol 3 (1) ◽  
pp. 37-46
Author(s):  
Robinson Simanungkalit
Keyword(s):  
Hiv And Aids ◽  
People Living With Hiv ◽  
Proper Understanding ◽  
Immunodeficiency Virus ◽  
History Of ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Living With Hiv ◽  
The Church ◽  
Hiv Aids

It is important to explain some important things on Human Immunodeficiency Virus (HIV) or Acquired Immunodeficiency Syndrome (AIDS). This study was aimed to to provide a proper understanding on the HIV/AIDS. Consequently, this study described what the HIV/AIDS is, the history of the emergence of HIV/AIDS, the transmission of HIV/AIDS, and the effects of HIV/AIDS on infected human. People infected with HIV and AIDS are referred to as PLWHA (People living with HIV and AIDS). They may be church citizens. Therefore, the church must not "turn a blind eye", but is required to be proactive in responding to people who have infected with HIV/AIDS.BAHASA INDONESIA ABSTRACT: Sangatlah penting untuk menjelaskan beberapa hal penting tentang HIV/AIDS guna memberikan pemahaman yang benar tentang HIV/AIDS. Dibutuhkan penjelasan tentang apa itu HIV/AIDS, Sejarah munculnya HIV/AIDS, Penularan HIV/AIDS dan dampak yang ditimbulkan oleh HIV/AIDS terhadap orang- orang yang terinfeksi. Orang yang terinfeksi HIV dan AIDS itu disebut sebagai ODHA (Orang yang hidup dengan HIV dan AIDS). Mungkin saja mereka adalah warga gereja dan karena itu gereja tidak boleh “menutup mata” tetapi dituntut untuk proaktif dalam menyikapi keberadaan warganya yang terinfeksi HIV/AIDS.Keywords: HIV/AIDS, ODHA

scholarly journals Distal Sensory Peripheral Neuropathy in Human Immunodeficiency Virus Type 1–Positive Individuals Before and After Antiretroviral Therapy Initiation in Diverse Resource-Limited Settings

2019 ◽  
Vol 71 (1) ◽  
pp. 158-165 ◽  
Author(s):  
Alyssa C Vecchio ◽  
Christina M Marra ◽  
Jeffrey Schouten ◽  
Hongyu Jiang ◽  
Johnstone Kumwenda ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Peripheral Neuropathy ◽  
Antiretroviral Therapy ◽  
People Living With Hiv ◽  
Older Individuals ◽  
Resource Limited Settings ◽  
Sensory Peripheral Neuropathy ◽  
Resource Limited ◽  
Immunodeficiency Virus ◽  
Living With Hiv

Abstract Background Distal sensory peripheral neuropathy (DSPN) is a complication of human immunodeficiency virus (HIV). We estimate DSPN prevalence in 7 resource-limited settings (RLSs) for combination antiretroviral therapy (cART)–naive people living with HIV (PLWH) compared with matched participants not living with HIV and in PLWH virally suppressed on 1 of 3 cART regimens. Methods PLWH with a CD4+ count <300 cells/mm3 underwent standardized neurological examination and functional status assessments before and every 24 weeks after starting cART. Matched individuals not living with HIV underwent the same examinations once. Associations between covariates with DSPN at entry were assessed using the χ2 test, and virally suppressed PLWH were assessed using generalized estimating equations. Results Before initiating cART, 21.3% of PLWH had DSPN compared with 8.5% of people not living with HIV (n = 2400; χ2(df = 1) = 96.5; P < .00001). PLWH with DSPN were more likely to report inability to work [χ2(df = 1) = 10.6; P = .001] and depression [χ2(df = 1) = 8.9; P = .003] than PLWH without DSPN. Overall prevalence of DSPN among those virally suppressed on cART decreased: 20.3%, week 48; 15.3%, week 144; and 10.3%, week 192. Incident DSPN was seen in 127 PLWH. Longitudinally, DSPN was more likely in older individuals (P < .001) and PLWH with less education (P = .03). There was no significant association between cART regimen and DSPN. Conclusions Although the prevalence of DSPN decreased following cART initiation in PLWH, further research could identify strategies to prevent or ameliorate residual DSPN after initiating cART in RLSs.

scholarly journals Chronic Cystoisospora belli infection in a Colombian patient living with HIV and poor adherence to highly active antiretroviral therapy

Biomédica ◽  
2021 ◽  
Vol 41 (Supl. 1) ◽  
pp. 17-22
Author(s):  
Ana Luz Galván-Díaz ◽  
Juan Carlos Alzate ◽  
Esteban Villegas ◽  
Sofía Giraldo ◽  
Jorge Botero ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Diarrheal Disease ◽  
Opportunistic Infections ◽  
Poor Adherence ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Living With Hiv

Cystoisospora belli is an intestinal Apicomplexan parasite associated with diarrheal illness and disseminated infections in humans, mainly immunocompromised individuals such as those living with the human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). An irregular administration of highly active antiretroviral therapy (HAART) in HIV patients may increase the risk of opportunistic infections like cystoisosporiasis.We describe here a case of C. belli infection in a Colombian HIV patient with chronic gastrointestinal syndrome and poor adherence to HAART. His clinical and parasitological cure was achieved with trimethoprim-sulfamethoxazole treatment. Although a reduction in the number of C. belli cases has been observed since the use of HAART, this parasite still has to be considered as a differential diagnosis of diarrheal disease in HIV/AIDS patients.Effective interventions enhancing adherence to HAART should be included in HIV patient care programs.

Risk Factors in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Patients Undergoing Antiretroviral Therapy in the State of Pernambuco, Brazil: A Case–Control Study

2010 ◽  
Vol 8 (3) ◽  
pp. 271-277 ◽  
Author(s):  
Thais Gelenske ◽  
Francisco Alfredo Bandeira e Farias ◽  
Ricardo Arraes de Alencar Ximenes ◽  
Heloísa Ramos Lacerda de Melo ◽  
Maria de Fátima Pessoa Militão de Albuquerque ◽  
...  
Keyword(s):  
Risk Factors ◽  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Acquired Immunodeficiency Syndrome ◽  
Case Control Study ◽  
Case Control ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Control Study

scholarly journals Quality of Life People Living with HIV-AIDS (PLWHA) with Antiretroviral therapy in Cendana Clinic Ngudi Waluyo Wlingi Hospital

2015 ◽  
Vol 2 (1) ◽  
pp. 006-014
Author(s):  
Erni Setiyorini
Keyword(s):  
Quality Of Life ◽  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
People Living With Hiv ◽  
Environment Problem ◽  
Immunodeficiency Virus ◽  
Long Time ◽  
Living With Hiv ◽  
Hiv Aids

Human Immunodeficiency Virus (HIV)is desease with high mortality and everyone have chancegot HIV. At Blitar HIV/AIDS prevalence increase since 2010. The incubation of HIV need long time tobecome AIDS. At this period PLWHA faced with physic, physichologic, sosial, environment problem andimpact to their quality of life. The purpose of this study was to describe quality of life PLWHA at physic,physichologic, sosial, environment dimension. Method: Research design was descriptive. Population ofthis study is PLWHA who receiving ARV at Cendana Clinic Ngudi Waluyo Wlingi Hospital. Samples 42respondent by using convenient sampling. Data collected at September 1st– 30, 2013 by questionaire.Result of this study in physic dimension much of them at good 16 peoples (38,1%), enough and less, eachof them 13 peoples (31%). Physhicology dimension at good and enough, each of them 20 peoples(47,6%) then at less 2 peoples (4,8%). Sosial dimension enough 25 peoples (59,5%), good 15 peoples(35,7%) and less 2 peoples (4,8%). Environment dimension enough 16 peoples (38,1%), good 15peoples (35,7%) dan kurang 11 orang (26,2%). It is suggested for nurse to implementation nursing careplan to PLWHA suitable with their quality of life dimension and enhance support to their sosial activity.

Human Immunodeficiency Virus: AIDS, the Current Plague

2020 ◽  
pp. 295-330
Author(s):  
Michael B. A. Oldstone
Keyword(s):  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Drug Therapy ◽  
Antiretroviral Therapy ◽  
Death Rate ◽  
Medical Problems ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Long Course ◽  
Immunodeficiency Syndrome

This chapter explores acquired immunodeficiency syndrome (AIDS), a lethal disease cause by the human immunodeficiency virus (HIV). Of the more than 75 million people HIV has infected in the 36 years (1983–2019) since the initial case report, nearly one-half of them have died. Not only the victims of this infection but also their families, communities, countries, and even continents endured years of suffering as AIDS proceeded on its long course of physical destruction. Today, however, the enormous advance in antivirus drug therapy has dramatically reduced the death rate and altered the portrait of this disease from an acute lethal disease to a chronic persistent infection. In 2019, the combination antiretroviral therapy has enabled those infected to survive at roughly the same rate as the general non-infected population. However, this increased longevity includes an upsurge in the former group’s medical problems caused by the side effects of antiretroviral therapy. Despite an outlay of $1 billion per year for AIDS research, no vaccine is on the horizon for preventing this medical catastrophe.

Mechanisms of immune aging in HIV

2022 ◽  
Vol 136 (1) ◽  
pp. 61-80
Author(s):  
Manon Chauvin ◽  
Delphine Sauce
Keyword(s):  
Immune Activation ◽  
Opportunistic Infections ◽  
People Living With Hiv ◽  
Adaptive Immune ◽  
Hiv Progression ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Living With Hiv ◽  
Hiv 1

Abstract Massive CD4+ T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many of the alterations that affect innate and adaptive immune subsets in HIV-infected individuals are reminiscent of the process of immune aging, characteristic of old age. These changes, of which the presumed cause is the systemic immune activation established in patients, likely participate in the immuno-incompetence described with HIV progression. With the success of antiretroviral therapy (ART), HIV-seropositive patients can now live for many years despite chronic viral infection. However, acquired immunodeficiency syndrome (AIDS)-related opportunistic infections have given way to chronic diseases as the leading cause of death since HIV infection. Therefore, the comparison between HIV-1 infected patients and uninfected elderly individuals goes beyond the sole onset of immunosenescence and extends to the deterioration of several physiological functions related to inflammation and systemic aging. In light of this observation, it is interesting to understand the precise link between immune activation and aging in HIV-1 infection to figure out how to best care for people living with HIV (PLWH).

scholarly journals Reduction of CD4 count induces opportunistic infections in people living with HIV (PLHIV)

2014 ◽  
Vol 13 (3) ◽  
pp. 285-291 ◽  
Author(s):  
Rashed Noor ◽  
Md. Morsalin ◽  
Bidhan Chakraborty
Keyword(s):  
Opportunistic Infections ◽  
Medical Science ◽  
Skin Lesions ◽  
The Body ◽  
Cd4 Count ◽  
People Living With Hiv ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Living With Hiv

Objective: Human immunodeficiency virus (HIV), a lentivirus (member of the retrovirus family) causing acquired immunodeficiency syndrome (AIDS), weakens the immune system of the body and hence associates different opportunistic infections. Present study undertook a survey on opportunistic infections. Materials and Methods: Data were collected from both HIV carriers (CD4 count more than 250/mL of blood) and AIDS patients (CD4 count less than 250/mL of blood). Results: Analyses of the data revealed that diarrhoea, pulmonary tuberculosis, gland tuberculosis, skin lesions and fever were the common opportunistic infections. Conclusion: It can be summarized that HIV infected patients having a reduced CD4 count (<250/mL) encounter different opportunistic infections and some of these infections could be continual for long as well. DOI: http://dx.doi.org/10.3329/bjms.v13i3.19151 Bangladesh Journal of Medical Science Vol.13(3) 2014 p.285-291

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