scholarly journals Clinical profile and changes in laboratory parameters among dengue patients at tertiary care hospital: an observational study

2019 ◽  
Vol 6 (5) ◽  
pp. 2276
Author(s):  
Pankaj Ashok Pande ◽  
Amit Jagdish Jogdande
Keyword(s):  
Observational Study ◽  
Clinical Features ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Lifestyle Changes ◽  
Common Symptom ◽  
Care Hospital ◽  
Rapid Urbanization ◽  
Dengue Patient ◽  
Laboratory Profile

Background: Globally the incidence of dengue has increased in the past three decades. It is predominantly found in the urban and semi-urban area however now it is spreading in rural areas also. In India the incidence of dengue has increased due to rapid urbanization, lifestyle changes and improper water storage practices. Hence this study was planned to study the clinical and laboratory profile of dengue patient as the number of dengue patients is on rise every year and there is varied presentation of clinical features in different parts of India.Methods: This observational study was carried out in tertiary care hospital. Confirmed cases of Dengue were included in the study. There cases were observed seven days. During this period their clinical and biochemical profile was recorded in pre structured and pre tested proforma. Data was compiled and analyzed by MS-Office (Excel) and SPSS-21.Results: In this study total 129 patients were enrolled. Out of total 91 were males and 38 were females. Laboratory profile of dengue patients suggested steep decline in total leucocytes count and platelet during first five days but started to increase by seventh day but platelets have not reached to its original normal value while TLC reverted to normal range. Fever and headache were most common symptom in our study.Conclusions: Clinical and laboratory profile of dengue patient changes with every new epidemic and different region in India. Clinical features like organomegaly are more common in paediatrics age group than adults. 

scholarly journals A Study On Clinical and Laboratory Profile of Children with COVID-19 Attending A Tertiary Care Hospital in Bangladesh

2021 ◽  
Vol 36 (2) ◽  
pp. 95-100
Author(s):  
Kazi Iman ◽  
Sharmin Mahbuba ◽  
Farhana Rahat ◽  
Morsheda Khanam ◽  
Azmeri Sultana ◽  
...  
Keyword(s):  
Clinical Features ◽  
Normal Limit ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Common Symptom ◽  
Care Hospital ◽  
Disease Category ◽  
Cross Sectional ◽  
Laboratory Profile ◽  
Wbc Count

Background: An outbreak of COVID-19 caused by 2019 novel coronavirus started first in Wuhan, Hubei province of China. Thereafter it spreaded to different countries of the world. Cases among children has been increasing day by day. Despite taking all measures of prevention virus spreading is uncontrolled. Objectives: To determine the clinical features and laboratory profile of children with COVID-19. Methods: This was a cross sectional study conducted in Dr. MR Khan Shishu Hospital and Institute of Child Health, Dhaka. Clinical and laboratory profile were analyzed among the children (aged 0-16 years) admitted between 1st May 2020 to November 2020 with positive RT-PCR for COVID-19. Data were analyzed by using SPSS. Results: Total 159 cases were included in the study. The most common symptom was fever (97.5%), then the second most common was cough (80.5%), other symptoms were diarrhea (28.3%), vomiting (17%), anorexia (30.8%) and weakness (30.2%). WBC count was within normal limit, leucocytosis was found in 5% cases and leucopenia in 3% cases. Few cases were reported with neutropenia and lymphopenia. Few cases were reported as thrombocytosis. ESR and CRP were high. Chest X-ray showed opacities in 62.9% cases. In most of the cases it was bilateral, few cases showed unilateral. In 37.1% cases it was normal. The disease category of all infected children remained same all through the hospital stay and no mortality was seen. Conclusion: Children with COVID-19 had distinct clinical features. Fever and cough were the most common symptoms. WBC count was found within normal limit but ESR and CRP were high. Chest radiograph showed opacities in majority cases. The outcome of COVID-19 in children was good. DS (Child) H J 2020; 36(2): 95-100

scholarly journals Association of clinical features, comorbidities and laboratory profile with outcomes among dengue patients admitted in a tertiary care hospital, Delhi NCR

2021 ◽  
Vol 9 (7) ◽  
pp. 1918
Author(s):  
Mohit Tiwari ◽  
Abhishek Tibrewal ◽  
Varun S. Pichika ◽  
Narinder P. Singh ◽  
Pankaj N. Choudhary ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Clinical Features ◽  
Tertiary Care Hospital ◽  
Wide Spectrum ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Chronic Obstructive ◽  
Care Hospital ◽  
Laboratory Profile

Background: Dengue fever is an endemic disease across multiple countries. Dengue infection results in a wide spectrum of non-specific clinical manifestations with unpredictable clinical course and outcome. Objective of the study was to understand the association of different clinical features, comorbidities and laboratory profile with outcomes (ICU use, ventilation use and blood transfusion) among dengue patients admitted in a tertiary care hospital in Delhi, National Capital Region.Methods This cross-sectional study included 75 dengue patients with fever <1 week confirmed based on NS-1 antigen and/or IgM antibody positivity. Descriptive analysis was used.Results: Gender was not significantly associated with the outcomes. The duration of fever was significantly higher among those with ICU use (median: 6 versus 4 days; p=0.005), ventilator use (median: 5.5 versus 4.0 days; p=0.049] and blood transfusion (median: 6 versus 4 days; p=0.013). Dengue patients with co-morbidities (diabetes, hypertension, or chronic obstructive pulmonary disease) or co-infection had a significantly higher odds of the outcomes. The platelet level was significantly lower while liver enzymes were significantly higher among those with the outcomes.Conclusions: The clinical features, comorbidities and laboratory profile can help in identifying critical patients for ICU admission and timely intervention to improve outcome.

scholarly journals Clinical features, laboratory profile and outcomes among dengue patients admitted in a tertiary care hospital, Delhi NCR

2020 ◽  
Vol 7 (8) ◽  
pp. 3232
Author(s):  
Mohit Tiwari ◽  
Abhishek Tibrewal ◽  
Varun S. Pichika
Keyword(s):  
Dengue Fever ◽  
Clinical Features ◽  
Liver Enzymes ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Specific Treatment ◽  
Major Public Health Problem ◽  
Care Hospital ◽  
Elevated Liver Enzymes ◽  
Laboratory Profile

Background: Globally, dengue, a mosquito-borne viral infection, is the most rapidly spreading vector-borne disease. Dengue fever is endemic in >100 countries including India. Dengue has a variety of clinical presentations. The objective of the study was to understand the clinical features, laboratory profile and outcomes of dengue fever among patients admitted in a tertiary care hospital in Delhi, National Capital Region.Methods: This was a cross-sectional study among 75 dengue confirmed (NS-1 antigen and/or IgM antibody positive) patients with fever <1 week. The variables included were socio-demographic; clinical features; laboratory and radiological profile and outcomes. Descriptive analysis was used.Results: The majority of the patients were aged between 18-40 years 72% and predominantly males 68%. A total of 18.7% patients (malaria: 13.3% and chikungunya: 5.3%) had co-infection. Fever was present in all the patients, followed by myalgia (74.7% patients), retro-orbital pain/headache 69.3%, and vomiting 45.3%. The mean hemoglobin was 13.9 gm/dl, leukopenia 46.7% patients, thrombocytopenia 96.0% and elevated liver enzymes 69.3%. Radiological examination showed pleural effusion 6.7%, gallbladder wall thickening 6.7%, splenomegaly 4.0%, and hepatomegaly 2.7%. The outcomes included ICU care 17.3%, ventilator support 13.3%, blood transfusion 14.7%, and mortality 1.3% during the hospital stay.Conclusions: Dengue has become a major public health problem in India. The most common clinical features are fever, myalgia, headache and vomiting; laboratory abnormalities are leukopenia, thrombocytopenia and deranged liver enzymes. No specific treatment exists, but early detection and proper medical care lowers fatality rates. 

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