scholarly journals Comparative study of brainstem evoked response audiometry in diabetic patients and non-diabetic subjects to assess the involvement of central auditory pathway

2021 ◽  
Vol 7 (12) ◽  
pp. 1877
Author(s):  
Shanthimalar R. ◽  
Muthuchitra S. ◽  
Mary Nirmala S. ◽  
Udhaya Chandrika G. ◽  
Mohamed Rasith H.
Keyword(s):  
Auditory Pathway ◽  
Evoked Response ◽  
Auditory Evoked Potential ◽  
Control Group ◽  
Diabetic Patients ◽  
Brainstem Evoked Response Audiometry ◽  
Absolute Latency ◽  
The Impact ◽  
Central Auditory Pathway ◽  
Evoked Response Audiometry

<p><strong>Background: </strong>Diabetes mellitus (DM) which is prevalent in world is associated with sensorineural hearing loss. Brainstem evoked response audiometry (BERA) is a simple, non-invasive procedure to detect early impairment of acoustic nerve and auditory pathway. The present study is under taken to evaluate the impact of DM on BERA parameters. Aim of the study was to compare the BERA of diabetic patients to those of age and gender matched controls to assess the involvement of central auditory pathway.</p><p><strong>Methods</strong>: A cross sectional study was conducted on 35 diabetic patients, aged 35 to 55 years, who were on treatment for at least 2 years, and 35 age and sex matched control participants, were subjected for BERA at 70,80 and 90 dB. The waveforms, absolute latency of wave I, wave III, wave V and interwave/ inter peak latency of I-III, III-V and I-V were analyzed with respect to both groups.</p><p><strong>Results</strong>: The absolute latency of wave III and wave V, interpeak/ interwave latency of I-III, interpeak/ interwave latency of I-V, III-V and absolute latency of wave V were highly significant at corresponding tested stimuli in the diabetic group compared to the control group.</p><p><strong>Conclusions</strong>: Early involvement of central auditory pathway in diabetic patients, can be detected with fair accuracy with auditory evoked potential studies; if done on a regular basis warrants meticulous glycemic control and prevents further damage.</p>

scholarly journals Role of Brainstem Evoked Response Audiometry in Evaluating Sensorineural Hearing Loss in Diabetic Patients

2021 ◽  
Vol 29 (2) ◽  
pp. 182-188
Author(s):  
Deepika Goswami ◽  
Saurabh Srivastava ◽  
Anuja Bhargava ◽  
Syed M Faiz ◽  
Zeba Siddiqi ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Auditory Pathway ◽  
Evoked Response ◽  
Sensorineural Hearing ◽  
Diabetic Patients ◽  
Brainstem Evoked Response Audiometry ◽  
Group I ◽  
Absolute Latency ◽  
Evoked Response Audiometry

Introduction Diabetes has become a global epidemic. Hearing loss has been long associated with diabetes. Brainstem Evoked Response Audiometry (BERA) is an objective, non-invasive, electro diagnostic test that not only evaluates the functional integrity of the subcortical auditory pathway but also provides topo-diagnosis of hearing loss. This study aims to identify the role BERA in detecting hearing loss early in diabetic patients.Materials and Methods In this study a total of 210 patients were taken and subjected to blood glucose levels followed by PTA were divided into two groups. Group I (n=105) consisted of diabetic patients with sensorineural hearing loss (SNHL) and Group II (n=105) had age and sex matched non-diabetics with SNHL. All the patients were evaluated with BERA.Results All the patients were subjected to Brain Stem Evoked Response Audiometry (BERA). Absolute latency of Wave I, III, V, I-III, III-V and I-V were assessed for both the ears. In both ear Absolute latency were significantly higher in diabetics as compared to non-diabetic patientsConclusion The findings of present study showed that the severity of hearing loss was significantly higher in diabetic patients as compared to non-diabetic controls. Level of glycemic control showed a possible link with severity of hearing loss.

scholarly journals A COMPARATIVE STUDY OF BRAINSTEM EVOKED RESPONSE AUDIOMETRY IN DIABETIC AND NON-DIABETIC SUBJECTS

2017 ◽  
Vol VOLUME 5 (VOLUME 5 NUMBER 2 JULY 2017) ◽  
pp. 11-14
Author(s):  
Ankur Wats
Keyword(s):  
Diabetes Mellitus ◽  
Auditory Pathway ◽  
Evoked Response ◽  
Diabetic Patients ◽  
Brainstem Evoked Response Audiometry ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
And Gender ◽  
Evoked Response Audiometry

INTRODUCTION: The Prevalence of Diabetes Melilites Is Increasing All Over the World Particularly in The Developing Countries. Diabetes Is Associated with Hearing Impairment Which Has Been Described as Sensorineural in Origin, But Evidence Favoring a Specific Mechanism Is Insufficient. Brainstem Evoked Response Audiometry Is a Simple, Non-Invasive Procedure to Detect Early Impairment of Acoustic Nerve and Auditory Pathway, Even in The Absence of Specific Symptoms. The Present Study Is Under Taken to Evaluate the Impact of Type 2 Diabetes Mellitus on BERA Parameters. OBJECTIVES: To Analyze and Compare the Brainstem Evoked Response Audiometry in Diabetic Patients and Age and Gender Matched Controls. METHODS: 40 Type 2 Diabetic Patients Attending Outpatient Department of Otorhinolaryngology and Medicine, C. S. S. Hospital, Meerut and 40 Non Diabetic Age and Gender Matched Subjects from General Population Were Selected Randomly, With None of Them Having Complains of Hearing Loss and Were Subjected to Brainstem Evoked Response Audiometry (BERA). BERA Parameters Such as Latency of Wave I, II, III, IV, And V; Inter-Peak Latencies I-III, I-V and III-V Were Analyzed. BERA Parameters Were also assessed according to The Duration of Diabetes and Fasting Blood Glucose Levels. RESULTS: Patients with Type 2 Diabetes Mellitus Were Found to Have Subclinical Hearing Impairment as Revealed by Impaired Auditory Brainstem Response. In This Study Diabetic Patients Showed a Statistically Significant (p value<0.05) Delay in The Latency of Waves I, III and V and Inter-Peak Latency of Waves I-III, I-V and III-V When Compared to Controls. There Was a Positive Correlation Between Prolongation of Latencies and Duration of Diabetes Mellitus. The Latencies Were Also Found to Be Prolonged with altered blood glucose levels. CONCLUSION: The present study correlates with earlier findings that impaired BERA response in diabetic patients is a consequence of microangiopathy. Meticulous control of blood sugar levels is a must to prevent the early complications of diabetes, so that further damage to auditory pathway can be prevented. KEY-WORDS: Diabetes mellitus; Hearing; Brainstem evoked response audiometry (BERA).

scholarly journals Evaluation of effect of brainstem evoked response audiometry in hyperlipidemic patients

2020 ◽  
Vol 6 (11) ◽  
pp. 1971
Author(s):  
Shivakumar Senniappan ◽  
Gowri Paramasivam
Keyword(s):  
Objective Assessment ◽  
Pure Tone Audiometry ◽  
Auditory Pathway ◽  
Evoked Response ◽  
Brainstem Evoked Response Audiometry ◽  
Medical College ◽  
Invasive Method ◽  
Interpeak Latency ◽  
Brain Stem Evoked Response ◽  
Evoked Response Audiometry

<p class="abstract"><strong>Background:</strong> Brain stem evoked response audiometry (BERA) is a useful objective assessment of hearing. The major advantage of this procedure is its ability to test even infants in whom conventional audiometry may not be useful. This investigation can be used as a screening test for deafness at high risk. This study is to correlate changes in brainstem evoked response audiometry parameters concerning lipid profile.</p><p class="abstract"><strong>Methods:</strong> The study was conducted between January 2019 to June 2020 on 50 patients attending ENT OPD in Vinayaka Mission’s Kirupanandha Variyar Medical College and Hospital, Salem. All patients with auditory and/or vestibular complaints were seen at the otorhinolaryngology OPD and underwent an otorhinolaryngological examination, audiological studies (pure tone audiometry) and an electrophysiological assessment BERA.  </p><p class="abstract"><strong>Results:</strong> The results of BERA was considered. A total of 5 waveforms and 3 interpeak latency waves were calculated. It was recorded from both the ears. There was a significant increase in the values of absolute waves II, III, IV, and V and interpeak latency wave values I-II and I-V.</p><p class="abstract"><strong>Conclusions:</strong> Early identification of hyperlipidemic patients is useful in preventing disease progression and associated morbidity and mortality. BERA is a non-invasive method which can help us to detect central auditory pathway dysfunction at early stages in hyperlipidemic patients even before the patient's experience symptomatic hearing loss.</p>

Assessment of Hearing Impairment in NICU Graduates by Otoacoustic Emission and Brainstem Evoked Response Audiometry Tests

2020 ◽  
Vol 34 (3) ◽  
pp. 109-117
Author(s):  
Aparna Aradhana ◽  
Gadadhar Sarangi ◽  
Prasant Saboth ◽  
Radha Tripathy
Keyword(s):  
Risk Factors ◽  
Hearing Impairment ◽  
Very Low Birth Weight ◽  
Birth Asphyxia ◽  
Otoacoustic Emission ◽  
Evoked Response ◽  
Complete Evaluation ◽  
Brainstem Evoked Response Audiometry ◽  
Tertiary Teaching ◽  
Evoked Response Audiometry

Objectives: To find out the incidence of hearing impairment in Neonatal Intensive Care Unit (NICU)-admitted newborns and to correlate between several risk factors. Design: Prospective observational study. Setting: In a tertiary teaching hospital of Odisha between October 2014 and October 2016. Study population: 100 newborns delivered in the institution and admitted in NICU with usual indications and risk factors that underwent otoacoustic emission 1 and 2 (OAE1, OAE2) and Brainstem Evoked Response Audiometry (BERA). Results: 84 babies in OAE1 and 86 babies in OAE2 got “pass” results. In BERA test, 92 babies got normal waveform. 7 (13.7%) of 51 premature babies, 5 (38.5%) of 13 very low birth weight babies, 7 (17.5%) of 40 babies receiving ototoxic medication for >5 days, 7 (31.8%) of 22 babies with hyperbilirubinemia, 6 (42.9%) of 14 babies with sepsis, 5 (20%) of 20 babies with birth asphyxia, 3 (60%) of 5 babies under mechanical ventilation for >5 days, 1 baby with ear abnormality, and 1 (50%) out of 2 babies with congenital infections had hearing impairment and statistically significant association with abnormal OAE and BERA test. Conclusion: There is high incidence of hearing loss in NICU-admitted newborns. OAE and BERA both should be performed for complete evaluation of hearing. Important risk factors are elaborated. Predischarge hearing assessment in NICU is most important.

A study of brainstem evoked response audiometry in high-risk infants and children under 10 years of age

2015 ◽  
Vol 21 (2) ◽  
pp. 134 ◽  
Author(s):  
Ramanathan Thirunavukarasu ◽  
GaneshKumar Balasubramaniam ◽  
RameshBabu Kalyanasundaram ◽  
Gitanjali Narendran ◽  
Sajee Sridhar
Keyword(s):  
High Risk ◽  
Evoked Response ◽  
Infants And Children ◽  
Brainstem Evoked Response Audiometry ◽  
High Risk Infants ◽  
Evoked Response Audiometry

scholarly journals Effect of alpha-lipoic acid on antioxidant gene expression and kidney injury in alloxan-induced diabetic rats

2018 ◽  
Vol 8 (1) ◽  
pp. 6-6 ◽  
Author(s):  
Parisa Jamor ◽  
Hassan Ahmadvand ◽  
Hesam Ashoory ◽  
Esmaeel Babaeenezhad
Keyword(s):  
Gene Expression ◽  
Lipoic Acid ◽  
Kidney Injury ◽  
Diabetic Rats ◽  
Pcr Analysis ◽  
Control Group ◽  
Diabetic Patients ◽  
Alpha Lipoic Acid ◽  
The Impact ◽  
Gpx Activity

Background: Myeloperoxidase (MPO) is involved in the initiation, progression, and complications of atherosclerosis in diabetic patients. Objectives: In the current study, the impact of alpha-lipoic acid (LA), a natural antioxidant and a cofactor in the enzyme complexes on MPO, catalase (CAT) and glutathione peroxidase (GPx) activity, glutathione (GSH) and malondialdehyde (MDA) level, histopathology of kidney and expression of antioxidant enzymes, superoxide dismutase (SOD), GPx and CAT which are involved in the detoxification of reactive oxygen species (ROS), was evaluated in alloxan-induced diabetic rats. Materials and Methods: In this study, 30 male Rattus norvegicus rats randomly divided into three groups; control (C), non-treated diabetic (NTD), and LA-treated diabetics (LATD) was induced by alloxan monohydrate (100mg/kg; subcutaneous [SC]). Then treatment was performed with alphaLA (100 mg/kg intraperitoneal (i.p) daily to 6 weeks). Blood sample of animals collected to measure levels of MPO, CAT and GPx activity GSH and MDA. Kidney paraffin sections were prepared to estimate histological studies and to measure quantitative gene expression SOD, GPX and CAT in kidney. Results: Induction of diabetes led to a significant increase in MPO and MDA, reduced GSH level and GPx and CAT activities (P < 0.05). However, treatment with alpha-LA led to a significant elevation in GPx, CAT and GSH levels with a reduction in MPO activities and MDA levels (P < 0.05). Furthermore, the real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis results showed increased expressions of GPx, CAT and SOD enzyme in the treatment group compared with the diabetic control group. Histopathological lesions such as increased glomerular volume and lymphocyte infiltration were attenuated in the alpha-LA treated group. Conclusions: Our findings indicated that alpha-LA supplementation is effective in preventing complications induced by oxidative stress and atherosclerosis in diabetic rats.

scholarly journals The influence of a community intervention on influenza vaccination knowledge and behavior among diabetic patients

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Lili Tao ◽  
Ming Lu ◽  
Xiaoning Wang ◽  
Xiaoyan Han ◽  
Shuming Li ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Community Intervention ◽  
Vaccination Rate ◽  
Control Group ◽  
Diabetic Patients ◽  
Vaccination Rates ◽  
Significant Difference ◽  
The Impact ◽  
Experimental Group

Abstract Background This study was conducted to evaluate the impact of a comprehensive community intervention on cognition and inoculation behaviors of diabetic patients immunized with influenza vaccine. Methods A total of 1538 diabetic patients aged 35 years and above for outpatient visits and follow-up treatments were selected from six community health service centers (three for the experimental group, and the other three for the control group) in Chaoyang District, Beijing. Comprehensive interventions applied to the experimental group include patient intervention and community climate interventions. We compared the total awareness of influenza vaccine knowledge and influenza vaccination rates between the two groups before and after the intervention. Results Before the intervention, the total awareness rate of influenza vaccine in the experimental group and the control group was similar (50.6 and 50.2%, respectively. P = 0.171). After the intervention, the awareness rate of influenza vaccine in the experimental group and the control group increased. The amplitude of the increase was similar (70.3 and 70.1%, respectively. P = 0.822,). Before the intervention, there was no significant difference in the influenza vaccination rate between the experimental group and the control group (29.0 and 26.8%, respectively. P = 0.334). After the intervention, the vaccination rate of the experimental group was higher than that of the control group. The difference was statistically significant (The vaccination rate 45.8 and 27.4% for the experimental group and the control group, respectively. P < 0.001). Conclusion Comprehensive community interventions had a positive effect on vaccination in diabetic patients. Trial registration ChiCTR1900025194, registered in Aug,16th, 2019. Retrospectively registered.

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