Skin care physicians insight on epidemiological patterns, diagnosis and treatment modalities for female pattern hair loss

Background: Female pattern hair loss (FPHL) is a common cause of hair loss in women characterized by a diffuse reduction in hair density over the crown and frontal scalp with retention of the frontal hairline. The underlying pathophysiology is multifactorial. There are no universally agreed treatment guidelines available. The objective of the study was to understand the diagnosis and treatment pattern of female pattern hair loss and the role of minoxidil topical formulation and its combination in the management of FPHL.Methods: Predesigned questionnaire on FPHL was prepared based on review of literature and was filled by 80 consultant dermatologists. Recorded data was statistically analyzed.Results: Common age of onset of FPHL was between 20 to 30 years. Majority (96.25%) have reported FPHL in association with psychological morbidity. The most preferred treatment in mild and severe FPHL was minoxidil 5% and platelet rich plasma (PRP) plus minoxidil respectively. Most dermatologists (47.5%) treated with minoxidil for over 6 months. Majority (27.5%) reported flaking as the most common side effect with minoxidil followed by dryness, scalp irritation and itching. Majority (27.5%) observed that long treatment duration was contributing to non-compliance followed by medication cost and side effects. Majority of the dermatologists (90%) felt the need for treatment guidelines in the current Indian scenario.Conclusions: Minoxidil was the most common preferred treatment for mild and severe FPHL. PRP is the most common choice of combination therapy with minoxidil. Minimizing side effects, patient education and universal treatment guidelines can help manage FPHL better.

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A Split Scalp Study of Single versus Double Spin Platelet-rich plasma Injections in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor in PRP

QJM ◽

10.1093/qjmed/hcab093.019 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Samar A Salem ◽

Rania M Elhusseiny ◽

Haitham M Saleh

Keyword(s):

Vascular Endothelial Growth Factor ◽

Hair Loss ◽

Platelet Rich Plasma ◽

Intradermal Injection ◽

Vascular Endothelial ◽

Single Spin ◽

Double Spin ◽

Female Pattern Hair Loss ◽

The Right ◽

Endothelial Growth Factor

Abstract Background Female pattern hair loss (FPHL) is the most common hair loss disorder in women. Platelet-rich plasma (PRP) provides an option for patients recalcitrant to the currently approved therapies. As there are many methods for the preparation of PRP, the most suitable for AGA therapy is not yet clear. Aims To compare the efficacy between single and double spin PRP injections in treatment of FPHL and to assess the relationship between the concentrations of vascular endothelial growth factor (VEGF) in the PRP preparation and the treatment results obtained. Patients and Methods 15 female patients with FPHL were enrolled. Each patient was subjected to intradermal injection of PRP (prepared by double-spin method) into the right half of the scalp, in addition to intradermal injection of PRP (prepared by singlespin method) into the left half of the scalp in the form of three treatment sessions three weeks apart. Evaluation of treatment response was done through comparing patients' global photographs, assessment of patients' satisfaction and folliscopic assessment before and after treatment. Results Our results showed clinically significant improvement by comparing patients' photographs in most of the treated patients. In addition, folliscopy revealed significant change of the terminal hair density in the right half of the scalp following treatment sessions.VEGF concentration didn't differ significantly between double-spin and single-spin prepared PRP, also it didn't differ significantly upon calcium activation. Conclusions PRP is an effective treatment modality for FPHL. Double-spin prepared PRP could yield better results in the treatment of FPHL than the single-spin method. However, adding Calcium gluconate prior to PRP injection is of no benefit as it didn't significantly increase the release of VEGF. Yet, further studies discussing different PRP preparation protocols and involving a larger number of cases are needed to minimize statistical errors and to detect the most accurate PRP preparation method with the greatest yield of growth factors.

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An update on diagnosis and treatment of female pattern hair loss

Expert Review of Dermatology ◽

10.1586/17469872.2013.814858 ◽

2013 ◽

Vol 8 (4) ◽

pp. 427-436 ◽

Cited By ~ 4

Author(s):

Thamer Mubki ◽

Omar Shamsaldeen ◽

Kevin J McElwee ◽

Jerry Shapiro

Keyword(s):

Hair Loss ◽

Diagnosis And Treatment ◽

Female Pattern Hair Loss

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Platelet‑rich plasma as a method of treatment of androgenetic alopecia in men — a case report

Journal of Face Aesthetics ◽

10.20883/jofa.28 ◽

2020 ◽

Vol 3 (1) ◽

pp. 27-33

Author(s):

Patrycja Przybylska ◽

Teresa Matthews‑Brzozowska

Keyword(s):

Case Report ◽

Side Effects ◽

Hair Loss ◽

Platelet Rich Plasma ◽

Nutritional Supplementation ◽

Androgenetic Alopecia ◽

Common Condition ◽

Minimal Invasiveness ◽

Photographic Documentation ◽

Hair Transplant

Androgenetic alopecia is a common condition, accounting for about 95% of all male hair loss. Standard therapeutic solutions recommend the use of minoxidil, finasteride, spironolactone, nutritional supplementation, phototherapy and hair transplant surgery. An increasingly popular alternative method that has been used in the case report is platelet rich plasma (PRP) mesotherapy characterized by autologous character, minimal invasiveness and no serious side effects. A series of 3 treatments was performed at 3-week intervals. The effects of using medical photographic documentation after completing a series of treatments.

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Platelet-Rich Plasma Therapy for Male and Female Pattern Hair Loss

Dermatologic Surgery ◽

10.1097/dss.0000000000001651 ◽

2019 ◽

Vol 45 (1) ◽

pp. 80-82 ◽

Cited By ~ 2

Author(s):

Marc R. Avram ◽

Robert Finney

Keyword(s):

Hair Loss ◽

Platelet Rich Plasma ◽

Plasma Therapy ◽

Male And Female ◽

Female Pattern Hair Loss

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The effect of autologous activated platelet-rich plasma injection on female pattern hair loss: A randomized placebo-controlled study

Journal of Cosmetic Dermatology ◽

10.1111/jocd.12357 ◽

2017 ◽

Vol 17 (1) ◽

pp. 47-53 ◽

Cited By ~ 27

Author(s):

Abeer Attia Tawfik ◽

Mai Abdel Raouf Osman

Keyword(s):

Hair Loss ◽

Platelet Rich Plasma ◽

Controlled Study ◽

Plasma Injection ◽

Female Pattern Hair Loss

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Investigating the Safety and Efficacy of Platelet-Rich Plasma (PRP) Treatment for Female Androgenetic Alopecia: Review of the Literature

Medicina ◽

10.3390/medicina57040311 ◽

2021 ◽

Vol 57 (4) ◽

pp. 311

Author(s):

Santo Raffaele Mercuri ◽

Giovanni Paolino ◽

Matteo Riccardo Di Nicola ◽

Laura Vollono

Keyword(s):

Hair Loss ◽

Platelet Rich Plasma ◽

Androgenetic Alopecia ◽

Cochrane Central Register ◽

Review Of The Literature ◽

Psychosocial Burden ◽

Female Pattern Hair Loss ◽

Central Register ◽

Topical Minoxidil

Background: female androgenetic alopecia (FAGA) is a common cause of non-scarring alopecia in women, affecting approximately 40% of women by age 50, bearing a significant psychosocial burden on affected patients. Platelet-rich plasma (PRP) has been widely investigated as a potential effective treatment for several dermatological conditions, including male androgenetic alopecia (MAGA). However, few studies have been conducted focusing on the use of PRP in FAGA. The aim of this review was to identify reports that investigated the use of PRP for the treatment of FAGA. Methods: Electronic databases of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to September 2020 have been searched using different combinations of the following terms: “androgenetic alopecia,” “FAGA,” “female pattern hair loss,” “platelet-rich fibrin,” “platelet-rich plasma,” and “PRP”. Results and conclusions: Eight (n = 8) clinical studies consistent with our research were identified. A total of 197 subjects has been enrolled in the included studies. All of them were adult female patients (mean age: 38.9) affected by female pattern hair loss. PRP is a well-tolerated procedure which showed promising results in males-only and mixed populations of AGA patients. PRP showed to produce high levels of satisfaction and improvement in the quality of life in patients affected by FAGA. In the light of this evidence, PRP may be proposed in patients who did not respond or did not tolerate topical minoxidil, as well as in combination with topical and oral treatments.

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A rare case of neomercazole induced hepatitis

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20181783 ◽

2018 ◽

Vol 6 (5) ◽

pp. 1812

Author(s):

Muralidhar Varma ◽

Jaikaran Mansingh ◽

Devyani Sivakumar ◽

Rabia Dhalla ◽

Sudha Vidyasagar ◽

...

Keyword(s):

Side Effects ◽

Liver Function ◽

Hair Loss ◽

Side Effect ◽

Rare Case ◽

Antithyroid Drug ◽

Disease Diagnosis ◽

The Other ◽

Common Side Effect ◽

Graves Disease

Neomercazole is one of the most commonly used drugs to treat hyperthyroidism. Common side effects include rash, hair loss and agranulocytosis. Hepatotoxicity is a common side effect of Propylthiouracil, the other major antithyroid drug, but it has been rarely described as a side effect of neomercazole. Here, a patient presents with hepatitis 6 months after starting neomercazole therapy for graves disease. Diagnosis is based on excluding other causes of hepatitis, and treatment involves removing the offending drug. This is followed by normalization of liver function. Rechallenging should not be done as it can lead to recurrence of symptoms.

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Clinical Characteristics of Female Patterned Hair Loss in Patients Attending Hair Clinic in Thailand

Siriraj Medical Journal ◽

10.33192/smj.2022.3 ◽

2022 ◽

Vol 74 (1) ◽

pp. 19-26

Author(s):

Warayuwadee Amornpinyo ◽

Rattapon Thuangtong ◽

Supisara Wongdama ◽

Daranporn Triwongwaranat

Keyword(s):

Family History ◽

Hair Loss ◽

Age Of Onset ◽

Ferritin Level ◽

Demographic Data ◽

Positive Family History ◽

Premenopausal Women ◽

Female Pattern Hair Loss ◽

Menopausal Women ◽

History Of

Objective: To study the clinical features and associated factors of female pattern hair loss (FPHL) in premenopausal and menopausal women patients. Materials and Methods: This is a retrospective chart review of FPHL patients visited hair clinic, Siriraj Hospital from June 2012 to May 2015. Demographic data, family history and history of hair loss were evaluated. Factors associated with FPHL were analysed. Results: There were 267 patients (180 premenopausal women and 87 menopausal women) in this study. The mean age of onset of patients was 35.5±12 years (premenopausal FPHL) and 60.5±7 years (menopausal FPHL). Positive family history of androgenetic alopecia (AGA) was 48.3%, mainly in first-degree relatives. The data showed an increased incidence of FPHL with advancing age. The most common presentation is Ludwig grade I. The study showed that patients also have dyslipidemia (16.9%), hypertension (16.5%), diabetes mellitus (10.9%), hypothyroidism (4.9%), anemia (3.7%), and hyperthyroidism (2.9%). In multivariate analysis, significant associations were found between low ferritin level < 70 µg/L and premenopausal FPHL (OR 5.51, 95% CI 2.26-15.14, P = 0.01). Conclusion: Maternal family history of AGA seems to have a greater influence on premenopausal FPHL. Low serum ferritin levels < 70 µg/L were significantly associated with FPHL in premenopausal women.

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