The effect of autologous activated platelet-rich plasma injection on female pattern hair loss: A randomized placebo-controlled study

2017 ◽  
Vol 17 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Abeer Attia Tawfik ◽  
Mai Abdel Raouf Osman
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Controlled Study ◽  
Plasma Injection ◽  
Female Pattern Hair Loss

A Split Scalp Study of Single versus Double Spin Platelet-rich plasma Injections in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor in PRP

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Samar A Salem ◽  
Rania M Elhusseiny ◽  
Haitham M Saleh
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Intradermal Injection ◽  
Vascular Endothelial ◽  
Single Spin ◽  
Double Spin ◽  
Female Pattern Hair Loss ◽  
The Right ◽  
Endothelial Growth Factor

Abstract Background Female pattern hair loss (FPHL) is the most common hair loss disorder in women. Platelet-rich plasma (PRP) provides an option for patients recalcitrant to the currently approved therapies. As there are many methods for the preparation of PRP, the most suitable for AGA therapy is not yet clear. Aims To compare the efficacy between single and double spin PRP injections in treatment of FPHL and to assess the relationship between the concentrations of vascular endothelial growth factor (VEGF) in the PRP preparation and the treatment results obtained. Patients and Methods 15 female patients with FPHL were enrolled. Each patient was subjected to intradermal injection of PRP (prepared by double-spin method) into the right half of the scalp, in addition to intradermal injection of PRP (prepared by singlespin method) into the left half of the scalp in the form of three treatment sessions three weeks apart. Evaluation of treatment response was done through comparing patients' global photographs, assessment of patients' satisfaction and folliscopic assessment before and after treatment. Results Our results showed clinically significant improvement by comparing patients' photographs in most of the treated patients. In addition, folliscopy revealed significant change of the terminal hair density in the right half of the scalp following treatment sessions.VEGF concentration didn't differ significantly between double-spin and single-spin prepared PRP, also it didn't differ significantly upon calcium activation. Conclusions PRP is an effective treatment modality for FPHL. Double-spin prepared PRP could yield better results in the treatment of FPHL than the single-spin method. However, adding Calcium gluconate prior to PRP injection is of no benefit as it didn't significantly increase the release of VEGF. Yet, further studies discussing different PRP preparation protocols and involving a larger number of cases are needed to minimize statistical errors and to detect the most accurate PRP preparation method with the greatest yield of growth factors.

scholarly journals Skin care physicians insight on epidemiological patterns, diagnosis and treatment modalities for female pattern hair loss

2020 ◽  
Vol 7 (1) ◽  
pp. 11
Author(s):  
Krishna Rajesh Kilaru ◽  
Suhasini Attada ◽  
Pooja Munnangi ◽  
Manogna Chowdary Kilaru
Keyword(s):  
Side Effects ◽  
Hair Loss ◽  
Treatment Guidelines ◽  
Age Of Onset ◽  
Platelet Rich Plasma ◽  
Diagnosis And Treatment ◽  
Treatment Modalities ◽  
Common Side Effect ◽  
Medication Cost ◽  
Female Pattern Hair Loss

<p class="abstract"><strong>Background:</strong> Female pattern hair loss (FPHL) is a common cause of hair loss in women characterized by a diffuse reduction in hair density over the crown and frontal scalp with retention of the frontal hairline. The underlying pathophysiology is multifactorial. There are no universally agreed treatment guidelines available. The objective of the study was to understand the diagnosis and treatment pattern of female pattern hair loss and the role of minoxidil topical formulation and its combination in the management of FPHL.</p><p class="abstract"><strong>Methods: </strong>Predesigned questionnaire on FPHL was prepared based on review of literature and was filled by 80 consultant dermatologists. Recorded data was statistically analyzed.</p><p class="abstract"><strong>Results: </strong>Common age of onset of FPHL was between 20 to 30 years. Majority (96.25%) have reported FPHL in association with psychological morbidity. The most preferred treatment in mild and severe FPHL was minoxidil 5% and platelet rich plasma (PRP) plus minoxidil respectively. Most dermatologists (47.5%) treated with minoxidil for over 6 months. Majority (27.5%) reported flaking as the most common side effect with minoxidil followed by dryness, scalp irritation and itching. Majority (27.5%) observed that long treatment duration was contributing to non-compliance followed by medication cost and side effects. Majority of the dermatologists (90%) felt the need for treatment guidelines in the current Indian scenario.</p><p class="abstract"><strong>Conclusions: </strong>Minoxidil was the most common preferred treatment for mild and severe FPHL. PRP is the most common choice of combination therapy with minoxidil. Minimizing side effects, patient education and universal treatment guidelines can help manage FPHL better.  </p>

The effect of CD34+ cell-containing autologous platelet-rich plasma injection on pattern hair loss: a preliminary study

2012 ◽  
Vol 28 (1) ◽  
pp. 72-79 ◽  
Author(s):  
J.-S. Kang ◽  
Z. Zheng ◽  
M.J. Choi ◽  
S.-H. Lee ◽  
D.-Y. Kim ◽  
...  
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Plasma Injection ◽  
Autologous Platelet Rich Plasma ◽  
Preliminary Study ◽  
Autologous Platelet

Platelet-Rich Plasma Therapy for Male and Female Pattern Hair Loss

2019 ◽  
Vol 45 (1) ◽  
pp. 80-82 ◽  
Author(s):  
Marc R. Avram ◽  
Robert Finney
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Plasma Therapy ◽  
Male And Female ◽  
Female Pattern Hair Loss

scholarly journals Investigating the Safety and Efficacy of Platelet-Rich Plasma (PRP) Treatment for Female Androgenetic Alopecia: Review of the Literature

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 311
Author(s):  
Santo Raffaele Mercuri ◽  
Giovanni Paolino ◽  
Matteo Riccardo Di Nicola ◽  
Laura Vollono
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Cochrane Central Register ◽  
Review Of The Literature ◽  
Psychosocial Burden ◽  
Female Pattern Hair Loss ◽  
Central Register ◽  
Topical Minoxidil

Background: female androgenetic alopecia (FAGA) is a common cause of non-scarring alopecia in women, affecting approximately 40% of women by age 50, bearing a significant psychosocial burden on affected patients. Platelet-rich plasma (PRP) has been widely investigated as a potential effective treatment for several dermatological conditions, including male androgenetic alopecia (MAGA). However, few studies have been conducted focusing on the use of PRP in FAGA. The aim of this review was to identify reports that investigated the use of PRP for the treatment of FAGA. Methods: Electronic databases of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to September 2020 have been searched using different combinations of the following terms: “androgenetic alopecia,” “FAGA,” “female pattern hair loss,” “platelet-rich fibrin,” “platelet-rich plasma,” and “PRP”. Results and conclusions: Eight (n = 8) clinical studies consistent with our research were identified. A total of 197 subjects has been enrolled in the included studies. All of them were adult female patients (mean age: 38.9) affected by female pattern hair loss. PRP is a well-tolerated procedure which showed promising results in males-only and mixed populations of AGA patients. PRP showed to produce high levels of satisfaction and improvement in the quality of life in patients affected by FAGA. In the light of this evidence, PRP may be proposed in patients who did not respond or did not tolerate topical minoxidil, as well as in combination with topical and oral treatments.

scholarly journals Effects of platelet-rich plasma injection on pain, range of motion, and disability in adhesive capsulitis: A prospective, randomized-controlled study

2021 ◽  
Vol 67 (4) ◽  
pp. 462-472
Author(s):  
Çağlar Karabaş ◽  
Havva Talay Çalış ◽  
Ulaş Serkan Topaloğlu ◽  
Çiğdem Karakükçü
Keyword(s):  
Range Of Motion ◽  
External Rotation ◽  
Platelet Rich Plasma ◽  
Adhesive Capsulitis ◽  
Controlled Study ◽  
Control Group ◽  
Plasma Injection ◽  
Active Flexion ◽  
Home Based ◽  
Significant Difference

Objectives: In this study, we aimed to investigate the effectiveness of intra-articular platelet-rich plasma (PRP) injection in adhesive capsulitis. Patients and methods: Between January 2019 and December 2019, a total of 40 patients (21 males, 19 females; mean age: 57.1±6.5 years; range, 44 to 72 years) with idiopathic adhesive capsulitis were included. The patients were randomly assigned into two equal groups as the PRP and the control group. The PRP group received two doses of PRP via intra-articular route biweekly under ultrasound guidance. No injection was performed to the control group. In both groups, stretching and Codman exercises were applied as a home- based program. The Visual Analog Scale (VAS), range of motion (ROM), and Shoulder Pain and Disability Index (SPADI) scores were evaluated before the treatment and at 2, 6 and 12 weeks after the treatment. Results: There were significant differences in all VAS, SPADI, and ROM scores at all time points after treatment compared to baseline in both groups. At the end of the study, there were significant differences in the active flexion, passive flexion, active abduction, passive abduction, and active external rotation scores at 12 weeks between the groups (p=0.012, p=0.015, p=0.008, p=0.019, and p=0.040, respectively). No significant difference was observed between the groups in terms of VAS and SPADI scores and the other parameters (active and passive extension, active and passive internal rotation, passive external rotation) at 2, 6, and 12 weeks (p>0.05). Conclusion: The addition of PRP to exercise treatment can improve patients' joint mobility, but not pain and disability in patients with adhesive capsulitis.

Comparison of the therapeutic effects of ultrasound-guided platelet-rich plasma injection and dry needling in rotator cuff disease: a randomized controlled trial

2012 ◽  
Vol 27 (2) ◽  
pp. 113-122 ◽  
Author(s):  
Dong-wook Rha ◽  
Gi-Young Park ◽  
Yong-Kyun Kim ◽  
Min Tae Kim ◽  
Sang Chul Lee
Keyword(s):  
Rotator Cuff ◽  
Adverse Effects ◽  
Shoulder Pain ◽  
Platelet Rich Plasma ◽  
Global Rating Scale ◽  
Controlled Study ◽  
Therapeutic Effects ◽  
Dry Needling ◽  
Rotator Cuff Disease ◽  
Plasma Injection

Objective: To compare the effects of platelet-rich plasma injection with those of dry needling on shoulder pain and function in patients with rotator cuff disease. Design: A single-centre, prospective, randomized, double-blinded, controlled study. Setting: University rehabilitation hospital. Participants: Thirty-nine patients with a supraspinatus tendon lesion (tendinosis or a partial tear less than 1.0 cm, but not a complete tear) who met the inclusion criteria recruited between June 2010 and February 2011. Intervention: Two dry needling procedures in the control group and two platelet-rich plasma injections in the experimental group were applied to the affected shoulder at four-week intervals using ultrasound guidance. Measurements: The Shoulder Pain and Disability Index, passive range of motion of the shoulder, a physician global rating scale at the six-month follow-up, adverse effects monitoring and an ultrasound measurement were used as outcome measures. Results: The clinical effect of the platelet-rich plasma injection was superior to the dry needling from six weeks to six months after initial injection ( P < 0.05). At six months the mean Shoulder Pain and Disability Index was 17.7 ± 3.7 in the platelet-rich plasma group versus 29.5 ± 3.8 in the dry needling group ( P < 0.05). No severe adverse effects were observed in either group. Conclusions: Autologous platelet-rich plasma injections lead to a progressive reduction in the pain and disability when compared to dry needling. This benefit is certainly still present at six months after treatment. These findings suggest that treatment with platelet-rich plasma injections is safe and useful for rotator cuff disease.

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