scholarly journals Cutaneous manifestations of COVID-19 in pediatric patients: literature review

2021 ◽  
Vol 7 (2) ◽  
pp. 314
Author(s):  
Ghadah Alhetheli
Keyword(s):  
Literature Review ◽  
Children And Adolescents ◽  
Early Period ◽  
Health Condition ◽  
Interferon Α ◽  
Cutaneous Manifestations ◽  
Skin Manifestations ◽  
Pediatric Age Group ◽  
Inflammatory Syndrome ◽  
Shed Light

<p class="abstract">Cutaneous manifestations of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are neglected during the early period of the spread of the pandemic. Moreover, the rational that children are immune against COVID-19 infections, allowed unnoticeable spread of the disease among children and adolescents. This review article aimed to shed light on the different cutaneous manifestations of COVID-19 among pediatric age group, its related pathogenesis and histopathological features. Review of literature published since the release of the details about the disease was conducted to examine various cutaneous manifestations related to the SARS-CoV-2 infection. Review of 35 articles concerned with COVID19-related skin manifestations in pediatrics showed that it was varied and included chilblain-like, maculopapular, urticarial, vesicular, targetoid, erythema multiforme-like and COVID-19 Kawasaki disease-like multisystem inflammatory syndrome in children (MIS-C), which is serious health condition. Despite of the previously documented higher production of interferon-α in children and adolescents, children are not immune against SARS-CoV-19 infection. Cutaneous manifestations in children are usually asymptomatic and are curable unless they are drug-related side effects during the course of treatment of COVID-19. This literature review and photo atlas provide a mini-analysis of COVID-19-related skin manifestations among pediatrics with reference to their tissue histopathological changes.</p>

scholarly journals Cutaneous manifestations in children with the new coronavirus infection COVID-19

2021 ◽  
Vol 25 (1) ◽  
pp. 16-24
Author(s):  
O. B. Tamrazova ◽  
A. S. Stadnikova ◽  
E. V. Rudikova
Keyword(s):  
Literature Review ◽  
Viral Infection ◽  
Causative Agent ◽  
The Novel ◽  
Cutaneous Manifestations ◽  
Skin Manifestations ◽  
The World ◽  
Coronavirus Infection ◽  
Novel Coronavirus

In late 2019, a new viral infection appeared in China, which spread around the world, causing a pandemic. The causative agent of the new coronavirus infection COVID-19 is the SARS-CoV-2 coronavirus. The review presents modern data on the epidemiology, pathogenesis and course of the novel coronavirus infection COVID-19 in children. Chinese, American and European scientists have described a variety of cutaneous manifestations in children with COVID-19. The article provides a literature review of the cutaneous manifestations of COVID-19 coronavirus infection in children. During our own observation of 301 patients with coronavirus infection COVID-19 caused by SARS-CoV-2 at the Bashlyaevs Children Hospital in Moscow from May 17 to November 16, 2020, it was revealed that 39 (13 %) patients had skin manifestations. The article presents a classification of skin manifestations characteristic of COVID-19. A brief description of each group is given.

scholarly journals Factors forming the health of modern children and adolescents

2020 ◽  
pp. 19-24
Author(s):  
O. P. Gritsina ◽  
L. V. Trankovskaya ◽  
E. V. Semaniv ◽  
E. A. Lisetskaya
Keyword(s):  
Literature Review ◽  
Children And Adolescents ◽  
Chronic Diseases ◽  
Health Indicators ◽  
Physical Development ◽  
Health Condition ◽  
Daily Routine ◽  
Functional Disorders ◽  
Factors Affecting ◽  
Development Data

The literature review analyzing national and international researches on health condition of children population and on factors affecting its development. It has been determined that nowadays the trend towards deterioration in health indicators of children and adolescents continues characterized by an increase in the prevalence of functional disorders and chronic diseases, a deterioration in indicators of physical development. Data on the influence of various factors on the health of children are summarized, among which a special place is given to intraschool factors and the regulation of the daily routine.

scholarly journals Skin Manifestations In Children With COVID-19: A Literature Review

2020 ◽  
Vol 10 (3) ◽  
Author(s):  
Poliana Poyanco
Keyword(s):  
Immune Response ◽  
Literature Review ◽  
New England ◽  
Pediatric Patients ◽  
Skin Involvement ◽  
Cutaneous Manifestations ◽  
Abnormal Immune Response ◽  
Spread Of Infection ◽  
Inflammatory Syndrome ◽  
Correlate Data

OBJECTIVES: Perform a literature review to correlate data on dermatological manifestations in pediatric patients with coronavirus disease 2019 (COVID-19). METHODS: A systematic literature review was performed, selecting articles involving COVID-19 and dermatological manifestations in pediatric patients, in databases such as PubMed, The New England Journal of Medicine, The British Medical Journal and The Lancet. RESULTS: Studies indicate that the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2) can cause dermatological manifestations, like macules, papules, rash, hives, erythema and oral mucositis. Skin involvement by COVID-19 in children may be associated with multisystemic inflammatory syndrome, in which there is an abnormal immune response associated of cytokines and activation of macrophages, which can justify the changes in the skin. CONCLUSION: Cutaneous manifestations, although unspecific, are important for the identification of the disease in pediatric patients and better control of the spread of infection to the population.

scholarly journals Cutaneous manifestations and COVID-19 infection in children and teenagers: an integrative review

2020 ◽  
Vol 10 (3) ◽  
Author(s):  
Alessandra Oliveira ◽  
Kamilla Pádua ◽  
Maria Carolina Alves ◽  
Karine Cardoso ◽  
Alexia Oliveira
Keyword(s):  
Children And Adolescents ◽  
English Language ◽  
Skin Lesions ◽  
Integrative Review ◽  
Childhood And Adolescence ◽  
Cutaneous Manifestations ◽  
Pediatric Age Group ◽  
Analysis And Synthesis ◽  
Skin Abnormalities ◽  
Coronavirus Infection

The study aims to analyse the cutaneous manifestations described in the literature so far, in children and adolescents, related to COVID-19. An integrative review was carried out using the descriptors and combinations in the English language: skin abnormalities, coronavirus infection, child, and adolescent. The inclusion criteria were articles that related skin manifestations in children and adolescents with COVID-19. The analysis and synthesis of the data obtained in a descriptive manner, characterizing the cutaneous manifestations analyzed. The study ended with 5 articles and it was observed that patients in the pediatric age group with COVID-19 may present diverse skin lesions as a single manifestation or accompanied by mild symptoms, and that these may be similar to those of other diseases common in childhood and adolescence.

scholarly journals Cutaneous Manifestations of COVID-19: A Systematic Review

2020 ◽  
Vol 3 ◽  
Author(s):  
Harjas Singh ◽  
Harleen Kaur ◽  
Kanhaiya Singh ◽  
Chandan Sen
Keyword(s):  
Systematic Review ◽  
Molecular Mechanisms ◽  
Age Groups ◽  
Rapid Identification ◽  
Health Condition ◽  
Cutaneous Manifestations ◽  
Potential Impact ◽  
Primary Focus ◽  
Skin Morphology ◽  
Inflammatory Syndrome

Background: Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), is currently a pandemic. Although pulmonary health has been the primary focus of studies during the early days of COVID-19, development of a comprehensive understanding of this emergent disease requires knowledge of all possible disease manifestations in affected patients.     Methods: This PRISMA-compliant review focuses on cutaneous manifestations reported in COVID-19 patients. Literature review was conducted using the PubMed database to examine various cutaneous manifestations related to the SARS-CoV-2 infection. Published articles related to search criteria from the onset of the COVID-19 pandemic to June 30, 2020 were included. In total 56 articles were used for data collection.     Results: Unique to many other symptoms of COVID-19, its cutaneous manifestations have been found in people of all age groups including children. The cutaneous manifestations of COVID-19 are varied and include maculopapular, chilblain-like, urticarial, vesicular, livedoid, and petechial lesions. In addition, rashes are common in multisystem inflammatory syndrome in children (MIS-C), a new and serious health condition that shares symptoms with Kawasaki disease and is likely related to COVID-19. Lastly, personal protective equipment (PPE)-related skin complications are of serious concern since broken cutaneous barriers can create an opening for potential COVID-19 infections and by inadvertently spreading the virus.    Conclusion and Potential Impact: As this virus continues to spread silently, mainly through asymptomatic carriers, an accurate and rapid identification of these cutaneous manifestations may be vital to early diagnosis and lead to possible better prognosis in COVID-19 patients. This systematic review provides a detailed analysis on the changes in skin morphology related to COVID-19 and discusses plausible underlying molecular mechanisms. Study of these cutaneous manifestations, their pathogenesis as well their significance in human health will help define COVID-19 in its entirety which is a prerequisite to its effective management.  

scholarly journals THU0617-HPR TOWARDS A UNIVERSAL DEFINITION OF DISEASE ACTIVITY SCORES THRESHOLDS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 551.1-551
Author(s):  
N. Foulquier ◽  
B. Chevet ◽  
G. Carvajal Alegria ◽  
L. Saraux ◽  
V. Devauchelle-Pensec ◽  
...  
Keyword(s):  
Literature Review ◽  
Disease Activity ◽  
Mobile Application ◽  
Inflammatory Diseases ◽  
Smart Phone ◽  
Linear Interpolation ◽  
Publication Date ◽  
Cutaneous Manifestations ◽  
Manual Search ◽  
Universal Definition

Background:For rheumatologists monitoring patients with various diseases and dealing with multiple scores with different maximum values (9 for RA-DAS, 6.4 for AS-DAS and 60 for PMR-AS) and values thresholds to characterize the different levels of disease activity (low, intermediate and high) can be a tedious task. The same problematic could arise in other specialty than rheumatology. Normalization of these scores seems to be necessary to facilitate daily clinical practice (1).Objectives:To indentify and standardize scores of activity of inflammatory diseases.Methods:We conducted a literature review on activity criteria using both a manual approach and the BIBOT software (2) published in English between 1.1.1975 and 31.12.2018. Within all extracted disease activity scores, we selected those with cut off values in four classes (remission, low, moderate and high disease activity). We used a linear interpolation to map all these disease activity scores to our new score, the AS-135, and developed a smart-phone application to perform the conversion automatically.Results:1068 articles were analyzed by BIBOT, 86 were excluded on the basis of the language used for their writing and 11 were excluded on the basis of their publication date. 599 were selected based on their titles, abstracts and keywords. 108 activity criteria from various fields (rheumatology, dermatology, gastroenterology, psychiatry, neurology and pneumology) were identified, but it is in rheumatology that we find separation into four classes. 10 scores met our inclusion criteria and were implemented in the Android app. These are: DAS28 (ESR), DAS28 (CRP), SDAI, ASDAS (ESR), ASDAS (CRP), ESSDAI, SLEDAI-2K, DAPSA, PMR-AS (ESR) and PMR-AS (CRP). We built the AS135 score modification for each selected score using a linear interpolation of the existing criteria. It was defined on the interval [0,10] and values 1, 3 and 5 were used as thresholds. These arbitrary thresholds are then associated with the thresholds of the existing criteria and an interpolation can be calculated, allowing the conversion of the existing criteria into AS135 criterion. We have finally created a mobile application that allows each user to obtain both the original value of the activity criterion.Conclusion:We have created a mobile application that allows any user to obtain in a simple way the level of disease activity, whatever the criterion used to describe it, since the application returns, in addition to the value of the activity criterion calculated from data returned by the physician, the transformation of this value into AS135 criterion and its interpretation in terms of level of activity of the pathology. The application is now available for Android devices and we plan to start developing a version for iOS devices.References:[1]Saraux L, Devauchelle-Pensec V, Saraux A. Plea for standardization of disease activity scores. Rheumatol Oxf Engl. 2019 Aug 1;58(8):1500–1[2]Orgeolet L, Foulquier N, Misery L, Redou P, Pers J-O, Devauchelle-Pensec V, et al. Can artificial intelligence replace manual search for systematic literature? Review on cutaneous manifestations in primary Sjögren’s syndrome. Rheumatol Oxf Engl. 2019 Aug 31;Disclosure of Interests:None declared

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