Ovarian teratomas in bimodal age groups- Case report

Ovarian teratomas are the most common germ cell tumors and are classified as mature, immature and malignant.Mature cystic teratomas, also called dermoid cysts, are the most common germ cell tumour, accounting for upto 70% of benign ovarian masses in the reproductive years and 20% in postmenopausal women.Immature ovarian teratoma affects primarily younger patients and mature cystic teratomas seen in reproductive age groups. This case report provides a brief summary of the clinicopathological features of the ovarian teratomas such as, the immature teratoma which being a rare tumour was diagnosed in a 15 year old adolescent girl, managed surgically by laparotomy followed by chemotherapy, and the other case of a benign mature cystic teratoma in an elderly 52 year old postmenopausal woman, managed surgically although benign cystic teratomas are rare in the postmenopausal age group.

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Ovarian teratomas: clinicopathological study at tertiary care center

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20193558 ◽

2019 ◽

Vol 8 (8) ◽

pp. 3318

Author(s):

Sunil Vitthalrao Jagtap ◽

Nitin S. Kshirsagar ◽

Shubham S. Jagtap ◽

Saswati Boral ◽

Nitesh Nasre

Keyword(s):

Germ Cell ◽

Histopathological Examination ◽

Mature Teratoma ◽

Tertiary Care ◽

Germ Cell Tumors ◽

Cystic Teratoma ◽

Ovarian Teratoma ◽

Care Hospital ◽

Palpable Mass ◽

Ovarian Teratomas

Background: Teratomas are belonging to a group of germ cell tumors. It is also referred to as dermoid cyst. Teratomas are most common germ cell tumor of the ovary. Teratomas are composed of various histological types. In this article we are presenting various morphological patterns, its clinical manifestation and its clinical significance.Methods: This is prospective study for a period of 3 years from March 2016 to February 2019 at tertiary care hospital. It consists of total evaluation of 82 cases of ovarian lesions which were surgically excised for clinically or radiologically suspected of ovarian neoplasm.Results: A total of 82 cases of ovarian specimen were included out of which 18 cases were of ovarian teratoma. In these 17 cases were benign teratomas, 1 case of immature teratoma. All the cases of mature teratoma were predominantly of cystic type with focal solid areas. Right sided ovary was involved in44.5% cases while left sided in 55.5% cases. The tumor size ranges from 2.5 cm to 20.8 cms. The age range in this study was from 20 to 60 year. The common age observed for ovarian teratoma was in group of 31-40 years, having 6 cases. The clinically most of cases were asymptomatic or presented with unexplained abdominal pain or palpable mass. USG finding in most of cases were diffuse or partial echogenic mass lesion with cystic nature and echogenic bands.Conclusions: In our study showed mature cystic teratoma is the most common type of ovarian teratomas. The immature and monodermal types are rare. The histopathological examination plays important role in final diagnosis and patient management.

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Mediastinal Cystic Teratoma with Right Sided Extra Renal Wilms’ Tumor - A Rare Case Report

Bangladesh Journal of Child Health ◽

10.3329/bjch.v42i3.39271 ◽

2018 ◽

Vol 42 (3) ◽

pp. 155-158

Author(s):

AKMA Morshed ◽

S Islam ◽

K Alam

Keyword(s):

Early Childhood ◽

Case Report ◽

Germ Cell ◽

Rare Case ◽

Wilms Tumor ◽

Germ Cell Tumors ◽

Cystic Teratoma ◽

Cell Tumor ◽

Mediastinal Teratoma ◽

Rare Case Report

A teratoma of the mediastinum is an uncommon germ cell tumor. Five percent of germ cell tumors are extragonadally located and men are affected more than women .Most mediastinal teratoma produce no symptoms, but we are presenting a case which was present with respiratory distress in early childhood. Classical wilm’s tumor usually found within the kidney but rarely it can occur in extra renal situations. Combination of these two is not reported until today we have searched extensively. We are presenting a 26 month old boy with mediastinal cystic teratoma with right sided extra renal wilms’ tumor which may be the first reported case. Combined effort of various concern departments ensures the diagnosis and management of such a rare case. Bangladesh J Child Health 2018; VOL 42 (3) :155-158

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Case Report of Three Immature Cystic Teratomas in Northern Ghana

Case Reports in Obstetrics and Gynecology ◽

10.1155/2019/1210509 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

E. M. Der ◽

S. Seidu

Keyword(s):

Case Report ◽

Histopathological Examination ◽

Germ Cell Tumour ◽

Cystic Teratoma ◽

Abdominal Ultrasound ◽

Northern Ghana ◽

Ovarian Teratoma ◽

Emergency Laparotomy ◽

Abdominal Masses ◽

High Sense

Background. Preoperative diagnosis of immature cystic teratoma can be challenging for clinicians. In this report, we present three cases.Methods. We describe three women aged 10, 20, and 23 years, respectively, who presented with abdominal masses which were diagnosed by abdominal ultrasound as mature cystic teratomas. All women had emergency laparotomy and oophorectomy.Results. Histopathological examination reported these ovarian tumours to be immature cystic teratomas. This case report also provided a brief summary of the clinicopathological features of all ovarian teratomas diagnosed in two centres during the period of review.Conclusion. Immature ovarian teratoma affects primarily younger patients; it is important for clinicians to have a high sense of suspicion whenever the diagnosis of a germ cell tumour is entertained.

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Histopathological evaluation of ovarian tumours in southern part of Assam

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20211356 ◽

2021 ◽

Vol 9 (4) ◽

pp. 1090

Author(s):

Madhusmita Choudhury ◽

Monoj K. Deka ◽

Shah A. Sheikh

Keyword(s):

Germ Cell ◽

Malignant Tumors ◽

Age Groups ◽

Germ Cell Tumors ◽

Reproductive Age ◽

Histopathological Study ◽

Age Group ◽

Malignant Tumours ◽

Morphological Pattern ◽

Ovarian Tumours

Background: Ovarian malignancy is the second most common cancer of the female reproductive system and the leading cause of death from gynecologic malignancy. With increase in longevity, the incidence of epithelial ovarian cancer is increasing and its etiopathology remains unknown. A female’s risk at birth of having ovarian tumour sometime in her life is 6-7%. Two third of ovarian tumours occur in women of reproductive age group. The aim was to study the distribution of morphological pattern of benign, malignant, and nonneoplastic lesions of the ovary in different age groups and to determine the likelihood of bilateral involvement in different morphologic subtypes.Methods: A retrospective study from January 2018 to December 2020 was undertaken. A total of 210 surgical specimens were obtained. Detailed clinical information and radiological findings were recorded from the case sheets. Grossing of the surgical specimens was done in the pathology department, followed by histological examination.Results: Of 210 cases, benign cases were 140 (66.7%), malignant cases were 70 (33.3%). Surface epithelial tumors were most common (116/55.2%) followed by germ cell tumors (76, 36.1%) followed by others. Serous cystadenoma was commonest benign tumor (58, 41.4%). Serous adenocarinoma was commonest malignant tumor (19, 27.1%). Benign tumours were more common in the younger age group i.e. <40 years of age whereas malignant tumours were supervenes with increase in age. Most benign ovarian tumors (54, 38.6%) were seen between 31-40 years whereas most malignant tumors (24, 34.3%) were seen above 40 years. In 1st two decades, germ cell tumors were more common than other tumours.Conclusions: The prognosis and varying therapeutic strategies of ovarian tumours necessitate an accurate pathological evaluation. Histopathological study is still the gold standard in diagnosing most of these tumours.

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Spectrum of ovarian tumors in a referral hospital in Nepal

Journal of Pathology of Nepal ◽

10.3126/jpn.v4i7.10295 ◽

2014 ◽

Vol 4 (7) ◽

pp. 539-543 ◽

Cited By ~ 3

Author(s):

S Vaidya ◽

P Sharma ◽

S KC ◽

SA Vaidya

Keyword(s):

Germ Cell ◽

Germ Cell Tumour ◽

Age Distribution ◽

Germ Cell Tumors ◽

Clinical Manifestations ◽

Cystic Teratoma ◽

Ovarian Tumors ◽

Serous Carcinoma ◽

Benign Tumors ◽

Malignant Germ Cell Tumors

Background: Ovarian tumors are common forms of neoplasia in women. Among cancers of the female genital tract, it ranks only below carcinoma of the cervix and the endometrium, but is responsible for approximately 50% of the deaths. They arise from different cell lineages and hence constitute a wide variety of neoplastic entities with diverse morphological and clinical manifestations. Materials and Methods: A descriptive study of 363 cases of ovarian tumors was carried out during a three year period from January 2011 to December 2013. Results: Of the 363 ovarian tumors, 293 (80.72%) cases were benign, 57 (15.70%) were malignant and 13 (3.58%) were borderline. Germ cell tumour was the most common class of tumour and seen in 187 (51.52%) cases, followed by surface epithelial in 158 (43.53%) cases. The age distribution of the patients ranged from 10-82 years with a median age of 33 years. Benign tumors were more common than malignant ones in all age groups. Conclusion: Most of the ovarian tumors in this study were of germ cell origin. The incidence of malignant germ cell tumors was also significantly higher than in other studies. Mature cystic teratoma was the most common benign tumour while serous carcinoma was the most common malignancy. The incidence of malignant germ cell tumors was higher compared to other studies. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10295 Journal of Pathology of Nepal (2014) Vol. 4, 539-543

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Mature Cystic Teratoma of Ovary– a Case Report & Review of Literature

10.21203/rs.3.rs-50261/v1 ◽

2020 ◽

Author(s):

Sunita Nayak ◽

Suren Prasad Dash

Keyword(s):

Case Report ◽

Germ Cell ◽

Ovarian Neoplasms ◽

Germ Cell Tumour ◽

Cystic Teratoma ◽

Good Prognosis ◽

Mature Cystic Teratoma ◽

Review Of Literature ◽

The Right

Abstract Mature cystic teratoma or dermoid cyst is the most common germ cell tumour of the ovary. The incidence ranges from 5 to 25% of all ovarian neoplasms out of which 13.7% are bilateral. Teratomas usually occur in the ovaries but they may be seen in other sites known as extragonadal teratomas the incidence of which is only 0.4%. Teratomas are usually benign but they may turn out to be highly malignant. Torsion is known to be the most frequent complication of ovarian teratomas followed by autoamputation. Teratomas are classified as “Mature” and “Immature” by WHO. Teratomas show good prognosis specially the mature ones. Surgery and follow up remains the standard approach. We report a case of mature cystic teratoma in the right ovary of a 28 years old nulliparous woman.

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Treatment outcomes in malignant ovarian germ cell tumors

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20175089 ◽

2017 ◽

Vol 6 (12) ◽

pp. 5256

Author(s):

Ram Kumar B.

Keyword(s):

Germ Cell ◽

Chemotherapy Regimen ◽

Primordial Germ Cells ◽

Germ Cell Tumour ◽

Germ Cell Tumors ◽

Cystic Teratoma ◽

Germ Cell Tumours ◽

Fertility Sparing Surgery ◽

Fertility Sparing ◽

Yolk Sac Tumour

Background: Malignant ovarian germ cell tumours are rare group of ovarian neoplasms derived from primordial germ cells of the ovary. Objective of present study was to evaluate the outcome of treatment in malignant germ cell tumours.Methods: 21 Patients of malignant ovarian germ cell tumours registered at Department of Medical Oncology, Institute of Obstetrics and Gynaecology, Chennai for the period from January 2012 to December 2015 were retrospectively analyzed for treatment outcomes.Results: The median age at presentation was 21 years with age range between 14 and 40 years. 9patients (43%) presented with mixed germ cell tumour, 6 patients (29%) with dysgerminoma, 3 patients (14%) with yolk sac tumour and 3 patients (14%)with mature cystic teratoma. 13 patients (62%) presented with Stage I disease, 5 patients (24%) with Stage III and 3 patients (14%) with Stage II. Fertility sparing surgery was done in 15 patients (71%), and 4 patients (19%) who completed family had TAH with BSO done. Adjuvant Chemotherapy was given for 16 patients (76%) and as Neoadjuvant in 2patients (10%) who had biopsy alone performed. 4patients (19%) developed recurrence and was taken for salvage PVI chemotherapy.Conclusions: Malignant ovarian germ cell tumours are relatively uncommon neoplasms characterized by high chemo sensitivity. This study confirms that malignant ovarian germ cell tumours have excellent prognosis and the effectiveness of BEP chemotherapy regimen. Fertility sparing surgery is feasible in most cases. Advanced Stage configured as an important risk factor for survival. The chemotherapy regimen was associated with significant but manageable toxicity.

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Age-Dependent Presentation and Clinical Course of 1465 Patients Aged 0 to Less than 18 Years with Ovarian or Testicular Germ Cell Tumors; Data of the MAKEI 96 Protocol Revisited in the Light of Prenatal Germ Cell Biology

Cancers ◽

10.3390/cancers12030611 ◽

2020 ◽

Vol 12 (3) ◽

pp. 611 ◽

Cited By ~ 4

Author(s):

Gabriele Calaminus ◽

Dominik T. Schneider ◽

Dietrich von Schweinitz ◽

Heribert Jürgens ◽

Nacera Infed ◽

...

Keyword(s):

Germ Cell ◽

Cell Biology ◽

Age Groups ◽

Germ Cell Tumors ◽

Risk Groups ◽

Ovarian Teratoma ◽

Progression Rate ◽

Testicular Germ Cell ◽

Repeated Surgery ◽

Chemotherapy Patients

Objective: To evaluate prognostic factors in pediatric patients with gonadal germ cell tumors (GCT). Methods: Patients <18 years with ovarian and testicular GCT (respectively OGCT and TGCT) were prospectively registered according to the guidelines of MAKEI 96. After resection of the primary tumor, patients staged ≥II received risk-stratified cisplatin-based combination chemotherapy. Patients were analyzed in respect to age (six age groups divided into 3-year intervals), histology, stage, and therapy. The primary end point was overall survival. Results: Between January 1996 and March 2016, the following patients were registered: 1047 OGCT, of those, 630 had ovarian teratoma (OTER) and 417 had malignant OGCT (MOGCT); and 418 TGCT, of those, 106 had testicular teratoma (TTER) and 312 had malignant TGCT (MTGCT). Only in MTGCT, older age correlated with a higher proportion of advanced tumors. All 736 teratomas and 240/415 stage I malignant gonadal GCT underwent surgery and close observation alone. In case of watchful waiting, the progression rate of OGCT was higher than that of TGCT. However, death from disease was reported in 8/417 (1.9%) MOGCT and 8/312 (2.6%) MTGCT irrespective of adjuvant chemotherapy and repeated surgery. Conclusions: The different pathogenesis and histogenesis of gonadal GCT reflects sex- and age-specific patterns that define clinically relevant risk groups. Therefore, gender and age should be considered in further research on the biology and clinical practice of pediatric gonadal GCT.

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Clinical presentation and management of malignant germ cell ovarian tumours in BPKMCH

10.1055/s-0039-1685406 ◽

2016 ◽

Author(s):

Jitendra Pariyar ◽

Binuma Shrestha

Keyword(s):

Neoadjuvant Chemotherapy ◽

Germ Cell ◽

Clinical Presentation ◽

Early Stage ◽

Germ Cell Tumour ◽

Cystic Teratoma ◽

Germ Cell Tumours ◽

Early Stage Disease ◽

Cancer Hospital ◽

Disseminated Disease

Background: Germ cell malignancies account for about 5% of all ovarian cancers. These tumours grow rapidly and often produce symptoms quicker than the slow growing epithelial tumour. Commonly seen in the first two decades of life germ cell malignancies are highly chemosensitive and are potentially curable with surgery and chemotherapy. This study is the first of its kind regarding the epidemiology, management and outcome of patients with malignant germ cell tumour in Nepal. Objective: To analyze the clinical presentation and management outcomes of malignant germ cell tumours managed in B.P. Koirala Memorial Cancer Hospital, Nepal. Methodology: Descriptive study conducted in B.P. Koirala Memorial Cancer Hospital, Nepal. Case records of malignant germ cell tumours attending the hospital from January 1999 to December 2009 were analyzed regarding their illness history, clinical examination, investigations, treatment, follow-up and outcomes measured. Observations: Total 65 cases of malignant germ cell tumours with age range from 2 to 58 years (mean 21.7 years) were received. 42% cases were Tibeto-Burmese; 30% were Indo-Aryans. There were 15 cases (23%) of dysgeminoma, 21 endodermal sinus tumor (32%), 16 Immature Cystic Teratoma (24.5%), 9 (14%) Mixed Germ Cell, 2 unclassified GCT (3.5%) and 2 malignant transformation in teratoma (3.5%). 33 (49.5%) patients had early stage disease, 37 (57%) underwent fertility preserving surgery. 4 cases (9%) due to disseminated disease, underwent neoadjuvant chemotherapy followed by debulking surgery. 51 cases (78.5%) received adjuvant chemotherapy (BEP or EP regimen). The overall survival was 70%. Conclusion: Early stage germ cell malignancies can be safely managed by fertility preserving surgery followed by, chemotherapy if indicated. For advanced diseases, neoadjuvant chemotherapy followed by surgery can be undertaken with curable intent.

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