scholarly journals Histopathological evaluation of ovarian tumours in southern part of Assam

2021 ◽  
Vol 9 (4) ◽  
pp. 1090
Author(s):  
Madhusmita Choudhury ◽  
Monoj K. Deka ◽  
Shah A. Sheikh
Keyword(s):  
Germ Cell ◽  
Malignant Tumors ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Reproductive Age ◽  
Histopathological Study ◽  
Age Group ◽  
Malignant Tumours ◽  
Morphological Pattern ◽  
Ovarian Tumours

Background: Ovarian malignancy is the second most common cancer of the female reproductive system and the leading cause of death from gynecologic malignancy. With increase in longevity, the incidence of epithelial ovarian cancer is increasing and its etiopathology remains unknown. A female’s risk at birth of having ovarian tumour sometime in her life is 6-7%. Two third of ovarian tumours occur in women of reproductive age group. The aim was to study the distribution of morphological pattern of benign, malignant, and nonneoplastic lesions of the ovary in different age groups and to determine the likelihood of bilateral involvement in different morphologic subtypes.Methods: A retrospective study from January 2018 to December 2020 was undertaken. A total of 210 surgical specimens were obtained. Detailed clinical information and radiological findings were recorded from the case sheets. Grossing of the surgical specimens was done in the pathology department, followed by histological examination.Results: Of 210 cases, benign cases were 140 (66.7%), malignant cases were 70 (33.3%). Surface epithelial tumors were most common (116/55.2%) followed by germ cell tumors (76, 36.1%) followed by others. Serous cystadenoma was commonest benign tumor (58, 41.4%). Serous adenocarinoma was commonest malignant tumor (19, 27.1%). Benign tumours were more common in the younger age group i.e. <40 years of age whereas malignant tumours were supervenes with increase in age. Most benign ovarian tumors (54, 38.6%) were seen between 31-40 years whereas most malignant tumors (24, 34.3%) were seen above 40 years. In 1st two decades, germ cell tumors were more common than other tumours.Conclusions: The prognosis and varying therapeutic strategies of ovarian tumours necessitate an accurate pathological evaluation. Histopathological study is still the gold standard in diagnosing most of these tumours. 

scholarly journals Histopathological Study of Ovarian Tumors at a Tertiary Care Hospital of Central Nepal

2019 ◽  
Vol 15 (1) ◽  
pp. 22-29
Author(s):  
Binita Goyal ◽  
T Sheshagiri Rao ◽  
Himanshu Regmi
Keyword(s):  
Germ Cell ◽  
Size Range ◽  
Malignant Tumors ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Ovarian Tumors ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Age Group ◽  
Stromal Tumors

Background: Ovarian tumors are histogenetically varied and complex tumors spanning all age groups. They account for 30% of all gynaecologic cancers. Malignant tumors carry a high mortality due to its late detection and ineffective screening programs. Current study aims at finding association between age at presentation and size of tumor with behavior of tumors and also association between category of tumor and age at presentation. Methods: This Hospital record based cross-sectional (historical) study was carried out on 158 cases of ovarian tumors received in Department of Pathology, College of Medical Sciences and Teaching Hospital during a time period of five and a half years from January 2012 to June 2017. Results: Age of the patients ranged from 12 to 88 years with maximum cases 96 (60.8%) in 20 – 40 years age group. The mean ±SD of age was 36.6±14.4 years. Majority of the cases 137 (86.7%) were benign. Sixteen (10.1%) cases were malignant and 5 (3.2%) cases were borderline. Majority of both benign and malignant cases were seen in 20 – 40 years age group. Size of the tumors ranged from 2 – 30 cm with mean±SD of 9.9±5.0 cm and maximum 93 (58.9%) cases in the size range of 5 – 10 cm. Majority of both benign and malignant tumors were in the size range of 5 – 10 cm. There was no association of age at presentation and size of tumor with behavior of tumor (p > 0.05). Sevety five (47.5%) cases were germ cell tumors, 72 (45.6%) cases were surface epithelial-stromal tumors, 9 (5.7%) cases were sex cord-stromal tumors, 1 (0.6%) was bilateral with surface epithelial tumor in right ovary and germ cell tumor in left ovary and 1 (0.6%) case was soft tissue tumor not specific to ovary. Majority of cases of germ cell tumors were seen below 40 years age whereas significant proportion of surface epithelial-stromal tumors was seen after 40 years with significant association between category and age at presentation (p < 0.05). Most common histopathological diagnosis overall was dermoid cyst in 43.7% cases. Conclusions: Benign ovarian tumors were more common than  malignant ones. Malignancy was seen in all age groups and in any size tumor. Surface epithelial-stromal   tumors and germ cell tumors were roughly equal in frequency with slight predominance of latter. Germ cell tumors were common in younger whereas surface epithelial-stromal tumors were more common in older   individuals. Histopathological examination in any ovarian tumor at any age with any size is mandatory.

scholarly journals Clinicopathological analysis of ovarian tumours: a 10 year retrospective study

2018 ◽  
Vol 7 (8) ◽  
pp. 3216
Author(s):  
Sahana N. Naik ◽  
Sunil Kumar K. S. ◽  
Girija B.
Keyword(s):  
Malignant Tumors ◽  
Female Genital Tract ◽  
Germ Cell Tumors ◽  
Mucinous Cystadenoma ◽  
Ovarian Tumors ◽  
Reproductive Age ◽  
Benign Tumors ◽  
Age Group ◽  
Epithelial Tumors ◽  
Neoplastic Lesions

Background: Ovarian tumors account for 30% of all cancers of female genital tract which represents the sixth most common cancer and fourth leading cause of death in women. The present study was done with an objective to determine the frequency and distribution of various ovarian tumors and to study their clinical and histopathological presentations.Methods: It is a retrospective observational study of patients with ovarian tumors subjected to surgery in the department of obstetrics and gynecology, SDM College of Medical Sciences and Hospital from January 2005 to December 2015.Results: There were 642 cases comprising of 77.7% of neoplastic lesions and 22.3% of non-neoplastic lesions. Majority of the ovarian tumors (83%) were seen in the age group of 20 to 50 years. Mean age for ovarian tumors was 38 years.  Among the neoplastic lesions 84% were benign, 14.2% were malignant and 1.8% were borderline tumors. Surface epithelial tumors were the commonest tumors (60.9%) followed by germ cell tumors (12.8%).  Serous cystadenoma was the most common benign tumors (47.1%) followed by mucinous cystadenoma (18.4%). Among the ovarian malignant tumors; serous cystadenocarcinoma was the most common (4.5%) followed by mucinous cystadenocarcinoma (2.6%). Chocolate cysts were the most common among the non-neoplastic lesions (36.4%).Conclusions: Ovarian neoplastic lesions were more common than non-neoplastic lesions. Benign ovarian tumors were common in reproductive age group.  The mean age of occurrence for ovarian tumor was 38 years. The most common neoplasm was surface epithelial tumors, of which serous tumors was the commonest. Chocolate cysts were the most frequently encountered histopathological finding among the non-neoplastic lesions.

HISTOPATHOLOGICAL SPECTRUM OF OVARIAN TUMOURS IN REPRODUCTIVE AGE GROUP WOMEN OBSERVED AT A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 73-76
Author(s):  
Sivakumar Vulava ◽  
P.R.D. Ganesh Basina ◽  
Aluri Anjanapriyanka ◽  
Uram. Arunajyothi
Keyword(s):  
Clinical Presentation ◽  
Reproductive Age ◽  
Metastatic Tumour ◽  
Care Hospital ◽  
Age Group ◽  
Malignant Tumours ◽  
Reproductive Age Women ◽  
Ovarian Tumours ◽  
Epithelial Tumours ◽  
Reproductive Age Group

Aim and objectives: Ovarian tumours present with a wide variation in clinical presentation and morphological features. Ovaries apart from being a common sites of primary tumors, they are frequent sites for metastasis from organs like stomach, colon and breast. The present work has been undertaken to study the common morphologic and histological types of ovarian tumours in reproductive age group women. Materials and methods: A prospective study s study is conducted for a period of 3 years (August 2010 to September 2013). 100 cases of ovarian tumors in reproductive age women were selected for the present study. Age between 15 and 49 was taken as reproductive age. 100 cases of ovarian tumours in reproductive age women were selected for the present study. Age between 15 and 49 was taken as reproductive age. Out of the 100 cases 99 Results: were primary ovarian tumours, 1 was secondary / metastatic tumour. Out if the 99 primary tumours 94 were benign, 1 was borderline tumour and 4 were malignant tumours. Most tumours occurred in age between 30-40 years. Of the 99 primary tumours 85(90.4%) were surface epithelial tumours, 10 (10.6%) were germ cell tumours and 4 (4.2%) were sex-cord stromal tumours. 1 metastatic tumour, were noted. Benign ovarian tumours are more common than malignant tumours. Conclusion: Surface epithelial tumours are the most common type of all ovarian tumours. Surface epithelial tumours are the most common benign and malignant tumours in reproductive age group. The incidence, clinical presentation of the different types of ovarian tumours is extremely variable. Histopathology is still the gold standard in diagnosing most of ovarian tumours. Studying the macroscopic and microscopic features of different ovarian tumours will enable proper categorization into denite morphologic type.

Histopathological profile of ovarian tumors in a tertiary care center- a descriptive study

2021 ◽  
Vol 9 (4) ◽  
pp. 1010
Author(s):  
Anitha Pallikkara V. ◽  
Shameem K. Ummer Ali
Keyword(s):  
Germ Cell ◽  
Malignant Tumors ◽  
Care Center ◽  
Tertiary Care ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
Medical College ◽  
Epithelial Tumors

Background: Ovarian neoplasms are a heterogeneous group of tumors with varied clinical, morphological and histological features. Ovarian cancer accounts for about 3% of all cancer in females and is the 5th most common cause of death due to cancer because most ovarian tumors spread beyond ovary by the time of diagnosis. The objective of the study was to document the histological pattern and prevalence of ovarian tumors in specimens received at department of pathology government medical college Alappuzha.Methods: This was a prospective study of 18 months duration which comprised of 245 cases of ovariectomy and ovariotomy specimens received in the department of pathology, govt. T.D medical college Alappuzha, Kerala. After detailed and thorough gross examination of the specimens, bits from representative areas were routinely processed and stained with H and E. Tumors were classified as per WHO classification. Appropriate immunohistochemical studies were performed wherever required.Results: Out of 245 cases studied, majority were benign tumors (78.36%), followed by malignant tumors (15. 11%). Borderline tumors comprised (6.53%) of the total cases. Age groups studied ranged from 11-70 years. Epithelial tumors were the most common (76.32%) followed by germ cell tumors (17.55%), sex cord stromal tumors (5.03%) and carcinoma arising in germ cell tumors (0.81%). Serous cystadenoma was found to be the commonest benign tumor and serous cystadenocarcinoma was the commonest malignant ovarian neoplasm.Conclusions: Surface epithelial tumors were the most common ovarian tumors. The maximum number of tumors were noted in the age group 21-40 years. Malignant tumors were common above 40 years. 

scholarly journals Ovarian Germ Cell Tumor – Histopathological and statistical analysis

2013 ◽  
Vol 3 (6) ◽  
pp. 441-446
Author(s):  
A Ghosh ◽  
D Magar Gharti ◽  
B Sathian ◽  
R Narasimhan ◽  
Op Talwar
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Malignant Tumors ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Mature Cystic Teratoma ◽  
Age Group ◽  
Malignant Germ Cell Tumors

Background: Ovarian cancers are common among females. The ovarian tumors are classified according to its histogenesis. In the present study, we analyzed the germ cell ovarian tumors reported in our institute. Materials and Methods: This study was a hospital based retrospective study. All ovarian germ cell tumor reported from Jan 2001 to Feb 2013 were retrieved and analyzed. The specimens were routinely processed and the slides were stained with H&E and special stains wherever required. Results: A total of 340 cases of ovarian tumors were reported and 150 cases (44%) were of germ cell origin. We had 137 cases of benign and 13 cases of malignant germ cell tumors. Most common subtype was mature cystic teratoma comprising 125 cases. Among the malignant cases, the most common was immature teratoma (5 cases). Age range in our series was from 8 to 82 years (mean 28 years). The most common age group affected was 21-30 years. Most of the malignant cases (76.9%) were in less than 30 years. Among the malignant cases majority (84.6%) were more than 10 cm in size. None of the malignant germ cell tumors were bilateral. Conclusion: Among germ cell tumors of ovary, mature cystic teratoma is the most common tumor and malignant subtypes are uncommon. Malignant tumors tend to occur in younger age group. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8990 Journal of Pathology of Nepal (2013) Vol. 3, 441-446

scholarly journals Extragonadal Germ Cell Tumors in Children and Adolescents - a 20 Year Study

2020 ◽  
Vol 27 (4) ◽  
pp. 281-287
Author(s):  
Felice FAIZAL ◽  
Alka KALGUTKAR ◽  
Vandana DAHAKE
Keyword(s):  
Germ Cell ◽  
Treatment Options ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Response To Treatment ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group ◽  
Sacrococcygeal Region ◽  
Extragonadal Germ Cell Tumors

Germ cell tumors (GCT) are rare neoplasms which are seen in all age groups and both sexes. Gcts in the pediatric age group show considerable variation from their adult counterparts in relation to site, histological type, clinical and radiological features and response to treatment. Extragonadal gcts are much more common in the pediatric age group with the most common sites being sacrococcygeal region, head and neck, retroperitoneum and mediastinum. Unusual sites like the vagina and urinary bladder have also been reported. Therefore, the varied presentations and different treatment options should be considered.

scholarly journals Ovarian teratomas in bimodal age groups- Case report

2021 ◽  
Vol 8 (3) ◽  
pp. 416-419
Author(s):  
Bharathi Rao ◽  
Shweta Bhatia ◽  
Pooja K Suresh ◽  
Anusha S Bhatt
Keyword(s):  
Case Report ◽  
Germ Cell ◽  
Germ Cell Tumour ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Reproductive Age ◽  
Ovarian Teratoma ◽  
Rare Tumour ◽  
Ovarian Teratomas

Ovarian teratomas are the most common germ cell tumors and are classified as mature, immature and malignant.Mature cystic teratomas, also called dermoid cysts, are the most common germ cell tumour, accounting for upto 70% of benign ovarian masses in the reproductive years and 20% in postmenopausal women.Immature ovarian teratoma affects primarily younger patients and mature cystic teratomas seen in reproductive age groups. This case report provides a brief summary of the clinicopathological features of the ovarian teratomas such as, the immature teratoma which being a rare tumour was diagnosed in a 15 year old adolescent girl, managed surgically by laparotomy followed by chemotherapy, and the other case of a benign mature cystic teratoma in an elderly 52 year old postmenopausal woman, managed surgically although benign cystic teratomas are rare in the postmenopausal age group.

scholarly journals Age specific clinicopathological profile of ovarian mass

2019 ◽  
Vol 6 (2) ◽  
pp. 18-22
Author(s):  
Laxmi R.C. Karki ◽  
Nishchal Bogati
Keyword(s):  
Germ Cell ◽  
Ovarian Tumor ◽  
Malignant Tumors ◽  
Germ Cell Tumors ◽  
Clinical Profile ◽  
Age Group ◽  
Ovarian Mass ◽  
Peak Incidence ◽  
Neoplastic Lesion ◽  
Ovarian Masses

Introductions: Ovarian cancer is seventh leading cause of cancer death among women. Ovarian mass has age specific occurrence and may may help in screening and management plans. This study was conducted to determine the age-wise clinical profile of the ovarian mass. Methods: This review done to analyse the histologically diagnosed ovarian masses in cases operated during three years at Patan Hospital, Patan Academy of Health Sciences, Nepal. Clinical profile of the patients and age-wise distribution of histological types of ovarian mass were analyzed descriptively using Microsoft Excel. Results: Peak incidence of ovarian tumor was in age group of 20-29 years with 93 (36%) cases out of 258 ovarian masses. All eight malignant tumors were in age group of ≥40 years. Neoplastic masses were 188 (72.9%), 95 (50.5%) germ cell tumor. In 70 (27.1%) non-neoplastic lesion, corpus luteal cyst were 24 (34.3%). Conclusions: Peak incidence of ovarian tumor was seen in age group of 20-29 years. Germ cell tumors accounted for half of the neoplastic lesions. All malignant ovarian tumors were in found in age group ≥40 years.

scholarly journals Clinicopathological Correlation of Germ Cell Tumours in Gonads

2021 ◽  
pp. 44-61
Author(s):  
V. Lokeshwari ◽  
Shanthi Vijayalakshmi ◽  
S. Mary Lilly
Keyword(s):  
Germ Cell ◽  
Undescended Testis ◽  
Germ Cell Tumors ◽  
Malignant Tumour ◽  
Reproductive Age ◽  
Age Group ◽  
Testicular Germ Cell ◽  
Immunohistochemical Markers ◽  
The People ◽  
Risk Of Malignancy

Ovaries are paired pelvic organs located on thesides of the uterus. Although it is rare in the general population, between the age group of 20-40 years in males,Testicular germ cell neoplasms are the most common form of malignant tumour reported. In young women ovarian tumours rank second among the ovarian germ cell tumors and in males, the testicular germ cell tumorsserves as the leading percentage of tumors among all the testicular tumors seen in the early and late adulthood (3rd and 4th decade) of life. The people of reproductive age group are most vulnerable to gonadal germ cell tumours.Curing this age group without affecting their fertility is a challenging task. The risk of malignancy increases in existence of cryptorchidism/ undescended testis as in our study, 1 case of classical seminoma presented with undescended testis. To study germ cell tumors in gonads in relation to age, parity and mode of presentation and the correlation of biochemical markers and immunohistochemical markers at places in gonadal germ cell tumors.

scholarly journals Prognostic Value of Apoptosis-Inducing Factor (AIF) in Germ Cell Tumors

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 776
Author(s):  
Katarina Letkovska ◽  
Pavel Babal ◽  
Zuzana Cierna ◽  
Silvia Schmidtova ◽  
Veronika Liskova ◽  
...  
Keyword(s):  
Germ Cell ◽  
Nuclear Translocation ◽  
Malignant Tumors ◽  
Expression Patterns ◽  
Germ Cell Tumors ◽  
Testicular Tissue ◽  
Testicular Germ Cell ◽  
Visceral Metastases ◽  
Apoptosis Inducing Factor ◽  
Clinicopathological Variables

Apoptosis is a strictly regulated process essential for preservation of tissue homeostasis. This study aimed to evaluate expression of apoptosis inducing factor (AIF) in testicular germ cell tumors (GCTs) and to correlate expression patterns with clinicopathological variables. Formalin-fixed and paraffin-embedded specimens of non-neoplastic testicular tissue and GCTs obtained from 216 patients were included in the study. AIF expression was detected by immunohistochemistry, scored by the multiplicative quickscore method (QS). Normal testicular tissue exhibits higher cytoplasmic granular expression of AIF compared to GCTs (mean QS = 12.77 vs. 4.80, p < 0.0001). Among invasive GCTs, mean QS was the highest in embryonal carcinoma, yolk sac tumor and seminoma, lower in teratoma and the lowest in choriocarcinoma. No nuclear translocation of AIF was observed. Nonpulmonary visceral metastases were associated with lower AIF expression. Metastatic GCTs patients with high AIF expression had better overall survival compared to patients with low AIF expression (HR = 0.26, 95% CI 0.11–0.62, p = 0.048). We observed significantly lower AIF expression in GCTs compared to normal testicular tissue, which is an uncommon finding in malignant tumors. AIF downregulation might represent one of the mechanisms of inhibition of apoptosis and promotion of cell survival in GCTs.

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