scholarly journals Role of Macronutrients in the Prevention of Pre-Eclampsia - A Cross Sectional Study at a Tertiary Care Centre in North India

2020 ◽  
Vol 7 (42) ◽  
pp. 2414-2419
Author(s):  
Vandana Gangadharan ◽  
Gaurie Srivastava ◽  
George Koshy ◽  
Varghese Koshy
Keyword(s):  
Serum Calcium ◽  
Serum Magnesium ◽  
Tertiary Care ◽  
Normal Pregnancy ◽  
Maternal Serum ◽  
North India ◽  
Base Line ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Calcium And Magnesium

BACKGROUND Role for macronutrient supplementation in preventing pre-eclampsia is now backed with evidence which is evolving rapidly. We wanted to study and compare serum calcium and serum magnesium levels in pre-eclamptic women and women with normal pregnancy. METHODS 30 women with normal pregnancy and 30 women with preeclampsia were included in the study. Their serum calcium and magnesium levels were estimated using colorimetry. RESULTS Serum calcium levels in normotensive patients was found to be 9.3 ± 0.95 mg / dL and in preeclamptic patients, it was 8.3 ± 0.85 mg / dL. Serum magnesium levels were found to be 1.94 ± 0.24 mg / dL and 1.57 ± 0.125 mg / dL in normal and pre-eclamptic women respectively. These values were affected by age, parity, BMI, socio-economic status, and nutrition before and during pregnancy. CONCLUSIONS Low values of maternal serum calcium along with magnesium are related to preeclampsia which might have an association in this disease. We also realised that evaluation of base-line levels of serum calcium and magnesium are necessary during early pregnancy. Constant monitoring of blood pressure is also essential. Adequate intake of macronutrients is essential for maintaining health of both mother and child. Hence, measurable and realistic efforts must be made along these lines. Nutrition is a key concern in pregnant women and is pivotal in ensuring health in this vulnerable group. KEYWORDS Pre-Eclampsia, Serum Calcium, Serum Magnesium, Pregnancy, Macronutrients

scholarly journals Evaluation of mineral status in hypothyroidism in a tertiary care centre

2020 ◽  
Vol 8 (2) ◽  
pp. 667
Author(s):  
Shikha Saxena ◽  
Prem Chandra Srivastava ◽  
Rashmi Katyal ◽  
Biswajit Das ◽  
Sileena Jaideep Pannu
Keyword(s):  
Serum Calcium ◽  
Serum Magnesium ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Serum Zinc ◽  
The Body ◽  
Endocrine Disorders ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Mineral Status

Background: Hypothyroidism is known to be the commonest form of endocrine disorders and has been linked with disturbances in various minerals metabolism. Calcium, phosphorus and magnesium and trace element zinc are required for many enzymes in various metabolic pathways which are directly or indirectly regulated by thyroid hormones. Aim and objectives of the study was to estimate serum zinc, calcium, magnesium and phosphorus in hypothyroid patients, with the objectives to evaluate any relationship with TSH and to compare them with euthyroid controls.Methods: The analytical cross-sectional study included 50 hypothyroid subjects with TSH levels >4.5 mcg IU/mL and 50 euthyroid subjects of 20-50 years in RMCH, Bareilly. TSH was estimated by ECLIA, serum calcium and phosphorus were estimated by autoanalyzer and serum zinc & magnesium by the kit method using semi autoanalyzer. All the biochemical parameters were expressed as median with Interquartile Range (IQR). Mann-Whitney test was applied to compare the parameters of cases and control. Spearman’s rank correlation coefficient 2-tailed was used to correlate the parameters among the cases.Results: A significantly decreased level of serum calcium and increased level of serum magnesium and phosphorus were observed in hypothyroid cases. A significant negative correlation between TSH and serum calcium while a significant positive correlation of serum magnesium and phosphorus with TSH was observed.Conclusions: The indexed study indicates the significant effect of overt or subclinical hypothyroidism over the mineral status of the body which may have inconsistent effect over the various metabolism and enzymes and thereby clinical manifestations.

scholarly journals Clinical profile of pediatric patients with tuberculosis in a tertiary care centre in India

2020 ◽  
Vol 7 (9) ◽  
pp. 1906
Author(s):  
Ashna Kumar ◽  
Javid Ahmad ◽  
Pooja Bharti ◽  
Vasundhara Bakshi
Keyword(s):  
Pediatric Population ◽  
Tertiary Care ◽  
Significant Proportion ◽  
Abdominal Tuberculosis ◽  
Childhood Tuberculosis ◽  
Diagnostic Methods ◽  
North India ◽  
Tuberculous Lymphadenitis ◽  
Tertiary Care Centre ◽  
Cross Sectional

Background: India has one of the highest TB burden globally. Children contribute a significant proportion of TB burden, in whom the diagnosis can be challenging because many childhood diseases mimic TB. Therefore, a high index of suspicion is required for early diagnosis of childhood tuberculosis to prevent poor outcome. Objectives was to evaluate the prevalence and profile of childhood tuberculosis cases and to determine the risk factorsMethods: An observational cross-sectional study was conducted over a period of 6 months at a hospital in north India and the prevalence and profile of the children admitted with the clinical suspicion of tuberculosis was studied. Case specific diagnostic approach was used for diagnosis and the appropriate treatment was instituted.Results: The prevalence of childhood TB was 2.3% among hospitalized children. Of these, 66.5% were males and 33.49% were females. The majority of cases were more than 8 years. The history of contact was present only in 31.1%. Tuberculin skin test was positive in 53.11%. Pulmonary tuberculosis was the most common type of childhood tuberculosis (45.45%) followed by neurological tuberculosis (42.8%), abdominal tuberculosis (6.45%), tuberculous lymphadenitis (2.63%), others (2.61%). Malnutrition was a potent contributing factor present in 91.86%. The mortality rate observed in the study was 9.56%.Conclusions: Owing to the high burden of tuberculosis among pediatric population in India, there is an alarming need to develop more economical and advanced diagnostic methods for better patient management and above all there is urgent need of the hour to educate the masses about the transmission and risk factors for this disease.

scholarly journals CARDIAC MANIFESTATIONS IN DENGUE FEVER: A CROSS SECTIONAL STUDY FROM A TERTIARY CARE CENTRE OF NORTH INDIA

2019 ◽  
Vol 6 (17) ◽  
pp. 1300-1305
Author(s):  
Mansi Singh ◽  
Ajay Kumar ◽  
Sanjay Mehrotra ◽  
Virendra Atam ◽  
Ravi Mishra ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
North India ◽  
Care Centre ◽  
Sectional Study ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Cardiac Manifestations

scholarly journals A Study of Serum Calcium and Magnesium Levels in Idiopathic Epilepsy Patients of Hubli, Karnataka, India

2021 ◽  
Vol 8 (25) ◽  
pp. 2187-2191
Author(s):  
Chandrashekar Kachapur ◽  
Seetaram N. Kallimani ◽  
Gayathri B.H ◽  
Ishwar S. Hasabi ◽  
Zahura M. Devarhoru
Keyword(s):  
Serum Calcium ◽  
Calcium Influx ◽  
Serum Magnesium ◽  
Idiopathic Epilepsy ◽  
Total Serum ◽  
Cross Sectional ◽  
Total Serum Calcium ◽  
Study Results ◽  
Significant Difference ◽  
Calcium And Magnesium

BACKGROUND Magnesium is a potential modulator of seizure activity because of its ability to antagonize the excitatory calcium influx through N-methyl-D-aspartate (NMDA) receptor which is thought to play a role in many human forms of epilepsy. When the extracellular concentration of calcium ion falls below normal, the nervous system becomes more excitable, allowing easy initiation of action potentials. Consequently, hypocalcaemia causes seizures because of its action of increasing excitability in the brain. We wanted to estimate the serum concentration of calcium and magnesium in idiopathic epilepsy patients and its co-relation. METHODS 94 cases of idiopathic epilepsy with breakthrough seizures admitted to KIMS Hospital, Hubli, meeting the inclusion criteria were considered for the study which was for 2-years’ time period. It’s a single centred, time bound and cross sectional study. RESULTS Mean serum calcium was low 8.36 ± 0.45 mg / dL and mean serum magnesium was 1.79 ± 0.28 mg / dL. 64.9 % had total serum calcium less than 8.5 mg / dL and 44.7 % had serum magnesium of < 1.8 mg / dL. 35.1 % had both low calcium and magnesium. There was significant difference in mean serum calcium with respect to number of episodes. There was no significant difference in mean serum magnesium with respect to number of episodes. CONCLUSIONS Serum calcium and magnesium levels which play a role in seizure initiation should be measured in all idiopathic epilepsy patients with breakthrough seizures as a seizure trigger. Considering the role of calcium and magnesium in the pathophysiology of seizures and by evaluating the results from the present study, breakthrough seizure could be provoked by hypocalcaemia and hypomagnesemia. Hence they may be used for the treatment of intractable seizures. KEYWORDS Calcium, Magnesium, Idiopathic Epilepsy

scholarly journals A study of maternal serum calcium and serum magnesium levels in pre-eclamptic and normotensive pregnancies

2020 ◽  
Vol 9 (8) ◽  
pp. 3129
Author(s):  
Pranshi Gupta
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Serum Magnesium ◽  
Maternal Serum ◽  
Magnesium Level ◽  
Serum Magnesium Level ◽  
Related Factors ◽  
Calcium And Magnesium ◽  
Major Factors

Background: Hypertensive disorders are major factors responsible for morbidity and mortality in pregnancy and pre-eclampsia is the leading cause. The etiopathology of pre-eclampsia is not known even after significant research done on it. A strong strategy in its management is to try to reduce the incidence and severity by predicting its occurrence. In this study, the effect of serum calcium and serum magnesium levels is being investigated with occurrence pre-eclampsia.Methods: Total 120 pregnant patients attending Tirath Ram Shah Hospital were included in the study. They were divided into two groups namely normotensive and hypertensive of 60 each. The serum calcium and serum magnesium levels were estimated and the correlation of these levels was studied with the pre-eclampsia related factors. The data was analysed by application of statistical test of significance.Results: Mean serum calcium level in the normotensive group was 10.119±1.27 mg/dl while mean serum calcium level in the hypertensive group was 9.461±1.164. Mean serum magnesium level in the normotensive women in the study was 1.979±0.405 mg/dl. In the hypertensive women, mean serum magnesium level was 1.723±0.414 mg/dl.Conclusions: This study shows that low levels of calcium and magnesium are found in serum of pre-eclampsia patients as compared to normotensive cases of the study population. The severity of pre-eclampsia is inversely proportional to the levels of serum calcium and magnesium.

scholarly journals A comparative study of serum calcium, magnesium and LDH as the best predictor for severity of pregnancy induced hypertension in the rural population

2017 ◽  
Vol 6 (10) ◽  
pp. 4652
Author(s):  
Mehul Salve ◽  
Aditi Rajgire
Keyword(s):  
Comparative Study ◽  
Serum Calcium ◽  
Magnesium Deficiency ◽  
Serum Magnesium ◽  
Serum Levels ◽  
Normal Pregnancy ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Calcium And Magnesium ◽  
In Pregnancy

Background: Hypertensive disorders of pregnancy are one of the commonly encountered problem by obstetrician of which, pregnancy induced hypertension leads the list. A number of dietary deficiencies or excesses have been blamed as the cause for preeclampsia over centuries. Studies have shown relationship between dietary deficiencies and incidence of preeclampsia. The lowering of serum calcium and the increase of intracellular calcium can cause an elevation of blood pressure in preeclamptic mothers. Recent investigations suggest that magnesium deficiency could play an important role in the pathogenesis of preeclampsia, particularly in regulating the tonus of arterioles and veins. The relationship of serum leptin and lactate dehydrogenase levels were increased in preeclampsia.Methods: A comparative study to evaluate the levels of serum calcium and serum magnesium and LDH in pregnancy induced hypertension and normal pregnancy and to correlate the serum levels of calcium and magnesium and LDH with the pregnancy induced hypertension.Results: The serum calcium and magnesium has significantly decreased in cases as compared to controls. Whereas the levels of LDH was significantly increased in cases compared to controls. Serum calcium decreased in severe PIH cases compared to mild PIH cases but statistically not significant. Serum magnesium in mild PIH is less compared to severe PIH cases. The decrease is not statistically significant. The increase in LDH in mild case is less compared to severe PIH case. The increase is stastically significant.Conclusion: Routine biochemical evaluation of serum concentration of calcium and magnesium early in pregnancy may be helpful in identifying at risk patients for preeclampsia. Hypocalcemia and Hypomagnesemia in patients with pregnancy induced hypertension may have a cause and effect relationship with the disorder. Amongst the biochemical markers studied LDH level was seen as the best predictor of severity of pregnancy induced hypertension.

scholarly journals Assessment of Depression, Anxiety, and Sleep Disturbance in COVID-19 Patients at Tertiary Care Centre of North India

2021 ◽  
Author(s):  
Ramakant Yadav ◽  
Prashant Yadav ◽  
Sushil Shukla Kumar ◽  
Raj Kumar
Keyword(s):  
Sleep Disturbance ◽  
Tertiary Care ◽  
Severity Of Illness ◽  
Cross Sectional Study ◽  
Psychological Problems ◽  
North India ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Patient Health ◽  
Novel Coronavirus

Abstract Background and Objective The novel Coronavirus pandemic surfaced in Wuhan, China in December 2019 and spread rapidly across the globe. In recent available literature, most of the studies were done to estimate the burden of psychiatric problems among general population due to this pandemic, Therefore, this study was planned to assess depression, anxiety, and sleep disturbance among Coronavirus disease-2019 (COVID-19) patients. Materials and Methods A hospital-based, cross-sectional study was done from June 2020 to August 2020 among 100 COVID-19 patients who were admitted and fulfilled the inclusion criteria. Assessment of depression, anxiety, and sleep disturbance were done by patient health questionnaire-9 (PHQ-9) scale, generalized anxiety disorder-7 (GAD-7) scale and Pittsburg sleep quality index (PSQI), respectively. Results In this study, 73% were males and 27% were females. The mean age of the patients in present study was 42.90 ± 16.33 years. This study reveals that depression was in 27%, anxiety in 67%, and sleep disturbance in 62% of patients. Depression and anxiety were found significantly associated with presence of comorbidity and severity of illness (p < 0 0.05). The association of sleep disturbance with severity of illness was also found statistically significant (p < 0.05). Conclusion The risk of psychological stress is high in COVID-19 patients. The psychological problems among COVID-19 patients are commonly related to the consequences of disease, and severity and contagiousness of the disease. Therefore, in this present pandemic situation, it is more important to identify these psychological problems among COVID-19 patients, so that better care and timely interventions can be done with respect to psychological issues.

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