CORECTION OF LOCAL IMUNITY AT PATIENTS WITH INFLAMATORY AND DESTRUCTIVE DISEASES OF ORAL CAVITY

<p>The purpose of the conducted research was the assessment of influence of means for an oral cavity on a basis pantogematogena and a bergenia on factors of local immunity of an oral cavity in group of healthy faces, at patients with aftosa stomatitis and lichen planus. It is revealed that in all groups of supervision after course application of means there is an increase of values of a number of indicators of local cellular and humoral immunity.</p>

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CONDITION OF CELLULAR AND HUMORAL RELATIONSHIPS OF IMMUNITY IN CANDIDA ASSOCIATED PARODONTITIS WITH MEDIUM AND HIGH DEGREE OF QUANTITATIVE REPLACEMENT OF PARADONTAL POCKETS

The actual problems in dentistry ◽

10.18481/2077-7566-2019-15-2-122-127 ◽

2019 ◽

Vol 15 (2) ◽

pp. 122-127

Author(s):

Фания Мирсаева ◽

Faniya Mirsaeva ◽

Тимур Ханов ◽

Timur Hanov

Keyword(s):

Humoral Immunity ◽

Pathogenic Bacteria ◽

Immunological Methods ◽

Immunological Study ◽

Local Immunity ◽

Humoral Factors ◽

Fungal Associations ◽

Cellular And Humoral Immunity ◽

High Degree ◽

Diagnostic Criterion

According to many researchers, the change in the course of chronic generalized periodontitis is associated with changes in the patient's immune status. As a result, colonization resistance decreases, the etiological role of opportunistic pathogens, fungal associations, which act synergistically with periodontal pathogenic bacteria and contribute to the development of candida-associated periodontitis, increases. Due to the fact that this disease has little specific symptoms, relapsing course and does not respond to standard therapy, characteristic disorders in the immune system can serve as a diagnostic criterion as well as a criterion for evaluating the effectiveness of the treatment. However, to date, this issue has not been studied, taking into account the degree of quantitative contamination of periodontal pockets with fungi of the genus Candida, which was the subject of this study. The aim is to study the state of cellular and humoral immunity during the exacerbation of candida - associated periodontitis with an average and high degree of dissemination of periodontal pockets by Candida fungi. Methodology. A survey of cellular and humoral immunity units of 25 people with intact periodontal disease and 60 patients with exacerbation of candida-associated periodontitis, taking into account the degree of dissemination of periodontal pockets by Candida fungi. Modern and informative immunological methods of research have been used, such as T and B lymphocytes and their subpopulations, phagocytic unit, humoral factors of systemic and local immunity. Results. An immunological study revealed that the exacerbation of candida-associated periodontitis is accompanied by changes in cellular and humoral immunity. The severity and nature of the changes depend on the degree of dissemination of periodontal pockets by Candida fungi. Conclusions. The obtained data on changes in the indices of cellular and humoral immunity can serve as a diagnostic criterion and a criterion for evaluating the effectiveness of the treatment being carried out.

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Assessment of cellular immunity in oil production operators with an imbalance of lipid metabolism

Russian Journal of Occupational Health and Industrial Ecology ◽

10.31089/1026-9428-2020-60-11-717-719 ◽

2020 ◽

Vol 60 (11) ◽

pp. 717-719

Author(s):

Inga N. Alikina ◽

Olga A. Kazakova

Keyword(s):

Lipid Metabolism ◽

Humoral Immunity ◽

Cellular Immunity ◽

Comparison Group ◽

Oil Production ◽

Observation Group ◽

Immunological Parameters ◽

Production Factors ◽

Cellular And Humoral Immunity ◽

Atherosclerotic Process

Introduction. Studies indicate the high pathogenetic significance of the immune component in the development of atherosclerosis. The aim of the study is a comparative assessment of immunological parameters in workers of petrochemical production with varying degrees of imbalance in lipid metabolism and the development of the atherosclerotic process. Materials and methods. Men working at an oil production enterprise in the Perm Region were examined. The observation group consisted of oil production operators with a diagnosis of atherosclerosis, the comparison group - with dyslipidemia syndrome. To determine the parameters of lipid metabolism, the results of a biochemical blood test were used. CD-immunogram parameters were identified by flow cytometry. Specific antibodies to benzene were determined by the allergosorbent method. Results. The results of a comparative study of fat metabolism confirmed violations of the physiological ratio of lipids in the blood of oil production workers, which were expressed in a significant imbalance in the levels of lipidogram. There was an increased level of specific IgG antibodies to benzene in the observation group in relation to the comparison group. An imbalance of cellular immunity was found, which was characterized by signs of indicators activation of cellular differentiation clusters. Conclusions. Studies of immune system compartments demonstrate excessive activation of cellular and humoral immunity in oil production workers under the influence of a combination of harmful production factors. The simultaneously formed imbalance of lipid metabolism is associated with various degrees of clinical manifestation of atherosclerotic disorders, with the influence of harmful production factors, aggressiveness of cellular and humoral immunity, and smoking.

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The role of probiotics in correction of microbiocenosis and cytokine balance of the oral cavity of patient with chronic inflammatory disease of periodont

Periodontology ◽

10.33925/1683-3759-2020-25-4-323-330 ◽

2020 ◽

Vol 25 (4) ◽

pp. 323-330

Author(s):

E. S. Ovcharenko ◽

V. V. Erichev ◽

S. I. Risovannij ◽

T. V. Aksenova ◽

S. V. Melekhov ◽

...

Keyword(s):

Oral Cavity ◽

Periodontal Diseases ◽

Treatment Protocol ◽

Chronic Inflammatory Disease ◽

Oral Microbiome ◽

Comprehensive Treatment ◽

Local Immunity ◽

Treatment Techniques ◽

Before And After

Relevance. A long-term inflammation in the oral cavity, unreasonable treatment of periodontal patients with antibiotics cause imbalance between certain types of fungal-bacterial associations accompanied by oral dysbiosis and change of local immune status. So, development and application of new comprehensive diagnosis and treatment techniques in periodontal patients, use of products for correction of microbiota and local immunity are a current and a long-term task. Purpose is to optimize the comprehensive treatment protocol of inflammatory periodontal diseases by introducing probiotics and evaluation of oral microbiome and cytokine profile.Materials and methods. 140 patients were examined. Of these 60 patients had chronic generalized plaque-induced gingivitis and 60 patients suffered from moderate chronic generalized periodontitis. Bacterial and fungal microbiome was assessed and the host immune response was evaluated in all patients before and after the treatment. Half of the patients were treated conventionally and the other half were treated according to a modified scheme: probiotic “Bifidumbacterin Forte” was added.Results. A large number of yeast-like fungi Candida and commensal bacteria were detected in periodontal pockets of patients with chronic generalized plaque-induced gingivitis and moderate chronic generalized periodontitis. That correlates with a significant increase of pro-inflammatory cytokines (TNF-α, IL—8), decrease of concentration of INF-γ and increase of antiinflammatory cytokine IL-4.Conclusion. Changes in clinical, microbiological and immunological values during a modified combination therapy with a probiotic and during a conventional treatment demonstrated that effectiveness of treatment of chronic gingivitis and chronic periodontitis increased by 40% and 37% respectively.

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Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin

Life ◽

10.3390/life11040298 ◽

2021 ◽

Vol 11 (4) ◽

pp. 298

Author(s):

Daniele Focosi ◽

Angelo Genoni ◽

Ersilia Lucenteforte ◽

Silvia Tillati ◽

Antonio Tamborini ◽

...

Keyword(s):

Humoral Immunity ◽

Cross Reactivity ◽

Clinical Severity ◽

World Health ◽

Laboratory Findings ◽

Cellular And Humoral Immunity ◽

Rate Ratios ◽

Original Antigenic Sin

Antibody-dependent enhancement (ADE) of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) infection has been hypothesized. However, to date, there has been no in vitro or in vivo evidence supporting this. Cross-reactivity exists between SARS CoV-2 and other Coronaviridae for both cellular and humoral immunity. We show here that IgG against nucleocapsid protein of alphacoronavirus NL63 and 229E correlate with the World Health Organization’s (WHO) clinical severity score ≥ 5 (incidence rate ratios was 1.87 and 1.80, respectively, and 1.94 for the combination). These laboratory findings suggest possible ADE of SARS CoV-2 infection by previous alphacoronavirus immunity.

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The HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy

npj Vaccines ◽

10.1038/s41541-021-00304-9 ◽

2021 ◽

Vol 6 (1) ◽

Author(s):

Hyundong Jo ◽

Bong Yoon Kim ◽

So Hui Park ◽

Hyun Mi Kim ◽

Sung Ho Shin ◽

...

Keyword(s):

Humoral Immunity ◽

Broad Spectrum ◽

Protective Efficacy ◽

Foot And Mouth Disease ◽

Mouth Disease ◽

Host Defenses ◽

Vaccination Site ◽

Oil Emulsion ◽

Foot And Mouth ◽

Cellular And Humoral Immunity

AbstractCurrent foot-and-mouth disease (FMD) vaccines have significant limitations, including side effects due to oil emulsions at the vaccination site, a narrow spectrum of protective efficacy, and incomplete host defenses mediated by humoral immunity alone. To overcome these limitations, new FMD vaccines must ensure improved safety with non-oil-based adjuvants, a broad spectrum of host defenses within/between serotypes, and the simultaneous induction of cellular and humoral immunity. We designed a novel, immune-potent, recombinant protein rpHSP70-AD that induces robust cellular immunity and elicits a broad spectrum of host defenses against FMD virus (FMDV) infections. We demonstrated that an oil emulsion-free vaccine containing rpHSP70-AD mediates early, mid-term, and long-term immunity and drives potent host protection against FMDV type O and A, suggesting its potential as an FMD vaccine adjuvant in mice and pigs. These results suggest a key strategy for establishing next-generation FMD vaccines, including novel adjuvants.

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Enhancement of cellular and humoral immunity following embryonic exposure to melatonin in turkeys (Meleagris gallopavo)

General and Comparative Endocrinology ◽

10.1016/j.ygcen.2005.03.008 ◽

2005 ◽

Vol 143 (2) ◽

pp. 178-183 ◽

Cited By ~ 9

Author(s):

C.B. Moore ◽

T.D. Siopes

Keyword(s):

Humoral Immunity ◽

Meleagris Gallopavo ◽

Embryonic Exposure ◽

Cellular And Humoral Immunity

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Superior cellular and humoral immunity towards SARS-CoV-2 reference and alpha and beta VOC strains in COVID-19 convalescent as compared to the prime boost BNT162b2 vaccinated dialysis patients

Kidney International ◽

10.1016/j.kint.2021.07.006 ◽

2021 ◽

Author(s):

Arturo Blazquez-Navarro ◽

Lema Safi ◽

Toni L. Meister ◽

Constantin J. Thieme ◽

Sviatlana Kaliszczyk ◽

...

Keyword(s):

Humoral Immunity ◽

Dialysis Patients ◽

Cellular And Humoral Immunity

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IMMU-29. B-CELL-BASED VACCINE PRODUCES GLIOBLASTOMA-REACTIVE ANTIBODIES THAT CONTRIBUTE TO TUMOR CLEARANCE

Neuro-Oncology ◽

10.1093/neuonc/noab196.388 ◽

2021 ◽

Vol 23 (Supplement_6) ◽

pp. vi98-vi98

Author(s):

Brandyn Castro ◽

Mark Dapash ◽

David Hou ◽

Aida Rashidi ◽

Deepak Kanojia ◽

...

Keyword(s):

B Cells ◽

B Cell ◽

Humoral Immunity ◽

Ex Vivo ◽

Murine Models ◽

Effector Functions ◽

Tumor Bearing ◽

Tumor Clearance ◽

Cellular And Humoral Immunity

Abstract Glioblastomas (GBM) are characterized by a strong immunosuppressive environment, contributing to their poor prognosis and limited therapeutic response to immunotherapies. B-cells represent a unique opportunity to promote immunotherapy due to their potential to kill tumors by both cellular and humoral immunity. To generate our B-cell-based vaccine (BVax) platform, we activated 41BBL+ B cells from tumor bearing mice or GBM patient blood with BAFF, CD40, and IFNg. We have previously demonstrated that BVax potentiates radiation therapy, temozolomide and checkpoint blockade in murine models of GBM via enhancement of CD8+ T-cell based immunity. The aim of this current study is to evaluate the humoral effector functions of BVax. We examined the antibody (Ab) repertoire in vivo from serum of tumor-bearing B-cell knockout mice treated with BVax or by ex vivo stimulation of patient-derived BVax. Upon systemic administration, BVax infiltrates the tumor where it differentiates into plasmablasts. Murine BVax- and BNaive-derived serum immunoglobulin generated in vivo showed that the majority of murine BVax-derived Ab were IgG isotype, while BNaive mainly produced IgM isotype. Transfer of IgG from BVax treated mice directly into tumors of recipient animals significantly prolonged their survival, demonstrating anti-tumor cytotoxicity directly through humoral immunity. Patient-derived BVax activated ex vivo showed a plasmablast phenotype and the Ab repertoire supports the previous findings seen in our murine model. Our work suggests BVax-derived IgGs role in antibody-dependent cellular cytotoxicity and improved survival in murine models. This function, in addition to its role in cellular immunity against GBM, renders BVax a potentially effective alternative immunotherapeutic option for GBM patients.

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